Astrocytic NLRP3 cKO mitigates depression-like behaviors induced by mild TBI in mice. by Hui-Tao Miao, Jun Wang, Jing-Jing Shao, Rong-Xin Song, Wen-Guang Li, Jian-Kai Sun, Shi-Yan Jia, Dong-Xue Zhang, Xiao-Ming Li, Jian-Yong Zhao, Li-Min Zhang

“…Notably, under mild TBI conditions, astrocyte-specific NLRP3 exhibited greater neuroprotective effects in female knockout mice compared to males. …”
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Enhancement of CD8+T cell cytotoxicity activity by IFN-α implies alternative pathologic role in systemic lupus erythematosus by Chen-xing Zhang, You-ying Mao, Yu-pin Tan, Mei-yu Zhang, Kang Shao, Shu-jun Wang, Ping Ji, Jia-yuan Wang, Lei Yin, Ying Wang

“…Up to date, however, no research has ever investigated the effect of IFN-α on CD8+T cells, which might be implicated in the pathogenesis of SLE. …”
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<i>Sambucus nigra</i>-Lyophilized Fruit Extract Attenuated Acute Redox–Homeostatic Imbalance via Mutagenic and Oxidative Stress Modulation in Mice Model on Gentamicin-Induced Nephr... by Kamelia Petkova-Parlapanska, Ivaylo Stefanov, Julian Ananiev, Tsvetelin Georgiev, Petya Hadzhibozheva, Veselina Petrova-Tacheva, Nikolay Kaloyanov, Ekaterina Georgieva, Galina Nikolova, Yanka Karamalakova

“…<b>Results:</b> The antioxidant-protective effect of <i>S. nigra</i> extract (120 mg kg⁻¹) was demonstrated by reduced MDA, ROS, and RNS and increased activation of endogenous enzymes. …”
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Clinical manifestations of dual-gene variants involving ABCA4 in retinal dystrophies by Lasse Wolfram, David A. Merle, Laura Kühlewein, Milda Reith, Melanie Kempf, Krunoslav Stingl, Tobias Haack, Pascale Mazzola, Karin Poths, Nicole Weisschuh, Bernd Wissinger, Susanne Kohl, Katarina Stingl

“…Thus, careful patient selection and complete genotype and phenotype assessment before treatment is essential to manage potential risks and costs effectively.…”
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Longitudinal study of cognitive and mental functions among adult Hodgkin-lymphoma survivors, based on data from a primary treatment center in Hungary by István Virga, István Virga, Karolina Kósa, Anna Illés, Zsófia Miltényi, Zsófia Miltényi, Tibor Ivánka, Roland Berecz, Anikó Égerházi, Árpád Illés, Árpád Illés, Ferenc Magyari, Ferenc Magyari

“…IntroductionDue to risk and response-adapted treatment strategies, more than 80% of newly diagnosed adult classical Hodgkin lymphoma (HL) patients at any stage can be cured and become long-term survivors. A well-known side effect is cognitive dysfunction that appears in HL patients after chemotherapy (chemobrain). …”
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Supplemental oxygen for pulmonary embolism (SO-PE): study protocol for a mechanistic, randomised, blinded, cross-over study by Nour Al Jalbout, Hamid Shokoohi, Christopher Kabrhel, David M Dudzinski, Mads Dam Lyhne, Andrew S Liteplo, Oana Alina Zeleznik, Asger Andersen, Onyinyechi Franca Eke, Christina C Morone, Calvin K Huang, Thomas F Heyne, Mannudeep K Kalra

“…For metabolomic analyses, we will perform multivariable mixed effects logistic regression models and calculate false discovery rate (q-value ≤0.05) to account for multiple comparisons. …”
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Pulmonary arterial hypertension patients display normal kinetics of clot formation using thrombelastography by Mengyun Lu, Kevin P. Blaine, Ann Cullinane, Courtney Hall, Alina Dulau‐Florea, Junfeng Sun, Herman F. Chenwi, Grace M. Graninger, Bonnie Harper, Keshia Thompson, Janell Krack, Christopher F. Barnett, Samuel B. Brusca, Jason M. Elinoff, Michael A. Solomon

“…Pulmonary arterial hypertension is characterized by endothelial dysfunction and microthrombi formation. The role of anticoagulation remains controversial, with studies demonstrating inconsistent effects on pulmonary arterial hypertension mortality. …”
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The Proportion of Regulatory T Cells in Patients with Systemic Lupus Erythematosus: A Meta-Analysis by Sheng-Xiao Zhang, Xiao-Wen Ma, Yu-Feng Li, Na-Ling Lai, Ze-Hao Huang, Kai Fan, Cai-Hong Wang, Xiao-Feng Li

“…Accumulating evidence indicates that a deficiency in or dysfunction of regulatory T cells (Tregs) is involved in the pathogenesis of systemic lupus erythematosus (SLE). …”
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Clinical efficacy analysis of extrapedicular unilateral percutaneous vertebroplasty via the upper edge of the transverse process for lumbar osteoporotic vertebral compression fract... by Junru Zheng, Haopeng Luan, Ying He, Lei Hong, Pengyuan Han, Xiaonan Wang, Xing Wang, Qiaojuan Wang, Qisong Shang

“…Abstract Objective To investigate the clinical effect of vertebroplasty through unilateral upper edge of transverse process in the treatment of lumbar osteoporotic vertebral compression fracture (OVCF), and to explore the surgical indications and operation points of this technique. …”
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Psychosocial experiences of prostate cancer survivors after treatment: a systematic review of qualitative studies by Junlian Xiang, Lifei Dai, Lifei Dai, Lin Tan, Dong Lv, Yongbo Chen, Liangyou Tang, Jiali Zhang, Xin Yi, Xiaoli Liu

“…BackgroundProstate cancer, the second most common male malignancy worldwide, treatment-related complications cause both physical dysfunction and psychosocial sequelae, significantly impairing quality of life. …”
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Acetyltransferase NAT10 inhibits T-cell immunity and promotes nasopharyngeal carcinoma progression through DDX5/HMGB1 axis by Yi Xu, Weihong Jiang, Rui Wu, Siyu Zhang, Kaiwen Zhang, Haijing Xie, Haimeng Yin, Si Pan, Yumo Han, Bo You

“…Additionally, HLTF was found to transcriptionally regulate NAT10, indicating the formation of an HLTF-NAT10 positive feedback loop.Conclusions Our study elucidates the mechanism by which the NAT10/DDX5/HMGB1 axis promotes the immunosuppression of NPC by promoting T-cell dysfunction. In addition, NAT10 knockdown can enhance anti-PD-1 treatment sensitivity as a combination therapy for NPC.…”
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Sex differences in myocardial flow reserve among individuals with type 2 diabetes: insights from the DiaHeart study by Anne-Cathrine Skriver-Møller, Philip Hasbak, Ida K. B. Rasmussen, Martin B. Blond, Victor S. Wasehuus, Mats C. H. Lassen, Morten Lindhardt, Allan Kofoed-Enevoldsen, Urd L. Kielgast, Emilie H. Zobel, Jens P. Goetze, Lene Holmvang, Tor Biering-Sørensen, Peter Rossing, Andreas Kjaer, Rasmus S. Ripa, Tine W. Hansen

“…Abstract Background Type 2 diabetes is a stronger risk factor for cardiovascular disease (CVD) in women compared with men possibly due to higher susceptibility to develop myocardial microvascular dysfunction. We investigated sex-dependent effects of risk factors on myocardial blood flow (MBF) and myocardial flow reserve (MFR) in individuals with type 2 diabetes without overt CVD. …”
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A Pilot Randomized Controlled Trial Assessing the Feasibility and Acceptability of Family-Partnered Delirium Prevention, Detection, and Management in Critically Ill Adults: The Act... by Kirsten M. Fiest, PhD, Karla D. Krewulak, PhD, Bonnie G. Sept, Judy E. Davidson, DNP, E. Wesley Ely, MD, Chel H. Lee, PhD, Andrea Soo, PhD, Henry T. Stelfox, MD

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Transcriptomic Profiling Reveals Differences in Slow‐Twitch and Fast‐Twitch Muscles of a Cigarette Smoke‐Exposed Rat Model by Timothy K. H. Fung, Kwok Kuen Cheung, Xia Wang, Benson W. M. Lau, Shirley P. C. Ngai

“…Most studies showed diminished cross‐sectional area and fibre type shifting in slow‐twitch muscles such as the soleus, while effects on fast‐twitch muscles were seldom reported and the differential responses between muscle types in response to exposure to cigarette smoke (CS) were largely unknown. …”
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Mammalian Ste20-like kinase 1 regulates AMPK to mitigate the progression of non-alcoholic fatty liver disease by Lijuan Wang, Chenglei Zhang, Jie Ma, Jiarui Li, Yuanyuan Wu, Yanru Ren, Jianning Li, Yan Li, Yi Yang

“…Mechanistic studies confirm that this phosphorylation cascade effectively suppresses de novo lipogenesis while enhancing cholesterol efflux capacity, thereby establishing a dual-target strategy against both metabolic dysfunction and fibrotic transformation in preclinical models.…”
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Functioning in patients with major depression treated with duloxetine or a selective serotonin reuptake inhibitor in East Asia by Novick D, Montgomery W, Haro JM, Moneta MV, Zhu G, Yue L, Hong J, Duenas H, Brugnoli R

“…In addition, this study examined the impact of painful physical symptoms (PPS) on the effects of these treatments.Patients and methods: Data for this post hoc analysis were taken from a 6-month prospective observational study involving 1,549 patients with major depressive disorder without sexual dysfunction. …”
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Fibrinogen and D-dimer protein levels in patients with preeclampsia: a systematic review and meta-analysis by Ermiyas Alemayehu, Alemu Gedefie, Fasil Getu, Zewudu Mulatie, Muluken Walle, Ousman Mohammed, Getachew Mesfin Bambo, Habtu Debash, Yenealem Solomon, Abdurehman Eshete Mohammed, Hussen Ebrahim, Melaku Ashagrie Belete

“…Abstract Introduction Preeclampsia (PE) is a significant obstetric and global health concern associated with fetal growth restriction, poor placental perfusion, and maternal organ dysfunction. Early detection through simple, routine antenatal indicators is essential. …”
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Dose-Dependent Cellular Phenotypic Change Induced by ¹⁷⁷Lu-Oxodotreotide Treatment in IMR-32 Cells by Shuai Xue, Xiaobei Zheng, Bingbing Pu, Xiao Li, Jun Li, Meng Huang, Jian Yang, Jingjing Lou

“…<b>Results</b>: Lutathera induced dose-dependent cytotoxic effects. Cell viability declined linearly with increasing dose (control: 100% vs. high-dose: 13.48%; r = −0.955, <i>p</i> < 0.001). …”
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Study of otoacoustic emissions in workers of various professional groups of the coal industry by Shydlovska T.A., Basanets A.V., Gvozdetskiy V.A., Shevtsova T.V.

“…Many scientific studies have shown the diagnostic effectiveness of method of otoacoustic emissions recording in the early diagnosis of lesions of receptor part of auditory analyzer. …”
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Association Between Platelet and Cerebral Small Vessel Disease: A Secondary Analysis Based on a Retrospective Cross‐Sectional Study in Korean Adults by Shujuan Huang, Hanbo Chen, Linbo Cai, Zhaoxi Liu, Zhanbo Yu, Yuqin Dan, Danghan Xu, Yunxuan Huang

“…Further longitudinal studies are needed to evaluate the effectiveness of these interventions in reducing MS‐cWMH risk. …”
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