Magnetic Resonance Imaging as a Readout of CLN5 Gene Therapy Efficacy in Sheep by Samantha J. Murray, Mustafa M. Almuqbel, Simon A. Felton, Nickolas J. Palmer, Ashley R. Deane, Daniel J. Myall, Reza Shoorangiz, Arsène Ella, Matthieu Keller, David N. Palmer, Tracy R. Melzer, Nadia L. Mitchell

“…The diseases share a common set of symptoms, including motor and cognitive dysfunction, progressive loss of vision, and seizure activity. …”
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Gpbar1-mediated SIRT1-PGC-1α axis maintains mitochondrial homeostasis and mitigates renal injury in obstructive jaundice by Mingchen Li, Kai Luo, Xu Sun, Yuting Zhao, Haiyang Chen, Courtney Quan, Caiming Xu, Guixin Zhang

“…Mitochondrial structural disorder occurred in the kidneys, with significant reductions in SOD, GSH, and ATP levels, while MDA levels were significantly increased, indicating impaired antioxidant capacity and energy metabolism dysfunction. IHC, WB, and qRT-PCR revealed that protein and mRNA levels of Gpbar1, SIRT1, and PGC-1α in kidney tissues were lower in the model group. …”
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Interpretable machine learning analysis of immunoinflammatory biomarkers for predicting CHD among NAFLD patients by Wenyuan Dong, Hongcheng Jiang, Yu Li, Luo Lv, Yuxin Gong, Bao Li, Hongjie Wang, Hesong Zeng

“…Abstract Background Coronary Heart Disease (CHD) and Non-Alcoholic Fatty Liver Disease (NAFLD) share overlapping pathogenic mechanisms including adipose tissue dysfunction, insulin resistance, and systemic inflammation mediated by adipokines. …”
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Outcomes and risk factors of mechanical circulatory support by peripheral venoarterial extracorporeal membrane oxygenation in heart transplant candidates needing urgent heart trans... by V. N. Poptsov, V. M. Zakharevich, E. A. Spirina, S. G. Uhrenkov, A. A. Dogonasheva, E. Z. Aliev

“…Before of VA ECMO these patients (n = 14) had more severe (p < 0.05) hemodynamic disorders, organ dysfunction, electrolyte and metabolic disorders compared to patients TC successfully supported to HT. …”
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Analysis of sleep quality and influencing factors in migraine patients with patent foramen ovale by Hu Yijun, Zhang Diwen, Wang Libo, Liu Bo, Ye Hongmei, Zhao Xiongfei

“…Current research primarily focuses on the pathological mechanism and the therapeutic effects of interventional closure， with limited attention paid to the impact of PFO on sleep quality in migraine patients.ObjectiveTo compare the difference in sleep quality between PFO-positive and PFO-negative migraine patients， and to analyzes influencing factors of sleep quality in PFO-positive migraine patients， so as to provide references for clinical interventions to improve sleep quality in PFO-positive migraine patients.MethodsA total of 673 migraine patients who met the diagnostic criteria of migraine in the International Classification of Headache Disorders， third edition （ICHD-3）， and all patients underwent contrast-enhanced transcranial Doppler （c-TCD） and transthoracic echocardiographic right heart contrast echocardiography （cTTE） in the Third Hospital of Mianyang from January 2020 to October 2024. …”
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Using Social Media Data to Assess the Impact of Infertility on French Patients’ Quality of Life: Retrospective Observational Study by Mouna Mael-Ainin, Pierre-Emmanuel Bouet, Paméla Voillot, Joelle Malaab, Manissa Talmatkadi, Stéphane Schück, Nathalie Massin

“…The social impact of infertility (n=654/5786, 11.3%)—notably its effects on the couple’s relationship (438/651, 67.3%)—the financial burden of infertility treatments (521/5786, 9%), and the impact on activities (503/5786, 8.7%) were also identified. …”
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Nucleoporin 153 deficiency in adult neural stem cells defines a pathological protein-network signature and defective neurogenesis in a mouse model of AD by Claudia Colussi, Alessia Bertozzi, Lucia Leone, Marco Rinaudo, Raimondo Sollazzo, Federica Conte, Elena Paccosi, Luca Nardella, Giuseppe Aceto, Domenica Donatella Li Puma, Cristian Ripoli, Maria Gabriella Vita, Camillo Marra, Marcello D’Ascenzo, Claudio Grassi

“…Nup153-bound proteins in AD-NSCs were involved in pathways of neurodegeneration, mitochondrial dysfunction, proteasomal processing and RNA degradation. …”
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Coniferaldehyde reverses 3-nitropropionic acid-induced Huntington’s disease pathologies via PKM2 restoration and JAK2/STAT3 inhibition by Ayooluwa Gabriel Ibiayo, Peeraporn Varinthra, Mukundan Nagarajan, Ingrid Y Liu

“…Western blot assay and immunofluorescence staining were used to examine CFA’s effect. Additionally, molecular docking was performed to analyze CFA’s interaction with STAT3. …”
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Association between ECG Abnormalities and Hookah and Cigarette Smoking in the MASHAD Cohort Study Subjects by Maryam Mohammadi-Bajgiran, Reyhaneh Saffar-Khorasani, Muhammad Islampanah, Reza Nejad Shahrokh Abadi, ‌Bahram Shahri, Sara Saffar Soflaei, Souren Nemati-Khorasani, Habibollah Esmaily, Gordon Ferns, Mohsen Moohebati, Majid Ghayour-Mobarhan

“…Cigarette and hookah smoking introduce harmful substances that lead to atherosclerosis, endothelial dysfunction, and myocardial ischemia, resulting in significant cardiovascular morbidity and mortality. …”
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Impact of hepatic steatosis on the efficacy of antiviral treatment for chronic hepatitis B and the establishment of predictive model: a cohort study by Guanghui Ren, Kaining Jia, Shi Yin, Yunpeng Guan, Qingwei Cong, Ying Zhu

“…Abstract Aim Metabolic dysfunction-associated steatotic disease (MASLD) and chronic hepatitis B (CHB) are prevalent liver disorders. …”
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Impact of Di-(2-Ethylhexyl)-Phthalate on Metabolic Syndrome: Insights from Network Toxicology and Molecular Docking and Dynamics by Chen L, Huang YL, Liu F, Huang N, Zeng DC, Zhong YB, Liao JH, Wang MY

“…Molecular dynamics simulation further verified the results of molecular docking.Conclusion: Our study highlights the interaction between environmental pollutants and metabolic dysfunction. These findings highlight the potential role of DEHP in exacerbating MetS and provide a basis for mitigating its health risks through targeted interventions. …”
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Pengaruh Ekstrak Benalu Mangga Terhadap Kadar Malondealdehid (MDA) pada Tikus Hipertensi yang Dipapar DOCA- Garam by Rahayu Dwi Lestari, Nour Athiroh Abdoes Sjakoer, Nurul Jadid Mubarakati

“…Hypertension is associated with increased production of superoxide radicals and endothelial dysfunction, which causes oxidative stress characterized by increased levels of MDA. …”
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Reduction in Acetylation of Superoxide Dismutase 2 in Skeletal Muscle Improves Exercise Capacity in Mice With Heart Failure by Tomoka Masunaga, Tomoyasu Suenaga, Shouji Matsushima, Toru Hashimoto, Shingo Takada, Eri Noda, Yoshizuki Fumoto, Soichiro Hata, Takashi Yokota, Shintaro Kinugawa

“…ABSTRACT Background Skeletal muscle abnormalities, including mitochondrial dysfunction, play a crucial role in decreasing exercise capacity in patients with heart failure (HF). …”
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Clinical Characteristics, Risk Factors, and Predictors of Nonobese Fatty Liver Disease: A Cross-Sectional Study by Zhang X, Wang S, Xu S, Min R, Ling Y, Sun S, Gong R

“…Correlation between non-obese fatty liver and high blood lipids, hypertension, hyperuricemia, diabetes, thyroid dysfunction were analyzed using the Pearson and Spearman methods. …”
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m6A-methylated TAL1 exacerbates lipid accumulation in ethylene bisdithiocarbamate metabolite–induced anorectal malformations in rat fetuses via miR-205/LCOR signaling by Yifan Yao, Shuo Yang, Yuzuo Bai, Zhengwei Yuan, Zhonghua Yang

“…Background: Ethylene thiourea (ETU), the primary metabolite of the ethylene bisdithiocarbamate (EBDC) class of fungicides, has several harmful health effects. Anorectal malformations (ARMs), which can be induced by ETU in rats, are congenital conditions in humans that often lead to postoperative defecation dysfunction despite advances in surgical methods. …”
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Resting-state EEG associated with clinical measures to predict upper limb motor recovery of subacute stroke by Ling Ding, Ling Ding, Xiang Tian, Huiming Ren, Zihang Chen, Xiaokang Shu, Shugeng Chen, Jie Jia, Jie Jia, Jie Jia, Jie Jia

“…BackgroundAfter stroke, upper limb dysfunction seriously affects patients’ quality of life. …”
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One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidn... by Mengsi Zhou, Mengsi Zhou, Mengsi Zhou, Xiaoya Li, Xiaoya Li, Nenqun Xiao, Nenqun Xiao, Zhoujin Tan, Zhoujin Tan

“…These findings highlight the multitarget therapeutic potential of SSP in addressing dysfunction in the intestinal-microbiome-enzymatic-organ axis in diarrhea with kidney Yang deficiency syndrome.…”
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Association of decreased glomerular filtration rate with renal hemodynamic disorders and inflammatory biomarkers in patients with medically-controlled hypertension of high cardiova... by O. A. Koshelskaya, O. A. Zhuravleva, I. V. Kologrivova, N. Yu. Margolis

“…The data obtained shows the need for early prescription of combination antihypertensive therapy with nephro- and vasoprotective effects in this category of patients, as well as with an ability to depress the chronic subclinical inflammation.…”
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Cohort profile: patient characteristics and quality-of-life measurements for newly-referred patients with atrial fibrillation—Keio interhospital Cardiovascular Studies-atrial fibri... by Iwao Nakamura, Ikuko Ueda, Keiichi Fukuda, Shun Kohsaka, John A Spertus, Taku Inohara, Nobuhiro Ikemura, Takehiro Kimura, Kenneth Mahaffey, Kojiro Tanimoto, Masahiro Suzuki, Makoto Akaishi, Hideo Mitamura, Seiji Takatsuki

“…All patients were requested to answer the Atrial Fibrillation Effect on Quality-of-Life (AFEQT) questionnaire both at baseline and 1 year, with planned clinical follow-up for 5 years. …”
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Utility of an artificial intelligence-based lung CT airway model in the quantitative evaluation of large and small airway lesions in patients with chronic obstructive pulmonary dis... by Zheng Liu, Jing Li, Bo Li, Guozhen Yi, Shaoqian Pang, Ruinan Zhang, Peixiu Li, Zhaoping Yin, Jing Zhang, Bingxin Lv, Jingjing Yan, Jiao Ma

“…Pulmonary function classification and small and medium airway dysfunction are also affected by the diameter, thickness and arc length of large and small airways. …”
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