A heat-shocked melanoma cell lysate vaccine enhances tumor infiltration by prototypic effector T cells inhibiting tumor growth by María Alejandra Gleisner, Cristián Pereda, Andrés Tittarelli, Mariela Navarrete, Camila Fuentes, Ignacio Ávalos, Fabian Tempio, Juan Pablo Araya, María Inés Becker, Fermín Eduardo González, Mercedes Natalia López, Flavio Salazar-Onfray

“…Optimal delivery of multiple tumor-associated antigens combined with potent adjuvants seems to be crucial for vaccine effectiveness.Methods Here, a prototype for a generic melanoma vaccine, named TRIMELVax, was tested using B16F10 mouse melanoma model. …”
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The Coaching for Cognition in Alzheimer's (COCOA) trial: Study design by Jared C. Roach, Junko Hara, Deborah Fridman, Jennifer C. Lovejoy, Kathleen Jade, Laura Heim, Rachel Romansik, Adrienne Swietlikowski, Sheree Phillips, Molly K. Rapozo, Maria A. Shay, Dan Fischer, Cory Funk, Lauren Dill, Michael Brant‐Zawadzki, Leroy Hood, William R. Shankle

“…AD and other dementias result from the interplay of multiple interacting dysfunctional biological systems. Monotherapies have had limited success. …”
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Enhanced Anti-Melanoma Activity of Nutlin-3a Delivered via Ethosomes: Targeting p53-Mediated Apoptosis in HT144 Cells by Arianna Romani, Giada Lodi, Fabio Casciano, Arianna Gonelli, Paola Secchiero, Giorgio Zauli, Olga Bortolini, Giuseppe Valacchi, Daniele Ragno, Agnese Bondi, Mascia Benedusi, Elisabetta Esposito, Rebecca Voltan

“…The expression of these molecules is known to be altered or dysfunctional in a large percentage of melanoma tumors. …”
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Cardiovascular-kidney-metabolic syndrome definition and its role in the prevention, risk staging, and treatment. An opportunity for the Nephrology by Aleix Cases, Jose Jesus Broseta, Maria Marqués, Secundino Cigarrán, Juan Carlos Julián, Roberto Alcázar, Alberto Ortiz

“…The recent conceptualization of the cardiovascular-kidney-metabolic (CKM) syndrome by the American Heart Association (AHA) opens an opportunity for a multidisciplinary and lifelong approach in the risk stratification, early prevention, and treatment of the vicious circle generated by the interaction of cardiovascular, renal and metabolic risk factors and aggravated by the development of cardiovascular diseases (including their full spectrum: heart failure, atrial fibrillation, coronary heart disease, stroke, and peripheral arterial disease), chronic kidney disease or type 2 diabetes mellitus, with the excess or dysfunctional adiposity as the trigger. Three publications offer the rational basis of a conceptual decalogue and action plan and a new cardiovascular risk stratification equation since the age of 30 that includes measures of renal function/damage, among others, to promote effective cardiovascular, renal, and metabolic prevention. …”
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Hypoxia-driven angiogenesis and metabolic reprogramming in vascular tumors by Lu Liu, Lu Liu, Lu Liu, Lu Liu, Lu Liu, Jiayun Yu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Yang Liu, Liang Xie, Liang Xie, Liang Xie, Liang Xie, Liang Xie, Fan Hu, Fan Hu, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu, Hanmin Liu

“…This includes the upregulation of pro-angiogenic factors like VEGF, which promotes the formation of dysfunctional blood vessels, contributing to the worsening of the hypoxic microenvironment. …”
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Nontargeted and targeted metabolic profile of metabolic syndrome patients: a study based on Yi and Han populations in Yunnan by Yanmei Ji, Ni Guo, Wenjun Li, Xianyu He, Mengyao Dao, Ni Meng, Dan Zhou, Haitao Tian, Ting Pi, Xiaofeng Zong, Qing Xiong, Zhongjuan Wang, Xingfang Jin

“…In the Yi population, six differential amino acids were identified, with significant enrichment in D-glutamine and D-glutamate metabolism, sulfur metabolism, and valine, leucine, and isoleucine biosynthesis.ConclusionOur study investigates metabolic differences in metabolic syndrome (MS) between Yi and Han populations through nontargeted and targeted metabolomics approaches, identifying both common and unique metabolites and metabolic pathways associated with MS, especially amino acid metabolic disorders, including glycine, serine, and threonine metabolism, D-glutamine and D-glutamate metabolism, which may play critical roles in regulating different metabolic dysfunctions and worth further exploration in MS pathogenesis, which might provide insights for the effective prevention and treatment of MS in various populations.…”
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Dual diagnosis of UQCRFS1-related mitochondrial complex III deficiency and recessive GJA8-related cataracts by Elizabeth E. Blue, Samuel J. Huang, Alyna Khan, Katie Golden-Grant, Brenna Boyd, Elisabeth A. Rosenthal, Madelyn A. Gillentine, Leah R. Fleming, David R. Adams, Lynne Wolfe, Aimee Allworth, Michael J. Bamshad, Nikeisha J. Caruana, Sirisak Chanprasert, Jingheng Chen, Nitsuh Dargie, Daniel Doherty, Marisa W. Friederich, Fuki M. Hisama, Martha Horike-Pyne, Jessica C. Lee, Tonia E. Donovan, Daniella H. Hock, Kathleen A. Leppig, Danny E. Miller, Ghayda Mirzaa, Jane Ranchalis, Wendy H. Raskind, Cole R. Michel, Richard Reisdorph, Ulrike Schwarze, Sam Sheppeard, Samuel Strohbehn, David A. Stroud, Virginia P. Sybert, Mark H. Wener, Andrew B. Stergachis, Christina T. Lam, Gail P. Jarvik, Katrina M. Dipple, Johan L.K. Van Hove, Ian A. Glass

“…A multi-modal approach combining enzyme assays and cellular proteomics analysis provided clear evidence of complex III respiratory chain dysfunction and low abundance of the Rieske iron-sulfur protein, validating the pathogenic effect of the UQCRFS1 variant. …”
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Analysis and comparison of the trends in burden of spinal cord injury in China and worldwide from 1990 to 2021: an analysis of the global burden of disease study 2021 by Hao Qin, Yuhang Diao, Mingyu Hao, Zhitan Wang, Minghao Xie, Xiaojun Hu, Tao Zhu

“…BackgroundSpinal cord injury (SCI) is a globally prevalent neurological condition, often resulting in motor, sensory, and autonomic dysfunctions that lead to permanent disability. However, outdated epidemiological data hinder the development and implementation of effective public health policies. …”
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Elabela alleviates cuproptosis and vascular calcification in vitaminD3- overloaded mice via regulation of the PPAR-γ /FDX1 signaling by Rui-Qiang Qi, Yu-Fei Chen, Jing Cheng, Jia-Wei Song, Yi-Hang Chen, Si-Yuan Wang, Ying Liu, Kai-Xin Yan, Xiao-Yan Liu, Jing Li, Jiu-Chang Zhong

“…Elabela supplementation and cuproptosis suppression serve as effective therapeutic approaches for managing vascular calcification and related cardiovascular disorders.…”
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A photodynamic nanohybrid system reverses hypoxia and augment anti-primary and metastatic tumor efficacy of immunotherapy by Haitao Yuan, Xiaoxian Wang, Xin Sun, Di Gu, Jinan Guo, Wei Huang, Jingbo Ma, Chunjin Fu, Da Yin, Guohua Zeng, Ying Long, Jigang Wang, Zhijie Li

“…Photodynamic immunotherapy is a promising strategy for cancer treatment. However, the dysfunctional tumor vasculature results in tumor hypoxia and the low efficiency of drug delivery, which in turn restricts the anticancer effect of photodynamic immunotherapy. …”
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ZNFX1 suppresses apoptosis-associated mRNA stability in cardiomyocyte to protect against myocardial infarction by Yang Shi, Zeqi Sun, Yongchao Chen, Yanli Xie, Chen Chen, Han Lou, Jan Mohammad Omar, Lei Wang, Ling Liu, Heng Liu, Limin Zhao, Henghui Xu, Xiaohan Li, Run Xu, Zhouxiu Chen, Khuzin Dinislam, Yong Zhang, Xin Liu

“…Overexpression of ZNFX1 significantly attenuated myocardial dysfunction, reduced infarct size, inhibited collagen deposition and alleviated cardiac hypertrophy which was ascribed to MI in mice, whereas knockdown of ZNFX1 produced the opposite effects. …”
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Better public housing management in Ghana by Samson Aziabah

“…They make reference to leaking roofs, rotten ceilings, cracked walls, faded paint, and dysfunctional electrical and plumbing systems, among other problems in public housing. …”
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Kesesuaian Tujuan, Perilaku Disfungsional Rekan Kerja, Asimetri Informasi sebagai Prediktor Disfungsional Bawahan (Studi Empiris pada Manajer Pemasaran) by Se Tin .

“…In turn, role conflict increases job tension and job tensions increases the extent of dysfunctional behavior. However, no effects for the person-role conflict/dysfimctional behavior link were found. …”
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A mediating role of interpersonal sensitivity in the relationship between schematic mentalities and incompatible conflict resolution in single-parent women by negar razeghi, akram dehghani, shahrbanoo Ghahari, abbas haghayegh

“…Schema modes had a direct effect on dysfunctional conflict resolution and an indirect effect through interpersonal sensitivity as a mediator (p< 0.05). …”
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Ribonucleases in Mendelian disease: Characterization and insight from model organisms by Annasha Dutta, Anastasiia Zaremba, Paulina Jackowiak

“…These models are vital for uncovering rare molecular dysfunctions and potential therapeutic targets, demonstrating the effectiveness of integrated research approaches in addressing complex genetic disorders. …”
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A biochemical screening platform to target chromatin states using condensates as a tool by Laura J. Hsieh, Tracy Lou, Muryam A. Gourdet, Emily Wong, Geeta J. Narlikar

“…Chromatin states define cell fates and consequently dysfunctional chromatin states drive disease. Conventional approaches to target dysfunctional chromatin states typically rely on targeting a defined, structured binding pocket of a specific chromatin protein. …”
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Androgens and Female Sexuality: Molecular Insights, Neuroendocrine Crosstalk and Future Therapeutic Directions by Giulia Montan, Massimo Carollo, Luciano Torres, Giovanni Buzzaccarini, Andrea Giannini, Andrea Etrusco, Erich Cosmi, Marcello Rigano, Vito Chiantera, Antonio Simone Laganà, Gaspare Cucinella, Giuseppe Gullo

“…Currently, there are limited androgen therapies available for women, and the evidence for their effectiveness and safety is still limited. Conclusions: The knowledge of neuroendocrine interactions that underlie sexual arousal and pleasure is rapidly expanding, and ongoing research is striving to develop more appropriate clinical practices for managing sexual dysfunctions in women.…”
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Reproductive Health of Female Patients with Connective Tissue Dysplasia by Irina V. Karachentsova, Anastasia V. Goryainova, Elena V. Sibirskaya, Marina Yu. Alekhina, Amina F. Askerova

“…The analysis of original studies on this topic has revealed that connective tissue dysplasia has significant effect on female reproductive function development and can be complicated by various menstrual dysfunctions (hypomenorrhea syndrome, oligomenorrhea, opsomenorrhea, uterine bleedings, and secondary amenorrhea) as well as by endocrine changes (anti-Mullerian hormone deficiency, hypoprolactinaemia, hypoestrogenemia, etc.). …”
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Induction of a Transient Dysexecutive Syndrome in Parkinson’s Disease using a Subclinical Dose of Scopolamine by M. A. Bédard, S. Lemay, J. F. Gagnon, H. Masson, F. Paquet

“…Parkinson’s Disease (PD) is often associated with a subcortico-frontal syndrome (SCFS) that is mainly characterized by executive dysfunctions. The complete biochemistry of these dysfunctions remain misunderstood although many studies have suggested a role of the dopaminergic lesions. …”
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Causal Model of Aggression based on Personality Traits, Early Maladaptive Schema and Aggression: Mediating Role of Emotion Regulation Strategies by Shila Mohseni, Majid Barzegar, Azarmidokht Rezaei, Hossein Baghooli

“…In addition, the personality trait of agreeableness had a negative direct effect, while the schemas of abandonment, social isolation, failure, emotional inhibition, and entitlement had a positive direct effect on aggression. …”
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