Phase I study of efineptakin alfa (NT-I7) for the treatment of Kaposi sarcoma by Leonard D’Amico, Martin Cheever, Steven P Fling, Anna Wright, Kathryn Lurain, Ramya Ramaswami, Irene Ekwede, Thomas S Uldrick, Robert Yarchoan, Judith C Kaiser, Angela Shaulov Kask, Manoj P Menon, Paul Couey, Eli Burnham, Allysson Angeldekao, Byung Ha Lee, Li-Lian Kwok, Chia-Ching Jackie Wang

“…Background CD4+ T-cell lymphocytopenia and immune dysfunction are factors that drive the onset and persistence of Kaposi sarcoma (KS) in people with (PWH) and without HIV. …”
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Identification of novel genetic Loci associated with thyroid peroxidase antibodies and clinical thyroid disease. by Marco Medici, Eleonora Porcu, Giorgio Pistis, Alexander Teumer, Suzanne J Brown, Richard A Jensen, Rajesh Rawal, Greet L Roef, Theo S Plantinga, Sita H Vermeulen, Jari Lahti, Matthew J Simmonds, Lise Lotte N Husemoen, Rachel M Freathy, Beverley M Shields, Diana Pietzner, Rebecca Nagy, Linda Broer, Layal Chaker, Tim I M Korevaar, Maria Grazia Plia, Cinzia Sala, Uwe Völker, J Brent Richards, Fred C Sweep, Christian Gieger, Tanguy Corre, Eero Kajantie, Betina Thuesen, Youri E Taes, W Edward Visser, Andrew T Hattersley, Jürgen Kratzsch, Alexander Hamilton, Wei Li, Georg Homuth, Monia Lobina, Stefano Mariotti, Nicole Soranzo, Massimiliano Cocca, Matthias Nauck, Christin Spielhagen, Alec Ross, Alice Arnold, Martijn van de Bunt, Sandya Liyanarachchi, Margit Heier, Hans Jörgen Grabe, Corrado Masciullo, Tessel E Galesloot, Ee M Lim, Eva Reischl, Peter J Leedman, Sandra Lai, Alessandro Delitala, Alexandra P Bremner, David I W Philips, John P Beilby, Antonella Mulas, Matteo Vocale, Goncalo Abecasis, Tom Forsen, Alan James, Elisabeth Widen, Jennie Hui, Holger Prokisch, Ernst E Rietzschel, Aarno Palotie, Peter Feddema, Stephen J Fletcher, Katharina Schramm, Jerome I Rotter, Alexander Kluttig, Dörte Radke, Michela Traglia, Gabriela L Surdulescu, Huiling He, Jayne A Franklyn, Daniel Tiller, Bijay Vaidya, Tim de Meyer, Torben Jørgensen, Johan G Eriksson, Peter C O'Leary, Eric Wichmann, Ad R Hermus, Bruce M Psaty, Till Ittermann, Albert Hofman, Emanuele Bosi, David Schlessinger, Henri Wallaschofski, Nicola Pirastu, Yurii S Aulchenko, Albert de la Chapelle, Romana T Netea-Maier, Stephen C L Gough, Henriette Meyer Zu Schwabedissen, Timothy M Frayling, Jean-Marc Kaufman, Allan Linneberg, Katri Räikkönen, Johannes W A Smit, Lambertus A Kiemeney, Fernando Rivadeneira, André G Uitterlinden, John P Walsh, Christa Meisinger, Martin den Heijer, Theo J Visser, Timothy D Spector, Scott G Wilson, Henry Völzke, Anne Cappola, Daniela Toniolo, Serena Sanna, Silvia Naitza, Robin P Peeters

“…Individual and combined effects (genetic risk scores) of these variants on (subclinical) hypo- and hyperthyroidism, goiter and thyroid cancer were studied. …”
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The relationship between the ratio of non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol (NHHR) and both MASLD and advanced liver fibrosis: evidence f... by Juyi Li, Juyi Li, Juyi Li, Chunjia Kou, Chunjia Kou, Yuwei Chai, Yuwei Chai, Yuchen Li, Yuchen Li, Xue Liu, Xue Liu, Li Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang, Haiqing Zhang

“…Finally, ROC curve analysis was conducted to evaluate the effectiveness of NHHR.ResultsIn the main analysis, this study included a total of 9,864 participants. …”
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Efficacy and safety of dapagliflozin in patients hospitalized with COVID-19 with and without type 2 diabetes: a prespecified analysis of the DARE-19 randomized trial by Mohammad Abdel Jawad, Remo H. M. Furtado, Russell Esterline, Jan Oscarsson, Samvel B. Gasparyan, Gary G. Koch, Felipe Martinez, Omar Mukhtar, Subodh Verma, Anna Maria Langkilde, Philip Ambery, Shachi Patel, Kensey Gosch, Sheryl L. Windsor, Ronaldo V. P. Soares, Diogo D. F. Moia, Matthew Aboudara, Ali Javaheri, J. F. Kerr Saraiva, Lilia Nigro Maia, Otavio Berwanger, Andrew J. Sauer, Mikhail N. Kosiborod

“…Dual primary outcomes were evaluated: prevention (time to new or worsened organ dysfunction or death) and a hierarchical composite outcome of recovery (change in clinical status by day 30). …”
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Chronic sleep deprivation induces plasma exosome-derived miR-150-5p downregulation as a novel mechanism involved in Parkinson’s disease progression by targeting DCLK1 by Li Liu, Xiangting Liu, Runze Zhang, Xiao Sun, Keping Zhang, Beibei Zheng, Ruoxi Yang, Kaiyue Yang, Guohua Song, Zhaoqiang Zhang

“…Abstract Background Researches have suggested that chronic sleep deprivation (SD) can lead to neurological dysfunction and facilitate the onset and progression of Parkinson’s disease (PD). …”
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Characterization of Netrin-1 and Its Receptors UNC5B and Neogenin-1 in a Rat Rotator Cuff Tear Model: Associations with Inflammatory Mediators and Neurite Extension by Kosuke Inoue, Kentaro Uchida, Mitsuyoshi Matsumoto, Ryo Tazawa, Etsuro Ohta, Akito Hattori, Tomonori Kenmoku, Yuka Ito, Yui Uekusa, Gen Inoue, Masashi Takaso

“…Rotator cuff tears are a leading cause of shoulder pain and dysfunction, yet the molecular mechanisms that link tendon injury to inflammation and nociceptive signaling remain poorly understood. …”
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Association Between Fractional Exhaled Nitric Oxide (FeNO) and Cognitive Function in Patients with Obstructive Sleep Apnea by Zhu Q, Huang L, Zhu L, Zhang X, Ji H, Niu D, Ji W, Ma Q, Chen R, Shi H, Wang Y, Xu L

“…Higher FeNO50 correlates with memory decline, supporting a link between airway inflammation and cognitive dysfunction in OSA.Plain language summary: OSA is a common sleep disorder in which breathing repeatedly stops and restarts during the night. …”
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Efficacy of Tripterygium glycosides in immune-mediated kidney diseases as a immunomodulation drug in combination with conventional immunosuppressive agents: a systematic review and... by Yaotan Li, Yaotan Li, Jinyi Hou, Jinyi Hou, Xiaochang Wu, Xiaochang Wu, Chang Liu, Mengqi Zhou, Shijia Lin, Weijing Liu, Weijing Liu, Yaoxian Wang, Yaoxian Wang, Huijuan Zheng, Huijuan Zheng

“…BackgroundImmune-mediated kidney diseases involve the immune system attacking the kidneys, resulting in damage and dysfunction. Tripterygium glycosides (TG) are known for their strong immunosuppressive and anti-inflammatory effects and are commonly used alongside traditional immunosuppressive agents. …”
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Impact of Acute Kidney Injury, Co-Existing with and without Chronic Kidney Disease on the Short‐Term Adverse Outcomes Following Atherosclerotic Cardiovascular Disease Events... by Chou CL, Zheng CM, Chiu HW, Tsou LLC, Kao PF, Hsu YH, Lin CL, Sung LC

“…Although ASCVD risk is elevated in diabetic populations, the effect of acute kidney injury (AKI), especially when chronic kidney disease (CKD) is present, on post-ASCVD outcomes remain unclear. …”
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ASSESSMENT OF THE OCCLUSAL RELATIONS NATURE AT THE STAGES OF ORTHOPEDIC REHABILITATION OF PERSONS WITH PERIODONTAL TISSUE DISEASES COMPLICATED BY DENTITION DEFECTS by О.V. Bida, О.V. Bida

“…The aim of the study is to improve the effectiveness of orthopedic treatment of periodontal diseases complicated by defects of the dentition with the control of occlusal relationships with a computerized T-Scan III system. …”
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The role of autophagy in the pathogenesis and treatment of multiple sclerosis by Giulio Righes, Luana Semenzato, Konstantinos Koutsikos, Veronica Zanato, Paolo Pinton, Carlotta Giorgi, Simone Patergnani

“…These processes are essential for the removal of toxic substrates like protein aggregates and dysfunctional mitochondria, which are vital for neuronal health. …”
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The impact of postoperative pain interventions on circadian rhythm disruptions: mechanisms and clinical implications by Dongmei Ma, Li Li, Wei Liu, Jianhong Xu

“…Recent studies have shown that postoperative pain not only affects the physiological state of patients but may also disrupt their circadian rhythms, leading to decreased sleep quality and physiological dysfunctions. This review aims to explore the effects of postoperative pain interventions on circadian rhythm disturbances, analyze the underlying mechanisms, and summarize the effective strategies currently used in clinical practice. …”
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A Preliminary Outcome Study of Brief Cognitive Therapy for Management of Suicidal Thoughts and Behaviors: An Open-label Trial Protocol by Swarnalakshmi S, Munivenkatappa Manjula, Venkata Senthil Kumar Reddi

“…Objectives: The study aims to assess the effectiveness of a brief CT-SP intervention in reducing the severity of suicidal ideation and behaviors. …”
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Cognitive behavioral therapy for the management of cardiometabolic disease risk factors; a systematic meta-review of meta-analyses by Vasiliki C. Baourda, Demosthenes Panagiotakos

“…Findings suggest that CBT is effective in decreasing depressive symptoms and anxiety. …”
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INTEGRATING HYPERTONIA REHABILITATION, INTRAORAL REHABILITATION, AND ANXIETY MANAGEMENT FOR COMPREHENSIVE PATIENT CARE- PART.3 –DIAGNOSIS AND TREATMENT PLAN COMPLEX ORAL REHABILIT... by Ștefan Lucian Burlea, Ovidiu Stamatin, Mihaela Salceanu, Violina Budu, Vlad Proca, Bogdan Petru Bulancea, Tudor Hamburda, Doriana Agop Forna, Maria Antonela Beldiman

“…The masticatory apparatus, which includes the jaw and related muscles, can suffer from dysfunctions like muscle rigidity. This condition is often treated with muscle relaxants, medications that ease muscle tension, with Botulinum toxin (Botox) being one of the most effective options. …”
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INTEGRATING HYPERTONIA REHABILITATION, INTRAORAL REHABILITATION, AND ANXIETY MANAGEMENT FOR COMPREHENSIVE PATIENT CARE- PART2 -clinical examination by Lucian Stefan Burlea, Doriana Agop Forna, Mihaela Salceanu, Violina Budu, Vlad Proca, Bogdan Petru Bulancea, Tudor Hamburda, Maria Antonela Beldiman

“…The stomatognathic system, which includes the jaw and associated muscles, can suffer from dysfunctions like hypertonia (muscle tightness). This condition is often treated with miorelaxants, medications that relax muscles, with Botulinum toxin (Botox) being one of the most effective options. …”
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Impact of Induction Therapy on Clinical Outcomes of Kidney Transplant Recipients: A Single-Centre Cohort Study by Vijaya Madhuri Devraj, Gangadhar Taduri, Swarnalatha Guditi, Uttara Das, MP Shamsudheen, Megha Saigal, Raja Kartik Kalidindi

“…Patients with stable graft survival were observed more with ATG (85%) than BAS (70%); in contrast, graft dysfunctions, graft nephrectomy, rejection episodes, and patient deaths were more prevalent with BAS than ATG, with statistically significant differences in long-term graft functioning. …”
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Clinical and Psychological Features of Patients With Poisoning By Antihypertensive and Antiarrhythmic Drugs as a Result of Suicidal Actions by A. B. Kholmogorova, O. D. Pugovkina, M. I. Subotich, A. V. Komova, M. M. Potskhveria, G. N. Sukhodolova

“…The effective care for patients with self-poisoning with antihypertensive and antiarrhythmic drugs is associated with taking into account both clinical and adverse social, psychological and environmental stress factors. …”
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Graphene oxide–chloroquine conjugate induces DNA damage in A549 lung cancer cells through autophagy modulation by Braham Dutt Arya, Sandeep Mittal, Prachi Joshi, Alok Kumar Pandey, Jaime E. Ramirez-Vick, Govind Gupta, Surinder P. Singh

“…Autophagy is a highly regulated catabolic process by which unnecessary, dysfunctional, or damaged proteins and other cellular components are degraded and recycled to promote cellular differentiation, survival, and development. …”
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Resolvin D1-mediated cellular crosstalk protects against MASH by Amaia Navarro-Corcuera, Yiwei Zhu, Fanglin Ma, Neha Gupta, Haley Asplund, Bruno Cogliati, Jerry E. Chipuk, Oren Rom, Scott L. Friedman, Brian E. Sansbury, Xin Huang, Bishuang Cai

“…Background & aims: Recent studies have highlighted the beneficial effect of resolvin D1 (RvD1), a docosahexaenoic acid-derived specialized pro-resolving mediator, on chronic liver diseases, but the underlying mechanisms are not well understood. …”
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