Natural compounds targeting inflammation and oxidative stress in intestinal ischemia-reperfusion injury: a comprehensive review by Balaji Venkataraman, Aya A. Touny, Shamanth Neralagundi Harihar gowdru, Bhoomendra A. Bhongade, Rajesh B. Patil, Shreesh Ojha, Mauro Pessia, Sandeep B. Subramanya

“…Through their multi-targeted effects on oxidative stress, inflammation, and intestinal barrier integrity, these natural compounds can significantly reduce tissue damage and support recovery. …”
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Hepatic IR and IGF1R signaling govern distinct metabolic and carcinogenic processes upon PTEN deficiency in the liver by Monika Gjorgjieva, Nicolas Calo, Cyril Sobolewski, Dorothea Portius, Jean-Luc Pitetti, Flavien Berthou, Anne-Sophie Ay, Marion Peyrou, Lucie Bourgoin, Christine Maeder, Margot Fournier, Marta Correia de Sousa, Etienne Delangre, Laurent Vinet, Xavier Montet, Christine Sempoux, Serge Nef, Michelangelo Foti

“…Our findings on the distinct and combined effects of these receptors in PTEN-deficient mice offer key insights into the mechanisms driving metabolic dysfunction-associated steatotic liver disease and related hepatocarcinogenesis. …”
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THE VASCULAR ENDOTHELIUM FUNCTION INDICATORS IN ORAL LIQUID OF IQOS SMOKING ADOLESCENTS by T.M. Popova, O.A. Nakonechna, O.V. Tishchenko, L.S. Kryvenko

“…These results showed interrelation between adverse IQOS effect on vascular endothelium of adolescents duration of IQOS smoke. …”
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Astragalin-functionalized ultrasmall nanoparticles modulate the complement pathway to inhibit microglial synaptic phagocytosis for reducing anesthetic neurotoxicity by Gang Wang, Yaobao Han, Ke Peng, Zhilin Jiang, Tingting Wang, Qing Zheng, Wenting Li, Hanbing Xu, Fuhai Ji, Zhen Li

“…Astragalin, a natural flavonoid compound, exhibits diverse bioactivities, such as anti-tumor, anti-complement, and anti-inflammatory effects. Herein, astragalin-functionalized Cu2-xSe nanoparticles (CSPA NPs) can effectively inhibit the complement pathway, mitigating microglia-mediated synaptic phagocytosis and promoting synaptic restoration to repair sevoflurane-induced neurotoxicity. …”
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Study protocol: a randomized controlled clinical trial on the use of electroacupuncture for postoperative abdominal distension following laparoscopic cholecystectomy by Qi Kong, Qi Kong, Qi Kong, Wei Wang, Xin-Yi Chen, Li-Ming Chen, Long-Kai Sun, Long-Kai Sun, Shao-Hua Qu, Wen-Tao Wu, Jia-Hua Yang, Yu Shu, Sen Li, Pei-Hao Yin, Pei-Hao Yin, Pei-Hao Yin, Wei Li, Wei Li

“…However, pneumoperitoneum and various factors leading to abdominal distension and other gastrointestinal dysfunctions are common postoperative complications. …”
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Assembly of ceria-Nrf2 nanoparticles as macrophage-targeting ROS scavengers protects against myocardial infarction by Wenjing Liao, Jinduan Lin, Wenli Wang, Ming Zhang, Yanfang Chen, Xin Li, Huan Liu, Pan Xia Wang, Guojun Zhao, Jijun Fu, Xiaoqian Wu

“…The CeO2/Nrf2 nanocomposites effectively activated the Nrf2/antioxidant response element (ARE) signaling pathway both in vivo and in vitro. …”
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Endotoxin and Cytokines Removal with Adsorption Device in a Child with Sepsis After Transplantectomy (Case Report) by A. A. Eremenko, T. V. Marchenko, V. V. Nikoda, A. K. Zokoev, D. A. Skripalenko

“…Sepsis is one of the leading causes of death in kidney transplant recipients.We present our experience of effective removal of bacterial endotoxins and endogenous inflammatory mediators using a multimodal hemosorbent in sepsis, caused by gram-negative polyresistant Klebsiella spp. including K. pneumoniae. …”
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Low dose exposure to dioxins alters hepatic energy metabolism and steatotic liver disease development in a sex-specific manner by Oluwanifemi E. Bolatimi, Yuan Hua, Frederick A. Ekuban, Tyler C. Gripshover, Abigail Ekuban, Bana Luulay, Walter H. Watson, Josiah E. Hardesty, Banrida Wahlang

“…We therefore investigated sex-dependent effects of low-level exposures to a mixture of dioxins: 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), 2,3,4,7,8-Pentachlorodibenzofuran (PeCDF) and Polychlorinated biphenyl 126 (PCB126), in the context of SLD and associated metabolic dysfunction. …”
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C3d-targeted complement inhibitors to correct complement dysregulation in aHUS patients by Valeria Guaschino, Donata Santarsiero, Sara Gastoldi, Joshua M. Thurman, V. Michael Holers, Shelia M. Violette, Fei Liu, Kelly C. Fahnoe, Chiara Guarinoni, Ariela Benigni, Giuseppe Remuzzi, Marina Noris, Sistiana Aiello

“…We demonstrate that anti-C3d-antibody conjugated with CR11-10, or CR11-17, or FH1–5 effectively prevented aHUS serum-induced complement activation on HMEC-1, outperforming their non-targeted soluble counterparts. …”
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Chronic intermittent fasting impairs β cell maturation and function in adolescent mice by Leonardo Matta, Peter Weber, Suheda Erener, Alina Walth-Hummel, Daniela Hass, Lea K. Bühler, Katarina Klepac, Julia Szendroedi, Joel Guerra, Maria Rohm, Michael Sterr, Heiko Lickert, Alexander Bartelt, Stephan Herzig

“…Here, we investigated the effects of IF on systemic metabolism and β cell function in old, middle-aged, and young mice. …”
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Sirt2 ablation exacerbates Sod1 knockout-induced progeroid phenotype in mice by Anke Geng, Xiaona Wang, Zhenkai Wu, Zhihao Liu, Xiao Huang, Xiyue Wang, Xiaoxiang Sun, Yingjie Wang, Jiayu Chen, Ying Jiang, Huanyin Tang, Zhiyong Mao

“…While free radicals cause DNA damage and cellular dysfunction, they also regulate essential signaling pathways. …”
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12,13-diHOME protects against the age-related decline in cardiovascular function via attenuation of CaMKII by Shinsuke Nirengi, Benjamin Buck, Devleena Das, Carmem Peres Valgas da Silva, Jazmin Calyeca, Lisa A. Baer, Hsiang-Ling Huang, Pablo Vidal, Revati S. Dewal, Kelsey M. Pinckard, Elisa Félix-Soriano, Diego Hernandez-Saavedra, Andrew Gerea, Kavya Dathathreya, Silvia Duarte-Sanmiguel, Ty A. Saldana, Harrison L. Hookfin, Matthew W. Gorr, Valerie Bussberg, Juan J. Aristizabal-Henao, Michael A. Kiebish, Roeland J. W. Middelbeek, Laurie J. Goodyear, Paul M. Coen, Krishna Chinthalapudi, Loren E. Wold, Ana L. Mora, Thomas J. Hund, Daniel Gallego-Perez, Kristin I. Stanford

“…Transplantation of BAT or sustained upregulation of 12,13-diHOME effectively preserved cardiac function in aged male and female mice. …”
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A1AT dysregulation of metabolically stressed hepatocytes by Kupffer cells drives MASH and fibrosis by Jeong-Su Park, Jin Lee, Feng Wang, Hwan Ma, Zixiong Zhou, Yong-Sun Lee, Kwangyeon Oh, Haram Lee, Guoyan Sui, Sangkyu Lee, Yoon Mee Yang, Jang-Won Lee, Yong-Ha Ji, Chun-Woong Park, Hwan-Soo Yoo, Bang-Yeon Hwang, Sang-Bae Han, Nan Song, Soohwan Oh, Bumseok Kim, Ekihiro Seki, Jin Tae Hong, Yoon Seok Roh

“…Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is associated with the activation of Kupffer cells (KCs) and hepatic stellate cells, at which point a metabolically stressed hepatocyte becomes integral to the progression of the disease. …”
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Targeted Delivery of Exosome-Derived miRNA-185-5p Inhibitor via Liposomes Alleviates Apoptosis and Cuproptosis in Dilated Cardiomyopathy by Xu S, Zeng Y, Tan X, Zhang G, Xu A, Fan H, Yu F, Qin Z, Song Y, Jiang Y, Wang X, Zhang D, Nong Y, Lian D, Tang J, Zhou Y

“…These findings underscore the therapeutic potential of this targeted delivery strategy for the treatment of dilated cardiomyopathy.Conclusion: Lipo@miR-185-5p inhibitor, utilizing exosome-derived miRNA and targeted liposomal delivery, effectively alleviates DCM-induced myocardial dysfunction. …”
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The value of echocardiography in the staging of preexcitation syndrome and the assessment of left ventricular wall dyskinesia in children by Yahui Yuan, Shu Li, Jun Chen, Yu Mao, Ming Yang, Shiwei Yang, Wentao Kong, Hao Liu

“…Conventional echocardiography lacks specificity and was limited to assessing the effects of WPWs on cardiac structure, while changes in cardiac function, ventricular wall dysfunction and different subtypes of WPWs were less commonly addressed. …”
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The impact of high-salt diet and diuretics on the development of the aestival phenomenon in patients with chronic heart failure by Dmitrii O. Dragunov, Dmitrii O. Dragunov, Anna V. Sokolova, Anna V. Sokolova, Vadim M. Mitrokhin, Grigory P. Arutyunov

“…However, such therapy may lead to adverse effects, including deterioration of renal function and electrolyte imbalance. …”
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Vitamin D Alleviates Osteoarthritis Progression by Targeting Cartilage and Subchondral Bone via Myd88-TAK1-ERK Axis Suppression by Gao X, Min Y, Lin R, Liang D, Zhang M, Xiao Q, Lu Y, Zhang F, Xu B, Liu Y

“…Emerging evidence suggests subchondral bone metabolic dysfunction may initiate OA. While vitamin D (VitD) is well-established for bone metabolism regulation in osteoporosis, its therapeutic potential in OA remains unclear despite observational studies suggesting protective effects. …”
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Efficacy of Cyclosporine in the Induction and Maintenance of Remission in a Systemic Lupus Erythematosus Patient Presenting with Macrophage-Activating Syndrome by Franchesca Cruz-Pérez, Salvador Vilá, Grissel Ríos, Luis M. Vilá

“…Macrophage-activating syndrome (MAS) is a rare condition characterized by dysfunctional macrophage activation leading to overproduction of cytokines and phagocytosis of erythrocytes, leukocytes, and platelets. …”
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FOXK2 in skeletal muscle development: a new pathogenic gene for congenital myopathy with ptosis by Peixuan Wu, Nan Song, Yang Xiang, Zhe Tao, Bing Mao, Ruochen Guo, Xin Wang, Dan Wu, Zhenzhen Zhang, Xin Chen, Duan Ma, Tianyu Zhang, Bingtao Hao, Jing Ma

“…Abstract Congenital ptosis, a genetic disorder involving levator palpebrae muscle dysfunction, is often associated with congenital myopathy. …”
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Pathological variants in TOP3A cause distinct disorders of mitochondrial and nuclear genome stability by Direnis Erdinc, Alejandro Rodríguez‐Luis, Mahmoud R Fassad, Sarah Mackenzie, Christopher M Watson, Sebastian Valenzuela, Xie Xie, Katja E Menger, Kate Sergeant, Kate Craig, Sila Hopton, Gavin Falkous, Genomics England Research Consortium, Joanna Poulton, Hector Garcia‐Moreno, Paola Giunti, Carlos A de Moura Aschoff, Jonas A Morales Saute, Amelia J Kirby, Camilo Toro, Lynne Wolfe, Danica Novacic, Lior Greenbaum, Aviva Eliyahu, Ortal Barel, Yair Anikster, Robert McFarland, Gráinne S Gorman, Andrew M Schaefer, Claes M Gustafsson, Robert W Taylor, Maria Falkenberg, Thomas J Nicholls

“…We present a comprehensive characterisation of the effect of TOP3A variants, from individuals with mitochondrial disease and Bloom‐like syndrome, upon mtDNA maintenance and different aspects of enzyme function. …”
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