miR-210 overexpression increases pressure overload-induced cardiac fibrosis by G. Zaccagnini, D. Baci, S. Tastsoglou, I. Cozza, A. Madè, C. Voellenkle, M. Nicoletti, C. Ruatti, M. Longo, L. Perani, C. Gaetano, A. Esposito, F. Martelli

“…This study investigated the effects of miR-210 on cardiac fibrosis caused by pressure overload.Using a mouse model with inducible miR-210 over-expression, we subjected mice to transverse aortic constriction (TAC) to induce pressure overload. …”
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Allantoin Serves as a Novel Risk Factor for the Progression of MASLD by Weiqiang Lv, Xueqiang Wang, Zhaode Feng, Cunxiao Sun, Hansen Wu, Mengqi Zeng, Tianlin Gao, Ke Cao, Jie Xu, Xuan Zou, Tielin Yang, Hao Li, Lei Chen, Jiankang Liu, Shanshan Dong, Zhihui Feng

“…However, Mendelian randomization analysis of over 2 million samples demonstrated causal effects of urate solely on serum triglycerides and T2D risk. …”
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Wharton’s Jelly Bioscaffolds Improve Cardiac Repair with Bone Marrow Mononuclear Stem Cells in Rats by Luize Kremer Gamba, Laiza Kremer Gamba, Camila da Costa, Aline Luri Takejima, Rossana Baggio Simeoni, Isabella Cristina Mendes Rossa, Anna Clara Faidiga Silva, Julia Letícia de Bortolo, Marcos Antônio Denk, Seigo Nagashima, Carlos de Almeida Barbosa, Paulo Cesar Lock Silveira, Júlio César Francisco, Luiz César Guarita-Souza

“…This study assessed the impact of implanting mononuclear stem cells and Wharton’s Jelly (WJ), either separately or together, on left ventricular dysfunction following myocardial infarction in Wistar rats. …”
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Enhancer Profiling Reveals a Protective Role of RXRα Against Calcium Oxalate‐Induced Crystal Deposition and Kidney Injury by Yu Yang, Xudan Dou, Yongzhan Sun, Mengyao Wang, Jing Wang, Xinyi Cao, Haijie Xie, Linguo Xie, Weiping Tian, Jing Nie, Yupeng Chen, Chunyu Liu, Lirong Zhang

“…Abstract During the formation of kidney stones, the interaction between crystals and tubular epithelial cells (TECs) leads to tubular injury and dysfunction, which in turn promote stone formation. …”
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Assessment of pit viper associated subclinical myocardial injury by speckle tracking imaging by Jing Chen, Yang Feng, Jiaqi Chen, Chunmei Yin, Jiaming Xia, Li Fan, Liqun Sun, Chunjiang Yang

“…This approach fails to detect early systolic dysfunction sensitively, which is key for managing envenomation-induced myocardial damage and impacts treatment and prognosis. …”
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IDH1 regulates human erythropoiesis by eliciting chromatin state reprogramming by Mengjia Li, Hengchao Zhang, Xiuyun Wu, Mengqi Yu, Qianqian Yang, Lei Sun, Wei Li, Zhongxing Jiang, Fumin Xue, Ting Wang, Xiuli An, Lixiang Chen

“…Thus, our current work provided novel insights for further clarifying fundamental biological function of IDH1 which has substantial implications for an in-depth understanding of pathogenesis of diseases with IDH1 dysfunction and accordingly development of therapeutic strategies.…”
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Protocol for the REBOUND study: a cohort study to uncover fundamental mechanisms of accelerated ageing and impaired resilience following cancer surgery and treatment by Carly Welch, Animesh Acharjee, Rebecca Birch, João Pedro de Magalhães, Niharika A. Duggal, Alison Hainsworth, Jose R. Hombrebueno, Simon W. Jones, Jonathan Lewis, Ali Mazaheri, Helen M. McGettrick, Thomas Nicholson, Judith Partridge, Thomas Pinkney, Claire J Steves, Kristina Tomkova, Daisy Wilson, Thomas A Jackson

“…Cancer surgery and treatment may be associated with accelerated ageing in some older people; studying this process will improve understanding to enable treatments to prevent adverse effects on physical and cognitive function. Methods This study will recruit 172 participants aged 65 years and older scheduled to undergo elective colorectal surgery for cancer from two hospital sites (Guy’s and St Thomas’ NHS Foundation Trust and University Hospitals Birmingham NHS Foundation Trust). …”
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Uric acid-induced cardiomyocytic polyamines’ insufficience: a potential mechanism mediates cardiomyocytic injury by Cuiting Lin, Cuiting Lin, Cuiting Lin, Cuiting Lin, Qiang Zheng, Qiang Zheng, Qiang Zheng, Haiyan Yu, Haiyan Yu, Ting Wu, Lin Chen, Lin Chen, Weihao Lin, Weihao Lin, Jianxin Pang, Yang Yang, Yang Yang, Yang Yang

“…Notably, exogenous supplementation with spermidine or spermine effectively mitigated the uric acid-induced decline in cardiomyocyte viability and mitochondrial membrane potential.DiscussionUric acid disrupts polyamine homeostasis, leading to mitochondrial dysfunction and cardiomyocyte damage. …”
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Transgenerational hepatotoxicity induced by bisphenol B as a substitute for bisphenol A by Huifeng Yue, Yangcheng Hu, Xiaoyun Wu, Yuchai Tian, Xiaomin Liang, Jiyue Zhang, Bin Li, Huizhen Zhu, Xiaotong Ji

“…To elucidate the gene markers and signaling pathways involved in the developmental origins of liver dysfunction induced by direct/maternal BPB exposure. …”
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Consensus document APAIR: atopic dermatitis in children — update 2019 (short version) Part 1. by Yu. S. Smolkin, I. I. Balabolkin, I. A. Gorlanov, L. S. Kruglova, A. V. Kudryavtseva, R. Y. Meshkova, H. B. Migacheva, R. F. Khakimova, A. A. Cheburkin, E. A. Kuropatnikova, N. A. Lyan, A. V. Maksimova, S. S. Masalskiy, O. Y. Smolkina

“…Morphological and age-related classifications of AD are conditional and have little effect on the therapeutic strategy. Clinical variants of AD (allergic and non-allergic) are a single nosological form that requires  common  approaches to therapy. …”
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Integrated Omics Reveal <i>Dendrobium nobile</i> Lindl.’s Anti-Diabetic Mechanisms via Arginine/Proline and Glycerophospholipid Pathways by Zhibo Wang, Xian Wang, Sifan Guo, Ying Cai, Dandan Xie, Yujuan Wang, Aihua Zhang, Jun Dai, Shi Qiu

“…This study integrated pharmacodynamic evaluation and multi-omics to elucidate DNL’s anti-diabetic effects in <i>db</i>/<i>db</i> mice. <b>Results</b>: DNL intervention significantly ameliorated T2DM phenotypes, reducing hyperglycemia, insulin resistance, and renal dysfunction. …”
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Salvia miltiorrhiza extract ameliorated ovarian damage induced by cyclophosphamide in mice by multidimensional mechanisms by Lin Zhou, Hua-lin Bai, Ling-juan Wang, Juan Xiao, Yi Liu, Ji-hui Ai, Ke-zhen Li, Ding Ma, Yingyan Han

“…Conclusion Our findings verified that SM could significantly reduce primordial follicle (PMF) loss and follicular atresia, and ameliorate CTX-induced ovarian dysfunction and poor fertility, but didn’t affect the anti-tumor effect of CTX and tumor growth. …”
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Optogenetic control of mitochondrial aggregation and function by Luhao Zhang, Luhao Zhang, Luhao Zhang, Xuechun Liu, Min Zhu, Min Zhu, Yuanfa Yao, Zhichao Liu, Xianming Zhang, Xin Deng, Yi Wang, Liting Duan, Xiaogang Guo, Junfen Fu, Yingke Xu, Yingke Xu, Yingke Xu

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Clinical Outcomes and Mortality Predictors in Patients Hospitalized in the Pediatric Intensive Care Unit due to Sepsis by Esra Usluer, Ayşe Berna Anıl, Murat Anıl, Fulya Kamit, Ümüt Altuğ, Gökçen Özçifçi, Neslihan Zengin, Fatih Durak

“…This study aims to evaluate the effectiveness of clinical findings, laboratory parameters, and scoring systems in predicting mortality and morbidity in pediatric sepsis cases in the pediatric intensive care unit (PICU). …”
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Interferon-γ Signaling in Eosinophilic Esophagitis Affects Epithelial Barrier Function and Programmed Cell DeathSummary by Megha Lal, Caitlin M. Burk, Ravi Gautam, Zoe Mrozek, Karina E. Canziani, Tina Trachsel, Jarad Beers, Margaret C. Carroll, Duncan M. Morgan, Amanda B. Muir, Wayne G. Shreffler, Melanie A. Ruffner

“…Conclusions: These findings reveal that interferon, especially IFN-γ, plays a central role in epithelial cell dysfunction, significantly affecting gene expression, cellular differentiation, and barrier integrity. …”
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L-Phenylalanine promotes liver steatosis by inhibiting BNIP3-mediated mitophagy by Ying Sun, Lingli Cai, Bowei Yu, Haojie Zhang, Ziteng Zhang, Xiaoqin Xu, Yuefeng Yu, Jiang Li, Chi Chen, Fangzhen Xia, Yingli Lu, Kun Zhang, Ningjian Wang

“…Abstract Background L-Phenylalanine (L-Phe) levels are elevated in patients with metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Time-restricted feeding protects against septic liver injury by reshaping gut microbiota and metabolite 3-hydroxybutyrate by Jing-Juan Hu, Fan Deng, Qi-Shun Sun, Qing-Ming Xiong, Yue Min, Si-Yuan Feng, Ze-Bin Lin, Peng-Han Chen, Zhen Hu, Ling Wu, Xiao-Feng Chen, Sun Xie, Wei-Feng Liu, Cai Li, Ke-Xuan Liu

“…Liver injury is an independent risk factor for multiple organ dysfunction and high mortality in patients with sepsis. …”
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A strain-guided trial of cardioprotection in early-stage breast cancer patients on anti-HER2 therapy (PROTECT HER2) by Fei Fei Gong, Eli Grunblatt, Woo Bin Voss, Vibhav Rangarajan, Sasan Raissi, Kimberly Chow, Lua Jafari, Nikita P. Patel, Inga Vaitenas, Milica Marion, Haydee Ramirez, Manyun Zhao, Adin-Christian Andrei, Abigail S. Baldridge, Gillian Murtagh, Kameswari Maganti, Vera H. Rigolin, Nausheen Akhter

“…Abstract Background Global longitudinal strain (GLS) has been used to identify patients at risk for cancer-therapy related cardiac dysfunction (CTRCD). However, there is limited data on the effectiveness of initiating cardioprotective therapy based on a strain-guided strategy in early stage HER2+ breast cancer patients. …”
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Mechanosensory Piezo2 regulated by gut microbiota participates in the development of visceral hypersensitivity and intestinal dysmotility by Haonan Zheng, Yuzhu Chen, Siqi Lu, Zuojing Liu, Yinchao Ma, Cunzheng Zhang, Yiming Zhang, Jindong Zhang, Chang Liu, Ming Chu, Fei Pei, Shuangjiang Liu, Liping Duan

“…The gut microbiota plays a crucial role in the manifestation of intestinal dysfunction associated with irritable bowel syndrome (IBS). …”
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Herbal Cuscutae Semen Contributes to Oxidative Stress Tolerance and Extends Lifespan via Sirtuin1 in <i>Caenorhabditis elegans</i> by Chunyan Chen, Yudie Liu, Jing Hu, Yihan Gu, Weiwei Li, Hui Yue, Sijing An, Na Sun, Peng Zhang, Nan Li, Lin Miao

“…Collectively, our results provided evidence that CS prolonged the lifespan of <i>C. elegans</i> by ameliorating oxidative stress damage and mitochondrial dysfunction via SIRT1.…”
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