T-cell immune checkpoint inhibition plus hypomethylation for locally advanced HER2-negative breast cancer: a phase 2 neoadjuvant window trial of decitabine and pembrolizumab follow... by Monique Williams, Patrick Dillon, Harry D Bear, Andrew S Poklepovic, Maciej Kmieciak, Kandace P McGuire, Xiaoyan Deng, Dipankar Bandyopadhyay, Michael Idowu, Taylor M Jenkins, Giovanni Archer, Lindsey Gwaltney, Daniel Flora, Daniel Stover, Mary Hackney, Masey Ross, Hetal Vachhani, Raphael Louie, Amelia Grover, Tasnim Rahman, Amber Hendrix

“…We have shown that the DNMTi decitabine augments the effectiveness of immunotherapy using murine triple-negative breast cancer (TNBC) models. …”
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Modified cavocavostomy technique for deceased donor liver transplantation by S. E. Voskanyan, A. I. Artemyev, A. I. Sushkov, K. K. Gubarev, D. S. Svetlakova, M. V. Popov, V. S. Rudakov, A. N. Bashkov, E. V. Naydenov, M. Muktarzhan

“…The refinement of liver transplantation technique, the development and implementation of new surgical technologies into clinical practice, including those for inferior vena cava reconstruction, are important for the improvement of surgery outcomes.The study purposes were to present our own modification of cavocavostomy and options for its technical implementation in deceased donor liver transplantation, as well as to study the clinical effects and the impact of new surgical technique on the outcomes.Material and methods. …”
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Machine learning based screening of biomarkers associated with cell death and immunosuppression of multiple life stages sepsis populations by Jie Yang, Fanyan Ou, Binbin Li, Lixiong Zeng, Qiuli Chen, Houyu Gan, Jianing Yu, Qian Guo, Jihua Feng, Jianfeng Zhang

“…Abstract Sepsis is a condition resulting from the uncontrolled immune response to infection, leading to widespread inflammatory damage and potentially fatal organ dysfunction. Currently, there is a lack of specific prevention and treatment strategies for sepsis across different age groups. …”
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Role of hypoxia-inducible-factor-1α (HIF-1α) in ferroptosis of adipose tissue during ketosis by Yunhui Fan, Li Ma, Xinxin Fang, Shuyu Du, John Mauck, Juan J. Loor, Xudong Sun, Hongdou Jia, Chuang Xu, Qiushi Xu

“…This study aimed to explore the effect of HIF-1α on oxidative stress and ferroptosis in bovine subcutaneous adipose tissue and isolated adipocytes. …”
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The Impact of Gut Microbiota on Chronic Obstructive Pulmonary Disease: A Dual-Sample Mendelian Randomization Study by Niu N, Zhao J, Li H, Miao Y, Chen F, Liu J, Cao L, Ji T, Gao F, Xie S, Zhang Y

“…Summary data for COPD (6,915 cases and 186,723 controls), Early onset COPD (3,508 cases and 212,197 controls), admission rate of COPD (9,113 cases and 212,292 controls), related infection of COPD (59,925 cases and 159,867 controls), respiratory dysfunction of COPD (1,031 cases and 186,723 controls), were from FinnGen consortium R7 GWAS.Result: Our analysis revealed statistically significant correlations between several genera and COPD. …”
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Optimization of Surgical Procedure and Efficacy Evaluation of Aortic Calcification Model in Rats with Chronic Kidney Disease by PAN Yicong, JIANG Wenhong, HU Ming, QIN Xiao

“…Real-time fluorescence quantitative PCR was used to detect the gene expression of smooth muscle actin-associated protein alpha (Sm22), Runt-related transcription factor 2 (Runx2), and osteopontin (OPN) in rat aortic tissue to evaluate the effectiveness of the model. Results The exploratory optimization experiment of different surgical procedures found that the survival rate of group D rats,which underwent 2/3 left kidney resection followed by right whole kidney resection via the dorsal approach, was the highest, indicating that this surgical procedure was the best method for establishing a chronic kidney disease model with renal dysfunction. …”
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A review on exploration–exploitation trade-off in psychiatric disorders by Ali Jami, Sajjad Abbaszade, Abdol-Hossein Vahabie

“…This suggests that such disorders may originate from dysfunctional foraging processes applied to decision-making. …”
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Designing and psychometric evaluation of the nursing instructors clinical leadership style scale (CLSS): a sequential exploratory mixed-methods design by Moluk Pouralizadeh, Abbas Ebadi, Ehsan Kazemnezhad Leyli, Ali Bazzi

“…Abstract Background Effective leadership in clinical nursing education is crucial for shaping competent practitioners and ensuring quality patient care. …”
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The Complexity of Sleep Disorders in Children with FASD by Laura Więcko, Katarzyna Trela, Aleksander Tuteja, Liwia Olczyk, Daria Podleśna, Kamila Gęborys, Klaudia Burzykowska

“…Importantly, the most effective approach remains prevention — namely, complete abstinence from alcohol during pregnancy. …”
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The unique role of the associative thalamus in cognitive processing by Bin A. Wang, Shumei Li, Michael M. Halassa, Burkhard Pleger

“…We additionally summarize recent evidence on how thalamic dysfunctions contribute to mental disorders, using schizophrenia as a key example, and highlight the potential of targeting the associative thalamus for novel diagnostic and therapeutic strategies. …”
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Porphyran from discolored nori prevents metabolic syndrome through microbiota-bile acid-ceramide pathway by Yoko Yokoyama, Yoko Takashina, Jean-David Morel, Tanon Taworntawat, Naho Kitamura, Utana Nagano, Tatsuya Tanigaki, Anna Nakamura, Teruo Miyazaki, Hiroki Taoka, Adrienne Mottis, Alessia Perino, Atsushi Shinjo, Norihiro Suzuki, Setsuo Takekawa, Shinji Fukuda, Akira Honda, Kenji Ishihara, Makoto Arita, Kazuo Tsubota, Johan Auwerx, Mitsuhiro Watanabe

“…The Japanese have a low prevalence of obesity and cardiovascular disease worldwide, and components of nori may have disease-preventive effects. Here, we focused on porphyran, which is abundant in nori that is discarded due to discoloration, and investigated the effects of nori-derived porphyran on gut microbiota, bile acid composition, and ceramide synthesis. …”
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Sense of Coherence and Caregiver Burden Among Informal Caregivers of People with Dementia in China: The Mediating Role of Coping Strategies by Long D, Gu Y, Wang Y

“…The relationship between SOC and caregiver burden was partially mediated by emotion-focused strategies and dysfunctional coping strategies.Conclusion: Significant relationship was found that SOC correlated with caregiver burden; To some extent, emotion-focused and dysfunctional coping strategies moderated the relationship between SOC and caregiver burden. …”
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COGNITIVE IMPAIRMENTS IN VITAMIN B12 AND FOLIC ACID DEFICIENCIES AND HYPERHOMOCYSTEINEMIA by P. R. Kamchatnov, I. V. Damulin

“…Vitamin metabolic disorders can cause diverse dysfunctions of both the peripheral and central nervous systems. …”
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Gonadoliberin – Synthesis, Secretion, Molecular Mechanisms and Targets of Action by A. O. Shpakov, K. V. Derkach

“…New experimental data are analyzed, which significantly change the current understanding of the functioning of GnRH-producing neurons and the secretion of GnRH, which is very important for the development of effective approaches for correcting the functions of the HPG axis.…”
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Obesity and mitochondrial uncoupling – an opportunity for the carbon monoxide-based pharmacology of metabolic diseases by Aleksandra Danielak, Marcin Magierowski

“…Despite advancements in lifestyle interventions, pharmacological therapies, and bariatric surgery, substantial barriers to effective and sustained obesity management persist. …”
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Efficacy and Safety of Mirabegron Compared to Solifenacin in Treatment of Non-neurogenic Overactive Bladder in Children: A Randomized Controlled Trial by Islam Mansour, Mahmoud Laymon, Ahmed Abdelhalim, Mohamed S. Dawaba, Ahmed S. El-Hefnawy

“…However, their frequent side effects necessitate searching for therapeutic alternatives. …”
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The Management of Children and Adolescents with Overactive Bladder Refractory to Treatment with Parasacral Transcutaneous Electrical Nerve Stimulation by Carlos Eduardo Rocha Macedo, Antônio Vitor Nascimento Martinelli Braga, Felipe Santos Marimpietri, Beatriz Paixão Argollo, Glicia Estevam de Abreu, Maria Luiza Veiga da Fonseca, Ana Aparecida Nascimento Martinelli Braga, Ubirajara Barroso Jr.

“…Outcomes were evaluated using the Dysfunctional Voiding Scoring System (DVSS) and the Visual Analogue Scale (VAS). …”
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Neurostimulation devices to treat Alzheimer’s disease by Felipe P. Perez, Brett Walker, Jorge Morisaki, Haitham Kanakri, Maher Rizkalla

“…Several EMF devices have shown a beneficial or harmful effect in cell cultures and animal models but not in AD human studies. …”
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The results of two-stage optico-functional rehabilitation of patients with refractive disorders and the risk of postoperative asthenopic syndrome after FemtoLASIK by I. A. Mushkova, M. L. Mitronina, T. A. Kornyushina, N. V. Maychuk, L. T. Shamsetdinova

“…To eliminate accommodation dysfunctions, a medical device OXYS was used. Diploptic treatment was carried out using a Speckle-M laser apparatus and Bagolini raster glasses. …”
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Posttraumatic stress, anxiety, and depression in mothers after preterm delivery and the associated psychological processes by Gilles Ndjomo, Erero Njiengwe, Béatrice Moudze, Odette Guifo, Sylvie Blairy

“…Behavioral activation could be an effective intervention to target these dysfunctional processes and thus improve maternal symptoms.…”
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