Psychological distress and coping in military cadre candidates by Nakkas C, Annen H, Brand S

“…Results: Recruits selected for promotion had lower scores for depressive symptoms and hostility, engaged more in active coping, and considered their coping to be more effective. Dysfunctional and functional coping were associated with higher and lower distress levels, respectively. …”
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Confronting power in low places: historical analysis of medical dominance and role-boundary negotiation between health professions in Nigeria by Seye Abimbola, Okikiolu Badejo, Helen Sagay, Sara Van Belle

“…While the introduction of new medical diagnostic technology opened up occupational vacancies which facilitated consensual role-boundary change in some cases, it constrained professional collaboration in others.Conclusions Health workforce governance can contribute to better functioning of health systems and voiding dysfunctional interprofessional relations if the human resource for health interventions are informed by contextual understanding (informed by comparative institutional and health systems research) of conditions that facilitate or constrain effective interprofessional collaboration.…”
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Circulating mitochondrial biomarkers in acute coronary syndrome by Andrea Iboleon-Jimenez, María J. Sánchez-Quintero, María J. Sánchez-Quintero, María J. Sánchez-Quintero, Ada D. M. Carmona-Segovia, Ada D. M. Carmona-Segovia, Ada D. M. Carmona-Segovia, Bélen Sojo, Bélen Sojo, Ana María Fernández-Ramos, Ana María Fernández-Ramos, Luis García-Rodríguez, Luis García-Rodríguez, Ana I. Molina-Ramos, Ana I. Molina-Ramos, Ana I. Molina-Ramos, José Manuel García-Pinilla, José Manuel García-Pinilla, José Manuel García-Pinilla, José Manuel García-Pinilla, Manuel Jimenez-Navarro, Manuel Jimenez-Navarro, Manuel Jimenez-Navarro, Manuel Jimenez-Navarro, Almudena Ortega-Gomez, Almudena Ortega-Gomez, Almudena Ortega-Gomez

“…BackgroundAcute coronary syndrome (ACS) is the leading cause of mortality in developed countries. Mitochondrial dysfunction is a hallmark of various cardiometabolic diseases, including ACS. …”
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Targeted inhibition of Gus-expressing Enterococcus faecalis to promote intestinal stem cell and epithelial renovation contributes to the relief of irinotecan chemotoxicity by dehyd... by Ruiyang Gao, Bei Yue, Cheng Lv, Xiaolong Geng, Zhilun Yu, Hao Wang, Beibei Zhang, Fangbin Ai, Ziyi Wang, Donghui Liu, Zhengtao Wang, Kaixian Chen, Wei Dou

“…Herein, we discovered that dehydrodiisoeugenol (DDIE), isolated from nutmeg, alleviates CPT11-induced intestinal mucositis alongside a synergistic antitumor effect with CPT11 by improving weight loss, colon shortening, epithelial barrier dysfunction, goblet cells and intestinal stem cells (ISCs) loss, and wound-healing. …”
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The clinical efficacy and mechanism of gamma frequency electroacupuncture stimulation on the rehabilitation of upper limb motor function in stroke patients: study protocol of a ran... by Xiaoyu Tian, Xiaoyu Tian, Xiaoyu Tian, Xiaoyu Tian, Xiaoming Yu, Hongli Ma, Hongli Ma, Hongli Ma, Hongli Ma, Minghui Lai, Ruiren Wu, Ruiren Wu, Ruiren Wu, Ruiren Wu, Xinglin Zhang, Jingjing Zhang, Zifan Luo, Zifan Luo, Zifan Luo, Zifan Luo, Wang Fu, Wei Feng, Wei Feng, Jun Hu, Chunlei Shan, Chunlei Shan, Chunlei Shan, Cong Wang, Cong Wang, Cong Wang, Cong Wang, Cong Wang, Feng Wang

“…The secondary indicators include electroencephalogram, National Institutes of Health Stroke Scale, Mini-mental State Examination and Modified Barthel Index.DiscussionThis trial offers novel perspectives on the application of 40-Hz electroacupuncture stimulation in neural oscillation regulation and the effectiveness of this clinically widespread technique in treating upper extremity dysfunction after a stroke and improving patients’ quality of life. …”
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Dual and plasticity-dependent regulation of cerebello-zona incerta circuits on anxiety-like behaviors by Yue Zhao, Jin-Tao Wu, Jia-Bin Feng, Xin-Yu Cai, Xin-Tai Wang, Luxi Wang, Wei Xie, Yan Gu, Jun Liu, Wei Chen, Lin Zhou, Ying Shen

“…Our data support the close relationship between the cerebellum and emotional processes and suggest that targeting cerebellar outputs may be an effective approach for treating anxiety.…”
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Is Osteopathic Manipulative Treatment Clinically Superior to Sham or Placebo for Patients with Neck or Low-Back Pain? A Systematic Review with Meta-Analysis by Luis Ceballos-Laita, Sandra Jiménez-del-Barrio, Andoni Carrasco-Uribarren, Ricardo Medrano-de-la-Fuente, Román Robles-Pérez, Edzard Ernst

“…<b>Objectives</b>: The aim of this systematic review and meta-analysis was to compare whether osteopathic manipulative treatment (OMT) for somatic dysfunctions was more effective than sham or placebo interventions in improving pain intensity, disability, and quality of life for patients with neck pain (NP) or low-back pain (LBP). …”
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The myeloid cell-driven transdifferentiation of endothelial cells into pericytes promotes the restoration of BBB function and brain self-repair after stroke by Tingbo Li, Ling Yang, Jiaqi Tu, Yufan Hao, Zhu Zhu, Yingjie Xiong, Qingzhu Gao, Lili Zhou, Guanglei Xie, Dongdong Zhang, Xuzhao Li, Yuxiao Jin, Yiyi Zhang, Bingrui Zhao, Nan Li, Xi Wang, Jie-Min Jia

“…Ischemic stroke, one of the leading causes of death in the world, is accompanied by the dysfunction of the blood-brain barrier (BBB), which aggravates neuron damage. …”
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Interaction of Dissolved Oxygen and Feed Fat Levels on Physiological Functions of Nile Tilapia by Dandan WANG, Kai HUANG, Ting LIU, Ruijie GUO, Yuda LI, Xiangli LI

“…This study aimed to investigate the interactive effects of DO content and fat levels on the growth performance, hepatic antioxidant capacity, immune parameters, and liver tissue structure of Nile Tilapia. …”
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Molecular mechanism of hypoxia-induced spermatogenesis impairment by inhibiting the stability of sperm cilial microtubules by WANG Xiao, ZHANG Mengjie, DENG Fang

“…Objective‍　‍To explore the effects of hypoxia on spermatid differentiation and stability of sperm flagellar microtubule, and investigate the underlying molecular mechanisms in order to clarify the potential adverse effects of hypoxia on male reproductive function. …”
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Assessing the impact of COmorbidities and Sociodemographic factors on Multiorgan Injury following COVID-19: rationale and protocol design of COSMIC, a UK multicentre observational... by Christopher E Brightling, Kamlesh Khunti, Naveed Sattar, Colin Berry, John P Greenwood, Gerry P McCann, Kelly S Parke, Joanne V Wormleighton, Stefan Neubauer, Betty Raman, Charalambos Antoniades, Elizabeth M Tunnicliffe, Alastair Moss, Jayanth Ranjit Arnold, Mark Toshner, Sue Francis, Sandeep S Hothi, Stephen M Smith, Mohamed Elshibly, Simran Shergill, Rachel J England, George J Hudson, James Wild

“…Results will be disseminated via peer-reviewed journals and scientific meetings.Trial registration number COSMIC is registered as an extension of C-MORE (Capturing Multi-ORgan Effects of COVID-19) on ClinicalTrials.gov (NCT04510025).…”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…What are the differential effects on other outcomes? What is the cost-effectiveness from an NHS secondary care perspective? …”
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Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…What are the differential effects on other outcomes? What is the cost-effectiveness from an NHS secondary care perspective? …”
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Cardiomyocyte-specific knockout of ADAM17 alleviates doxorubicin-induced cardiomyopathy via inhibiting TNFα–TRAF3–TAK1–MAPK axis by Lin Xie, Fei Xue, Cheng Cheng, Wenhai Sui, Jie Zhang, Linlin Meng, Yue Lu, Wenjing Xiong, Peili Bu, Feng Xu, Xiao Yu, Bo Xi, Lin Zhong, Jianmin Yang, Cheng Zhang, Yun Zhang

“…ADAM17 acted as a positive regulator of cardiomyocyte apoptosis and cardiac remodeling and dysfunction induced by doxorubicin by upregulating TRAF3/TAK1/MAPKs signaling. …”
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CD40-TRAF6 inhibition suppresses cardiovascular inflammation, oxidative stress and functional complications in a mouse model of arterial hypertension by Lea Strohm, Henning Ubbens, Dominika Mihalikova, Alexander Czarnowski, Paul Stamm, Michael Molitor, Stefanie Finger, Matthias Oelze, Dorothee Atzler, Philip Wenzel, Philipp Lurz, Thomas Münzel, Christian Weber, Esther Lutgens, Andreas Daiber, Steffen Daub

“…The TRAF6 inhibitor treatment normalized endothelial dysfunction and reduced blood pressure in hypertensive wild type animals. …”
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Influence of Family Functioning on Depressive Symptoms in Adolescents in the City of Milagro by Isabel Amarilis Leal Maridueña, Jennifer Carolina Velasco Zea, Luz Virginia Flores Valencia, Ketty Zoraida Vergara Mendoza, Elvia Isabel Elvia Isabel Crespo Baldeón

“…Although gender showed no influence, the high prevalence of family dysfunctionality underscores the need for targeted interventions to improve cohesion, communication, and emotional support in the family unit. …”
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Osteopontin acts as a negative regulator of autophagy accelerating lipid accumulation during the development of nonalcoholic fatty liver disease by Min Tang, Yan Jiang, Haoyu Jia, Bhuvanesh Kinish Patpur, Bo Yang, Jing Li, Changqing Yang

“…Increasing evidence supports that autophagy can constitute an effective Defence mechanism against NAFLD conditions. …”
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Pan-tumor analysis to investigate the obesity paradox in immune checkpoint blockade by Evan J Lipson, Ludmila Danilova, Elizabeth M Jaffee, Won Jin Ho, Mark Yarchoan, Yasser Ged, Jean Hoffman-Censits, Jennifer Durham, Sanjay Bansal, Chester Kao, Rajat Mohindra, Stephanie L Alden, Tanguy Y Seiwert, Soren Charmsaz, Howard L Li, Kabeer Munjal, Hua-Ling Tsai, Alexei Hernandez, Erin M Coyne, Rachel Garonce-Hediger, Laura Tang, Marina Baretti, Kathryn Howe, G Scott Chandler, Madelena Brancati, Aanika Warner, Ervin Griffin, Mari Nakazawa, Chris Thoburn, Jennifer Gizzi, Nicole E Gross, Elsa Hallab, Sarah S Shin, Aditi Guha

“…ICI-based therapy may more effectively reverse T-cell dysfunction in obese patients, potentially contributing to the paradoxically improved responses in this population.…”
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The Impact of Mechanical Power Normalized to Predicted Body Weight on Outcomes in Pediatric ARDSTake-Home Points by Herng Lee Tan, MSc, Rehena Sultana, MSc(stat), Phuc Huu Phan, MD, Muralidharan Jayashree, MD, Hongxing Dang, MD, Soo Lin Chuah, MBBS, Chin Seng Gan, MBBS, Siew Wah Lee, MD, Karen Ka Yan Leung, MBBS, MSc, Ellis Kam Lun Hon, MBBS, MD, Xuemei Zhu, MD, Pei Chuen Lee, MMed(Paeds), Chian Wern Tai, MD, Jacqueline Soo May Ong, MB BChir, Lijia Fan, MD, Kah Min Pon, MD, Li Huang, MD, Kazunori Aoki, MD, Hiroshi Kurosawa, MD, PhD, Rujipat Samransamruajkit, MD, Jia Yueh Chong, MD, Felix Liauw, MD, Nattachai Anantasit, MD, Wei Xu, MD, Chunfeng Liu, MD, Jan Hau Lee, MBBS, Louise Ngu, MB BCh BAO, Yek Kee Chor, MD, Suparyatha Ida Bagus Gede, MD, Dyah Kanya Wati, MD, Judith Ju Ming Wong, MB BCh BAO

“…In the causal analysis, OI showed a significant indirect effect on the causal pathway of MP on VFDs (indirect effect, –4.30 [P < .001]; direct effect, –1.17 [P = .635]; total effect, –5.47 [P = .024]) and IFDs [indirect effect, –3.13 [P < .001]; direct effect, –0.72 [P = .635]; total effect, –3.84 [P = .024]), but not ICU mortality. …”
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Therapeutic Targeting of Decr1 Ameliorates Cardiomyopathy by Suppressing Mitochondrial Fatty Acid Oxidation in Diabetic Mice by Qing‐Bo Lu, He‐Ting Sun, Kuo Zhou, Jia‐Bao Su, Xin‐Yu Meng, Guo Chen, Ao‐Yuan Zhang, An‐Jing Xu, Chen‐Yang Zhao, Yuan Zhang, Yao Wang, Hong‐Bo Qiu, Zhuo‐Lin Lv, Zheng‐Yang Bao, Jian Zhu, Feng Xiao, Xue‐Xue Zhu, Hai‐Jian Sun

“…Deletion of Decr1 prevented high glucose/palmitate (HG/HP)‐induced hypertrophy (−22%, p = 0.0006), mitochondrial dysfunction and apoptosis (−74%, p < 0.0001) in cultured cardiomyocytes. …”
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