Mechanism of metabolic memory: progression in diabetic nephropathy—a descriptive review by Farhana Begum, Karpagavel Lakshmanan

“…It involves various molecular processes causing cellular shifts, tissue and organ dysfunctions, disease progression, and effects on offspring. …”
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Proposing Bromo-Epi-Androsterone (BEA) for Post-Traumatic Stress Disorder (PTSD) by Coad Thomas Dow, Liam Obaid

“…Bromo-epi-androsterone (BEA), a synthetic analog of dehydroepiandrosterone (DHEA), has shown potent anti-inflammatory effects in clinical trials, significantly reducing IL-1β, IL-6, and TNF-α. …”
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Identification of putative allosteric inhibitors of BCKDK via virtual screening and biological evaluation by Chunqiong Li, Quanjun Yang, Li Zhang

“…Taken together, our findings highlight two novel BCKDK inhibitors as potent therapeutic candidates for metabolic diseases and cancers associated with BCAA dysfunctional metabolism.…”
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LRG1 Alters Pericyte Phenotype and Compromises Vascular Maturation by Alexandra E. Hoeh, Jui-Hsien Chang, Ronja S. Mueller, Mark Basche, Alessandro Fantin, Anastasios Sepetis, Giulia De Rossi, Athina Dritsoula, Robin R. Ali, Patric Turowski, Stephen E. Moss, John Greenwood

“…Here, we investigated the vasculopathic properties of LRG1 by examining its effect on developing retinal blood vessels. By injecting recombinant protein or an expression vector into the mouse retina during vascular development, we showed that exogenous LRG1 reduces pericyte coverage and NG2 expression. …”
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Preoperative methionine restriction induces perivascular adipose tissue browning and improves vein graft remodeling in male mice by Peter Kip, Thijs J. Sluiter, Michael R. MacArthur, Ming Tao, Nicky Kruit, Sarah J. Mitchell, Jonathan Jung, Sander Kooijman, Josh Gorham, Jonathan G. Seidman, Paul H. A. Quax, Julius L. Decano, Masanori Aikawa, C. Keith Ozaki, James R. Mitchell, Margreet R. de Vries

“…This study shows that the detrimental effects of dysfunctional PVAT on vascular remodeling can be reversed by MetR, and identifies pathways involved in MetR-induced browning of PVAT. …”
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Kawasaki like illness due to COVID-19: a review of the literature by Yulin Fang, Veeraraghavan Meyyur Aravamudan, Gurusaravanan Kutti Sridharan, Keyur Kamlesh Mehta, Ramkumar Sekhar, Nagendra Boopathy Senguttuvan, Indumathi Venkatachalam, Muhammad Bilal Abid

“…More studies are required to evaluate the effectiveness of these treatment options. …”
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Discordant CAR-T cell signaling: implications of divergence from physiological T cell activation by Pablo Gonzalez-Garcia, Noelia Moares, Isabel Serrano-García, Ricardo Fernandez-Cisnal, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Wenjie Yi-He, Juan P. Muñoz-Miranda, Antonio Gabucio, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar

“…Despite the great success and widespread presence of CAR-T cells in clinical trials, they still have some shortcomings that may stem in part from their failure to fully mimic physiological TCR-mediated T cell activation, causing dysfunctional states and impaired responses that limit their persistence and causes incomplete remission of tumors or severe side effects. …”
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Detection of viral antigen and inflammatory mediators in fatal pediatric dengue: a study on lung immunopathogenesis by Leandro Junqueira Moragas, Laíza Vianna Arruda, Laíza Vianna Arruda, Lucca de Lima Siqueira Oliveira, Felipe de Andrade Vieira Alves, Felipe de Andrade Vieira Alves, Natália Gedeão Salomão, Natália Gedeão Salomão, Jemima Fuentes Ribeiro da Silva, Carlos Alberto Basílio-de-Oliveira, Rodrigo Panno Basílio-de-Oliveira, Ronaldo Mohana-Borges, Caio Gonçalves Azevedo, Gabriela Xavier de Oliveira, Jorge José de Carvalho, Fernando Colonna Rosman, Fernando Colonna Rosman, Marciano Viana Paes, Kíssila Rabelo, Kíssila Rabelo

“…Such findings contribute to the study and description of dengue, especially its effects on lung tissue.…”
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Alpha-Lipoic Acid Protects Cardiomyocytes against Heat Stroke-Induced Apoptosis and Inflammatory Responses Associated with the Induction of Hsp70 and Activation of Autophagy by Hsin-Hsueh Shen, Yu-Shiuan Tseng, Ni-Chun Kuo, Ching-Wen Kung, Sherif Amin, Kwok-Keung Lam, Yen-Mei Lee

“…In conclusion, ALA ameliorated the deleterious effects of HS by exerting antioxidative and anti-inflammatory capacities. …”
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Treating non-motor symptoms in dystonia: a systematic review by Dana Sugar, Sarah Pirio Richardson

“…IntroductionDystonia is characterized by dysfunctional movements and postures and current treatments aim to reduce unwanted muscle activity. …”
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The intricate interplay between ferroptosis and efferocytosis in cancer: unraveling novel insights and therapeutic opportunities by Ali Ahmadizad Firouzjaei, Samira Mohammadi-Yeganeh

“…However, dysregulation of efferocytosis can have profound effects on cancer. Apoptotic cells accumulate because of impaired efferocytosis, which triggers chronic inflammation and the release of pro-inflammatory chemicals. …”
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Clinical features and long-term outcomes of idiopathic urethrorrhagia by Serdar Moralıoğlu, Ayşenur Cerrah-Celayir, Oktav Bosnalı

“…In our opinion, it seems that dysfunctional voiding and infrequent voiding might cause delayed remission and/or recurrence of urethrorrhagia. …”
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Nothing but a piano-key: populism as a consequence of relational pathology by Pavel Dufek, Pavel Dufek, Adam Ruzicka, Adam Ruzicka

“…The paper examines populism as a symptom of a dysfunctional relationship between the few (elites) and the many (the masses) in liberal democracies. …”
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Interconnections between governance shortcomings and resource curse in a resource-dependent economy by Fisayo Fagbemi, Richard Angelous Kotey

“…Findings – Findings support the notion that overreliance on natural resources could exacerbate the growing number of dysfunctional economic outcomes in the country. The study confirms that a mix of weak governance quality and natural resource rents could have a negligible effect on economic growth and possible retardation impact on the economy in the long run as well as in the short run. …”
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Chronic endometritis and reproductive disorders: versions and contraversions (review) by O. Ya. Leshchenko

“…Among married couples of childbearing age, the frequency of infertility in different regions of Russia and the world ranges from 10 to 21%. The effectiveness of the results of in vitro fertilization (IVF) and embryo transfer is determined by two factors: the functional completeness of the embryo at the blastocyst stage and the absence of intrauterine pathology. …”
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Insomnia in patients undergoing Autologous Hematopoietic Stem Cell Transplantation by Mayra Veronese, Federica Lacarbonara

“… Background: Insomnia has an elevated incidence in patients who receive autologous Hematopoietic Stem Cell Transplantation (HSCT), which can lead to psychic and physical dysfunctions and impair immunological and neuroendocrine processes, hence compromising the response to treatment. …”
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Shikonin Inhibits Endoplasmic Reticulum Stress-Induced Apoptosis to Attenuate Renal Ischemia/Reperfusion Injury by Activating the Sirt1/Nrf2/HO-1 Pathway by Qian Huang, Zilu Shi, Dandan Zheng, Huiqin Chen, Qiuhong Huang

“…Results: For in vivo analysis, renal dysfunctions and tissue structural damage induced by I/R were relieved by shikonin. …”
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Cell-Mediated Immune Responses in Paraneoplastic Neurological Syndromes by Mikolaj Piotr Zaborowski, Slawomir Michalak

“…Paraneoplastic neurological syndromes (PNS) are disorders of the nervous system that are associated with remote effects of malignancy. PNS are considered to have an autoimmune pathology. …”
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The role of textured material in supporting perceptual-motor functions. by Dominic Orth, Keith Davids, Jon Wheat, Ludovic Seifert, Jarmo Liukkonen, Timo Jaakkola, Derek Ashford, Graham Kerr

“…No effect was shown for walking tasks: Tau(2) = 0.00; Chi(2) = 3.45, df = 4, P = 0.27, I(2) = 22.99%. …”
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Quercetin activates energy expenditure to combat metabolic syndrome through modulating gut microbiota-bile acids crosstalk in mice by Xiaoqiang Zhu, Xiaojuan Dai, Lijun Zhao, Jing Li, Yanhong Zhu, Wenjuan He, Xinlei Guan, Tao Wu, Li Liu, Hongping Song, Liang Lei

“…In this study, we investigated the potential roles of gut microbiota-bile acids (BAs) interactions in quercetin-induced anti-obesity effects and metabolic benefits. Oral administration of quercetin significantly enhanced energy metabolism through activating thermogenesis of brown adipose tissues (BAT) and browning of white adipose tissues (WAT), thus mitigating metabolic dysfunctions in an abdominal obesity-related MetS mouse model. …”
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