Disrupted calcium dynamics and electrophysiological activity in the stratum pyramidale and hippocampal alveus during fear conditioning in the 5xFAD model of Alzheimer’s disease by Alexander Erofeev, Alexander Erofeev, Egor Vinokurov, Anastasia Bol’shakova, Ilya Bezprozvanny, Ilya Bezprozvanny, Olga Vlasova

“…These findings enhance our understanding of the specific neural dysfunctions contributing to the cognitive decline associated with memory loss in AD and emphasize the value of applying in vivo methods to elucidate neurodegenerative mechanisms. …”
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The unique hypertrophic and fibrotic features of neonatal right ventricle in response to pressure overload by Yingying Xiao, Yiting Xue, Debao Li, Lincai Ye, Zheng Wang, Sixie Zheng, Peisen Ruan, Hao Chen, Haifa Hong

“…This study reveals the unique features of hypertrophy and fibrosis in the neonatal RV in response to pressure overload, which partly explains why adult-effective anti-HF drugs fail to treat pediatric HF. …”
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Aberrant anabolism hinders constructive metabolism of chondrocytes by pharmacotherapy in osteoarthritis by Raquel Largo, Aranzazu Mediero, Cristina Villa-Gomez, Ismael Bermejo-Alvarez, Gabriel Herrero-Beaumont

“…Therefore, prioritizing the control of chronic innate pro-inflammatory pathways presents the most viable and promising therapeutic strategy for the effective management of OA. As research continues, this approach may offer the best opportunity to alleviate the burden of this incapacitating disease. …”
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Developing a feasible fast-track testing method for developmental neurotoxicity studies: alternative model for risk assessment of micro- and nanoplastics by Xian Wu, TinChung Leung, TinChung Leung, Dereje D. Jima, Dereje D. Jima, Majemite Iyangbe, John Bang, John Bang

“…They originate from industrial processes, consumer products, and environmental degradation, inducing oxidative stress through cellular dysfunctions such as membrane interaction, internalization, mitochondrial damage, inflammation, metal ion leaching, and impaired antioxidant defense. …”
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The role of the mitochondrial dynamic distribution in oocyte development arrest induced by F-53B by Chu Chu, Kun Zhao, Yuan-Yuan Fan, Marjut Roponen, Pasi Jalava, Mo Yang, Yong-Qi Luo, Li-Zi Lin, Yun-Ting Zhang, Jun-Heng Ma, Shu-Li Xu, Wen-Wen Bao, Wei-Hong Tan, Lin-Tao Xue, Guang-Hui Dong, Xiao-Miao Zhao

“…In vitro, F-53B exposure led to meiotic arrest, spindle defects, chromosome misalignment, and mitochondrial dysfunction. Single-cell transcriptomic analysis revealed mitochondria as the primary organelle affected by F-53B exposure. …”
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Contribution of hypoxia-inducible factor 1alpha to pathogenesis of sarcomeric hypertrophic cardiomyopathy by Sarala Raj Murthi, Andreas Petry, Bachuki Shashikadze, Jan B. Stöckl, Manuel Schmid, Gianluca Santamaria, Karin Klingel, Damir Kračun, Xinpei Chen, Sabine Bauer, Joachim P. Schmitt, Florian Flenkenthaler, Josh Gorham, Christopher N. Toepfer, David Potěšil, Pavel Hruška, Zbyněk Zdráhal, Zsuzsanna Mayer, Mathieu Klop, Luisa Lehmann, Yishi Qin, Laura Papanakli, Nadine Spielmann, Alessandra Moretti, Thomas Fröhlich, Peter Ewert, Stefan Holdenrieder, Jonathan G. Seidman, Christine E. Seidman, Agnes Görlach, Cordula M. Wolf

“…HCM is associated with myocardial hypertrophy, fibrosis and ventricular dysfunction. Hypoxia-inducible transcription factor-1α (Hif-1α) is the central master regulators of cellular hypoxia response and associated with HCM. …”
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Reduced circulating NrCAM as a biomarker for fetal growth restrictionResearch in context by Lucy A. Bartho, Susan P. Walker, Danica Idzes, Alexander E.P. Heazell, Lucy E. Higgins, Amanda N. Sferruzzi-Perri, Natalie J. Hannan, Catherine A. Cluver, Lina Bergman, Georgia P. Wong, Manju Kandel, Ping Cannon, Tuong-Vi Nguyen, Anna Nguyen, Stephen Tong, Tu'uhevaha J. Kaitu'u-Lino

“…Neuronal Cell Adhesion Molecule (NrCAM) may be a promising biomarker of placental dysfunction. This study investigated whether NrCAM can predict diseases of placental insufficiency. …”
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Spatial imaging unlocks the potential of charting multiple myeloma and extramedullary disease by Vanessa Desantis, Alessandro Andriano, Tim Düking, Olga Hartwig, Giuseppe Ingravallo, Marta Biondo, Cirino Botta, Roberto Ria, Angelo Vacca, Antonio Giovanni Solimando

“…These findings underscore profound biological heterogeneity in MM and its BM emancipated disease phenotype, emphasizing dysfunctional apoptosis, immune evasion and resistance to CD38-targeting therapies in EMD, conceivably informing future validations. …”
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Prediction of postoperative visual cognitive impairment using graph theory and machine learning based on resting-state brain networks by Songbin Liu, Zhaoshun Jiang, Pei Ye, Feidong Lv, Fei Tao, Yuxi Cai, Lina Yi, Shihong Li, Guoqing Wu, Jun Zhang, Weidong Gu

“…However, effective preoperative prediction methods remain lacking. …”
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Biofilm Formation of <i>Pseudomonas aeruginosa</i> in Cystic Fibrosis: Mechanisms of Persistence, Adaptation, and Pathogenesis by Dayana Borisova, Tsvetelina Paunova-Krasteva, Tanya Strateva, Stoyanka Stoitsova

“…Elucidating the molecular mechanisms driving persistence, hypermutability, and biofilm resilience is critical for the development of effective therapeutic strategies targeting chronic <i>P. aeruginosa</i> infections in CF.…”
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TLR4-dependent neuroinflammation mediates LPS-driven food-reward alterations during high-fat exposure by Sabrina J. P. Huwart, Clémence Fayt, Giuseppe Gangarossa, Serge Luquet, Patrice D. Cani, Amandine Everard

“…Unravelling these gut–brain connections is crucial for developing effective interventions against eating and metabolic disorders, particularly in the context of obesity. …”
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The role of high-resolution manometry in the diagnosis of esophageal disorders (literature review and personal clinical observations) by Yu.M. Stepanov, N.V. Prolom, S.O. Tarabarov, O.M. Babii, I.M. Adamska

“…This innovative technique enables a detailed assessment of esophageal function, particularly the coordination of muscular contractions during swallowing and the effectiveness of the lower esophageal sphincter. HRM has established itself as an exceptionally effective method for detecting motor disorders such as achalasia, gastroesophageal reflux disease, diffuse esopha­geal spasm, as well as other functional abnormalities that may cause dysphagia or impair bolus transit. …”
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Experimental modeling of cornea wound healing in diabetes: clinical applications and beyond by Louis Tong, Yashan Bu, Kendrick Co Shih, Sum Sum Kwok, Yau Kei Chan, Amy Cheuk-Yin Lo, Tommy Chung Yan Chan, Vishal Jhanji

“…This suggests a potential association between the dysfunctional wound healing response and altered inflammation on the ocular surface. …”
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Marburg Virus Disease: A Narrative Review by Arash Letafati, Somayeh Sadat Hosseini Fakhr, Ali Qaraee Najafabadi, Negin Karami, Hassan Karami

“…This virus is clinically characterized by a range of symptoms and organ dysfunctions. The disease is often fatal in a significant proportion of infected individuals. …”
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Food addiction and associated factors in newly diagnosed patients with schizophrenia: a cross-sectional comparison with siblings and healthy controls by Feten Fekih-Romdhane, Youssef Boukadida, Abir Hakiri, Wided Homri, Majda Cheour, Souheil Hallit

“…Limited knowledge on FA in patients with schizophrenia may impede progress in developing effective treatments for pathological eating patterns and the common obesity and metabolic syndrome problems in this population. …”
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Efficacy of suspension exercise training in spinal cord injury: a systematic review and meta-analysis by Yuntao Li, Minmin Wu, Jiguang Pan, Luwen Zhu

“…Significant improvements were observed in all of the aforementioned outcome indicators, suggesting that SET is likely to be effective in restoring function in patients with SCI. …”
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Sauchinone Ameliorates Senescence Through Reducing Mitochondrial ROS Production by Myeong Uk Kuk, Yun Haeng Lee, Duyeol Kim, Kyeong Seon Lee, Ji Ho Park, Jee Hee Yoon, Yoo Jin Lee, Byeonghyeon So, Minseon Kim, Hyung Wook Kwon, Youngjoo Byun, Ki Yong Lee, Joon Tae Park

“…One of the major causes of senescence is oxidative stress caused by ROS, which is mainly generated from dysfunctional mitochondria. Strategies to limit mitochondrial ROS production are considered important for reversing senescence, but effective approaches to reduce them have not yet been developed. …”
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Cetylpyridinium chloride disrupts maternal-to-zygotic transition during early embryonic development by impairing mitochondrial function and histone modification by Caiyun Wu, Zhiming Ding, Xuanxi Li, Yan Xu, Huilei Chen, Hongzhen Ruan, Ping Zhou, Zuying Xu, Huifen Xiang

“…Previous studies have highlighted its toxic effects across various cell types, including reproductive toxicity. …”
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Navigating the shadows: the impact of mindfulness, cognitive fusion, and coping strategies on psychological distress among mental health workers in Timor Leste by Gaspar Quintao, Noviyanti Carla Tilman Leite, Nicholas Tze Ping Pang, Eugene Boon Yau Koh, Jhia Mae Woo, Marina Abdul Rahman Sabri, Kah Mun Wan, Noor Melissa Noor Hadi, Ming Gui Tan, Assis Kamu, Chong Mun Ho

“…Overall, the results suggest that higher levels of depression, anxiety, and stress are linked to greater cognitive fusion and dysfunctional coping, while effective coping skills are negatively associated with depression. …”
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Upper Crossed Syndrome and Scapulae Upper-Trapping: A Mesotherapy Protocol in Cervicoscapulobrachial Pain—The 8:1 Block by Luyddy Pires, Napoliane Santos, João Vitor Lana, Alex Pontes de Macedo, Fábio Ramos Costa, Gabriel Ohana Marques Azzini, Tomas Mosaner, Daniel de Moraes Ferreira Jorge, Gabriel Silva Santos, Arthur Medeiros, José Alexandre Reale Pereira, José Fábio Lana

“…This protocol offers a feasible, cost-effective intervention that enhances the efficacy of traditional therapeutic exercises by addressing underlying muscular and biomechanical dysfunctions. …”
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