Unveiling therapeutic targets and preventive components for kidney insufficiency and blood stasis-type BPH: bridging metabolomics, network pharmacology and reverse screening by Xiangpeng Kong, Xiangpeng Kong, Haiqin Ren, Ke Pei, Yajun Yao, Zhigang Liang, Yunfeng Xue, Shuang Liang, Tongtong Li, Jing Zhang, Yuxia Guo, Miaorong Pei, Huifeng Li

“…However, due to the complex pathogenesis of BPH, these drugs can only partially alleviate symptoms and have shortcomings such as high treatment costs and significant side effects. BPH is similar to the descriptions of “Jīng Lóng” and “Lóng Bì” in traditional Chinese medicine (TCM), and its onset is closely related to liver and kidney dysfunction. …”
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Analysis of the relevant factors for corneal graft rejection in the southern Liaoning region from 2019 to 2023 by Chunxiao Yan, Chunxiao Yan, Zhijian Zhang, Zhijian Zhang, Lin Jin, Mengxin Liu, Tianyi Wang, Tianyi Wang, Jinghao Yang, Jinghao Yang, Lijun Zhang, Lijun Zhang, Lijun Zhang

“…In addition, virus-derived keratitis was considered to be the main risk factor for corneal neovascularization, and deep anterior lamellar keratoplasty was not found to have an effect on corneal graft rejection in this study.…”
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Liver specific transgenic expression of CYP7B1 attenuates early western diet-induced MASLD progression by Genta Kakiyama, Nanah Bai-Kamara, Daniel Rodriguez-Agudo, Hajime Takei, Kei Minowa, Michael Fuchs, Sudha Biddinger, Jolene J. Windle, Mark A. Subler, Tsuyoshi Murai, Mitsuyoshi Suzuki, Hiroshi Nittono, Arun Sanyal, William M. Pandak

“…Effect of liver specific oxysterol 7α-hydroxylase (CYP7B1) overexpression on the Western diet (WD)-induced metabolic dysfunction-associated steatotic liver disease (MASLD) progression was studied in mice. …”
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In vivo protein half-life analysis identifies the SREBF1-SLC27a5 axis governs antioxidant response in preclinical alcoholic rat model by Nupur Sharma, Sadam H. Bhat, Shweta Chaudhary, Babu Mathew, Sushmita Pandey, Sanju Yadav, Manisha Yadav, Vasundhra Bindal, Gaurav Tripathi, Neha Sharma, Vipul Sharma, Abhishak Gupta, Ranjan Nanda, Anupama Kumari, Shvetank Sharma, Jaswinder Singh Maras

“…Background: ALD causes liver dysfunction with inflammation, steatosis, and fibrosis. …”
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The binuclear cyclopalladated complex CP2 is targeting ubiquinol-cytochrome c reductase (complex III) of Leishmania amazonensis by Angela Maria Arenas Velásquez, Irwin Alexander Patino Linares, Lawrence D. Gaspers, Paula J. Bartlett, Jecika M. Velasques, Adelino V.G. Netto, Andrew P. Thomas, Marcia A.S. Graminha

“…Metal-based drugs such as cyclopalladated complex [Pd(dmba)(μ-N3)]2 (CP2), a Leishmania topoisomerase IB inhibitor involved in calcium dysregulation and mitochondrial dysfunction of the parasite, had been an alternative to outline the appearance of chemoresistance. …”
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Aerobic exercise improves clearance of amyloid-β via the glymphatic system in a mouse model of Alzheimer's Disease by Shengxiang Liang, Huanhuan Liu, Xiuxiu Wang, Huawei Lin, Ling Zheng, Yusi Zhang, Lixin Peng, Saie Huang, Lidian Chen

“…However, it remains unclear whether AQP4 regulates glymphatic clearance of Aβ which contributes to the beneficial effects of aerobic exercise in AD patients. Here, the goal of this study was to investigate the mechanisms about aerobic exercise whether AQP4 could modulate glymphatic system using APP/PS1 mice. …”
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Polycystic ovary syndrome and excessive body weight impact independently and synergically on fertility treatment outcomes by Emídio Vale-Fernandes, Mafalda V. Moreira, Raquel L. Bernardino, Daniela Sousa, Raquel Brandão, Carla Leal, Márcia Barreiro, Mariana P. Monteiro

“…This study aimed to disentangle the relative contributions of PCOS and obesity for reproductive dysfunction in women undergoing in vitro fertilization (IVF). …”
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A murine model of gestational diabetes reveals MASLD risk and alterations in markers of hepatic mitochondrial metabolism by Grace E. Shryack, Grace E. Shryack, Grace E. Shryack, Alexa A. Krause, Alexa A. Krause, Alexa A. Krause, Simone Hernandez Ruano, Laura C. Schulz, Kathleen A. Pennington, R. Scott Rector, R. Scott Rector, R. Scott Rector

“…IntroductionGestational Diabetes Mellitus (GDM) impacts roughly 1 in 7 pregnancies and results in metabolic dysfunction-associated steatotic liver disease (MASLD) in 30% of these women. …”
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Targeting P21‐Activated Kinase 2 as a Novel Therapeutic Approach to Mitigate Endoplasmic Reticulum Stress in Heart Failure With Preserved Ejection Fraction by Hongyuan Zhang, Honglin Xu, Fangchao Zhou, Tayyiba Azam, Sultan Samman, Pablo Binder, Binh Nguyen, Elizabeth J. Cartwright, Oliver J. Müller, Susanne S. Hille, Fay Pu, Darren Green, Yanrong Liu, Min Zi, Xin Wang

“…Conclusions Pak2 prevents HFpEF progression, exerting cardioprotective effects against ER stress. These insights underscore the therapeutic value of Pak2 in HFpEF.…”
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Identifying Molecular Properties of Ataxin-2 Inhibitors for Spinocerebellar Ataxia Type 2 Utilizing High-Throughput Screening and Machine Learning by Smita Sahay, Jingran Wen, Daniel R. Scoles, Anton Simeonov, Thomas S. Dexheimer, Ajit Jadhav, Stephen C. Kales, Hongmao Sun, Stefan M. Pulst, Julio C. Facelli, David E. Jones

“…Spinocerebellar ataxia type 2 (SCA2) is an autosomal dominant neurodegenerative disorder marked by cerebellar dysfunction, ataxic gait, and progressive motor impairments. …”
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Down-regulation of serum SIRT6 levels is associated with an increased risk of chronic intestinal inflammation in children exposed to airborne particulate matter and polycyclic arom... by Tengyang Huang, Xijin Xu, Shuqin Chen, Zhiping Liu, Yu Huang, Xia Huo, Guangcan Chen

“…Informal e-waste recycling releases airborne particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs), which are linked to intestinal barrier dysfunction and chronic inflammation. SIRT6, a histone deacetylase, modulates inflammation by suppressing NF-κB signaling, but its role in mitigating e-waste pollutant-induced childhood enteritis remains unclear. …”
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Sleep disturbances in SCN8A‐related disorders by Francesca Furia, Katrine M. Johannesen, Claudia M. Bonardi, Roberto Previtali, Angel Aledo‐Serrano, Massimo Mastrangelo, Jacopo Favaro, Silvia Masnada, Valentina diMicco, Jacopo Proietti, Pierangelo Veggiotti, Guido Rubboli, Gaetano Cantalupo, Kern Olofsson, Rikke S. Møller, Elena Gardella

“…Animal studies showed sleep disturbances in SCN8A‐ and SCN1A‐Dravet Syndrome mice models, suggesting a role for voltage‐gated sodium channels in the regulation of sleep. Understanding the effects of SCN8A dysfunction on sleep stability may guide future therapeutic efforts to alleviate this often distressing symptom also in seizure‐free SCN8A patients. …”
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Polygonatum sibiricum polysaccharides enhance pancreatic β-cell function in diabetic zebrafish by mitigating mitochondrial oxidative damage via the AMPK-SIRT1 pathway by Fan Lin, Wenjing Yu, Wenjing Yu, Ping Li, Ping Li, Shuyao Tang, Yitong Ouyang, Liya Huang, Di Wu, Shaowu Cheng, Shaowu Cheng, Zhenyan Song, Zhenyan Song

“…Polygonatum sibiricum polysaccharides (PSP) have demonstrated potential anti-diabetic effects; however, their precise mechanism, particularly through the AMPK-SIRT1 pathway, remains unclear.MethodsA diabetic zebrafish model was established by exposure to 2% glucose for 28 days. …”
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Metabolomic profiling reveals interindividual metabolic variability and its association with cardiovascular-kidney-metabolic syndrome risk by Meng Zhou, Wenxiu Sun, Yuhan Gao, Bei Jiang, Tianwei Sun, Rui Xu, Xiujuan Zhang, Qian Wang, Qiuhui Xuan, Shizhan Ma

“…Conventional CKM staging often detects risk only after substantial organ dysfunction and may overlook early metabolic heterogeneity. …”
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Clinical Efficacy of Repetitive Peripheral Magnetic Stimulation at Quchi （LI11） Acupoint on Improving Upper Limb Motor Function in Stroke Patients by CHEN Jie, LIN Zhicheng, LI Xinlei, ZHAO Yuqing, KONG Weicheng, ZHAN Wenbin, XU Peitao, XUE Xiehua

“…ObjectiveTo explore the effect of repetitive peripheral magnetic stimulation (rPMS) at Quchi (LI11) acupoint on the upper limb motor function of stroke patients.MethodsA total of 32 patients with upper limb motor dysfunction after stroke who met the inclusion criteria were selected from May to October 2024 at the Affiliated Rehabilitation Hospital of Fujian University of Traditional Chinese Medicine. …”
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Dynamic cardiac changes in low cardiovascular risk patients with triple negative breast cancer treated with chemo-immunotherapy by Jean Philippe Nesseler, Katrina D. Silos, Olivia Peony, Asneh Singh, Patrick Belen, Mitchell R. Kamrava, Julie K. Jang, Stephen L. Shiao, Alan C. Kwan, Cody Ramin, Raymond H. Mak, Andriana P. Nikolova, Katelyn M. Atkins

“…Longer follow-up and further studies are warranted, given the degree of recovery and later effects of these treatments may not yet be fully observed.…”
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Dynamic changes in macrophage populations and resulting alterations in Prostaglandin E2 sensitivity in mice with diet-induced MASH by Madita Vahrenbrink, C. D. Coleman, S. Kuipers, I. Lurje, L. Hammerich, D. Kunkel, J. Keye, S. Dittrich, B. M. Schjeide, R. Hiß, J. Müller, G. P. Püschel, J. Henkel

“…Abstract Background The transition from metabolic dysfunction-associated steatotic liver disease (MASLD) to steatohepatitis (MASH) is characterized by a chronic low-grade inflammation, involving activation of resident macrophages (Kupffer cells; KC) and recruitment of infiltrating macrophages. …”
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Predicting diabetic kidney disease with serum metabolomics and gut microbiota by Yuyun Hu, Xue Ni, Qinghuo Chen, Yihui Qu, Kanan Chen, Gaohui Zhu, Minqiao Zhang, Ningjie Xu, Xu Bai, Jing Wang, Yanhong Ma, Qun Luo, Kedan Cai

“…It demonstrated the potential utility of three specific serum metabolites and three genera of bacteria in diagnosing patients with DKD and assessing their renal dysfunction.…”
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Navigating Care Challenges in Elderly Patients Following Hypoglossal Nerve Stimulator Implantation by Michael Joo, Erin Gurski, Efstathia Polychronopoulou, Mukaila Raji, Rizwana Sultana

“…There were no statistically significant differences in the rates of other more commonly reported adverse effects such as headaches, dry mouth, and anxiety between the two age groups. …”
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Polygonati Rhizoma Prevents Glucocorticoid‐Induced Growth Inhibition of Muscle via Promoting Muscle Angiogenesis Through Deoxycholic Acid by Shiyi Shi, Rui Li, Yanxu Han, Jiahao Xie, Shaoshuai Wang, Jie Liu, Fangyan Wan, Gaifeng Hou, Zuhong Liu, Xiaobo Sun, Bo Zuo, Zhihao Jia, Zhinan Mei, Tongxing Song

“…These findings suggest that fructose‐containing treatments are novel strategies to address skeletal muscle dysfunction.…”
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