Mitochondrial Unfolded Protein Response (mtUPR) Activation Improves Pathological Alterations in Cellular Models of Ethylmalonic Encephalopathy by José Manuel Romero-Domínguez, Paula Cilleros-Holgado, David Gómez-Fernández, Rocío Piñero-Pérez, Diana Reche-López, Ana Romero-González, Mónica Álvarez-Córdoba, Alejandra López-Cabrera, Marta Castro De Oliveira, Andrés Rodríguez-Sacristán, Susana González-Granero, José Manuel García-Verdugo, Angeles Aroca, José A. Sánchez-Alcázar

“…Ethylmalonic encephalopathy (EE) is a serious metabolic disorder that usually appears in early childhood development and the effects are seen primarily in the brain, gastrointestinal tract, and peripheral vessels. …”
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Tetramethyl bisphenol F exposure induces human ovarian granulosa cell senescence and mouse ovarian damage by regulating ESRRB signalling by Huiyu Fan, Chunming Li, Yifei Lv, Tongyun Qi, Yizhou Huang, Linjuan Ma, Yibing Lan, Peiqiong Chen, Zheng Lou, Jianhong Zhou

“…The human granulosa-like tumor cell line KGN was employed as an experimental model to assess the toxic effects of TMBPF on GCs. The findings revealed that sublethal concentrations of TMBPF induced mitochondrial dysfunction, cellular senescence, and disrupted redox homeostasis in GCs in vitro. …”
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Hypothalamic kisspeptin alleviates myasthenia gravis by regulating Th1/Th17/Treg balance through Inhibition of NF-κB signaling pathway by Dan Lu, Linqi Liu, Wenjun Que, Rui Fan, Pingyang Ke, Jing Dong, Yaoqi Gan, Fei Xiao

“…While neuroendocrine-immune system dysfunction plays a crucial role in the development of autoimmune diseases, its involvement in MG remains largely unexplored. …”
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Defective Endothelial Glutaminolysis Contributes to Impaired Angiogenesis and Poor Ischemic Tissue Repair in Diabetes by Meina Zhao, Jiaheng Zhou, Yang Hu, Xinpei Wang, Jiong An, Meijie Liu, Pengfei Zhang, Xing Zhang, Jingwen Wang, Xing Jin, Miaomiao Xi, Jia Li

“…Among diabetic mice subjected to myocardial ischemia/reperfusion (MI/R), SalB administration or α-KG supplementation promoted myocardial revascularization and improved cardiac dysfunction. Notably, endothelial-specific GLS1 deletion in mice blocked the beneficial effects afforded by SalB but not those afforded by α-KG. …”
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Photobiomodulation mitigates blood–brain barrier disruption in APP/PS1 mouse model of Alzheimer’s disease by activating the AMPK pathway by Chunyan Ma, Yutong Ye, Xinyu Shi, Na Li, Zhiming Mu, Tao Tan, Huijuan Yin, Jianwu Dai, Yi Liu, Hongli Chen

“…Although PBM has shown therapeutic potential, its effects on BBB integrity and the underlying mechanisms remain unclear. …”
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Experience of application of proproceptive modeling of walking in children of early age with motor disorders by A. G. Prityko, N. V. Chebanenko, V. P. Zykov, P. L. Sokolov, E. A. Bukreeva, T. A. Sednenkova, E. Yu. Sergeenko

“…Proprioceptive correction is an effective method for habilitation of children suffering from this disease. …”
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Angiogenesis related gene signatures predict prognosis and guide therapeutic strategies in renal clear cell carcinoma by Yuhe Zhou, Weixiong Ma, Hengda Hu, Qirui He, Chengshuai Yu, Wenpu Chen, Guofeng Yu

“…The developed nomogram model effectively visualizes and accurately predicts patient prognosis. …”
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Smartphone-based Monitoring and cognition Modification Against Recurrence of Depression (SMARD): An RCT of Memory Bias Modification Training vs. Cognitive Control Training vs. Atte... by N. Ikani, A. Tyborowska, N. Kohn, N. Günther, G J. Siegle, A. H. Schene, J. A. S. Vorstman, C. J. Harmer, M. J. Kas, J. N. Vrijsen, H. G. Ruhé

“…Discussion The SMARD study aims to 1. assess the effects of the cognitive training programs versus their training-specific (active-) sham conditions on changes in memory, cognitive control dysfunction and attention; 2. relate training effects to neural networks previously identified in (recurrence of) MDD (therefore we obtain functional Magnetic Resonance Imaging ((f)MRI) scans before and after the training in a subset of participants); 3. link baseline and change in memory, cognitive control, attention and neural functioning, and ESM data to prospective recurrences; 4. examine whether passive smartphone-use monitoring can be used for prediction of recurrences. …”
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Exploration of the molecular mechanism of melatonin against polycystic ovary syndrome based on a network pharmacology approach and experimental validation by Ran Cheng, Ran Cheng, Ran Cheng, Ying Zhu, Sheng-kai Wang, Chun-Xiao Zong, Hong-Li Zhao, Hong-Li Zhao, Hong-Li Zhao, Qin Zhang, Qin Zhang, Qin Zhang

“…Finally, animal studies validated the effect of melatonin on the identified targets.ResultsAnimal experiments showed that melatonin ameliorated hyperandrogenism and ovarian dysfunction in constant darkness-induced PCOS-like rats. …”
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Epidemiological Analysis of Outcomes of Small Obstetric Operations by I. V. Taranenko, A. V. Lubimova

“…High rates of non-communicable complications confirm the need for further study of long-term effects and ways to improve the quality of care for women in the postpartum period. …”
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In vitro phenotypic re-orientation of functionally important neutrophil subpopulations and their microbicidal activity in the children with purulent inflammatory diseases influence... by I. V. Nesterova, G. A. Chudilova, M. N. Mitropanova, V. N. Pavlenko, L. V. Lomtatidze, S. V. Kovaleva, V. A. Tarakanov, N. K. Barova

“…The new data on GMDP effects revealed by in vitro system, i.e. phenotype rearrangement of functionally significant NG subpopulations CD64-CD16+CD32+CD11b+, CD64+CD16+CD32+CD11b+, CD62L+CD63-, CD62L+CD63+ in atypical purulent inflammatory diseases in children, may be used in the future in order to develop innovative strategies of immunotherapy aiming for correction of NG dysfunction in children with MPI.…”
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Umbilical mesenchymal stem cells mitigate T-cell compartments shift and Th17/Treg imbalance in acute ischemic stroke via mitochondrial transfer by Shuna Chen, Chao Han, Zihan Shi, Xin Guan, Liyuan Cheng, Liang Wang, Wei Zou, Jing Liu

“…They can regulate immune responses and reduce neuroinflammation, potentially enhancing recovery by fostering a pro-regenerative peripheral immune environment. However, the effect of UMSCs on T-cell dynamics in AIS remains underexplored. …”
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Prophylactic Chronic Zinc Administration Increases Neuroinflammation in a Hypoxia-Ischemia Model by Constantino Tomas-Sanchez, Victor Manuel Blanco-Alvarez, Juan Antonio Gonzalez-Barrios, Daniel Martinez-Fong, Guadalupe Garcia-Robles, Guadalupe Soto-Rodriguez, Eduardo Brambila, Maricela Torres-Soto, Alejandro Gonzalez-Vazquez, Ana Karina Aguilar-Peralta, José-Luis Garate-Morales, Luis-Angel Aguilar-Carrasco, Daniel I. Limón, Jorge Cebada, Bertha Alicia Leon-Chavez

“…Acute and subacute administration of zinc exert neuroprotective effects in hypoxia-ischemia animal models; yet the effect of chronic administration of zinc still remains unknown. …”
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The beauty of the beast: Suggestions to curb the excesses of dog breeding and restore animal welfare - Invited review by C Diederich

“…Finally, based on these factual and conceptual insights, suggestions to improve canine welfare will be proposed. To be effective, all these must be assessed against real-world conditions.…”
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A Critical Role for the Mitochondrial Pyruvate Carrier in Hepatic Stellate Cell ActivationSummary by Mohammad Habibi, Daniel Ferguson, Sophie J. Eichler, Mandy M. Chan, Christina Fu, Terri A. Pietka, Andrea L. Bredemeyer, Andrew LaPoint, Trevor M. Shew, Mai He, Kim H.H. Liss, Andrew J. Lutkewitte, Kevin Cho, Joel D. Schilling, Gary J. Patti, Brian N. Finck

“…An MPC inhibitor has shown promise as a novel therapeutic for MASH and HSC activation, but a mechanistic understanding of the direct effects of MPC inhibition on HSC activation is lacking. …”
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Chronic ozone exposure induces hippocampal microglia activation by microbial dysbiosis in rat lungs by Qiuyu Yang, Xueshan Cao, Shanshan Li, Xiaoqi Yang, Pengyu Bai, Yuandong Yan, Changcun Qi, Zhaorui Deng, Bailin Wu, Bo Song

“…Ozone (O3) pollution has become a significant international public health issue with adverse effects on human health. Recent studies have confirmed that O3 exposure induces neuroinflammation and cognitive dysfunction. …”
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Advancing the modified face name associative memory exam in cognitive aging research: insights into connectomic correlates and task reliability by Yilin Liu, Yilin Liu, Mark H. Sundman, Mark H. Sundman, Dalen Hinderaker, Allison Yu-Chin Chen, Allison Yu-Chin Chen, Jacob M. Green, Jacob M. Green, Lisbeth G. Haaheim, Lisbeth G. Haaheim, Hannah M. Siu, Hannah M. Siu, Catherine Jezerc, Kaitlyn Lai, Carol Chen, Parker Guss, Ying-hui Chou, Ying-hui Chou, Ying-hui Chou

“…Experiment 1 (descriptive observational, repeated-measures design) (N = 85) evaluates the alternate form reliability of a modified FNAME (mFNAME) by serially administering eight distinct versions of the task, revealing good reliability for mFNAME metrics and the absence of significant practice effects. Experiment 2 (cross-sectional observational design) (N = 32) examines structural and functional network topology to investigate neural correlates of mFNAME performance in non-demented older adults.ResultsExperiment 1 demonstrated good alternate form reliability with no significant practice effect. …”
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Multi-omics integration reveals Vha68-3 as a testicular aging-specific factor that coordinates spermatid elongation through mitochondrial metabolic homeostasis by Jun Yu, Qiuru Huang, Yangbo Fu, Lei He, Cong Shen, Xia Chen, Zhiran Li, Jiaxin Li, Chenyu Wang, Xinda Wang, Binbin Yang, Ziwen Lin, Chen Qiao, Xiaofang Tan, Xiaoqing Yang, Hao Chen, Ying Zheng, Bo Zheng, Fei Sun

“…Moreover, dietary supplementation with pyruvate (PA), S-lactoylglutathione (SLG), and phosphoenolpyruvate (PEP) effectively alleviated mitochondrial dysfunction and testicular aging linked to Vha68-3 deficiency. …”
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Speech and language biomarkers for Parkinson’s disease prediction, early diagnosis and progression by Fangyuan Cao, Adam P. Vogel, Puya Gharahkhani, Miguel E. Renteria

“…Advances in digital voice processing allow cost-effective, remote and scalable monitoring for larger populations.…”
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Rice bran-derived peptide KF-8 attenuates dexamethasone-induced myopathy in Caenorhabditis elegans by regulating locomotion-related genes by Yixin Wu, Jianqiang Wang, Fang Huang, Yajuan Chen, Qinlu Lin, Zhongxu Chen, Zhigang Liu, Yao Jiang, Wenqing Xie, Hengzhen Li, Yusheng Li, Ying Liang

“…Dexamethasone is a common glucocorticoid medication with adverse effects that can cause muscle atrophy, but no drug intervention has been approved or recommended for this condition. …”
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