Wearable dynamic electrocardiogram monitor-based screening for atrial fibrillation in the community-dwelling elderly population by Lili Wei, Enyong Su, Jianfang Xie, Wangqiong Xiong, Xiaoyue Song, Junqiang Xue, Chunyu Zhang, Ying Hu, Peng Yu, Ming Liu, Hong Jiang

“…Conclusion: Many elderly people have silent AF, and wearable dynamic ECG monitoring can be used to screen for AF effectively.…”
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Multi-omics analysis of gestational PM2.5 exposure induces abnormal cardiac metabolism and development in offspring by Li Tian, Qinglin Sun, Jianong Lv, Shiqian Liu, Kexin Zhang, Yang Li, Zhiwei Sun, Lili Cao, Junchao Duan

“…This study aimed to investigate the effects of gestational PM2.5 exposure on offspring cardiac development and to elucidate the potential mechanisms involved. …”
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The impact of polyethylene terephthalate microplastics on the pathogenesis of atherosclerosis: Focusing on network toxicology and target gene detection by Lingling Xie, Yan Zhao, Yuqing Pan, Yuxin Shang, Youjin Kong, Yangyang Gu, Tingting Chen, Wei Mao

“…In vitro results showed that PET significantly increased the mRNA levels of TNF-α, CXCR4, CX3CR1, and PTPRC, triggering an inflammatory response and causing chemokine receptor dysfunction. In an AS mouse model, increased aortic plaque area and aortic valve collagen deposition were observed, along with elevated expression of core target genes' mRNA, even without direct exposure to PET-MPs, exhibiting effects consistent with those seen in vitro. …”
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High fructose rewires gut glucose sensing via glucagon-like peptide 2 to impair metabolic regulation in mice by Eya Sellami, Paulo Henrique Evangelista-Silva, Caio Jordão Teixeira, Khoudia Diop, Patricia Mitchell, Fernando Forato Anhê

“…Objective: Increased fructose consumption contributes to type 2 diabetes (T2D) and metabolic dysfunction-associated steatotic liver disease (MASLD), but the mechanisms are ill-defined. …”
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Sulfhydrated albumin transmits H2S signaling and ameliorates DOX-induced multiorgan injuries by Yijun Xu, Yang Sui, Rui Jiang, Xin Wang, Mika Suda, Manabu Niimi, Zhimin Mao, Zhen Zhang, Shao-Ling Zhang, Jianglin Fan, Jian Yao

“…It improved mouse mortality, and alleviated ferroptotic cardiac injury and gut barrier dysfunction. These therapeutic benefits were associated with rebalanced local and systemic redox status. …”
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MicroRNA-27b alleviates septic cardiomyopathy by targeting the Mff/MAVS axis by Xincai Wang, Long Huang, Jingqing Xu, Min Li, Hongxuan Zhang, Yuqing Yao, Yaqing Liu, Xingsheng Lin, Xiuling Shang

“…LPS-induced SCM model exhibited cardiac dysfunction, myocardial injury, mitochondrial abnormalities, decreased miR-27b expression, and increased Mff and MAVS levels. miR-27b targeted Mff to maintain mitochondrial homeostasis, thus attenuating LPS-induced cardiomyocyte inflammation and apoptosis, while Mff overexpression reversed this protective effect.ConclusionmiR-27b alleviates myocardial injury and inflammation in SCM by targeting the Mff/MAVS axis to maintain mitochondrial homeostasis, representing a potential novel therapeutic target for SCM.…”
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Urinary and plasma donor-derived cell-free DNA for noninvasive monitoring of BK polyomavirus-associated nephropathy in kidney transplant recipients: a prospective cohort study by Luying Guo, Sulin Luo, Rongfang Shen, Pengpeng Yan, Meifang Wang, Tianlu Zhang, Junhao Lv, Guangjun Liu, Hongfeng Huang, Zhimin Chen, Huiping Wang, Wenhan Peng, Jianyong Wu, Jianghua Chen, Rending Wang

“…In the EISR cohort, urinary dd-cfDNA levels remained stable, suggesting early therapeutic response. Plasma dd-cfDNA effectively identified acute rejection, with elevations in two CISR patients. …”
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Impact of Pitching on Infraspinatus Muscle Elasticity in High School Baseball Pitchers: A Continuous Shear Wave Elastography Study by Hitoshi Shitara, Ren Koda, Tsuyoshi Tajika, Tsuyoshi Sasaki, Masataka Kamiyama, Ryosuke Miyamoto, Yuhei Hatori, Koichiro Yanai, Kurumi Nakase, Fukuhisa Ino, Takuma Kachi, Yoshiki Yamakoshi, Hirotaka Chikuda

“…<b>Background/Objectives</b>: The repetitive overhead throwing of baseball stresses the posterior shoulder, including the rotator cuff and capsule, causing stiffness, tissue thickening, and dysfunction. Previous studies on collegiate baseball players have linked these changes to glenohumeral internal rotation deficits, pain, and injuries. …”
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The surface protein Gbp of Fusobacterium nucleatum inhibits osteogenic differentiation by inactivating the Wnt/β-catenin pathway via binding to Annexin A2 by Rui Dong, Meihui Li, Xiu Feng Gu, Haiting Gao, Ziyi Wei, Houbao Qi, Jun Zhang, Qiang Feng

“…An experimental periodontitis model in mice and primary osteoblast cultures were used to investigate the effects of Fn and Gbp on osteogenic differentiation. …”
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Lower limb lymphoedema-related mental depression: A systematic review and meta-analysis of non-cancer-related studies by Tegene Atamenta Kitaw, Addisu Getie, Solomon Gebremichael Asgedom, Molalign Aligaz Adisu, Befkad Derese Tilahun, Alemu Birara Zemariam, Addis Wondmagegn Alamaw, Abebe Merchaw Faris, Tesfaye Engdaw Habtie, Melesse Abiye Munie, Eyob Shitie Lake, Gizachew Yilak, Mulat Ayele, Molla Azmeraw, Biruk Beletew Abate, Ribka Nigatu Haile

“…Abstracts: Background: Lower limb lymphoedema, characterized by persistent swelling in the legs due to lymphatic dysfunction, not only imposes a physical burden but is also associated with significant mental depression. …”
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Prediction of menstrual recovery patterns in premenopausal women with breast cancer taking tamoxifen after chemotherapy: an ASTRRA Substudy by Young Joo Lee, Woo Chul Noh, Sungchan Gwark, Hyun-Ah Kim, Jai Min Ryu, Seung Il Kim, Eun-Gyeong Lee, Seock-Ah Im, Yongsik Jung, Min Ho Park, Kyong Hwa Park, Su Hwan Kang, Joon Jeong, Eunhwa Park, Sung Yong Kim, Min Hyuk Lee, Lee Su Kim, Woosung Lim, Seonok Kim, Hee Jeong Kim

“…Abstract Background Chemo-endocrine therapy can lead to various side effects associated with ovarian dysfunction. Predicting menstrual recovery is necessary to discuss the treatment-related issues regarding fertility and premature menopause with patients. …”
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Harnessing genomic and bioinformatic data to broaden understanding of leukaemia across continents by Gumelar Gugun, Ulfa Mia Maria, Amukti Danang Prasetyaning, Irham Lalu Muhammad, Yuliani Sapto, Adikusuma Wirawan, Khairi Sabiah, Darmawi Darmawi, Chong Rockie, Ates Ilker, Singh Dilpreet, Chavan Aditya Ashok

“…Current management of acute leukaemia still uses chemo therapy as the main therapy but has many side effects, therefore a new approach is needed to identify genetic factors involved in leukaemia. …”
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Exogenous Mitochondrial Transplantation Facilitates the Recovery of Autologous Nerve Grafting in Repairing Nerve Defects by Dongdong Li, Haolin Liu, Chaochao Li, Yanjun Guan, Xing Xiong, Ruichao He, Zhibo Jia, Lijing Liang, Jinjuan Zhao, Xinyu Miao, Yu Wang, Jiang Peng

“…However, its efficacy in nerve repair still requires improvement. Mitochondrial dysfunction resulting from nerve injury may be a significant factor limiting nerve function restoration. …”
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Triphenyl phosphate induces lipid metabolism disorder and promotes obesity through PI3K/AKT signaling pathway by Tianlan Li, Yiwa Liu, Jingyi Cao, Xianzhu Lu, Yinghan Lu, Yuhan Wang, Chunmei Zhang, Meifen Wu, Song Deng, Li Li, Ming Shi

“…This study provides compelling evidence for the obesogenic effects of TPHP and information for risk assessment of organophosphorus flame retardants.…”
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Cardiovascular function shows early impairment in asymptomatic adolescents diagnosed with type 1 diabetes mellitus: an ultrasound-derived myocardial work study by Martina Ghirardo, Martina Ghirardo, Irene Cattapan, Irene Cattapan, Jolanda Sabatino, Jolanda Sabatino, Alice Pozza, Alice Pozza, Jennifer Fumanelli, Jennifer Fumanelli, Martina Avesani, Joaquin Gutierrez De Rubalcava Doblas, Carlo Moretti, Biagio Castaldi, Giovanni Di Salvo

“…BackgroundCardiac dysfunction and endothelial damage are known complications of type 1 diabetes mellitus (T1D) mainly affecting adults. …”
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A Single 48 mg Sucralose Sip Unbalances Monocyte Subpopulations and Stimulates Insulin Secretion in Healthy Young Adults by Angélica Y. Gómez-Arauz, Nallely Bueno-Hernández, Leon F. Palomera, Raúl Alcántara-Suárez, Karen L. De León, Lucía A. Méndez-García, Miguel Carrero-Aguirre, Aaron N. Manjarrez-Reyna, Camilo P. Martínez-Reyes, Marcela Esquivel-Velázquez, Alejandra Ruiz-Barranco, Neyla Baltazar-López, Sergio Islas-Andrade, Galileo Escobedo, Guillermo Meléndez

“…Unbalance in monocyte subpopulations expressing CD11c and CD206 hallmarks metabolic dysfunction but has not yet been studied in response to sucralose. …”
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Extracellular vesicles derived from salivary gland stem cells cultured on microwell scaffolds loaded with WNT3A promote the recovery of salivary gland function damaged by radiation... by Jae-Min Cho, Sujeong Ahn, Yeo-Jun Yoon, Sunyoung Park, Hyeon Song Lee, Seungyeon Hwang, Ye Jin Jeong, Yongpyo Hong, Sunyoung Seo, Dohyun Kim, Hyo-Il Jung, Won-Gun Koh, Jae-Yol Lim

“…YWHAZ-enriched EVs promote SG repair via PI3K-AKT activation, offering a promising strategy for scalable, cell-free regenerative therapy in SG dysfunction.…”
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Gene networks for use in metabolomic data analysis of blood plasma from patients with postoperative delirium by V. A. Ivanisenko, N. V. Basov, A. A. Makarova, A. S. Venzel, A. D. Rogachev, P. S. Demenkov, T.  V. Ivanisenko, M. A. Kleshchev, E. V. Gaisler, G. B. Moroz, V. V. Plesko, Y. S. Sotnikova, Y. V. Patrushev, V. V. Lomivorotov, N. A. Kolchanov, A. G. Pokrovsky

“…The regulators associated with CVP are expectedly related to the effects on myocardial tissue during surgery. It is hypothesized that dysfunction of NPD-associated regulators may specifically account for the development of POD after cardiac surgery. …”
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Porphyromonas gingivalis hijacks mitophagy and lysosomal function to persist in endothelial cells by Cheng Zheng, Jianmin Huang, Shengming Xu, Bin Lu, Hanxin Que, Tianhao Chen, Yubo Hou, Yubo Hou, Linlin He, Linlin He, Xia Fan, Fa-Ming Chen, Yi Wang, Yi Wang, Hui Deng, Hui Deng

“…This blockage of autophagy/mitophagy flux was linked to lysosomal dysfunction, characterized by increased lysosome number, lysosomal membrane permeabilization, disruption of the lysosomal acidic environment, and decreased enzymatic activity. …”
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Cross-sectional and longitudinal quantification of total white matter perivascular space volume fraction in Dutch-type Cerebral Amyloid Angiopathy by Manon R. Schipper, Thijs W. van Harten, Arie-Tjerk Razoux-Schultz, Kanishk Kaushik, Lydiane Hirschler, Sabine Voigt, Ingeborg Rasing, Emma A. Koemans, Rosemarie van Dort, Reinier G.J. van der Zwet, Sanne E. Schriemer, Erik W. van Zwet, Jeroen van der Grond, Mark A. van Buchem, Steven M. Greenberg, Marieke J.H. Wermer, Matthias J.P. van Osch, Marianne A.A. van Walderveen, Sanneke van Rooden

“…Enlarged perivascular spaces (PVS) in the centrum semiovale are an important marker of Cerebral Amyloid Angiopathy (CAA) and are thought to reflect brain clearance dysfunction. However, the current golden standard for assessing PVS is limited to a unilateral, single slice, qualitative analysis, which has the disadvantage of a strong ceiling effect. …”
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