The role of gene polymorphisms in individually changing of the lipid profile among patients with coronary artery disease under the influence of the statin therapy by I. M. Fushtey, E. V. Sid, V. V. Litvinenko

“…The therapeutic drugs effect is individual and depends on the genetic characteristics of the patient. …”
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Association between eGDR and MASLD and liver fibrosis: a cross-sectional study based on NHANES 2017–2023 by Wenjing Peng, Zeyu Li, Nian Fu

“…A two-piecewise linear regression model was used to examine threshold effects. Subgroup analyses were conducted to assess effect modification. …”
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Inability of α-cyclodextrins to accommodate cholesterol potentially underlies their lack of efficacy and ototoxicity in Niemann-Pick disease type C treatment by Yusei Yamada, Mayuko Tanaka, Yusei Ikeda, Yuki Kondo, Toru Takeo, Naomi Nakagata, Toru Miwa, Hiroki Takeda, Yorihisa Orita, Keiichi Motoyama, Taishi Higashi, Hidetoshi Arima, Takahiro Seki, Yuki Kurauchi, Hiroshi Katsuki, Katsumi Higaki, Kotaro Matsusaka, Kentaro Minami, Naoki Yoshikawa, Ryuji Ikeda, Muneaki Matsuo, Tetsumi Irie, Yoichi Ishitsuka

“…However, the impact of substituent variations on these effects is unconfirmed for cyclic hexasaccharides, α-CD derivatives. …”
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SYNTHESIS, ANTIAGGREGATION AND ANTITROMBOTIC ACTIVITIES OF NEW DERIVATIVES OF HYDROXYBENZOIC ACIDS WITH TAURIC FRAGMENT by A. K. Brel, N. V. Atapina, Yu. N. Budaeva, S. V. Lisina, S. S. Tsaruk, D. V. Kurkin, I. N. Tyurenkov

“…An analysis of modern scientific literature revealed the protective effect of taurine in diabetes mellitus and cardiovascular diseases, liver dysfunction, gastrointestinal tract, and kidney diseases.The aim of the article is to study synthesis of new compounds, determination of their physical characteristics and assessment of their antiplatelet and antithrombotic activities in vitro and in vivo.Materials and methods. …”
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Congenital and acquired mitochondrial disorders of the central nervous system by V. V. Nikitina, A. N. Pravdina

“…Clinical presentations of disorders of the nervous system manifest in young and middle-aged patients with congenital and acquired mitochondrial dysfunctions and cognitive disorders manifest in patients with mitochondrial diseases more often. …”
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Characterization and Evaluation of Department of Veterans Affairs Commission on Accreditation of Rehabilitation Facilities–Accredited Interdisciplinary Pain Rehabilitation Programs... by Jolie N Haun, Christopher A Fowler, Dustin D French, Megan C McHugh, Jacquelyn N Heuer, Lisa M Ballistrea, Rachel C Benzinger, S Angel Klanchar, Friedhelm Sandbrink, Jennifer L Murphy

“… BackgroundVeterans are more likely to experience chronic pain than civilians, with significant negative impacts on long-term health outcomes. Evidence for the effectiveness of prescription opioids for chronic pain management is limited, and chronic use of opioids is associated with an increased risk of sleep-disordered breathing, cardiovascular complications, and bowel dysfunction, as well as opioid misuse and overdose. …”
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Faecalibacterium prausnitzii enhances intestinal IgA response by host-microbe derived inecalcitol in colitis by Wenfei Qin, Nuoming Yin, Binqiang Xu, Qixiang Mei, Yang Fu, Junjie Fan, Yingying Lu, Guangqiang Wang, Lianzhong Ai, Zhanjun Lu, Yue Zeng, Chunlan Huang

“…Conclusions F. prausnitzii effectively alleviated colonic inflammation and modulated dysbiosis via enhancing colonic IgA response, thus showing promise as a UC treatment. …”
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Astaxanthin supplementation mitigated intestinal damage and immunity in overfed Pekin ducks by regulating gut morphology, intestinal inflammation, and antioxidant balance by Xueze Lv, Uchechukwu Edna Obianwuna, Weifang Yang, Ziyue Zhang, Keying An, Bozhi Shi, Yingchao Dong, Shugeng Wu, Zhaofei Xia

“…Additionally, overfeeding caused increased apoptotic cell counts in the duodenal and jejunal mucosa of the control group (P < 0.05), culminating in intestinal tissue damage and dysfunction. Dietary supplementation of AST mitigated these adverse effects, alleviated intestinal damage and promoted gut health. …”
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Ginsenoside Rb₁ Ameliorates Heart Failure Ventricular Remodeling by Regulating the Twist1/PGC-1α/PPARα Signaling Pathway by Ziwei Zhou, Zhimin Song, Xiaomeng Guo, Qi Wang, Meijing Li, Minyu Zhang, Muxin Gong

“…While ginsenoside Rb₁ has demonstrated anti-fibrotic effects in HF, the underlying mechanism remains unclear. …”
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Oxidative damage to lipids improves with Omega-5 fatty acid supplementation treatment in patients with severe alcoholic hepatitis by Moisés Martínez-Castillo, Jacqueline Cordova-Gallardo, Abigail Hernandez-Barragan, Marisela Hernández-Santillán, Diana Mungía-Ramos, Froylan Martínez-Sánchez, Daniel Santana-Vargas, Gabriela Gutiérrez-Reyes

“…Glucocorticoids have a transient beneficial effect in AH; however, it is necessary to understand the effect of antioxidant therapy in this pathology. …”
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Manganese mitigates atrazine-induced oxidative stress and hepatorenal toxicity: insights from network pharmacology and in vivo experimentation by Solomon E. Owumi, Tella T. Adedayo, Joseph Chimezie, Bayode Oluwawibe, Harieme Agbarogie, Jesutosin O. Babalola, Oludare M. Ogunyemi, Uche O. Arunsi, Moses T. Otunla, Chioma E. Irozuru, Ahmad Altayyar, Eziuche A. Ugbogu

“…Abstract Network analysis has provided valuable insights into the mechanisms underlying the hepatoprotective effects of manganese (Mn) in rats subjected to atrazine (ATZ) intoxication. …”
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Hydrogel-mediated mitochondrial reprogramming for inducing cell death: a novel approach to overcoming gemcitabine resistance in pancreatic ductal adenocarcinoma by Qixin Zhao, Shenglu Liu, Tao Bi, Ting Wang, Lei Chen, Juan Huang, Xuemei Yang, Xiyu Dai, Zengjin Liu, Qin Sun

“…Our study further demonstrated that SWMU690@PUE effectively mitigates the chemoresistance phenotype associated with mitochondrial dysfunction. …”
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Uremic toxins levels are associated with miR-223 in chronic kidney disease-associated anemia by Emma Brisot, Pierre-Marie Leprêtre, Eya Hamza, Ophélie Fourdinier, Benjamin Brigant, Hakim Ouled-Haddou, Gabriel Choukroun, Ziad A. Massy, Francis Verbeke, Valérie Metzinger-Le Meuth, Griet Glorieux, Laurent Metzinger

“…Here, the role of non-coding RNAs in this toxic effect was evaluated. The effect of IS on microRNA expression was measured in human erythropoietic cell line UT7/EPO, using nanostring. …”
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Oxidized protein aggregate lipofuscin impairs cardiomyocyte contractility via late-stage autophagy inhibition by Sophia Walter, Steffen P. Häseli, Patricia Baumgarten, Stefanie Deubel, Tobias Jung, Annika Höhn, Christiane Ott, Tilman Grune

“…Induction of autophagy with rapamycin mitigated contractile dysfunction in lipofuscin-treated cardiomyocytes, whereas inhibition of autophagic flux revealed stage-dependent effects. …”
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Polyphenol-based self-assembled nanoparticles treating uveitis by inflammation-oxidative stress suppression by Haoxiang Chen, Qiwei Yang, Minghao Li, Mengyao Ren, Shuliang Liu, Guangqi An, Yaxin Ren, Pei Liu, Liping Du, Xinzhi Sun, Xuemin Jin

“…This synergistic interaction establishes a self-amplifying pathological cascade that ultimately leads to BRB dysfunction. As a natural bioactive compound, epigallocatechin gallate (EGCG) demonstrates well-established ROS scavenging capacity, while metformin (MET), a clinically approved antidiabetic agent, effectively inhibits inflammatory responses. …”
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The Potential Mechanism and the Role of Antioxidants in Mitigating Oxidative Stress in Alzheimer’s Disease by Rayees Ahmad Naik, Mehak Naseer Mir, Ishfaq Ahmad Malik, Rima Bhardwaj, Fahad M Alshabrmi, Mahmoud Abdulrahman Mahmoud, Majid Alhomrani, Abdulhakeem S. Alamri, Walaa F. Alsanie, Ahmed Hjazi, Tanmoy Ghatak, Burkhard Poeggeler, Mahendra P Singh, Gopenath TS, Sandeep Kumar Singh

“…Within this framework, we have extensively examined the importance of oxidative stress in the advancement of Alzheimer’s disease, as well as the potential influence of antioxidants in mitigating its effects.…”
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Trimethylamine N-oxide Supplementation Enhances the Quality of Oocytes in Mice of Polycystic Ovary Syndrome by Jiayu Huang, Yin Tian, Xuemei Liu, Zixin Xu, Chong Li, Ling Zhu, Xiru Liu, Jiying Hou, Jingyu Li

“…Mechanically, we found that TMAO effectively reduced ROS levels by improving mitochondrial function in PCOS oocytes. …”
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Communication Skills in Toddlers Exposed to Maternal SARS-CoV-2 during Pregnancy by Enrico Apa, Nicole Carrie Tegmeyer, Concetta D’Adamo, Eleonora Lovati, Chiara Cocchi, Paola Allegra, Francesco Ostello, Daniele Monzani, Elisabetta Genovese, Silvia Palma

“…However, only a few studies on long-term effects on language development are currently available because of the recent onset of the pandemic. …”
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Dietary resistant starch protects against post-antibiotic intestinal damage by restoring microbial homeostasis and preserving intestinal barrier function in meat duck by Simeng Qin, Yifeng Zhu, Gang Tian, Martin Blomberg Jensen, Keying Zhang, Xuemei Ding, Shiping Bai, Jianping Wang, Yue Xuan, Qiufeng Zeng

“…To directly assess the effects of RS on gut microbiota and its role in improving intestinal barrier function in meat ducks, this study first established an antibiotic-induced microbial dysbiosis model, which was characterized by reduced gut microbial diversity, intestinal dysfunction, and an inflammatory outburst following antibiotic exposure. …”
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Mechanical signaling regulates vascular smooth muscle cell adaptation in aging by Amin Mohajeri, Song Yi Shin, Samuel Padgham, Devon J. Boland, Dana Pittman Ratterree, Jacob Blizman, Gang Han, Christopher R. Woodman, Andreea Trache, Andreea Trache

“…Preventing age-induced arterial dysfunction and the associated risk of cardiovascular disease remains a significant clinical challenge. …”
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