Comparison of Subconjunctival Mitomycin C and 5-Fluorouracil Injection for Needle Revision of Early Failed Trabeculectomy Blebs by Wei Liu, Jianrong Wang, Miaomiao Zhang, Yuan Tao, Yan Sun

“…Needle revision and subconjunctival MMC injection were more effective than needling and subconjunctival 5-FU injection for early dysfunctional filtration blebs after trabeculectomies.…”
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Designing a glycemic control strategy to maintain glucose homeostasis and prevent hypoglycemia for subjects with type 1 diabetes by A. Rafie Lak, O. Vahidi

“…It is indicated that the manipulation of glucagon infusion rate is effective in hypoglycemia prevention if more aggressive controller settings are chosen or dysfunctional insulin infusion occurs.…”
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Deep learning uncovers histological patterns of YAP1/TEAD activity related to disease aggressiveness in cancer patients by Benoit Schmauch, Vincent Cabeli, Omar Darwiche Domingues, Jean-Eudes Le Douget, Alexandra Hardy, Reda Belbahri, Charles Maussion, Alberto Romagnoni, Markus Eckstein, Florian Fuchs, Aurélie Swalduz, Sylvie Lantuejoul, Hugo Crochet, François Ghiringhelli, Valentin Derangere, Caroline Truntzer, Harvey Pass, Andre L. Moreira, Luis Chiriboga, Yuanning Zheng, Michael Ozawa, Brooke E. Howitt, Olivier Gevaert, Nicolas Girard, Elton Rexhepaj, Iris Valtingojer, Laurent Debussche, Emanuele de Rinaldis, Frank Nestle, Emmanuel Spanakis, Valeria R. Fantin, Eric Y. Durand, Marion Classe, Katharina Von Loga, Elodie Pronier, Matteo Cesaroni

“…Finally, we showed that histological markers of disease aggressiveness were associated with dysfunctional Hippo signaling.…”
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Exosome-derived miR-548ag drives hepatic lipid accumulation via upregulating FASN through inhibition of DNMT3B by Xiaolong Chu, Yanting Hou, Chaoling Peng, Wei Li, Maodi Liang, Jin Mei, Meiyu Qian, Juan Wang, Shibo Xu, Yidan Jiang, Xin Wen, Yao Chen, Fangyuan Yuan, Jianxin Xie, Cuizhe Wang, Jun Zhang

“…Metabolic dysfunction-associated steatotic liver disease (MASLD) is the leading cause of chronic liver disease worldwide. …”
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Time-restricted eating and supervised exercise for improving hepatic steatosis and cardiometabolic health in adults with obesity: protocol for the TEMPUS randomised controlled tria... by Jonatan R Ruiz, Federico Garcia, Idoia Labayen, Rocio Cupeiro, Alba Camacho-Cardenosa, Antonio Clavero-Jimeno, Juan J Martin-Olmedo, Francisco Amaro-Gahete, María Trinidad González Cejudo, Patricia Virginia García Pérez, Carlos Hernández-Martínez, Raquel Sevilla-Lorente, Alejandro De-la-O, Alejandro López-Vázquez, Marcos Molina-Fernandez, Almudena Carneiro-Barrera, Alba Rodríguez-Nogales, Julio Juan Gálvez Peralta, Rafael Cabeza, José L Martín-Rodríguez, Araceli Muñoz-Garach, Manuel Muñoz-Torres

“…Introduction Metabolic dysfunction-associated steatotic liver disease is a major public health problem considering its high prevalence and its strong association with extrahepatic diseases. …”
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Pulmonary Hypertension Induced by Right Pulmonary Artery Occlusion: Hemodynamic Consequences of Bmpr2 Mutation by Alban Todesco, Julien Grynblat, Kouamé Kan Firmin Akoumia, Damien Bonnet, Pedro Mendes‐Ferreira, Stéphane Morisset, Denis Chemla, Marilyne Levy, Mathilde Méot, Sophie‐Guiti Malekzadeh‐Milani, Birger Tielemans, Benoit Decante, Carine Vastel‐Amzallag, Paul Habert, Maria‐Rosa Ghigna, Marc Humbert, David Montani, David Boulate, Frédéric Perros

“…Conclusions Our novel 2‐hit rat model presents a promising avenue to explore the adaptation of the right ventricle and pulmonary vasculature to PH, shedding light on pertinent sex‐ and gene‐related effects.…”
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Therapeutic potential of Cordyceps militaris cultivated with Ginkgo biloba seeds for alleviating western diet-induced type 2 diabetes and diabetic nephropathy by Shinn-Zong Lin, Shinn-Zong Lin, Wei-Wen Kuo, Wei-Wen Kuo, Wei-Wen Kuo, Bruce Chi-Kang Tsai, Catherine Reena Paul, Chia-Hua Kuo, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Dennis Jine-Yuan Hsieh, Shih-Wen Kao, Shih-Wen Kao, Pei-Ying Pai, Pei-Ying Pai, Shan-Jun Chen, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Chih-Yang Huang, Kuan-Ho Lin, Kuan-Ho Lin

“…A T2DM mouse model was established using ApoE knockout mice fed a Western diet (WD).ResultsTreatment with the specially cultivated C. militaris ameliorated hyperglycemia, dyslipidemia and hepatic dysfunction, while mitigating T2DM-induced renal damage. …”
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Rhythmic modulation of subthalamo-pallidal interactions depends on synaptic rewiring through inhibitory plasticity by Mojtaba Madadi Asl, Caroline A. Lea-Carnall

“…Our findings demonstrate the critical role of neuroplasticity in shaping long-lasting stimulation effects and contribute to the optimization of a variety of multisite stimulation paradigms aimed at reshaping dysfunctional brain networks by targeting inhibitory plasticity.…”
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Fat tissue regulates the pathogenesis and severity of cardiomyopathy in murine chagas disease. by Kezia Lizardo, Janeesh P Ayyappan, Neelam Oswal, Louis M Weiss, Philipp E Scherer, Jyothi F Nagajyothi

“…Chronic Chagas cardiomyopathy (CCC) caused by a parasite Trypanosoma cruzi is a life-threatening disease in Latin America, for which there is no effective drug or vaccine. The pathogenesis of CCC is complex and multifactorial. …”
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Optimal choice of prophylactic anticoagulant therapy for nonvalvular atrial fibrillation in the context of COVID-19 pandemic by A. S. Polyakov, V. V. Tyrenko, E. V. Kryukov, Ya. A. Noskov

“…Atrial fibrillation is not only the most common type of supraventricular tachyarrhythmia, but it is also the main underlying cause of more than half of cardioembolic stroke cases, which requires effective thromboprophylaxis. While maintaining the infectious danger for patients, the anticoagulant selection should take into account the possible dysfunctions and drug interactions during the initial infection or reinfection of COVID-19, as well as the possibility of rapid anticoagulant action reverse if surgery is required or bleeding develops. …”
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Single cell sequencing and spatial multiomics of diabetic kidney segmentation insights zonation-specific therapeutic metabolic pathways by Shi Qiu, Zhibo Wang, Sifan Guo, Dandan Xie, Ying Cai, Xian Wang, Chunsheng Lin, Songqi Tang, Yiqiang Xie, Aihua Zhang

“…Cross-species integration identified GPX3 as a fibroblast-enriched biomarker strongly correlated with kidney dysfunction and closely related to clinical indicators. …”
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mTOR inhibition triggers mitochondrial fragmentation in cardiomyocytes through proteosome-dependent prohibitin degradation and OPA-1 cleavage by Hugo E. Verdejo, Valentina Parra, Andrea del Campo, Cesar Vasquez-Trincado, Damian Gatica, Camila Lopez-Crisosto, Jovan Kuzmicic, Leslye Venegas-Zamora, Ursula Zuñiga-Cuevas, Mayarling F. Troncoso, Rodrigo Troncoso, Beverly A. Rothermel, Mario Chiong, E. Dale Abel, Sergio Lavandero

“…Objective Here, we studied the role of mTOR in OPA-1 cleavage and its consequent effects on mitochondrial dynamics and energetics in cardiomyocytes. …”
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A decade of Benzodiazepine and Z-drug use in Hong Kong: a longitudinal studyResearch in context by Kyung Jin Lee, Yue Wei, Shek-Ming Leung, Caige Huang, Hei Hang Edmund Yiu, Eunice Kehui Deng, David J. Castle, Simon S.Y. Lui, Vincent K.C. Wong, Ian C.K. Wong, Esther W. Chan

“…Summary: Background: Concerns are growing about the long-term use of benzodiazepines (BZDs) and non-benzodiazepines (Z-drugs) due to adverse effects such as drug tolerance, dependence, cognitive dysfunction, and falls, particularly in the elderly. …”
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…In this study, new piperidine-based ligands, analogs of the potent and selective D4R compounds 77-LH-28-1 (<b>7</b>) and its 4-benzyl analog <b>8</b>, were synthesized and studied to investigate the effects produced by variations in the distances between the pharmacophoric features on the D4R affinity and selectivity. …”
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Gender differences in neurocognitive impairment among first-episode, drug-naïve schizophrenia patients: a cross-sectional study by Qing Zhang, AiMin Sui, Min Su, MingLiang Ju, YanYan Wei, XiaoChen Tang, LiHua Xu, HuiRu Cui, YingYing Tang, ZhengHui Yi, HaiChun Liu, Jin Gao, JiJun Wang, JiJun Wang, TianHong Zhang

“…These findings underscore the need for sex-sensitive approaches in characterizing cognitive dysfunction in early psychosis.…”
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Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid patholog... by Daniela M. Jimenez-Harrison, Michael J. Butler, Haanya Ijaz, Rami Alsabbagh, Menaz N. Bettes, James W. DeMarsh, Sabrina E. Mackey-Alfonso, Stephanie M. Muscat, Bryan D. Alvarez, Jade A. Blackwell, Ashton Taylor, Jeferson Jantsch, Andrew A. Sanchez, Sarah B. Peters, Ruth M. Barrientos

“…Overall, this study shows that combining Pd and AD-related genetic risk exacerbates inflammation, cognitive impairment, synaptic dysfunction, Aβ pathology, and neurodegeneration. Neither insult alone was sufficient to produce these effects, highlighting the synergistic impact. …”
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Evaluation of the neuroprotective potential of benzylidene digoxin 15 against oxidative stress in a neuroinflammation models induced by lipopolysaccharide and on neuronal different... by Gilvânia A. Cordeiro, Jessica A. Faria, Leticia Pavan, Israel J. P. Garcia, Eduarda P. F. I. Neves, Gustavo Fernando de Frazao Lima, Hericles M. Campos, Pâmela Y. Ferreira, Paulo C. Ghedini, Elisa M. Kawamoto, Maira C. Lima, José A. F. P. Villar, José A. F. P. Villar, Ana Maria M. Orellana, Leandro A. Barbosa, Cristoforo Scavone, Jacqueline A. Leite, Hérica L. Santos

“…BD-15 treatment reversed these effects, notably by restoring GSH levels and reducing protein carbonylation in the cerebellum. …”
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Systematic review and meta-analysis of polycystic ovary syndrome and mental health among Black Asian Minority Ethnic populations by Gayathri Delanerolle, Salma Ayis, Vanya Barzilova, Peter Phiri, Priyanka Jagadeesan, Yutain Zeng, Sandali Ranaweera, Ashish Shetty, Nyla Haque, Debasish Kar, Kingshuk Majumder, Shanaya Rathod, Vanessa Raymont, Jian Qing Shi, Dharani K. Hapangama

“…The finalised dataset was analysed using statistical methods such as random-effect models, subgroup analysis, and sensitivity analysis. …”
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Islet Stellate Cells Regulate Insulin Secretion via Wnt5a in Min6 Cells by Wei Xu, Peter M. Jones, Houfa Geng, Rui Li, Xuekui Liu, Yinxia Li, Qian Lv, Ying Liu, Jie Wang, Xiuli Wang, Zilin Sun, Jun Liang

“…Accumulating evidence has shown that β-cell dysfunction is an important mechanism underlying diabetes mellitus. …”
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Liver steatosis is positively associated with plasminogen activator inhibitor-1 in apparently healthy individuals with overweight and obesity: A FibroScan-Based Cross-Sectional stu... by Giuseppe Lisco, Davide Guido, Nicole Cerabino, Martina Di Chito, Rosanna Donvito, Caterina Bonfiglio, Endrit Shahini, Marianna Zappimbulso, Cristiana Randazzo, Domenico Barletta, Dolores Stabile, Anna Ancona, Sergio Coletta, Pasqua Letizia Pesole, Gianluigi Giannelli, Giovanni De Pergola

“…Abstract Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common cause of steatotic liver disease and has major implications on cardiovascular safety. …”
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