SCUBE-1 Levels and Their Relationship with Endothelial Dysfunction in Obstructive Sleep Apnea Syndrome Patients by Fazlıoğlu N, Aydın C, Demirkıran A, Özkaramanlı Gür D, Yılmaz A, Çelikkol A

“…ROC analysis demonstrated good diagnostic accuracy (AUC: 0.871, 95% CI: 0.797– 0.945) for SCUBE-1 in identifying severe OSAS.Conclusion: OSAS severity correlates with the rise in SCUBE-1 levels, and this biomarker may serve as an important attribute in profiling endothelial dysfunction. SCUBE-1 can indeed be an effective biomarker to identify subtle changes in the vascular biology of OSAS patients and aid early interventions.Keywords: obstructive sleep apnea syndrome, endothelial dysfunction, SCUBE-1 biomarker, cardiovascular risk, sleep-disordered breathing…”
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Surgical interventions in velopharyngeal dysfunction: comparative perceptual speech and nasometric outcomes for three techniques by Ryan Instrum, Agnieszka Dzioba, Anne Dworschak-Stokan, Murad Husein

“…Conclusion Operative management of VPD is highly effective in improving perceptual speech outcomes. …”
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AN INTERDISCIPLINARY APPROACH TO TREATMENT OF TEMPOROMANDIBULAR PAIN-DYSFUNCTION SYNDROME AGAINST THE BACKDROP OF CERVICAL OSTEOCHONDROSIS. by V.L. Melnik, V.K. Shevchenko

“…Therefore, the aim of our study was to: • Create a new algorithm for the treatment of patients with temporomandibular pain-dysfunction syndrome against the backdrop of cervical osteochondrosis; • Verify the effectiveness of methods of anesthesia in patients with temporo-mandibular pain-dysfunction against the backdrop of cervical osteochondrosis in applying acupuncture and light therapy; • Estimate the effectiveness of the proposed algorithm for treatment. …”
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Involvement of Oxidative Stress and Antioxidants in Modification of Cardiac Dysfunction Due to Ischemia–Reperfusion Injury by Naranjan S. Dhalla, Petr Ostadal, Paramjit S. Tappia

“…Thus, we are faced with the task of developing safe and effective antioxidants as well as agents for upregulating the expression of endogenous antioxidants for the therapy of I/R injury.…”
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Differential Effects of SGLT-2 Inhibitors on Liver Function and Nocturia in Patients with Type 2 Diabetes: A Randomized Controlled Trial by Kawahara T, Toda M, Kanagawa M, Toyama N, Suzuki G, Kawahara C, Inazu T

“…Tetsuya Kawahara,1,2 Mikio Toda,1 Maiko Kanagawa,3 Nagahiro Toyama,3 Gen Suzuki,4 Chie Kawahara,2 Tetsuya Inazu5 1Division of Endocrinology and Metabolism, Shinkomonji Hospital, Kitakyushu, 800-0057, Japan; 2First Department of Internal Medicine, University of Occupational and Environmental Health, Kitakyushu, 525-0058, Japan; 3Department of Internal Medicine, Shinkomonji Hospital, Kitakyushu, 800-0057, Japan; 4Department of Internal Medicine, Honaigo Medical Clinic, Kujigun, 319-3526, Japan; 5Department of Pharmacy, College of Pharmaceutical Science, Ritsumeikan University, Kusatsu, 807-8555, JapanCorrespondence: Tetsuya Kawahara, Division of Endocrinology and Metabolism, Shinkomonji Hospital, Kitakyushu, Fukuoka, 800-0057, Japan, Email k-tetsuy@med.uoeh-u.ac.jpPurpose: This study investigated whether sodium-glucose cotransporter-2 inhibitors (SGLT-2is) improve liver function as a class effect and evaluated their effect on nocturia in patients with type 2 diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD).Methods: A total of 135 patients with type 2 diabetes and MASLD were randomly assigned to receive tofogliflozin (20 mg/day), dapagliflozin (5 mg/day), or empagliflozin (10 mg/day). …”
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Association of wrist circumference with metabolic dysfunction associated fatty liver disease in the KADEM cohort by Fahad Al-Ajmi, Mohamed Abu-Farha, Mohamed Abu-Farha, Ahmed N. Albatineh, Zahraa Ali, Abdullah AL-Enezi, Mohammed Alterki, Rashed Alhammad, Retaj AlHarbi, Mohamed Shehab, Muhammad Abdul-Ghani, Muhammad Abdul-Ghani, Jehad Abubaker, Fahd Al-Mulla

“…IntroductionMetabolic dysfunction-associated fatty liver disease (MAFLD) is linked to metabolic dysfunction and to an increased risk of cardiovascular diseases. …”
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Metabolic syndrome, left ventricular diastolic dysfunction and heart failure with preserved ejective fraction by Dan Zhou, Shuisheng Lin, Zongchen Liu, Jiawen Yuan, Huixia Ren, Huiying Tan, Yi Guo, Xin Jiang

“…Even in the absence of overt obstructive coronary artery disease or valvular heart disease, patients with MetS often exhibit adverse cardiac remodeling and myocardial dysfunction. Left ventricular hypertrophy (LVH) and left ventricular diastolic dysfunction (LVDD) are the leading manifestations of heart failure with preserved ejection fraction (HFpEF). …”
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PREVENTION OF LEFT VENTRICLE SYSTOLIC DYSFUNCTION IN PATIENTS WITH ACUTE CORONARY SYNDROME WITH ST SEGMENT ELEVATION AFTER CARDIAC REVASCULARIZATION by A. L. Alyavi, B. A. Alyavi, M. L. Kenzhaev, S. R. Kenzhaev

“…Aim. To study effects of bioflavonoid quercetin (corvitin) on left ventricle (LV) systolic dysfunction in patients with acute coronary syndrome with ST segment elevation (ACS+ST) after cardiac revascularization.Material and methods. 60 patients with ACS+ST (44,2±1,3 y.o.) were examined. …”
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Association between peripheral and coronary microvascular function and the impact of myocardial bridging by Takumi Toya, Shotaro Yoshida, Kazuhiko Kuinose, Shun Akai, Tsukasa Urushima, Kaoru Naito, Masanori Oobori, Yusei Nakashima, Akira Miyauchi, Yuji Nagatomo, Takeshi Adachi

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Curcumin induces mitochondrial dysfunction-associated oxidative DNA damage in ovarian cancer cells. by Qi Bao, Zihan Wang, Tingting Yang, Xiao Su, Ying Chen, Lifen Liu, Qicheng Deng, Qingyang Liu, Changshun Shao, Weipei Zhu

“…Together, the results indicate that curcumin can exert its anti-tumor effect via inducing mitochondrial dysfunction-associated oxidative DNA damage and can be potentially used in combination with other DNA repair-interfering therapeutics, such as PARP inhibitor, in the treatment of ovarian cancer.…”
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Thinking Outside the Therapeutic Box: The Potential of Polyphenols in Preventing Chemotherapy-Induced Endothelial Dysfunction by Luke Tillman, Jaume Margalef Rieres, Elena Ahjem, Fynn Bishop-Guest, Meghan McGrath, Helena Hatrick, Md Zahidul Islam Pranjol

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Risks and ways of preventing kidney dysfunction in drug-induced immunosuppression in solid organ recipients by Sh. R. Galeev, S. V. Gautier

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Childhood Physical Victimization and Relationship Dysfunction in Justice-Involved Women: A Path Analysis by Megan Foster, Emily Salisbury

“…Interpersonal relationships have strong effects on women’s likelihood to offend. The relationship between risk factors like childhood victimization, adult relationship dysfunction, self-esteem, and self-efficacy are less clear. (2) Methods: Using a sample of justice-involved women, the current study uses a path analysis to investigate the impact of childhood physical abuse on adult relationship dysfunction and if this relationship is mediated by self-esteem and/or self-efficacy. (3) Results: Childhood physical abuse was found to have a significant negative effect on self-esteem and self-efficacy as well as a significant positive effect on adult relationship dysfunction. …”
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Neohesperidin Dihydrochalcone Alleviates Lipopolysaccharide‐Induced Vascular Endothelium Dysfunction by Regulating Antioxidant Capacity by Yuxin Nong, Junquan Lu, Danqing Yu, Xuebiao Wei

“…In this study, we evaluated the effects of neohesperidin dihydrochalone (NHDC) on lipopolysaccharide (LPS)‐induced vascular dysfunction and explored the potential mechanisms. …”
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Hypothalamic–pituitary–adrenal axis in anorexia nervosa; an underestimated endocrine dysfunction among adolescents by Valeria Calcaterra, Valeria Calcaterra, Vittoria Carlotta Magenes, Nadia Fratangeli, Giulia Nigro, Valentina Fabiano, Valentina Fabiano, Leonardo Mendolicchio, Gianvincenzo Zuccotti, Gianvincenzo Zuccotti

“…In patients affected by anorexia nervosa (AN) different endocrine abnormalities have been described, but, among them, hypothalamic–pituitary–adrenal (HPA) dysfunction, although associated to important side effects, is underestimated and has no therapeutical options. …”
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ANALYSIS OF A DIFFERENTIATED APPROACH TO THE APPOINTMENT OF DICK METHODS IN BIOFEEDBACK CORRECTION AUTONOMIC DYSFUNCTION by A. G. Polyakova, V. V. Matveeva

“…Goal of research: analysis of the effectiveness of Biofeedback therapy is differentiated depending on the clinical forms of autonomic dysfunction. …”
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COMBINATION THERAPY WITH ATENOLOL AND AMLODIPINE AND CORRECTION OF CARDIOVASCULAR AUTONOMIC DYSFUNCTION IN PATIENTS WITH ARTERIAL HYPERTENSION by A. R. Kiselev, V. I. Gridnev, A. S. Karavaev, O. M. Posnenkova, V. A. Shvartz, V. I. Ponomarenko, M. D. Prokhorov, B. P. Bezruchko

“…All participants demonstrated an increase in the influence of respiratory parasympathetic effects. Conclusion. The combination therapy with atenolol and amlodipine effectively corrected autonomic cardiovascular dysfunction in patients with Stage 1–2 AH.…”
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Chlorogenic acid alleviates the intestinal barrier dysfunction and intestinal microbiota disorder induced by cisplatin by Ruiqi Tian, Yinchuan Ding, Shijie Zhang, Min Li, Yiran Wang, Qi Wu, Huanhuan Ding, Chengjie Song, Ce Shi, Min Xue

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Laherradurin Inhibits Colorectal Cancer Cell Growth by Induction of Mitochondrial Dysfunction and Autophagy Induction by Izamary Delgado-Waldo, Svetlana Dokudovskaya, Yahir A. Loissell-Baltazar, Eduardo Pérez-Arteaga, Jossimar Coronel-Hernández, Mariano Martínez-Vázquez, Eloy Andrés Pérez-Yépez, Alejandro Lopez-Saavedra, Nadia Jacobo-Herrera, Carlos Pérez Plasencia

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Study of the possibility of using metformin by intranasal administration for the correction of behavioral and cognitive dysfunctions of rats by A. Z. Hafizova, I. I. Semina

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