Vortioxetine in the Treatment of Major Depressive Disorder Among Working Patients in Routine Clinical Practice: An Analysis of a Post-Marketing Surveillance Study in South Korea by Moon SW, Kim JW, Kim DH, Adair M, Åström DO, Reines EH, Lee M, Kim G

“…., Seoul, KoreaCorrespondence: Seok Woo Moon, Department of Psychiatry and Research Institute of Medical Science, Konkuk University School of Medicine, 82 Gugwon-daero, Chungju-si, Chungcheongbuk-do, 27376, South Korea, Tel +82-10-3276-1641, Email hessem@naver.comBackground: Patients with major depressive disorder (MDD) experience depressive symptoms such as anhedonia as well as cognitive dysfunction which can subsequently impair their work performance.Purpose: To assess the effectiveness and safety of vortioxetine in working patients with MDD in South Korea.Patients and Methods: This was a subgroup analysis of a prospective, multicenter, non-interventional, non-comparative post-marketing surveillance (PMS) study. …”
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NLRP3 inflammasome-modulated angiogenic function of EPC via PI3K/ Akt/mTOR pathway in diabetic myocardial infarction by Jia-Peng Li, Shu Qiu, Guang-Jie Tai, Yi-Ming Liu, Wei Wei, Meng-Meng Fu, Pan-Qi Fang, Joseph Nicolao Otieno, Tungalag Battulga, Xiao-Xue Li, Ming Xu

“…Abstract Background Inflammatory diseases impair the reparative properties of endothelial progenitor cells (EPC); however, the involvement of diabetes in EPC dysfunction associated with myocardial infarction (MI) remains unknown. …”
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Cdkn1a silencing restores myoblast differentiation by inducing selective apoptosis in senescent cells by Sujin Kim, Bonsang Gu, Chan-Young So, Keren Esther Kristina Mantik, Seung-Hyun Jung, Sohee Moon, Dong-Ho Park, Hyo-Bum Kwak, Jinkyung Cho, Eun-Jeong Cho, Jae-Seon Lee, Ju-Hee Kang

“…The upregulation of Cdkn1a appears to be linked to mitochondrial dysfunction and cellular senescence, underscoring its significance in sarcopenia pathogenesis. …”
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Ginsenoside C-K inhibits Aβ oligomer-induced Alzheimer's disease pathology progression by regulating microglia-neuron interactions by Chenghu Xie, Cunxin Zhang, Kefeng Zhang, Shanshan Zhang

“…Objective: To investigate the intervention effects and multi-target regulatory mechanisms of Ginsenoside C-K (GCK) on β-amyloid (Aβ) oligomer-induced Alzheimer's disease (AD) pathological progression. …”
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Liver-specific expression of ANGPTL8 promotes Alzheimer’s disease progression through activating microglial pyroptosis by Jiarui Wei, Lin Hu, Shufan Xu, Fan Yang, Fusheng Liao, Ying Tang, Xin Shen, Xiaoqiao Zhang, Xinggang Fang, Yifan Li, Li Ding, Zhuo Chen, Shanchun Su, Junhua Cheng, Yong Huang, Qian Chen, Daqing Ma, Qiufang Zhang, Xingrong Guo

“…Abstract Introduction Liver dysfunction contributes to Alzheimer’s disease (AD) pathogenesis, and evidence suggests that the liver is involved in amyloid β (Aβ) clearance, and regulates Aβ deposition in the brain. …”
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Novel Pt@PCN-Cu-induced cuproptosis amplifies αPD-L1 immunotherapy in pancreatic ductal adenocarcinoma through mitochondrial HK2-mediated PD-L1 upregulation by Pengyu Wang, Weihua Guo, Shuyue Liu, Shouyi Li, Jiaqi Li, Bowen Ding, Fengyi Yin, Yang Yang, Xingjiang Li, Pei Cao, Chaozhe Ma, Wanying Zhang, Yidan Song, Yating Geng, Lantao Liu, Jing Hu, Jihui Hao, Yukuan Feng

“…These findings underscore a more effective and innovative approach for treating PDAC.…”
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Preserving cognitive function in patients with Alzheimer's disease: The Alzheimer's disease neuroprotection research initiative (ADNRI) by Jie Liu, Heleen vanBeusekom, Xian‐Le Bu, Gong Chen, Paulo Henrique Rosado de Castro, Xiaochun Chen, Xiaowei Chen, Andrew N. Clarkson, Tracy D. Farr, Yuhong Fu, Jianping Jia, Jukka Jolkkonen, Woojin Scott Kim, Paula Korhonen, Shen Li, Yajie Liang, Guang‐Hui Liu, Guiyou Liu, Yu‐Hui Liu, Tarja Malm, Xiaobo Mao, Joaquim Miguel Oliveira, Mike M. Modo, Pedro Ramos‐Cabrer, Karsten Ruscher, Weihong Song, Jun Wang, Xuanyue Wang, Yun Wang, Haitao Wu, Lize Xiong, Yi Yang, Keqiang Ye, Jin‐Tai Yu, Xin‐Fu Zhou, Marietta Zille, Colin L. Masters, Piotr Walczak, Johannes Boltze, Xunming Ji, Yan‐Jiang Wang

“…The etiology of AD is multifactorial, encompassing Aβ and tau accumulation, neuroinflammation, demyelination, vascular dysfunction, and comorbidities, which collectively lead to widespread neurodegeneration in the brain and cognitive impairment. …”
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A multifunctional self-assembled hydrogel with bactericidal activity and macrophage metabolic reprogramming for diabetic bone defect repair by Liangliang Wang, Zebin Wu, Xu Chen, Jiaxiang Bai, Wenming Li, Gaoran Ge, Wei Zhang, Wenhao Li, Yi Qin, Gongyin Zhao, Yuji Wang, Guoqing Pan, Yaozeng Xu, Dechun Geng

“…Recent studies have identified macrophage metabolic dysfunction as a key contributor to this impaired regenerative process. …”
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Inhibition of Heat Shock Protein 90β by Catalpol: A Potential Therapeutic Approach for Alleviating Inflammation‐Induced Cartilage Injuries in Osteoarthritis by Zhenwei Zhou, Binghua Zhang, Lang Liu, Jie Yang, Yuting Wang, Cheng Lv, He Zhang, Yuchi Wei, Zhanliang Jiang, Zeyu Peng, Daqing Zhao, Xiangyang Leng, Xiangyan Li, Hang Su, Haisi Dong

“…Abstract Osteoarthritis (OA) is a degenerative joint disease characterized by the metabolic dysfunction of chondrocytes. A promising therapeutic strategy for OA involves suppressing the catabolism of the chondrocyte and promoting its anabolism to restore joint homeostasis. …”
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Viral sequence determines HLA-E-restricted T cell recognition of hepatitis B surface antigen by Gavuthami Murugesan, Rachel L. Paterson, Rakesh Kulkarni, Veronica Ilkow, Richard J. Suckling, Mary M. Connolly, Vijaykumar Karuppiah, Robert Pengelly, Archana Jadhav, Jose Donoso, Tiaan Heunis, Wilawan Bunjobpol, Gwilym Philips, Kafayat Ololade, Daniel Kay, Anshuk Sarkar, Claire Barber, Ritu Raj, Carole Perot, Tressan Grant, Agatha Treveil, Andrew Walker, Marcin Dembek, Dawn Gibbs-Howe, Miriam Hock, Ricardo J. Carreira, Kate E. Atkin, Lucy Dorrell, Andrew Knox, Sarah Leonard, Mariolina Salio, Luis F. Godinho

“…Chronic Hepatitis B virus (HBV) infection is driven in part by T cell dysfunction due to elevated levels of the HBV envelope (Env) protein hepatitis B surface antigen (HBsAg). …”
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Improved Efficacy of Triple‐Negative Breast Cancer Immunotherapy via Hydrogel‐Based Co‐Delivery of CAR‐T Cells and Mitophagy Agonist by Guodong Li, Ruoxin Du, Donghui Wang, Xiangmei Zhang, Lizhuo Wang, Shuangpeng Pu, Xiaoju Li, Shuning Wang, Juliang Zhang, Beichen Liu, Yuan Gao, Huadong Zhao

“…It is revealed that the inhibition of mitophagy‐mediated mitochondrial dysfunction diminished the antitumor efficacy of CAR‐T‐cell therapy. …”
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Chronic Exposure to Bioaerosols in PM2.5 from Garbage Stations Accelerates Vascular Aging via the NF‐κB/NLRP3 Pathway by Peier Chen, Xiaodong Ning, Weijing Feng, Yajing Li, Guoqin Chen, Xu Shi, YuXuan Pan, Xueqin Shi, Yafang Xiao, Yuhua Liu, Guoxia Zhang, Feiran Zhou, Caiwen Ou

“…Bioaerosols, as an important environmental exposure in PM2.5, can induce systemic chronic inflammation leading to vascular aging. Thus, the effects of bioaerosols are investigated from household garbage stations in PM2.5 on vascular aging, and the underlying mechanisms are explored. …”
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Multidisciplinary Approach to Obesity by Berna Bulut Çakmak, Aslýhan Dönmez

“…It may be used as an individiual therapy, but it may also be more effective when used as a group psychotherapy. In this article, the CBT techniques used in obesity treatment are summarized. …”
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The FGF13‐Caveolin‐1 Axis: A Key Player in the Pathogenesis of Doxorubicin‐ and D‐Galactose‐Induced Premature Cardiac Aging by Enzhao Shen, Yuecheng Wu, Weijian Ye, Sihang Li, Junjie Zhu, Meifan Jiang, Zhicheng Hu, Gaoyong Cao, Xiaojing Yi, Fan Li, Zhouhao Tang, Xiaokun Li, Kwang Youl Lee, Litai Jin, Xu Wang, Weitao Cong

“…Furthermore, Cav1 overexpression in murine hearts reversed the alleviatory effects of FGF13 deficiency on the Doxorubicin/D‐galactose‐induced myocardial aging phenotype and dysfunction. …”
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Cardiometabolic and anxiogenic consequences of chronic social defeat stress in male mice by Karen A. Scott, Sophia A. Eikenberry, Khalid Elsaafien, Caitlin Baumer-Harrison, Dominique N. Johnson, Jéssica Matheus Sá, Alessandro Bartolomucci, Colin Sumners, Eric G. Krause, Annette D. de Kloet

“…Finally, the results of heart rate variability, spontaneous baroreflex sensitivity and adrenal transcriptome analyses were consistent with CSDS-induced autonomic dysfunction, effects that may contribute to the hypertension observed. …”
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Human neuron chimeric mice reveal impairment of DVL-1-mediated neuronal migration by sevoflurane and potential treatment by rTMS by Youyi Zhao, Ya Zhao, Lirong Liang, Andi Chen, Yuqian Li, Ke Liu, Rougang Xie, Honghui Mao, Boyang Ren, Bosong Huang, Changhong Shi, Zhicheng Shao, Shengxi Wu, Yazhou Wang, Hui Zhang

“…Chemogenetic activation of human neurons rescued the defects of cell migration and social dysfunction of Sev-pretreated human neuronal chimeric mice. …”
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Adjusting blood redistribution to suppress flow disturbances of hemodialysis arteriovenous fistula: a computational fluid dynamics analysis by Yong-Jiang Li, Yong-Jiang Li, Hui-Min Hou, Zheng Liu, Chun-Dong Xue, Chun-Dong Xue, Jing-Tong Na, Qing-Mei Meng, Zhe-Yuan Li, Hai-Yang Sun, Yu-Lin Wu, Shu-Xin Liu, Shu-Xin Liu, Kai-Rong Qin, Kai-Rong Qin

“…IntroductionThe dramatic hemodynamic disturbances induced by arteriovenous fistula (AVF) creation are universally acknowledged as the triggering factors for AVF dysfunction. The postoperative blood redistribution is greatly relevant with the flow disturbances of the AVF, such as disturbed flow, low wall shear stress (WSS), and oscillating WSS. …”
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Intratracheal Administration of Polystyrene Micro(nano)plastics with a Mixed Particle Size Promote Pulmonary Fibrosis in Rats by Activating TGF-β1 Signaling and Destabilizing Mitoc... by Shuang Xia, Chunli Yuan, Wei Long, Zongcheng Wu, Xiuqin Li, Nan Wang, Mumu Gao, Zhe Li, Peilun Li, Peng Liu, Xiaoxi Qu, Lina Sun

“…A benchmark dose (BMD) of 0.151 mg/day and a benchmark dose lower confidence limit (BMDL) of 0.031 mg/day were identified on the basis of the subchronic effects of the intratracheal administration of the PS-MPs. …”
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Triple cardiovascular disease detection with an artificial intelligence-enabled stethoscope (TRICORDER): design and rationale for a decentralised, real-world cluster-randomised con... by Azeem Majeed, Rasha Al-Lamee, Ceire Costelloe, Daniel B Kramer, Carla M Plymen, Carys Barton, Emanuela Falaschetti, Nicholas S Peters, Josephine Mansell, Patrik Bachtiger, Mihir A Kelshiker, Camille F Petri, Abdullah Alrumayh, Saloni Nakhare, Melanie T Almonte, Alexei Peters

“…Introduction Early detection of cardiovascular disease in primary care is a public health priority, for which the clinical and cost-effectiveness of an artificial intelligence-enabled stethoscope that detects left ventricular systolic dysfunction, atrial fibrillation and cardiac murmurs is unproven but potentially transformative.Methods and analysis TRICORDER is a pragmatic, two-arm, multi-centre (decentralised), cluster-randomised controlled trial and implementation study. …”
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Gastrodin reduces myocardial ischemia/reperfusion injury via transgelin2/CNPase-mediated apoptosis regulation by Changyan Li, Peng Rao, Xiang Liu, Xiang Liu, Lin Yang, Lin Yang, Yongliang Jiang, Yongliang Jiang, Gaosheng Yin, Shuangxiu Li, Shuangxiu Li, Ping Yang, Ping Yang, Lin Sun

“…While Gastrodin (GAS) mitigates MIRI, its mechanism requires further exploration.MethodsWe evaluated GAS effect in SD rats following 45-min left coronary artery ligation and reperfusion. …”
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