Comparison of the proteomic landscape in experimental ischemia reperfusion with versus without ischemic preconditioning by Yalda Kakaei, Shafaat Hussain, Ahmed Elmahdy, Evelin Berger, Aaron Shekka Espinosa, Valentyna Sevastianova, Zahra Sheybani, Amin Al-Awar, Mana Kalani, Sandeep Jha, Ermir Zulfaj, Amirali Nejat, Abhishek Jha, Tetiana Pylova, Maryna Krasnikova, Erik Axel Andersson, Vagner Ramon Rodrigues Silva, Elmir Omerovic, Björn Redfors

“…Myocardial stunning is a transient, reversible dysfunction, while necrosis involves irreversible cell death. …”
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Bullying and depression among adolescents in East Asia: a scoping review on prevalence rates, risk and protective factors by Jennifer Sie Hee Kiing, Jennifer Sie Hee Kiing, Elizabeth Sarah Ragen, Mohamed Sufyan Bin Mohmed Sulaiman, Wei Sheng Goh, Norman Jun Hao Tan, Sok Hui Ng, Yang Luo, Miny Samuel, Doris Young, Doris Young, Victor Weng Keong Loh, Victor Weng Keong Loh

“…., sexual minority status) and teachers as bullies.ConclusionFindings of this scoping review suggest that strong relationships within families, peers and the school community coupled with adolescents’ positive coping style are protective against the negative effects of bullying. Conversely, poor parent-child attachment in the midst of family dysfunction, poor engagement with peers and the school community together with low self-esteem predispose East Asian adolescents to depressive symptoms as a result of victimization. …”
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SIRT1 Activation Suppresses Corneal Endothelial–Mesenchymal Transition via the TGF-β/Smad2/3 Pathway by Yi Yu, Ruilin Guo, Jie Ling, Chenjia Xu, Minglu Ma, Xiaojuan Dong, Jing Wu, Ting Huang

“…Overall, our results indicate that SIRT1 activation inhibits corneal EnMT via the TGF-β/Smad2/3 pathway, which may be a potential therapeutic target for corneal endothelium dysfunction.…”
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Sex differences in the mediating role of brain-derived neurotrophic factor between inflammation and memory in cirrhotic patients with minimal hepatic encephalopathy by Daniela Batallas, Juan José Gallego, Franc Casanova-Ferrer, Adriá López-Gramaje, Pablo Rivas-Diaz, Javier Megías, Desamparados Escudero-García, Lucía Durbán, Salvador Benlloch, Amparo Urios, Vanesa Hidalgo, Alicia Salvador, Carmina Montoliu

“…Brain-derived neurotrophic factor (BDNF) is associated with memory dysfunction, and plays a crucial role in modulating neuroplasticity. …”
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Rationale and design of APOLLO: a personalized rehAbilitation PrOgram in aLLOgeneic bone marrow transplantation by Edith Pituskin, Stephen Foulkes, Rachel J. Skow, Thomas McMurtry, Calvin Kruger, Janet E. Bates, Daena Lamoureux, Joseph Brandwein, Elena Lieuw, Cynthia Wu, Nancy Zhu, Peng Wang, Daniel Sawler, Minakshi Taparia, Marlene Hamilton, Tiffany Comfort-Riddle, Tara Meyer, Gabor T. Gyenes, Ian Paterson, Carla M. Prado, Mark J. Haykowsky, Justin G. Greiner, Margaret L. McNeely, Puneeta Tandon, Richard B. Thompson

“…While advances in transplant practice have improved cancer-specific outcomes, multiple and debilitating long term physical and psychologic effects remain. Patients undergoing allogeneic bone marrow transplantation (allo-BMT) are often critically ill at initial diagnosis and with necessary sequential treatments become increasingly frail and deconditioned. …”
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Targeting Drp1 inhibits ESCC progression via the ROS-PGC1-α-Nrf1/2 pathway by Zhixiong Jiang, Yating Yang, Jinchi Zhou, Xin Li, Qingqing Meng, Xiangyi Yu, Yaxin Xue, Mengyu Li, Yichen Cai, Pengchun Han, Mingjun Jiang, Huizhen Wang, Congrong Liu, Jing Zhao, Lixin Wan, Dengke Bao

“…Additionally, miR-203a-3p targeted and down-regulated Drp1 expression in ESCC cells, effectively inhibiting Drp1-mediated metastasis through the ROS-PGC1-α-Nrf1/2 pathway. …”
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Galectin 3‐binding protein (LGALS3BP) depletion attenuates hepatic fibrosis by reducing transforming growth factor‐β1 (TGF‐β1) availability and inhibits hepatocarcinogenesis... by Dae‐Hwan Kim, Minjeong Sung, Myong‐Suk Park, Eun‐Gene Sun, Sumin Yoon, Kyung Hyun Yoo, Kamalakannan Radhakrishnan, Sung Yun Jung, Woo‐Kyun Bae, Sang‐Hee Cho, Ik‐Joo Chung

“…Methods The expression levels of LGALS3BP and TGFB1 were analyzed in patients with metabolic dysfunction‐associated steatohepatitis (MASH) and HCC. …”
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Human urine stem cells protect against cyclophosphamide-induced premature ovarian failure by inhibiting SLC1A4-mediated outflux of intracellular serine in ovarian granulosa cells by Hao-Cheng Gu, Ling-Fang Wang, Yu-Wei Zhang, You-Qiong Zhuo, Zhou-Hang Zhang, Xing-Yu Wei, Quan-Wen Liu, Ke-Yu Deng, Hong-Bo Xin

“…Abstract Background Cyclophosphamide (CTX) is the first-line medication for the treatment of breast cancer, although it potentially leads to severe ovarian dysfunction and even premature ovarian failure (POF). …”
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An acute microglial metabolic response controls metabolism and improves memory by Anne Drougard, Eric H Ma, Vanessa Wegert, Ryan Sheldon, Ilaria Panzeri, Naman Vatsa, Stefanos Apostle, Luca Fagnocchi, Judith Schaf, Klaus Gossens, Josephine Völker, Shengru Pang, Anna Bremser, Erez Dror, Francesca Giacona, Sagar Sagar, Michael X Henderson, Marco Prinz, Russell G Jones, John Andrew Pospisilik

“…Chronic high-fat feeding triggers metabolic dysfunction including obesity, insulin resistance, and diabetes. …”
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Targeting MAD2B as a strategy for ischemic stroke therapy by Lijing Zhang, Hengzhen Cui, Wandi Hu, Xianfang Meng, Chun Zhang

“…Deletion of MAD2B resulted in the downregulation of ROCK2/LIMK1/cofilin. It effectively reduced ischemia-induced upregulation of BAX and cleaved caspase-3, which could be reversed by MAD2B overexpression. …”
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Sivelestat-Loaded Neutrophil-Membrane-Coated Antioxidative Nanoparticles for Targeted Endothelial Protection in Sepsis by Juexian Wei, Aijia Zhong, Yuting Zhang, Ehua Deng, Hengzong Mo, Hongyu Zhao, Jiayu Huang, Huaidong Peng, Kaiyin Zhang, Xiaohui Chen, Haifeng Mao, Yixin Chen, Yongcheng Zhu

“…This bioengineered system synergistically combines targeted drug delivery with multimodal therapeutic effects, including ROS mitigation, anti-inflammatory action, and endothelial protection. …”
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Inhibition of ceramide synthesis improves the outcome of ischemia/reperfusion injury in cardiomyocytes derived from human induced pluripotent stem cell by Pellumb Haxhikadrija, Jasmine M.F. Wu, Sascha Hübner, Katja Grün, Tom Kretzschmar, Tina Müller, Markus H. Gräler, Claudia Backsch, Anja Weise, Elisabeth Klein, P. Christian Schulze, Mohamed M. Bekhite

“…Abstract Background Ceramides are bioactive sphingolipids that have physiological effects on inflammation, apoptosis, and mitochondrial dysfunction. …”
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Influencing factors analysis of acute infective enteritis after colorectal surgery by Yao Yao, Jiang Jun, Feng Xiaobo, Li Xiangyang, Yang Yan, Ni Ling

“…[Results] Acute infective enteritis occurred in 60 patients between 2 and 12 days after surgery (median: 6.1 days), with 18 cases (30%) developing septic shock complicated by multiple organ dysfunction syndrome and 6 cases (10%) resulting in death. …”
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Comparing phthalate exposure between bottlenose dolphins (Tursiops truncatus) residing in urban and rural environments by Miranda K. Dziobak, Miranda K. Dziobak, Tita Curtin, Randall S. Wells, Ryan Takeshita, Cynthia R. Smith, Eric Zolman, Christina N. Toms, Christina N. Toms, Robyn F. Allen, Leslie B. Hart

“…The endocrine-disrupting effects of phthalates could exacerbate metabolic, reproductive, or immune dysfunction in dolphins, especially those with compromised health. …”
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Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity by Jingzeng Cai, Jiaqiang Huang, Di Li, Xintong Zhang, Bendong Shi, Qiaohan Liu, Cheng Fang, Shiwen Xu, Ziwei Zhang

“…Objectives: We hypothesize that SelenoM could effectively regulate metaflammation via the Hippo-YAP/TAZ-ROS signaling axis in obesity derived from a high-fat diet. …”
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Common and rare variant analyses implicate late-infancy cerebellar development and immune genes in ADHD by Yuanxin Zhong, Larry W. Baum, Justin D. Tubbs, Rui Ye, Lu Hua Chen, Tian Wu, Se-Fong Hung, Chun-Pan Tang, Ting-Pong Ho, Robert Moyzis, James Swanson, Chi-Chiu Lee, Pak C. Sham, Patrick W. L. Leung

“…In low-frequency / rare variant analyses, we discovered the correlations between ADHD and collapsing effects of rare damaging variants in TEP1, MTMR10, DBH, TBCC, and ANO1. …”
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Natural killer cells from endurance-trained older adults show improved functional and metabolic responses to adrenergic blockade and mTOR inhibition by Luciele Guerra Minuzzi, Helena Batatinha, Christopher Weyh, Vidya Srokshna Balasubramanian Lakshmi, Carmen Fiuza-Luces, Beatriz G. Gálvez, Alejandro Lucia, Ana Maria Teixeira, Natascha Sommer, José Cesar Rosa-Neto, Fabio Santos Lira, Karsten Krüger

“…Abstract Aging is associated with immune dysfunction, but long-term endurance training may confer protective effects on immune cell function. …”
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Identification and validation of neutrophil-related biomarkers in acute-on-chronic liver failure by Wei Lin, Yongping Chen, Yongping Chen, Mingqin Lu, Cheng Peng, Cheng Peng, Xiang Chen, Xiang Chen, Xiaoqin Liu, Yunyun Wang, Yunyun Wang

“…Dysfunction of peripheral blood neutrophils occurs in acute-on-chronic liver failure (ACLF). …”
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Efficacy of sacubitril/valsartan on improving clinical symptoms in patients with acute myocardial infarction complicated with heart failure: a retrospective study by Guiping Wang, Ruolin Zhang, Xuyang Li, Shuping Zuo, Boheng Zhang, Yanan Zhao, Suya Sun, Juanjuan Zhang, Xiaokun Liu

“…Conclusions This study found that S/V had similar effects to ACEIs in reducing NT-proBNP levels among Chinese patients with AMI complicated by HF, though S/V was associated with greater reductions in blood pressure. …”
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Severity, mortality, long COVID-19, and quality of life: Insights from a cohort study of hospitalized COVID-19 patients during the delta variant predominance period in Thailand. by Pimpinan Khammawan, Aksara Thongprachum, Kannikar Intawong, Suwat Chariyalertsak

“…This includes, but is not limited to, symptoms such as fatigue, dyspnea, chest pain, cough, cognitive dysfunction ("brain fog"), insomnia, anxiety, or depression.…”
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