Abusive supervision and employee reactions: The moderating roles of high-performing employees by Philip Mensah, Obianuju E. Okeke-Uzodike

“…Motivation for the study: Supervisors, as key facilitators of employee performance and commitment, often face immense pressure to achieve departmental and organisational goals. While effective leadership promotes collaboration, commitment and performance, some supervisors resort to dysfunctional behaviours, such as abusive supervision, to drive results. …”
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The efficacy of parasacral transcutaneous electrical nerve stimulation for the treatment of overactive bladder in children: a systematic review and meta-analysis by Zhuoqi Cheng, Yumeng Chai, Zhongbao Zhou, Yong Zhang

“…Further high-quality RCTs are needed to establish the most effective treatment protocol.…”
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Common neural patterns of substance use disorder: a seed-based resting-state functional connectivity meta-analysis by Xiaonan Zhang, Haoyu Zhang, Yingbo Shao, Yang Li, Feifei Zhang, Hui Zhang

“…Compared with HCs, SUD patients exhibited significant dysfunctions in the cortical-striatal-thalamic-cortical circuit. …”
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A novel antidepressant mechanism of baicalin: enhancing KIF5A-mediated axoplasmic transport and vesicular trafficking in glutamatergic neurons by Shuaifei Lu, Shuaifei Lu, Jiduo Shen, Jiduo Shen, Xiaohui Jin, Xiaohui Jin, Changjing Zhang, Changjing Zhang, Baoying Wang, Baoying Wang, Xianghua Liu, Xianghua Liu, Ming Bai, Ming Bai, Erping Xu, Erping Xu, Xiangli Yan, Xiangli Yan, Yucheng Li, Yucheng Li

“…IntroductionDysfunction of axoplasmic transport is closely linked to depression. …”
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Lymph nodes molecular subtypes unravel lymph nodes heterogeneity and clinical implications in colorectal cancer by Xu Guan, Yueyang Zhang, Ruifang Sun, Guiyu Wang, Xiaoman Bi, Zhen Zhang, Likun Zan, Yongsheng Meng, Yunxiao Liu, Jinyuan Guo, Jian Ma, Jiale Li, Hanqing Hu, Yixun Zhang, Xin Zhang, Maoxi Liu, Bo Jiang, Haiyi Liu, Shuangmei Zou, Yanfeng Xi, Haitao Zhou, Wenqi Bai, Deng Wu, Xishan Wang

“…NLN_C3/C4 are characterized by diminished T and B cell activity and fibroblast-driven fibrosis, with follicular dendritic cell loss contributing to B cell dysfunction. Immune checkpoint inhibitors partially reverse these effects, restoring FDC and B cell activity. …”
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TREM-1 as a potential gatekeeper of neuroinflammatory responses: therapeutic validation and mechanistic insights in experimental traumatic brain injury by Yunsheng Zhang, Yunsheng Zhang, Yunsheng Zhang, Yulian Zhang, Hanhan Dang, Hanhan Dang, Chuanpeng Zhang, Chuanpeng Zhang, Kun He, Kun He, Xu Yang, Xu Yang, Zixi Wang, Zixi Wang, Li Zhang, Li Zhang, Li Zhang, Yanbing Yu, Yanbing Yu, Yanbing Yu

“…These effects are mediated through suppression of TREM-1-dependent NF-κB signaling and pyroptosis. …”
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TREM-1-Linked Inflammatory Cargo in SARS-CoV-2-Stimulated Macrophage Extracellular Vesicles Drives Cellular Senescence and Impairs Antibacterial Defense by Pedro V. da Silva-Neto, Jonatan C. S. de Carvalho, Diana M. Toro, Bianca T. M. Oliveira, Juçara G. Cominal, Ricardo C. Castro, Maria A. Almeida, Cibele M. Prado, Eurico Arruda, Fabiani G. Frantz, Ana P. Ramos, Pietro Ciancaglini, Ronaldo B. Martins, Juliano C. da Silveira, Fausto Almeida, Kelen C. R. Malmegrim, Carlos A. Sorgi

“…This study investigated the composition and effects of macrophage-derived EVs stimulated by SARS-CoV-2 (MφV-EVs) on the recipient cell response. …”
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Conversion of T Effector Cells Into T Regulatory Cells in Type 1 Diabetes/Latent Autoimmune Diabetes of Adults by Inhibiting eIF5A and Notch Pathways by Rafiqi SI, Aldasouqi A, Paparodis RD, Dewan S, Farooqi A, Faisal S, Nemat Y, Salim N, Qureshi S, Mahmood A, Tovar Y, Jun JY, Kalinoski AL, Mirmira RG, Jaume JC, Imam S

“…Furthermore, GAD65+GC7+anti-DLL4 treatment had no adverse effects on immune cells.The present approach is a multipronged approach involving the inhibition of eIF5a and Notch pathways that addresses the upregulation of immune tolerance, differentiation, and proliferation of cytotoxic T cells and alleviates β-cell dysfunction. …”
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Targeting Decidual CD16+ Immune Cells with Exosome‐Based Glucocorticoid Nanoparticles for Miscarriage by Linlin Wang, Zhinang Yin, Yanqiong Shen, Gang Feng, Fangfang Dai, Dongyong Yang, Zhimin Deng, Jing Yang, Ruizhi Chen, Leifeng Yang, Xian Chen, Qing Sun, Chunyu Huang, Yanxiang Cheng, Hongbing Deng, Lianghui Diao, Longfei Li, Tailang Yin

“…Abstract Immune dysfunction in early pregnancy including overactivation of cytotoxic CD16+ NK cells and proinflammatory M1 macrophages at the maternal–fetal interface interferes with trophoblast invasion, spiral artery remodeling, and decidualization, potentially leading to miscarriage. …”
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MicroRNA‐483 amelioration of experimental pulmonary hypertension by Jin Zhang, Yangyang He, Xiaosong Yan, Shanshan Chen, Ming He, Yuyang Lei, Jiao Zhang, Brendan Gongol, Mingxia Gu, Yifei Miao, Liang Bai, Xiaopei Cui, Xiaojian Wang, Yixin Zhang, Fenling Fan, Zhao Li, Yuan Shen, Chih‐Hung Chou, Hsien‐Da Huang, Atul Malhotra, Marlene Rabinovitch, Zhi‐Cheng Jing, John Y‐J Shyy

“…Abstract Endothelial dysfunction is critically involved in the pathogenesis of pulmonary arterial hypertension (PAH) and that exogenously administered microRNA may be of therapeutic benefit. …”
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Belatacept in Kidney Transplantation: Reflecting on the Past, Shaping the Future by Johan Noble, Johan Noble, Juliette Leon, Arnaud Del Bello, Dany Anglicheau, Gilles Blancho, Gilles Blancho, Simon Ville, Simon Ville, Lionel Couzi, Lionel Couzi, Philippe Grimbert, Philippe Grimbert, Yannick Le Meur, Bruno Moulin, Nassim Kamar, Lionel Rostaing, Florence Herr, Antoine Durrbach, Dominique Bertrand

“…However, their use is associated with adverse effects, most notably chronic nephrotoxicity, which remains a leading cause of long-term allograft dysfunction. …”
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Adipose tissue from oesophageal adenocarcinoma patients is differentially affected by chemotherapy and chemoradiotherapy regimens altering immune cell phenotype and cancer cell met... by Fiona O'Connell, Eimear Mylod, Noel E. Donlon, Maria Davern, Christine Butler, Niamh O'Connor, Meghana S. Menon, Claire L. Donohoe, Narayanasamy Ravi, Derek G. Doherty, Margaret R. Dunne, John V. Reynolds, Helen M. Roche, Jacintha O'Sullivan

“…In contrast, the chemotherapy-treated adipose microenvironment enhanced mitochondrial dysfunction in cancer cells, increasing their reliance on glycolysis and enhancing pro-inflammatory marker expression on LPS-primed macrophages (p < 0.05). …”
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Repeated low-intensity noise exposure exacerbates age-related hearing loss via RAGE signaling pathway by Jianbin Sun, Na Sai, Tong Zhang, Chaoying Tang, Shuhang Fan, Qin Wang, Da Liu, Xianhai Zeng, Juanjuan Li, Weiwei Guo, Shiming Yang, Weiju Han

“…Auditory brainstem response (ABR) was monitored to assess changes in hearing thresholds, tracking the effects of noise exposure until the mice reached 12 months of age. …”
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Dietary Supplementation of <i>Lactobacillus reuteri</i> Modulates Amino Acid Metabolism and Extracellular Matrix in the Gut–Liver Axis of Weaned Piglets by Yiyi He, Yangyang Wei, Shihui Ruan, Qiwen Wu, Yunxia Xiong, Li Wang, Zongyong Jiang, E Xu, Hongbo Yi

“…Weaning stress leads to intestinal dysfunction and impaired growth performance and intestinal development in piglets. …”
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Inhibition of Dynamin-Related Protein 1-Dependent Mitochondrial Fission Ameliorates Apical Periodontitis by Attenuating NLRP3 Inflammasome-Mediated M1 Macrophage Polarisation by Yao Yang, Min Li, Lifei Pan, Yifei Tang, Yuting Wang, Xiaoyue Guan, Tiezhou Hou, Siyu Hou

“…In vitro experiments demonstrated that Mdivi-1 effectively inhibited the Pg-LPS induced abnormal mitochondrial fragmentation dependent on p-Drp1(Ser616), rescued mitochondrial dysfunction, and further suppressed the activation of NLRP3/Caspase1/IL1β and the expression of CD86. …”
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Usefulness of the CHA₂DS₂-VASc Score in Predicting the Outcome in Subjects Hospitalized with COVID-19—A Subanalysis of the COLOS Study by Katarzyna Resler, Pawel Lubieniecki, Tomasz Zatonski, Adrian Doroszko, Malgorzata Trocha, Marek Skarupski, Krzysztof Kujawa, Maciej Rabczynski, Edwin Kuznik, Dorota Bednarska-Chabowska, Marcin Madziarski, Tymoteusz Trocha, Janusz Sokolowski, Ewa A. Jankowska, Katarzyna Madziarska

“…Results: It was shown that gender had no effect on mortality. Significantly shorter hospitalization time was observed in the group of patients with low CHA₂DS₂-VASc scores. …”
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Randomised trial comparing weight loss through lifestyle and GLP-1 receptor agonist therapy in people with MASLD by Ahmad Moolla, Toryn Poolman, Nantia Othonos, Jiawen Dong, Kieran Smith, Thomas Cornfield, Sarah White, David W. Ray, Sofia Mouchti, Ferenc E. Mózes, Helena Thomaides-Brears, Stefan Neubauer, Jeremy F. Cobbold, Leanne Hodson, Jeremy W. Tomlinson

“…Background &amp; Aims: Glucagon-like peptide 1 receptor agonist (GLP-1RA) therapies deliver histological benefit in people with metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Efficacy of naloxone in reducing hypoxemia and duration of immobility following focal to bilateral tonic–clonic seizures by Sylvain Rheims, Fatima Chorfa, Véronique Michel, Edouard Hirsch, Louis Maillard, Luc Valton, Fabrice Bartolomei, Philippe Derambure, Vincent Navarro, Julien Biberon, Arielle Crespel, Anca Nica, Martine Lemesle Martin, Laure Mazzola, Jerome Petit, Vincent Rossero, Sébastien Boulogne, Mathilde Leclercq, Laurent Bezin, Catherine Mercier, Pascal Roy, Philippe Ryvlin, the ENALEPSY Study Group

“…Confirmation of this effect and its impact on SUDEP risk will require additional studies. …”
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Reconstruction of a lncRNA-Associated ceRNA Network in Endothelial Cells under Circumferential Stress by Zhuhui Huang, William Adiwignya Winata, Kui Zhang, Yang Zhao, Yang Li, Ning Zhou, Shaoyou Zhou, Wei Fu, Bokang Qiao, Guoqi Li, Yihui Shao, Jubing Zheng, Ran Dong

“…We also adopted ELISA and TUNEL to investigate the effect of si-NEAT1 on endothelial inflammation and apoptosis. …”
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How to Apply the Sequential Correction Technique to Treatment of Congenital Cervicothoracic Scoliosis: A Technical Note and Case Series by Saihu Mao, Kai Sun, Song Li, Jie Zhou, Hongda Bao, Benlong Shi, Xu Sun, Zhen Liu, Yong Qiu, Zezhang Zhu

“…Transitory bilateral nerve root paralysis causing upper limb dysfunction occurred in 1 patient. Additionally, 3 patients suffered severe distal curve progression with trunk tilt and were surgically revised with instrumentation extending to the stable zone. …”
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