AI-Driven Innovations for Early Sepsis Detection by Combining Predictive Accuracy With Blood Count Analysis in an Emergency Setting: Retrospective Study by Tai-Han Lin, Hsing-Yi Chung, Ming-Jr Jian, Chih-Kai Chang, Hung-Hsin Lin, Chiung-Tzu Yen, Sheng-Hui Tang, Pin-Ching Pan, Cherng-Lih Perng, Feng-Yee Chang, Chien-Wen Chen, Hung-Sheng Shang

“…Although the Sequential Organ Failure Assessment (SOFA) score standardizes the diagnosis of organ dysfunction, early sepsis detection remains challenging due to its insidious symptoms. …”
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Nopal and Pirfenidone Ameliorate Epididymal Fat Weight and Anthropometric Parameters in a Mouse Obesity Model with Diethylnitrosamine by Jorge Gutiérrez-Cuevas, Daniel López-Cifuentes, Ana S. Sandoval-Rodríguez, Juan Armendariz-Borunda

“…Mexico has a high prevalence of obesity and metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Impact of Chronic Intermittent Hypoxia on Cognitive Function and Hippocampal Neurons in Mice: A Study of Inflammatory and Oxidative Stress Pathways by Zhang K, Ma D, Wu Y, Xu Z

“…CIH can further lead to cognitive dysfunction by inducing processes such as neuroinflammation and oxidative stress. …”
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Short‐chain fatty acids enhance muscle mass and function through the activation of mTOR signalling pathways in sarcopenic mice by Chaoran Liu, Pui Yan Wong, Qianjin Wang, Hei Yuet Wong, Tao Huang, Can Cui, Ning Zhang, Wing Hoi Cheung, Ronald Man Yeung Wong

“…In vitro studies indicated that SCFAs inhibited FoxO3a/Atrogin1 and activated mTOR pathways to improve myotube growth (P < 0.05), and rapamycin attenuated the effect of SCFAs through the inhibition of mTOR pathways. …”
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Hepatoprotective Therapy Efficacy in Obstructive Hepatobiliary Diseases: A Prospective Randomized Study by Mykhailo Maksymenko, Olexii Kulivets, Roman Havryliuk, Walery Zukow

“…Despite significant advances in interventional and surgical approaches, liver dysfunction associated with these disorders continues to substantially impact patient morbidity and mortality. …”
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Altered microbiome and metabolome profiling in fearful companion dogs: An exploratory study. by Luigi Sacchettino, Michele Costanzo, Iolanda Veneruso, Valeria D'Argenio, Maria Mayer, Francesco Napolitano, Danila d'Angelo

“…Behavioral dysfunctions in dogs represent one of the main social concerns, since they can endanger animals and human-dog relationship. …”
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Nature’s blueprint for sugar metabolism: translating bee and ant strategies into human diabetes therapies by Fahrul Nurkolis, Raffaele Romano, Antonello Santini

“…Abstract Despite advances in pharmacological treatments, diabetes mellitus remains a significant global health challenge, characterized by chronic hyperglycemia and associated metabolic dysfunctions. Effective and sustainable glycemic control remains elusive, prompting exploration into unconventional sources of metabolic insights. …”
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Metformin-mediated intestinal AMPK activation ameliorates PCOS through gut microbiota modulation and metabolic pathways by Yating Xu, Li Ning, Yu Si, Xiu Li, Ruyue Wang, Qingling Ren

“…IntroductionPolycystic ovary syndrome (PCOS) is a complex disorder characterized by metabolic and ovulatory dysfunctions, often associated with an imbalance in gut microbiota. …”
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Optimization of anticoagulant therapy in patients undergoing mechanical heart valve replacement by S. A. Tkachenko, D. A. Astapov, A. V. Bogachev-Prokofiev, A. S. Zalesov, A. N. Pivkin, A. G. Makaev, Kh. A. Agaeva, R. M. Sharifulin

“…To date, surgery remains the only effective option to treat acquired heart disease, and replacement of the dysfunctional heart valves frequently relies on mechanical prosthetic heart valves which implantation requires lifelong anticoagulant therapy with vitamin K antagonists and constant monitoring of international normalised ratio. …”
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Nanosecond pulsed electric field applications rejuvenate aging endothelial cells by rescuing mitochondrial-to-nuclear retrograde communication by Meifang Yin, Jie Xiao, Guangtao Huang, Huanyu Xie, Hongwei Liu, Jianqiang Yuan, Xiaofang Liu, Anna Chiarini, Ubaldo Armato, Ilaria Dal Prà, Shumaila Ijaz, Naziat Begum, Lingyun Wang, Jun Wu

“…Nanosecond pulsed electric fields (nsPEF) were shown to exert biological effects by targeting mitochondria. However, the nsPEF regulation of MNRC is still unclear. …”
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Autophagy—Unlocking New Dimensions in the Pathology and Treatment of Depression by Qiang Luo, Yulong Zhao, Peng Ren, Xu Liu, Yingjian Chen, Qianru Ying, Junjie Zhou

“…As a disease with a significant burden, the effective treatment of depression has become a major challenge for global public health. …”
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Longitudinal patterns of disordered eating behaviors in children and adolescents from the Brazilian High-Risk Cohort study for mental conditions by Iara Peixoto de Oliveira, Ana C. Fernandéz, Giovanni A. Salum, Ary Gadelha, Pedro Mario Pan, Eurípedes Constantino Miguel, Daniel C. Mograbi, Patricia Bado

“… Objective: Disordered eating behaviors (DEB) are dysfunctional changes in eating behavior that do not meet the diagnostic criteria for eating disorders. …”
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Restoration of mitochondrial energy metabolism by electroconvulsive therapy in adolescent and juvenile mice by Ning Du, Ning Du, Yu Xie, Yu Xie, Dandan Geng, Dandan Geng, Jingran Li, Jingran Li, Heyan Xu, Heyan Xu, Yuna Wang, Yuna Wang, Jijia Gou, Jijia Gou, Xiwen Tan, Xiwen Tan, Xiaoming Xu, Xiaoming Xu, Lei Shi, Yujia Chen, Yujia Chen, Fengming Chen, Zixuan Zhou, Gang Liu, Li Kuang, Li Kuang

“…Previous studies suggest that mitochondrial dysfunction is closely related to the onset of depression. …”
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Exosomes derived from a mesenchymal-like endometrial regenerative cells ameliorate renal ischemia reperfusion injury through delivery of CD73 by Bo Shao, Hong-da Wang, Shao-hua Ren, Qiang Chen, Zhao-bo Wang, Yi-ni Xu, Tong Liu, Cheng-lu Sun, Yi-yi Xiao, Hong-yu Jiang, Yi-cheng Li, Peng-yu Zhao, Guang-mei Yang, Xu Liu, Yu-fan Ren, Hao Wang

“…Abstract Background Renal ischemia reperfusion (I/R) injury is a major contributor to graft dysfunction and inflammation leading to graft loss. …”
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Influence of Manual Therapy and Stretching Exercises on Mobility Status and Pulmonary Function Tests Among Patients with Ankylosing Spondylitis by Daniel Szewczyk, Teresa Sadura-Sieklucka, Beata Tarnacka, Tomasz Targowski

“…Introduction: AS (ankylosing spondylitis) is a systemic disease that impairs entire body functioning of a patient. The most common dysfunctions concern the area of the chest, spine and upper limb. …”
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Sudden acquired retinal degeneration syndrome may be an acquired primary ciliopathy, phenotypically similar to human Alström and Bardet-Biedl syndromes by Steven Toler, Kenneth Abrams, Daniel Ward

“…Recognizing SARDS as a possible acquired ciliopathy may be the first step toward seeking effective treatments.…”
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Endotoxicosis as the Contents of Posresuscitative Disease in Acute Poisoning by Ye. A. Luzhnikov, Yu. S. Goldfarb, K. K. Ilyashenko

“…The study pathology has been ascertained to have 3 developmental stages — from functional (primary) to developed and terminal clinical and laboratory manifestations as multiple organ dysfunctions. The best therapeutic results are achieved by effective therapeutic measures just in early-stage endotoxicosis, by substantially reducing the rates of death and pneumonia and the time of the latter’s resolution. …”
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Communication between the gut microbiota and peripheral nervous system in health and chronic disease by Tyler M. Cook, Virginie Mansuy-Aubert

“…Finally, we discuss how leveraging the power of our gut microbes on peripheral nervous system signaling may offer effective therapies to counteract the rise in chronic diseases crippling the western world.…”
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Microenvironment-responsive coating for vascular stents to regulate coagulation-inflammation interaction and promote vascular recovery by Qiongjun Zhu, Zhezhe Chen, Dan'an Wang, Xiaolu Jiao, Yi Luan, Min Wang, Rifang Luo, Yunbing Wang, Guosheng Fu, Yanan Wang, Wenbin Zhang

“…MMP9-responsive nanoparticles embedded in the coating released salvianolic acid A to modulate inflammatory cell behavior and inhibit SMC dysfunction. By effectively interfering with clotting and inflammation, the coating suppressed platelet-fibrin interaction and formation of platelet-monocyte aggregates, thereby mitigating adverse effects on reendothelialization. …”
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ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle by Mao Chen, Xiaoyu Huang, Bingshu Li, Ya Xiao, Liying Chen, Fangyi Zhu, Shasha Hong, Jianming Tang, Suting Li, Jie Min, Wenyi Jin, Yubiao Zhang, Lian Yang, Yang Li, Shufei Zhang, Li Hong

“…Knockdown of ArfGAP3 exacerbated impaired differentiation potential and induced aberrant mitochondrial morphology and functional dysfunction in ageing C2C12 myoblasts, whereas ArfGAP3 overexpression largely mitigated these effects. …”
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