Dysregulated inflammation, oxidative stress, and protein quality control in diabetic HFpEF: unraveling mechanisms and therapeutic targets by Simin Delalat, Innas Sultana, Hersh Osman, Marcel Sieme, Saltanat Zhazykbayeva, Melissa Herwig, Heidi Budde, Árpád Kovács, Mustafa Kaçmaz, Eda Göztepe, Natalie Borgmann, Gelareh Shahriari, Benjamin Sasko, Jan Wintrich, Peter Haldenwang, Wolfgang E. Schmidt, Wiebke Fenske, Muchtiar Khan, Kornelia Jaquet, Andreas Mügge, Domokos Máthé, Viktória E. Tóth, Zoltán V. Varga, Péter Ferdinandy, Ibrahim El-Battrawy, Loek van Heerebeek, Nazha Hamdani

“…HFpEF predominantly affects elderly individuals and women, and is characterized by dysfunctions associated with metabolic, inflammatory, and oxidative stress pathways. …”
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The function of T cells in immune thrombocytopenia by Siyuan Bu, Siyuan Bu, Min Liu, Min Liu, Lu Yang, Pamela Lee, Heather Miller, Chan-Sik Park, Maria Byazrova, Alexander Filatov, Kamel Benlagha, Timo Gaber, Timo Gaber, Frank Buttgereit, Frank Buttgereit, Quan Gong, Zhimin Zhai, Chaohong Liu

“…New therapies targeting T cells have emerged as potentially effective cures for this disease. This review summarizes the role of T cells in ITP.…”
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Identifying potential drugs for treating Cardiovascular-kidney metabolic syndrome via reverse network pharmacology by Si’ao Wen, Si’ao Wen, Si’ao Wen, Si’ao Wen, Si’ao Wen, Ao’ni Fu, Fen Liu, Fen Liu, Fen Liu, Fen Liu, Fen Liu, Yayu You, Yayu You, Yayu You, Yayu You, Yayu You, Linkai Li, Linkai Li, Linkai Li, Linkai Li, Linkai Li, Wen Xiao, Wen Xiao, Wen Xiao, Wen Xiao, Wen Xiao, Haoran Zhong, Xiuqin Hong, Xiuqin Hong, Xiuqin Hong, Xiuqin Hong, Xin Zhong, Yongjun Hu, Zhengyu Liu, Zhengyu Liu, Zhengyu Liu, Zhengyu Liu, Zhengyu Liu

“…In vivo experiments demonstrated that the “two-hit” HFpEF model, which is induced by a high-fat diet combined with L-NAME treatment for 12 weeks and is characterized by metabolic disorders, cardiac diastolic dysfunction, and renal fibrosis, can be used as a new model of CKM. …”
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Facing depression: evaluating the efficacy of the EmpkinS-EKSpression reappraisal training augmented with facial expressions – protocol of a randomized controlled trial by Marie Keinert, Lena Schindler-Gmelch, Lydia Helene Rupp, Misha Sadeghi, Klara Capito, Malin Hager, Farnaz Rahimi, Robert Richer, Bernhard Egger, Bjoern M. Eskofier, Matthias Berking

“…Abstract Background Dysfunctional depressogenic cognitions are considered a key factor in the etiology and maintenance of depression. …”
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Enhanced Antitumor Immunity Through T Cell Activation with Optimized Tandem Double-OX40L mRNAs by Deng Z, Tian Y, Wang J, Xu Y, Liu Z, Xiao Z, Wang Z, Hu M, Liu R, Yang P

“…The diOX40L mRNAs were encapsulated into lipid nanoparticles (LNPs) for effective delivery. The research explored its safety and antitumor effects through a series of in vivo and in vivo experiments.Results: Our results demonstrate that diOX40L mRNAs efficiently express increased levels of OX40L proteins. …”
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Aminoguanidine hemisulfate improves mitochondrial autophagy, oxidative stress, and muscle force in Duchenne muscular dystrophy via the AKT/FOXO1 pathway in mdx mice by Shiyue Sun, Tongtong Yu, Joo Young Huh, Yujie Cai, Somy Yoon, Hafiz Muhammad Ahmad Javaid

“…Abstract Background Duchenne muscular dystrophy (DMD) is a prevalent, fatal degenerative muscle disease with no effective treatments. Mdx mouse model of DMD exhibits impaired muscle performance, oxidative stress, and dysfunctional autophagy. …”
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Laboratory diagnostics performance in Uganda: A survey of test availability and constraints by Noel Namuhani, Suzanne Namusoke Kiwanuka, Martha Akulume, Simeon Kalyesubula, William Bazeyo, Angela Nakanwagi Kisakye

“…Introduction: Clinical laboratory services are a critical component of the health system for effective disease diagnosis, treatment, control and prevention. …”
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Prevalence and factors associated with physical activity in adolescents from five secondary schools in northern Peru by Mario J. Valladares-Garrido, Palmer J. Hernández-Yépez, Sebastián Arámbulo-Castillo, Luz A. Aguilar-Manay, Jassmin Santin Vásquez, Darwin A. León-Figueroa, Víctor J. Vera-Ponce, Danai Valladares-Garrido, Edwin Aguirre-Milachay, Virgilio E. Failoc-Rojas, César J. Pereira-Victorio

“…In contrast, frequent use of social networks (PR: 0.72), moderate (PR: 0.64) or severe (PR: 0.66) family dysfunctionality, medium (PR: 0.85) and low (PR: 0.80) levels of self-esteem, and an extreme effect on quality of life due to acne (PR: 0.66) were negatively associated with physical activity. …”
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Melatonin mediates the BMP4/MAPK signaling pathway to alleviate zearalenone-induced abnormal embryonic development in mice by Mengyao Wang, Zhixin Pu, Jing Zhang, Peiwen Wang, Yaxin Chen, Yating Zhu, Hongzhen Ruan, Dongmei Ji, Weiwei Zou, Huiru Cheng, Zhiming Ding, Yunxia Cao, Yajing Liu, Dan Liang

“…Furthermore, melatonin effectively mitigates the harmful effects of ZEA exposure by reducing reactive oxygen species (ROS) levels, preventing mitochondrial dysfunction, and decreasing cell apoptosis. …”
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In-depth analysis of the safety of CAR-T cell therapy for solid tumors by Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiayi Dong, Jiexiong Wu, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Ye Jin, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Zhu Zheng, Ting Su, Ting Su, Ting Su, Ting Su, Ting Su, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Lijuan Shao, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Jiaxin Bei, Size Chen, Size Chen, Size Chen, Size Chen, Size Chen

“…The long-term adverse effects and challenges in treating solid tumors underscore the need for ongoing research. …”
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Mental Illness Strikes at the Heart: Impact of Psychiatric Diseases on Ventricular Ejection Fraction in Patients with Acute Coronary Syndromes by Marianna Mazza, Giorgio Veneziani, Francesco Maria Lisci, Sofia Morini, Gianandrea Traversi, Greta Sfratta, Caterina Brisi, Maria Benedetta Anesini, Francesca Bardi, Elisabetta Benini, Claudia Calderoni, Luca Chisari, Arianna Crupi, Emanuela De Chiara, Luca Lo Giudice, Luca Onori, Ilenia Sessa, Marta Balocchi, Roberto Pola, Eleonora Gaetani, Benedetta Simeoni, Francesco Franceschi, Gabriele Sani, Marcello Covino, Carlo Lai, Enrico Romagnoli, Giuseppe Marano

“…A critical aspect of this interplay is the effect of psychiatric conditions on left ventricular ejection fraction (LVEF), a key parameter in evaluating cardiac function and predicting long-term outcomes in ACS patients. …”
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Inhibition of Cbl-b restores effector functions of human intratumoral NK cells by Alfred Zippelius, Mélanie Buchi, Petra Herzig, Heinz Läubli, Kirsten D Mertz, Viola Heinzelmann-Schwarz, Didier Lardinois, Marina Natoli, Clara Serger, Alberto Toso, Nicole Brodmann, Sofia Tundo, Marcel Trefny, Andrijana Rodić, Olivia Grueninger, Anastasiya Börsch, Jonas Fürst, Katarzyna Buczak, Alex T Müller, Lisa Sach-Peltason, Leyla Don, Aljaž Hojski, Karin Schaeuble, Thuy T Luu, Andrea Romagnani

“…After compound validation, we investigated the effect of the top performing compounds on dysfunctional NK cells that were generated by a newly developed in vitro platform. …”
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The infection characteristics and autophagy defect of dermal macrophages in STZ‐induced diabetic rats skin wound Staphylococcus aureus infection model by Xiaoying Xie, Rihui Zhong, Ling Luo, Xianghua Lin, Lisi Huang, Songyin Huang, Lijia Ni, Baiji Chen, Rui Shen, Li Yan, Chaohui Duan

“…Further understanding of the special immune crosstalk between diabetes host and S. aureus infection through autophagic factors will help to explain the complex clinical phenomenon and guarantee the development of effective therapies for diabetic foot infections.…”
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Cognitive and social functions of craniopharyngioma and germ cell tumor differ in patients with and without apathy by Ami Tabata, Keita Ueda, Katsutsugu Umeda, Takeshi Funaki, Tsukasa Ueno, Yohei Mineharu, Masahiro Tanji, Takayuki Kikuchi, Misa Komaki, Susumu Miyamoto, Toshiya Murai, Yoshiki Arakawa

“…Conclusion Apathy manifests as a neuropsychological complication and affects social functions in patients with diencephalon tumors. Effective interventions for apathy may ameliorate the social dysfunctions of patients with diencephalon tumors.…”
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SPP1 + macrophages cause exhaustion of tumor-specific T cells in liver metastases by Rajiv Trehan, Patrick Huang, Xiao Bin Zhu, Xin Wang, Marlaine Soliman, Dillon Strepay, Amran Nur, Noemi Kedei, Martin Arhin, Shadin Ghabra, Francisco Rodríguez-Matos, Mohamed-Reda Benmebarek, Chi Ma, Firouzeh Korangy, Tim F. Greten

“…Abstract Functional tumor-specific CD8+ T cells are essential for effective anti-tumor immune response and immune checkpoint inhibitor therapy. …”
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Identification of Urban Worn-Out Textures and Prioritization of Organizing Strategies through Remote Sensing Performance and BWM Method Combination: (A Case Study: Zanjan City) by Mohsen AHADNEJAD REVESHTY, Mohammad Taghi HEYDARI, Mohammad RASOOLI

“…Hence, this study tried to provide the latest method of information on urban worn-out textures with a new method and identify areas prone to becoming dysfunctional textures. For this purpose, Landsat 8 satellite images (December 2020) have been used. …”
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FTO (fat-mass and obesity-associated protein) deficiency aggravates age-dependent depression-like behaviors and cognitive impairment by Mengdie Li, Yating Yang, Tangcong Chen, Yueyang Luo, Yingqian Zhang, Huanzhong Liu, Michael Maes

“…This suggests that the development of FTO activators may be an effective treatment for depression in older adults.…”
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The impact of intradialytic elastic band exercise on physical and cognitive abilities in patients on maintenance hemodialysis: a randomized controlled trial by Xianxuan Feng, Jingwen Sun, Zihan Wang, Nina Zhang, Yumei Liu, Zhenhong Wang, Niansong Wang, Guihua Jian, Dongsheng Cheng, Xiaohua Sheng, Yanhong Ma

“…Exercise benefits patients on maintenance hemodialysis (MHD) by addressing complications and dysfunctions. Elastic band exercise is cost-effective, but its safety, efficacy, and feasibility during dialysis are not well-established. …”
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Dehydroacteoside rejuvenates senescence via TVP23C-CDRT4 regulation by Yoo Jin Lee, Eun Seon Song, Yun Haeng Lee, Kyeong Seon Lee, Byeonghyeon So, Ji Ho Park, Jee Hee Yoon, Duyeol Kim, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Ki Yong Lee, Joon Tae Park

“…One of the major factors inducing senescence is reactive oxygen species (ROS) produced from dysfunctional mitochondria. Therapeutic strategies that reduce mitochondrial ROS generation are considered essential for rejuvenating senescence, but effective methods have not yet been established. …”
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VULVAR AND VAGINAL GRAFT VERSUS HOST DISEASE IN A PATIENT WITH CHRONIC PHASE CHRONIC MYELOID LEUKEMIA AFTER ALLOGENEIC STEM CELL TRANSPLANTATION by Esra Pirinççi, M. Orhan Ayyıldız, Abdullah Karakuş, Reyhan Gündüz

“…In addition, studies have shown that hormone replacement therapy is used for the prophylaxis of this condition does not effects development rate of vulvo vaginal GVHD (11). …”
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