Mechanistic evaluation of a traditional herbal decoction in attenuating hepatic fibrosis via Nrf2/GPX4 pathway activation and ferroptosis inhibition by Jing-Jing Liu, Xiao-qi Zhou, Jia-Lin Zhou, Li-Jun Tong, Ling-Xiang Hu, Xiang Liu, Li-Mei Hu, Chang-Xiao Zhou, Qi Dai

“…This pathological process leads to liver dysfunction and potential progression to irreversible cirrhosis or hepatocellular carcinoma. …”
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INTERACTION BETWEEN DENTO-MAXILLOFACIAL ANOMALIES AND GENERAL-SOMATIC HUMAN CONDITION (LITERATURE REVIEW) by L.V. Smaglyuk, H.V. Voronkova, A.Ye. Karasiunok, A.V. Liakhovska, V.I. Smaglyuk

“…The position of the jaws has an effect on the spatial orientation of the head and this in turn affects the position of other structures of the body. …”
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SEVERE LIVER IRON CONCENTRATIONS (LIC) IN 24 PATIENTS WITH Β-THALASSEMIA MAJOR: CORRELATIONS WITH SERUM FERRITIN, LIVER ENZYMES AND ENDOCRINE COMPLICATIONS by Vincenzo De Sanctis

“…Although adequate oral iron chelation therapy (OIC) is promising for the treatment of transfusional iron-overload, some patients are less compliant with it and others suffer from long-term effects of iron overload. Objective: The aim of our study was to evaluate the prevalence of endocrinopathies and liver dysfunction, in relation to LIC and serum ferritin level, in a selected group of adolescents and young adult BTM patients with severe hepatic iron overload (LIC from 15 to 43 mg Fe/g dry weight). …”
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High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism by Lei Yao, Xuefei Zhou, Xianqi Jiang, Hao Chen, Yuanliang Li, Xiao Xiong, Yan Tang, Haogang Zhang, Pengfei Qiao

“…Additionally, HFD aggravated GDM in mice and gut microbiota depletion by antibiotics crippled the effect of excess fat intake. BAs profile altered in HFD GDM patients and mice models. …”
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TGF-β/JNK axis mediates mitochondrial damage and macrophage cGAS-STING activation in liver Mallory-Denk body pathogenesis by Yi Shi, Maoping Huang, Wanmei Zhou, Yi Zhao, Jiuying Zhao, Bei Zhong, Samuel W. French, Xiaoping Tang, Hui Liu

“…Furthermore, the TGF-β/JNK axis has been demonstrated to be activated in clinical patients with metabolic dysfunction-associated steatotic liver disease (MASLD), which implies the potential clinical implications of the TGF-β/JNK axis. …”
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Gratitude and sleep disturbance in primary care patients: the mediating roles of health self-efficacy, health behaviors, and psychological distress by Heather R. Altier, Jameson K. Hirsch, Annemarie Weber, Niko Kohls, Jörg Schelling, Loren L. Toussaint, Fuschia M. Sirois, Martin Offenbächer, Martin Offenbächer

“…IntroductionSleep disturbances are prevalent among primary care patients, and psychological dysfunction, including stress, anxiety, and depression, are robust contributors to poor sleep health. …”
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miR‐92a aggravates metabolic syndrome via KLF2/miR‐483 axis by Zhe Zhao, Chaofeng Ma, Longzhi Wang, Yuhang Xia, Jun Li, Wei Yang, Juan Pang, Hui Ding, Haifeng Wang, Liang Bai, Fenqing Shang, Feng Zhang

“…The level of miR‐92a was significantly increased in HepG2 cells, which were treated with exosomes derived from endothelial cells with miR‐92a overexpression. ob/ob mice showed the similar effects. Conclusions Endothelial dysfunction and fatty liver are critically involved in the pathogenesis of metabolic syndrome. …”
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Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…Background: Transcranial direct current stimulation (tDCS) has an impact on improving cognitive and motor dysfunction induced by ischemia-reperfusion injury. …”
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Development of a Correlation Model of Adherence to Sports With the Mental Health of Students Participating in Sports Leisure Time by Ahmad Mahmoudi, Mohammad Ghasemi, Reza Amin Zadeh, Danesh Zamani Rad

“…On the other hand, many studies have shown that regular and sustained moderate exercise has a significant effect on maintaining health.…”
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Non-immunogenic staphylokinase — a thrombolytic agent in the treatment of massive pulmonary embolism: results of the FORPE clinical trial by A. I. Kirienko, S. G. Leontyev, E. B. Yarovaya, S. I. Konstantinov, B. B. Orlov, Imad Meray, D. V. Duplyakov, V. E. Oleynikov, E. Yu. Vasilyeva, E. A. Ponomarev, S. A. Pribylov, A. G. Komarova, V. V. Bobkov, R. M. Rabinovich, G. V. Klein, Z. S. Shogenov, Yu. V. Karabach, V. N. Zolkin, V. V. Kulabukhov, V. V. Kashtalap, K. A. Linev, G. I. Stryabkova, N. V. Yasnopolskaya, V. Yu. Tolmacheva, Zh. Yu. Chefranova, Yu. A. Lykov, E. S. Panina, N. V. Solovieva, E. V. Rybin, N. V. Furman, E. V. Kulibaba, V. V. Makukhin, A. G. Koledinsky, I. S. Mullova, N. A. Cherepanova, T. V. Pavlova, P. P. Savvinova, I. A. Libov, A. S. Igoshin, I. Yu. Bogomazov, T. B. Pecherina, L. O. Lyudnev, P. N. Vlasov, I. V. Avdeeva, D. B. Maksimov, E. V. Komissarova, V. S. Ivanov, N. L. Vyazova, E. V. Vyshlov, D. S. Kurtasov, V. A. Kutsenko, O. E. Ivlev, A. G. Soplenkova, S. N. Tereshchenko, I. S. Yavelov, R. M. Shakhnovich, A. D. Erlikh, O. B. Talibov, A. M. Semenov, M. P. Semenov, S. V. Ivanov, Yu. A. Romashova, V. V. Beregovykh, A. I. Archakov, S. S. Markin

“…Non-immunogenic staphylokinase is at least as effective as alteplase in the treatment of patients with massive pulmonary embolism with hemodynamic instability and has a higher safety profile. …”
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ANGPTL8 is a negative regulator in pathological cardiac hypertrophy by Lin Hu, Jiarui Wei, Yue Zhang, Ziyuan Wang, Junming Tang, Jian Tang, Yujiu Gao, Xiaoqiao Zhang, Yifan Li, Yantong Liu, Shinan Ma, Xingrong Guo, Qiufang Zhang

“…Mechanistically, the antihypertrophic effects of ANGPTL8 depended on inhibiting Akt and GSK-3β activation, and the Akt activator SC-79 abolished the antihypertrophic effects of rANGPTL8 in vitro. …”
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Distinct mechanisms of electroacupuncture and manual acupuncture in modulating hypothalamic GnRH–tanycyte unit function of polycystic ovary syndrome by Yu Wang, Yicong Wang, Yuning Chen, Wenhan Lu, Xiaoyu Tong, Jiajia Li, Wenhao Gao, Rui Huang, Wei Hu, Yi Feng

“…MA displayed similar therapeutic effects but had less pronounced effects on GnRH axons. …”
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<i>In Vitro</i> Embryo Culture Impacts Heart Mitochondria in Male Adolescent Sheep by Reza Amanollahi, Stacey L. Holman, Ashley S. Meakin, Monalisa Padhee, Kimberley J. Botting-Lawford, Song Zhang, Severence M. MacLaughlin, David O. Kleemann, Simon K. Walker, Jennifer M. Kelly, Skye R. Rudiger, I. Caroline McMillen, Michael D. Wiese, Mitchell C. Lock, Janna L. Morrison

“…These changes may predispose IVC offspring to cardiac oxidative stress and mitochondrial dysfunction, particularly in males. This study provides insights into the sex-dependent effects of IVC on cardiac health, emphasizing the importance of evaluating long-term cardiovascular risks associated with IVC protocols.…”
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Flavonifractor Plautii or Its Metabolite Desaminotyrosine as Prophylactic Agents for Alleviating Myocardial Ischemia/Reperfusion Injury by Heng Du, Xu Liu, Jianghua Shen, Hailong Yuan, Hao Zhang, Gan Xi, Yujing Li, Yuhan Wang, Jiahe Zhang, Chaofan Yang, Pengfei Xu, Jiawan Wang, Fang Wang, Siqi Liu, Yanan Zhou, Qi Gu, Jingjing Lu, Tuo Wei, Zeyu Gao, Jingyi Zang, Jun Wang, Moshi Song

“…Here, the cardioprotective effects of a commensal bacterium Flavonifractor plautii (F. plautii) and its metabolite desaminotyrosine (DAT) against myocardial I/R injury are investigated. …”
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Cardiac fibroblast-derived mitochondria-enriched sEVs regulate tissue inflammation and ventricular remodeling post-myocardial infarction through NLRP3 pathway by Yuanyuan Zhao, Ya Hu, Yifei Wang, Hao Qian, Chenxu Zhu, Hongjian Dong, Chunshu Hao, Yao Zhang, Zhenjun Ji, Xinxin Li, Yue Chen, Rongfeng Xu, Jie Jiang, Hailong Cao, Genshan Ma, Lijuan Chen

“…Mechanistically, above effects were achieved via activation of NLRP3 and above effects could be reversed by NLRP3 inhibitor CY-09. …”
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Exosomes Derived From Human Mesenchymal Stem Cells Mitigate Follicular Interstitial Cell Ferroptosis via the miR-26a-5p/PTEN/GPX4 Axis in Rats with Chemotherapy-Induced Premature O... by Chen J, Huo X, Qian M, Xue Q, He Y, Xu P, Wang Y, Tang X, Luo Q, Bao H, Xiong Y

“…Further bioinformatics analysis revealed that the inhibition of the PTEN/GPX4 pathway-mediated ferroptosis in TICs might be the main mechanism through which exosomes exert their regulatory/therapeutic effects. In vitro experiments, where exosome miR-26a-5p was inhibited, further confirmed that the delivery of miR-26a-5p is crucial for the regulatory effect of exosomes.Conclusion: In conclusion, our results suggest that hUCMSC-Exos alleviates POI-related dysfunction of ovarian structure and function. …”
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Human neural stem cell-derived exosomes activate PINK1/Parkin pathway to protect against oxidative stress-induced neuronal injury in ischemic stroke by Mengke Zhao, Jiayi Wang, Shuaiyu Zhu, Shensen Zhang, Chao Han, Chengcheng Tan, Yubing Huang, Zhaokai Sun, Liang Wang, Jing Liu

“…Nonetheless, the precise mechanisms by which these exosomes target mitochondria to ameliorate the effects of IS remain only partially elucidated. This study investigates the protective effects of hNSC derived exosomes (hNSC-Exos) on neuronal damage. …”
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Elucidating the mechanism of stigmasterol in acute pancreatitis treatment: insights from network pharmacology and in vitro/in vivo experiments by Xuanlin Zhao, Fan Li, Ao Wen, Xiuxian Yu, Xinrui Xu, Chengyu Wan, Yu Cao, Guang Xin, Wen Huang

“…IntroductionAcute pancreatitis (AP) is a severe inflammatory disease of the pancreas that could trigger a systemic inflammation and multi-organ dysfunction. Stigmasterol, a natural plant sterol found in various herbs and vegetables, exhibits a significant anti-inflammatory, antioxidant, and cholesterol-lowering effects. …”
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Gallic acid mitigates high-fat and high-carbohydrate diet-induced steatohepatitis by modulating the IRF6/PPARγ signaling pathway by Jiahao Qiu, Jiahao Qiu, Lihong Fu, Yan Xue, Yan Xue, Yilan Yang, Fengjie Qiao, Wanchun Zhu, Yating Gao, Miao Fang, Yufei Liu, Zhujun Gao, Yunfeng Guan, Yunfeng Guan, Yueqiu Gao, Yueqiu Gao, Yueqiu Gao, Xin Zhang, Zhi Shang, Zhi Shang, Zhi Shang

“…The present study was carried out to uncover the alleviating effects of GA on metabolic dysfunction-associated steatohepatitis (MASH) and the underlying mechanisms of its action. …”
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The Expanding Role of GLP-1 Receptor Agonists: Advancing Clinical Outcomes in Metabolic and Mental Health by Mohamad Al Qassab, Mohammad Mneimneh, Ahmad Jradi, Bassem Derbas, Dana Dabboussi, Justine Khoury Baini, Nadia Katrib, Nadim Chaarani, Philippe Attieh, Amjad Kanaan, Frederic Harb, Sami Azar, Hilda E. Ghadieh

“…Recent research has highlighted their beneficial effects on liver, kidney, and cardiovascular health, mediated by both direct and indirect mechanisms. …”
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