Oncolytic adenovirus decreases the proportion of TIM-3+ subset of tumor-infiltrating CD8+ T cells with correlation to improved survival in patients with cancer by Matti Kankainen, Timo Joensuu, Akseli Hemminki, Juuso Juhila, Siri Tähtinen, Otto Hemminki, Anna Kanerva, Kristian Taipale, Ilkka Liikanen, Minna Oksanen, Dafne C A Quixabeira, Saru Basnet

“…Meanwhile, less is known about their effects on immune checkpoints, the main targets for passive immunotherapy of cancer. …”
Get full text

Association Between Sleep and Vertigo Severity in Benign Paroxysmal Positional Vertigo: Mediating Role of Psychological Factors by Xing J, Xu X, Shan H, Wu J, Liu P, Shi W, Ren P, Liu J, Huang Y, Mi B

“…Psychological factors emerged as significant mediators in this relationship, with anxiety accounting for 28.5% of the mediation effect, depression contributing 38%, and HADS mediating 37.7% of the association. …”
Get full text

Targeted therapy for advanced forms of systemic mastocytosis in real clinical practice by D. I. Shikhbabaeva, O. Yu. Vinogradova, A. L. Neverova, M. M. Pankrashkina, M. V. Chernikov, E. O. Detkina, Yu. N. Kobzev, S. G. Malakho, V. V. Ptushkin

“…To evaluate the effectiveness and safety of midostaurin in patients with advanced variants of systemic mastocytosis in real clinical practice.Materials and methods. …”
Get full text

Analysis of Cardiotoxicity and Risk Factors of Breast Cancer Chemotherapy Drugs: A Five-Year Single-Centre Retrospective Study in Early Breast Cancer by Ju F, Gu H, Yu L, Zhao G, Liu Y, Yin D, Niu J, Xue T, Yin C, Jiao L, Li C, Wu J, Ji Y

“…The Tei index increased over time (P < 0.001), indicating progressive subclinical cardiac dysfunction. The Tei index of patients after 4 courses of chemotherapy differed from that before chemotherapy (P < 0.05). …”
Get full text

Ranges, temporal trend, and determinants of novel obesity indices in middle-aged and older Chinese population: insights from a nationally representative and longitudinal study by Liufang Huang, Yifan Zhou, Kaiweisa Abuduxukuer, Kaiweisa Abuduxukuer, Chuchu Wang, Chuchu Wang, Chuchu Wang, Ya’nan Hou, Wenming Shi, Jianfeng Luo, Jianfeng Luo, Jianfeng Luo, Jin Wei, Yuhang Yue

“…BackgroundTraditional obesity assessment using body mass index (BMI) fails to adequately capture fat distribution, particularly central obesity, which is closely linked to metabolic dysfunction and obesity-related complications. Alternative obesity indices that better reflecting fat distribution and body composition have shown promise, yet large-scale population-based data remain limited. …”
Get full text

The Improvement of Intestinal Mucosal Epithelial Barrier Integrity by 1,3,4-Oxadiazole Derivatives of Pyrrolo[3,4-d]pyridazinone in Rat Experimental Colitis by Szandruk-Bender M, Wiatrak B, Merwid-Ląd A, Dzimira S, Szeląg A, Magdalan JM, Szczukowski Ł, Świątek P, Duda-Madej A, Gębarowski T, Nowak B

“…Compounds 7b and 13b (20 mg/kg) counteracted the TNBS-induced increase of MMP9 concentration and MAPK activation.Conclusion: New pyrrolo[3,4-d]pyridazinone derivatives normalized the colonic expression of TJ and mucus layer proteins and prevented goblet cells and mucus depletion in rats with experimental colitis, exerting a beneficial effect on mucosal epithelial barrier integrity. They protect against intestinal barrier dysfunction, and the potential mechanism may involve the inhibition of MAPKs and MMP9 activation.Keywords: inflammatory bowel disease, tight junctions, mucus layer, goblet cell, trinitrobenzenesulfonic acid…”
Get full text

Impact of maternal microplastic exposure on offspring lung structure and function: Insights into transcriptional misregulation and the TGF-β/α-SMA pathway by Hong-Ren Yu, Mao-Meng Tiao, Shun-Chen Huang, Jim Jinn-Chyuan Sheu, You-Lin Tain, Jiunn-Ming Sheen, I.-Chun Lin, Ching-Chou Tsai, Li-Tung Huang, Chien-Ning Hsu, Chih-Min Tsai, Yu-Hsiu Lin, Pei-Fen Lee, Yu-Tsun Su

“…This study investigated the effects of prenatal exposure to polystyrene microplastics (PS-MPs) on offspring lung development. …”
Get full text

Non-thermal atmospheric pressure plasma-irradiated cysteine protects cardiac ischemia/reperfusion injury by preserving supersulfides by Akiyuki Nishimura, Tomohiro Tanaka, Kakeru Shimoda, Tomoaki Ida, Shota Sasaki, Keitaro Umezawa, Hiromi Imamura, Yasuteru Urano, Fumito Ichinose, Toshiro Kaneko, Takaaki Akaike, Motohiro Nishida

“…Non-thermal atmospheric pressure plasma irradiation therapy is attracted attention as it exerts beneficial effects by producing various reactive molecular species. …”
Get full text

Chronic palmitoylethanolamide administration via slow-release subcutaneous pellets promotes neuroprotection and mitigates neuroinflammation in the Tg2576 mouse model of Alzheimer’s... by Daniel Tortolani, Daniel Tortolani, Davide Decandia, Davide Decandia, Giacomo Giacovazzo, Giacomo Giacovazzo, Lucia Scipioni, Lucia Scipioni, Anna Panuccio, Anna Panuccio, Francesca Ciaramellano, Fabiola Eugelio, Federico Fanti, Emanuele Claudio Latagliata, Livia La Barbera, Livia La Barbera, Debora Cutuli, Debora Cutuli, Dario Compagnone, Marcello D’Amelio, Marcello D’Amelio, Roberto Coccurello, Roberto Coccurello, Sergio Oddi, Sergio Oddi, Laura Petrosini, Mauro Maccarrone, Mauro Maccarrone

“…This study investigated the therapeutic effects of chronic (6-months) PEA administration via subcutaneous pellet in Tg2576 mice, a validated model of AD. …”
Get full text

Huoxiang Zhengqi dropping pills alleviate exertional heat stroke–induced multiple organ injury through sustaining intestinal homeostasis via regulating MAPK/NF-κB pathway and gut m... by Lei Li, Lei Li, Lei Li, Jun Ma, Jun Ma, Zeshi Li, Zeshi Li, Juelin Chen, Jiawei Zhou, Yawei Wang, Yankun Pei, Yitong Gong, Jianyao You, Yangyang Cao, Man Wang, Jikuai Chen, Wenjun Chang, Weiyi Ma, Hanyu Zhu, Chuhan Xiang, Shuogui Xu, Qing Song, Qing Song

“…Exertional heat stroke (EHS) is a life-threatening condition characterized by hyperthermia and multi-organ dysfunction, often associated with intestinal barrier disruption. …”
Get full text

Sr-MOF-based hydrogel promotes diabetic tissue regeneration through simultaneous antimicrobial and antiinflammatory properties by Siming Zhang, Gaoran Ge, Wenhao Li, Jiale Dong, Xianli Hu, Yi Qin, Peng Zhang, Jiaxiang Bai, Weiwei Zhang, Zheng Su, Dechun Geng, Chen Zhu

“…Severe tissue dysfunction in diabetic patients has been a challenging clinical problem. …”
Get full text

Nucleotide coordinated polymers, a ROS-based immunomodulatory antimicrobial, doubly kill Pseudomonas aeruginosa biofilms of implant infections by Jinghuang Chen, Xianqing Tang, Qihan Sun, Xin Ji, Xingbo Wang, Zhendong Liu, Xu Zhang, Haijiao Xu, Fan Yang, Jian Sun, Xiurong Yang

“…In an infected implant mouse model, Pseudomonas aeruginosa biofilms were effectively eliminated by GMC-2-mediated triggering of innate and adaptive immunity. …”
Get full text

HydroWrap for T2DM-Related Fractures: A smart H2S-delivery controller modulating Macrophage senescence by Siqi Zhang, Hannan Cui, Jing Wang, Jie Zhou, Hongli Chen, Xinli Wang, Qian Yang, Jiahao Cao, Kaili Hao, Shanshan Fu, Wuyang Zhang, Xu Wang, Xinsen Lin, Xiqing Sun, Wei Lei, Tengjiao Wang, Yafei Feng

“…This rapid delivery restores H2S levels, alleviating mitochondrial dysfunction and suppressing senescence-associated secretory phenotypes (SASP), thereby interrupting the senescence cascade. …”
Get full text

Microbial metabolite 3-indolepropionic acid alleviated PD pathologies by decreasing enteric glia cell gliosis via suppressing IL-13Rα1 related signaling pathways by Meiyu Shang, Jingwen Ning, Caixia Zang, Jingwei Ma, Yang Yang, Zhirong Wan, Jing Zhao, Yueqi Jiang, Qiuzhu Chen, Yirong Dong, Jinrong Wang, Fangfang Li, Xiuqi Bao, Dan Zhang

“…Although enteric glial cell (EGC) abnormal activation is reported to be involved in the pathogenesis of Parkinson's disease (PD), and inhibition of EGC gliosis alleviated gut and dopaminergic neuronal dysfunction was verified in our previous study, the potential role of gut microbiota on EGC function in PD still need to be addressed. …”
Get full text

Integrated dopamine sensing and 40 Hz hippocampal stimulation improves cognitive performance in Alzheimer’s mouse models by Shiya Lv, Fan Mo, Zhaojie Xu, Yu Wang, Yaoyao Liu, Meiqi Han, Yiming Duan, Luyi Jing, Fanli Kong, Qianli Jia, Ming Li, Wei Xu, Peiyao Jiao, Mixia Wang, Juntao Liu, Jinping Luo, Junbo Wang, Zhongwei Fan, Yilin Song, Yirong Wu, Xinxia Cai

“…Further studies could explore its utility in clarifying the relationship between dopamine dysfunction, neural activity, and amyloid pathology. …”
Get full text

Crosstalk of autophagy and ferroptosis in cardiovascular diseases: from pathophysiology to novel therapy by Changhao Hu, Siying Gao, Xinyi Li, Kaiqing Yang, Ye Cheng, Wei Guo, Huijun Wu, Xueqin Cheng, Weiwen Zhao, Yuxuan Kong, Haoyuan Hu, Songyun Wang

“…Autophagy, as an evolutionary conserved process that mediates the degradation and recycling of intracellular components, including proteins and organelles, exerts critical regulatory effects on iron metabolism and lipid homeostasis through various specialized forms, including ferritinophagy and lipophagy. …”
Get full text

Clinical and laboratory aspects of patients diagnosed with various inherited platelet disorders by Veysel Gök, Alper Ozcan, Fatma Türkan Mutlu, Ebru Yılmaz, Deniz Kocak Göl, Mustafa Ozay, Baver Demir, Hüseyin Taskiran, Hasan Bas, Mehmet Burak Mutlu, Muhammet Ensar Dogan, Atil Bisgin, Ido Somekh, Meino Rohlfs, Munis Dundar, Yusuf Ozkul, Christoph Klein, Musa Karakukcu, Ekrem Unal

“…Background: Inherited platelet disorders (IPDs) are characterized by thrombocytopenia, platelet dysfunction, or both, leading to recurrent bleeding and diagnostic challenges. …”
Get full text

AFP shields hepatocellular carcinoma from macrophage phagocytosis by regulating HuR-mediated CD47 translocation in cellular membrane by Yinglian Pan, Qiushi Yin, Zhaoliang Wang, Gang Wu, Kun Liu, Xiaowei Li, Jinchen Liu, Jiangzheng Zeng, Bo Lin, Wei Li, Mingyue Zhu, Mengsen Li

“…Objectives: Alpha fetoprotein(AFP) overexpression connecting with macrophage dysfunction remain poorly defined. In this study, explore AFP regulates macrophage immunomodulation in hepatocellular carcinoma(HCC) through comprehensive in vitro and in vivo studies. …”
Get full text

Artificial mesenchymal stem cell extracellular vesicles enhanced ischemic stroke treatment through targeted remodeling brain microvascular endothelial cells by Shengnan Li, Wei Lv, Jiangna Xu, Jiaqing Yin, Yuqin Chen, Linfeng Liu, Xiang Cao, Wenjing Li, Zhen Li, Hua Chen, Hongliang Xin

“…Disruption of the BBB induced by brain microvascular endothelial cells (BMECs) dysfunction is a key event that triggers secondary damage to the central nervous system, where blood-borne fluids and immune cells penetrate the brain parenchyma, causing cerebral edema and inflammatory response and further aggravating brain damage. …”
Get full text

L-Ergothioneine ameliorates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced Parkinson’s disease in C57BL/6J mice by activating DJ-1 by Xianshe Meng, Huawen Meng, Shuzeng Hou, Zequn Yin, Xuerui Wang, Ke Gong, Feng Zhang, Qingshan Li, Shuang Zhang, Yuanli Chen, Xiaoxiao Yang, Zhiwei Zhao, Chenzhong Liao, Yajun Duan

“…Our results show that EGT alleviated MPTP-induced behavioral dysfunction in mice. Mechanistically, we innovatively revealed that EGT was a key regulator of DJ-1. …”
Get full text