A citrullinated histone H3 monoclonal antibody for immune modulation in sepsis by Wenlu Ouyang, Yuchen Chen, Tao Tan, Yujing Song, Tao Dong, Xin Yu, Kyung Eun Lee, Xinyu Zhou, Zoe Tetz, Sophia Go, Xindi Zeng, Liujiazi Shao, Chao Quan, Ting Zhao, Yuzi Tian, Katsuo Kurabayashi, Hua Jin, Jichun Ma, Jingdong Qin, Brandon Williams, Qingtian Li, Gui-dong Zhu, Hasan B. Alam, Kathleen A. Stringer, Yongqing Li, Jianjie Ma

“…The hCitH3-mAb treatment effectively disrupts this cycle and restores macrophage function under septic conditions. …”
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Molecular Pathways Linking High-Fat Diet and PM_2.5 Exposure to Metabolically Abnormal Obesity: A Systematic Review and Meta-Analysis by Sagrario Lobato, Víctor Manuel Salomón-Soto, Claudia Magaly Espinosa-Méndez, María Nancy Herrera-Moreno, Beatriz García-Solano, Ernestina Pérez-González, Facundo Comba-Marcó-del-Pont, Mireya Montesano-Villamil, Marco Antonio Mora-Ramírez, Claudia Mancilla-Simbro, Ramiro Álvarez-Valenzuela

“…Following the PRISMA guidelines, articles from 2019 to 2024 were gathered from Scopus, Web of Science, and PubMed, and a random-effects meta-analysis was performed, along with subgroup analyses and pathway enrichment analyses. …”
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Mitochondrial oxidative phosphorylation (mtOXPHOS) serves as a sentinel to gauge fluctuations under heat stress in Arabidopsis thaliana elucidated by comparative transcriptomics by Muhammad Riaz, Erum Yasmeen, Moyang Liu, Hafiz Saqib Ali, Mengli Lv, Hu Shi, Chuanhui Du, Tiantian Dong, Zhenxin Liu, Qingwei Song, QiJun Ma, Kaijing Zuo

“…Heat stress has destructive effects on crop production and quality posing a grave threat to food security worldwide. …”
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DEcreased Cognitive functiON, NEurovascular CorrelaTes and myocardial changes in women with a history of pre-eclampsia (DECONNECT): research protocol for a cross-sectional pilot st... by Marc E A Spaanderman, Chahinda Ghossein-Doha, Sander MJ van Kuijk, Gwyneth Jansen, Walter H Backes, Emma B N J Janssen, Yentl Brandt, Robert-Jan Alers, Lisanne P W Canjels, Laura M Jorissen, Tamara Michelle Went, Dennis Koehn, Suzanne C Gerretsen, Petra P M Hurks, Vincent van de Ven, M Eline Kooi, Jacobus FA Jansen

“…These sequelae could result from microvascular dysfunction persisting after pre-eclampsia. This study will explore differences in cerebral and myocardial microvascular function between women after pre-eclampsia and women after normotensive gestation. …”
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All-Trans Retinoic Acid Induces CD4+CD25+FOXP3+ Regulatory T Cells by Increasing FOXP3 Demethylation in Systemic Sclerosis CD4+ T Cells by Xiaohong Sun, Yangfan Xiao, Zhuotong Zeng, Yaqian Shi, Bingsi Tang, Hai Long, Takuro Kanekura, Jiucun Wang, Haijing Wu, Ming Zhao, Qianjin Lu, Rong Xiao

“…The quantitative and functional defects of Tregs may mediate the immune dysfunction in SSc. The addition of all-trans retinoic acid (ATRA) to human naïve CD4+ cells could promote the maturation of Tregs and increase the stable expression of Foxp3. …”
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Immunosenescence-related T cell phenotypes, structural brain imaging, and cognitive impairment in patients with schizophrenia: a moderated mediation analysis by Na Li, Yanli Li, Ting Yu, Wenjin Chen, Mengzhuang Gou, Wenkai Zheng, Zhaofan Liu, Xiaoying Wang, Jiao Fang, Jinghui Tong, Song Chen, Baopeng Tian, Chiang-Shan R. Li, Li Tian, Yunlong Tan

“…Immunosenescence has been consistently implicated in the cognitive dysfunction observed in neurodegenerative diseases, but how it may relate to cognitive deficits in schizophrenia is still unclear. …”
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Treatment of Onychomycosis and the Drug–Drug Interactions in Patients with Diabetes Mellitus and Diabetic Foot Syndrome: A Systematic Review by David Navarro-Pérez, Aroa Tardáguila-García, Sara García-Oreja, Francisco Javier Álvaro-Afonso, Mateo López-Moral, José Luis Lázaro-Martínez

“…Mycological cures for mild to moderate onychomycosis were: <i>Ageratina pichinchensis</i> (8.6%), 8% ciclopirox (8.6% 24 weeks and 54.3% 48 weeks), 10% efinaconazole (56.5–58.33%), terbinafine (73–76.6%), itraconazole (88.2%), and laser therapy (43.8%). No serious adverse effects or drug interactions were observed because patients with major complications, such as peripheral vascular disease, diabetic neuropathy, liver and renal dysfunction, poorly controlled diabetes, and severe onychomycosis, were excluded. …”
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A new therapeutic pathway in autoimmune diseases: chimeric antigen receptor T cells (CAR-T) targeting specific cell subtypes or antigen-specific B lymphocytes—a brief review by María Fernanda Segovia, Diana Landoni, Yohana Defranchi, Rodrigo Calderón Jofré, Carlos A. Flores Olivares, Gerson D. Keppeke

“…CAAR-T allows the elimination of autoreactive B lymphocytes without compromising the general functionality of the immune system, minimizing common side effects in general immunosuppressive therapies, including immunobiologicals and CAR-T. …”
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Altered Lactylation Myocardial Tissue May Contribute to a More Severe Energy-Deprived State of the Tissue and Left Ventricular Outflow Tract Obstruction in HOCM by Ruoxuan Li, Jing Wang, Jia Zhao, Jiao Liu, Yuze Qin, Yue Wang, Yiming Yuan, Nan Kang, Lu Yao, Fan Yang, Ke Feng, Lanlan Zhang, Shengjun Ta, Bo Wang, Liwen Liu

“…Therefore, it is necessary to explore the possible causes of HOCM, which may help physicians better understand the disease and effectively control and manage the progression of the disease. …”
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Predictive value of glucose coefficient of variation for in-hospital mortality in acute myocardial infarction patients undergoing PCI: Insights from the MIMIC-IV database by Zixuan Zhang, Mengmeng Ji, Qingqing Zhao, Luying Jiang, Shilang Fan, Houjuan Zuo

“…Mediation analysis indicated that GluCV partially mediates the effect of comorbidities on organ dysfunction. Conclusions: GluCV is an important predictor of in-hospital mortality in AMI patients undergoing PCI. …”
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Maternal exposure to difenoconazole-induced developmental defects and its mechanisms in F1 zebrafish (Danio rerio) by Ying Zhang, Fuqi Yang, Qian Zhang, Yunan Wu, Jiaolong Huang, Peng Duan, Xingjian Zhou

“…Furthermore, neurosensory dysfunction manifested through attenuated spontaneous motility and compromised motor coordination capacities. …”
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Ligustrazine nano-drug delivery system ameliorates doxorubicin-mediated myocardial injury via piezo-type mechanosensitive ion channel component 1-prohibitin 2-mediated mitochondria... by Junyan Wang, Haowen Zhuang, Chun Li, Ruiqi Cai, Hongshuo Shi, Boxian Pang, Zhijiang Guo, Sang-Bing Ong, Yifeng Nie, Yingzhen Du, Hao Zhou, Xing Chang

“…Nanoparticle drug delivery technologies effectively address these constraints by encapsulating LIG into nanocarriers, significantly enhancing its solubility and bioavailability, hence maximizing its therapeutic efficacy. …”
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Resting-State Network Plasticity Induced by Music Therapy after Traumatic Brain Injury by Noelia Martínez-Molina, Sini-Tuuli Siponkoski, Linda Kuusela, Sari Laitinen, Milla Holma, Mirja Ahlfors, Päivi Jordan-Kilkki, Katja Ala-Kauhaluoma, Susanna Melkas, Johanna Pekkola, Antoni Rodríguez-Fornells, Matti Laine, Aarne Ylinen, Pekka Rantanen, Sanna Koskinen, Benjamin Ultan Cowley, Teppo Särkämö

“…Traumatic brain injury (TBI) is characterized by a complex pattern of abnormalities in resting-state functional connectivity (rsFC) and network dysfunction, which can potentially be ameliorated by rehabilitation. …”
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CRL2LRRC41-Mediated DDX5 Ubiquitination Enhances Interaction with ELAVL1 Preventing NOG mRNA Degradation and Sustaining Proliferation and Migration of Human Spermatogonial Stem Cel... by Bing Jiang, Kehan Wang, Haoyue Hu, Wenxin Gao, Cong Shen, Xia Chen, Xiaoyan Huang, Jun Yu, Yibo Wu, Bo Zheng

“…Results Our findings revealed that the disruption or dysfunction of CRL2LRRC41 led to reduced proliferative and migratory abilities in human SSCLCs. …”
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Mechanistic Insight into Serine Flux Regulation through Nanoscale Organization of Glucose and Serine Transporters by Substrate Probe-Based Direct Stochastic Optical Reconstruction... by Pengwei Jiang, Hao Hou, Jiaqi Wang, Xumin Wang, Yaqi Wang, Simin Liu, Junling Chen, Hongda Wang, Feng Liang

“…This work establishes a fundamental link between transporter spatial assembly and tumor serine metabolic reprogramming, providing a new perspective to better understand SerT dysfunction in tumor metabolic reprogramming, offering novel therapeutic avenues for targeting serine metabolism in cancer.…”
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Identification of a coagulation-related classification and signature that predict disease heterogeneity for colorectal cancer and pan-cancer patients by Junpeng Pei, Junpeng Pei, Yuye Gao, Yuye Gao, Baojian Xing, Yongjiu Chen, Yongjiu Chen, Aiwen Wu, Aiwen Wu

“…A validated nomogram incorporating age, TNM stage, and risk score accurately predicted overall survival, while experimental validations confirmed the bioinformatics predictions regarding TIMP1’s role in CRC progression.ConclusionsA coagulation-based classifier effectively categorizes CRC and potentially other cancers, interacting significantly with the immune microenvironment to influence disease progression and treatment responsiveness. …”
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Your patient has lower back pain. What should be done? by Natalia Vyacheslavovna Pizova

“…Cognitive and behavioral psychotherapy along with other methods is one of the effective directions for patients with chronic LBP. …”
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Obesity Reduces Cognitive and Motor Functions across the Lifespan by Chuanming Wang, John S. Y. Chan, Lijie Ren, Jin H. Yan

“…Substantial evidence has suggested exercise to be an effective way to improve obesity and related cognitive and motor dysfunctions. …”
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Impact of Time-To-Treatment on Outcomes in Autoimmune Membranous Nephropathy by Patrick Hamilton, Sebastian Bate, Omar Ragy, Mrityunjay Hiremath, Samar Bukhari, Anirudh Rao, Arif Khwaja, Durga Anil K Kanigicherla

“…Introduction: Despite new treatments, kidney dysfunction in autoimmune membranous nephropathy (aMN) remains challenging. …”
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A Comprehensive Safety Assessment of <i>Ralstonia eutropha</i> H16 for Food Applications: Integrating Genomic, Phenotypic, and Toxicological Analyzes by Xiaoyan You, Shuxia Song, Bing Li, Hui Wang, Le Zhang, Xiangyang Li, Junliang Chen, Zhiguang Zhu, Guoping Zhao

“…Subacute toxicity studies (28-day, 1 × 10⁸–1 × 10¹⁰ CFU/kg) revealed no significant effects on growth, hematology, or organ function. …”
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