Unveiling neurogenic biomarkers for the differentiation between sepsis patients with or without encephalopathy: an updated meta-analysis by Jiyun Hu, Wenchao Li, Shucai Xie, Ya Liao, Tao Chen, Xinrun Wang, Weiping Xia, Fang Huang, Zhaoxin Qian, Lina Zhang

“…Abstract Background Sepsis-associated encephalopathy (SAE) is characterized by brain dysfunction in the context of sepsis and frequently leads to significant cognitive and neurological impairments, as well as an elevated risk of mortality. …”
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Knockdown of eIF3a alleviates pulmonary arterial hypertension by inhibiting endothelial-to-mesenchymal transition via TGFβ1/SMAD pathway by Qiuhong Jiao, Xiufeng Xu, Longwu Xu, Yuying Wang, Shulan Pang, Jie Hao, Xiaohong Liu, Yudan Zhao, Wanpeng Qi, Limin Qin, Tao Huang, Jingtian Li, Tao Wang

“…In vitro, primary rat pulmonary artery endothelial cells (PAECs) were transfected with si-eIF3a to investigate the effects of eIF3a-knockdown on hypoxia-induced EndMT in PAECs and further elucidate its underlying molecular mechanisms. …”
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Analysis of complex chromosomal structural variants through optical genome mapping integrated with karyotyping by Xiaoxi Zhu, Huiling Zheng, Xue Wan, Hang Duan, Ying Qi, Weijia Tang, Fan Yang, Fan Yang, Limei Yu, Limei Yu

“…Additionally, the causal relationship between KIF7 gene dysfunction and recurrent miscarriage remains to be experimentally verified in subsequent research.…”
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DIAGNOSTIC SIGNIFICANCE OF NOVEL MARKERS FOR ASSESSMENT OF MYOCARDIUM CONDITION IN OBSTRUCTIVE DIFFUSE-GENERALIZED FORM OF HYPERTROPHIC CARDIOMYOPATHY by Yu. V. Frolova, O. V. Dymova, M. A. Babaev, S. Yu. Kim, E. Yu. Van, V. E. Sinitsin, E. A. Mershina, S. L. Dzemeshkevich

“…Comparing to BNP that make it possible to evaluate the effectiveness of treatment, G3 is not so effective in diagnostics and there is yet no convincing evidence to confirm the value of G3 concentration in blood as an instrument that can be applied in monitoring of surgery effect.…”
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Micro-computed tomography to visualize preserved vascular architecture in decellularized human vaginal tissue: explorative study by Jayson Sueters, Daniel Docter, Freek Groenman, Sophie C. Visser, Bernadette S. de Bakker, Theo H. Smit, Judith A. F. Huirne

“…Abstract When a vagina is dysfunctional or absent, a neovagina is typically created using an intestinal or dermal graft. …”
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Trehalose induces bladder smooth muscle hypercontractility in mice: involvement of oxidative stress and cellular senescence by Guilherme Lemos, Cícera Madri Alves de Souza Fernandes, Ingrid Kazue Mizuno Watanabe, Maria Andreia Delbin, Fábio Henrique Silva, Fabiano Beraldi Calmasini

“…Autophagy, a conserved catabolic process, is critical for cellular homeostasis and its dysregulation has been implicated in a number of conditions including hypertension, obesity and bladder dysfunctions. The autophagy inducer trehalose has shown promise in treating diseases; however, some studies have reported detrimental effects in vascular tissue under health conditions. …”
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Strength training and chromium picolinate supplementation do not reduce adiposity or improve muscle morphology in obese rats by Daniel da Silva, Lucas Domingos, Amanda Madureira, Suellem Torezani-Salles, Danilo Bocalini, Breno Nogueira, Ana Paula Lima-Leopoldo, André Leopoldo

“… Introduction: Obesity induces metabolic dysfunctions, such as insulin resistance and dyslipidemia, which negatively affect skeletal muscle remodeling and function. …”
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Relationships between burnout and coping strategies among assistant medical officers in Malaysian public healthcare facilities by Nor Haniza Zakaria, Nursyahda Zakaria, Kun Yun Lee

“…In contrast, the use of emotion-focused and dysfunctional coping strategies was detrimental in view of their significant correlations with burnout and its domains. …”
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High Valging Tibial Osteotomy in the Complex Treatment of Anterior Cruciate ligament Ruptures in Patients With Varus Gonarthrosis of the Knee by V. V. Zayats

“…The combined ACLR and HVTO allow reliable technology in the treatment of anterior instability in patients with GA (p< 0.05%). This approach is effective in young active middle-aged patients, with anterior instability of the knee joint and varus GA or prerequisites for its development, as well as with revision ACLR, posterior tibial plateau tilt of more than 12º. …”
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Immunotropic and Immunogenic Properties of Nonspecific Yersinia Porins by O. D. Novikova, O. Yu. Portnyagina, O. P. Vostrikova, V. A. Ivanis

“…It has been established that acute yersiniosis infections without effective treatment can pass into secondary focal forms, leading to the development of systemic diseases that were not previously considered infectious (for example, Grave’s disease). …”
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Micro nutrients as immunomodulators in the ageing population: a focus on inflammation and autoimmunity by Bhavani Sowndharya Balamurugan, Mathan Muthu Chinnakannu Marimuthu, Vickram Agaram Sundaram, Bharath Saravanan, Prasanth Chandrababu, Hitesh Chopra, Tabarak Malik

“…Such micro nutrients are crucial for modulating effective immune responses and their deficiencies have been associated with dysfunctional immunity in the elderly. …”
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The Organizational and Economic Support for the Formation of Crisis Management in Enterprises by Mushnykova Svitlana A., Abernikhina Iryna H.

“…It is demonstrated that effective operation of crisis headquarters, optimization of financial resources, implementation of modern information systems, and support for personnel ensure continuity of operations, enhance client trust, and strengthen market positions. …”
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The role of RAB GTPases in predicting prognosis and therapy response in pancreatic cancer by Jiayi Wang, Jiayao Ma, Shiying Lei, Yulei Zhai, Yangjie Liao, Chongrong Hu, Jingbo Li

“…Pancreatic cancer (PC), a highly aggressive malignancy, lacks effective therapeutic strategies. Using bioinformatics and experimental validation, we identified five RABs (RAB10, RAB11A, RAB39B, RAB28, and RAB11B) to construct a RAB prognostic model (RPM) for PC. …”
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Personalized Virtual Reality Human-Computer Interaction for Psychiatric and Neurological Illnesses: A Dynamically Adaptive Virtual Reality Environment That Changes According to Rea... by Iakovos Kritikos, Georgios Alevizopoulos, Dimitris Koutsouris

“…Virtual reality (VR) constitutes an alternative, effective, and increasingly utilized treatment option for people suffering from psychiatric and neurological illnesses. …”
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INSTITUTIONALIZING UKRAINE’S POST-WAR RECONSTRUCTION by Glib Aleksin

“…The paper concludes that institutionalizing recovery is Ukraine’s most strategic path toward rebuilding not only what has been destroyed, but also what was previously weak or dysfunctional. By embedding reconstruction within institutions that are transparent, participatory and adaptable, Ukraine can avoid the pitfalls of fragmented recovery and lay the groundwork for a democratic, secure and European future. …”
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A pilot feasibility trial of cognitive–behavioural therapy for insomnia in people with inflammatory bowel disease by Kelly A Aschbrenner, Corey A Siegel, Jessica K Salwen-Deremer, Michael T Smith, Hannah G Haskell, Brittany C Speed

“…It is unclear if CBT-I will be as effective in this group given the extent of night-time symptoms people with IBD experience. …”
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Autoimmune polyglandular syndromes by V. V. Smirnov, I. D. Gurova

“…Currently, there are no effective methods to block auto-aggression. Therapy of numerous endocrine and non-endocrine dysfunctions in APS consists of the treatment of particular components of the syndrome.…”
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MULTI-TYROSINE KINASE INHIBITOR-ASSOCIATED APLASTIC ANEMIA AND A BRIEF LITERATURE REVIEW by Veysel Erol, Zeki Guzel, Mustafa Gokoglu

“…This was followed by the development of second-generation (dasatinib, nilotinib, bosutinib) and third-generation (ponatinib) TKIs, which greatly improved disease outcomes and significantly reduced TKI resistance.Common side effects of TKIs include pleural/pericardial effusion, pretibial edema, hyperglycemia, hyperlipidemia, liver dysfunction, diarrhea, and thrombosis, most of which can be managed by temporarily discontinuing the drug or reducing the dosage. …”
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Cullin 3 mitigates nonesterified fatty acid–induced oxidative stress in mammary epithelial cells: Involvement of BCL2/BECN1 and autophagy by Yifei Dong, Wenwen Gao, Kai Liu, Cai Lin, Muhammad Usman, Juan J. Loor, Guojin Li, Liguang Cao, Zifeng Yang, Jianchun Luo, Depeng Li, Qianwen Sun, Lin Lei, Xiliang Du, Yuxiang Song, Guowen Liu, Xinwei Li

“…ABSTRACT: High nonesterified fatty acid (NEFA) concentrations in cows with clinical ketosis lead to metabolic dysfunction in mammary cells, resulting in oxidative stress. …”
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Decoding Schizophrenia: How AI-Enhanced fMRI Unlocks New Pathways for Precision Psychiatry by Valeria Di Stefano, Martina D’Angelo, Francesco Monaco, Annarita Vignapiano, Vassilis Martiadis, Eugenia Barone, Michele Fornaro, Luca Steardo, Marco Solmi, Mirko Manchia, Luca Steardo

“…Algorithms such as support vector machines (SVMs) and Vision Transformers (ViTs) have proven particularly effective in identifying biomarkers and aiding early diagnosis. …”
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