Proteostasis Decline and Redox Imbalance in Age-Related Diseases: The Therapeutic Potential of NRF2 by Brigitta Buttari, Antonella Tramutola, Ana I. Rojo, Niki Chondrogianni, Sarmistha Saha, Alessandra Berry, Letizia Giona, Joana P. Miranda, Elisabetta Profumo, Sergio Davinelli, Andreas Daiber, Antonio Cuadrado, Fabio Di Domenico

“…By inducing NRF2, it is possible to mitigate the damaging effects of oxidative stress, metabolic dysfunction, and inflammation, thus reducing protein misfolding. …”
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Overexpression in Plasmodium falciparum of an intrinsically disordered protein segment of PfUT impairs the parasite’s proteostasis and reduces its growth rate by Yunuen Avalos-Padilla, Yunuen Avalos-Padilla, Inés Bouzón-Arnáiz, Inés Bouzón-Arnáiz, Miriam Ramírez, Claudia Camarero-Hoyos, Claudia Camarero-Hoyos, Claudia Camarero-Hoyos, Marc Orozco-Quer, Elsa M. Arce, Diego Muñoz-Torrero, Diego Muñoz-Torrero, Xavier Fernàndez-Busquets, Xavier Fernàndez-Busquets, Xavier Fernàndez-Busquets

“…Combined with dihydroartemisinin treatment, PfUTf overexpression had a synergistic effect that further compromised the parasite´s viability, linking protein aggregation to proteasome dysfunction. …”
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Chronic Exposure to Field-Level Thiamethoxam Impairs Gut Tissue and Reduces Honeybee (<i>Apis cerana</i>) Survival by Yulong Guo, Changsheng Ma, Wenzheng Zhao, Haiou Kuang, Yakai Tian, Haoyuan Zhang, Yunfei Xue, Hongmei Li-Byarlay, Kun Dong, Xueyang Gong

“…We exposed newly emerged worker bees of <i>A. cerana</i> to a field-relevant dose of TMX (400 ng/g) under laboratory conditions to examine whether TMX exposure triggers similar or distinct effects in different biological processes and tissues. …”
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Fecal microbiota transplantation alleviates female offspring’s ovarian inflammation in arsenic and fluoride co-exposed rats through the PI3K/ Akt /NF-κB pathway by Yidi Li, Dongcai Yue, Yannan Zhao, Penghui Liu, Meng Li, Jinyao Chen, Xiaoting Yan, Linhua Fan, Guohua Song, Xiaolin Tian, Yi Lv, Qian Zhao, Yulan Qiu, Xiaoyan Yan

“…This study investigated the effects of As and F co-exposure on ovarian development and the potential protective role of fecal microbiota transplantation (FMT). …”
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Qishen Yiqi alleviates periostin-mediated cardiac fibrosis and hypertrophy in Dahl hypertensive rat hearts and angiotensin II-induced cardiac organoids by Siwen Fan, Siwen Fan, Hongxia Du, Hongxia Du, Siyu Li, Siyu Li, Guangxu Xiao, Guangxu Xiao, Yuhan Zhao, Yuhan Zhao, Shuang He, Shuang He, Guanwei Fan, Guanwei Fan, Guanwei Fan, Yan Zhu, Yan Zhu

“…We have previously shown that a component-based Chinese medicine Qishen Yiqi (QSYQ) lowered the blood pressure and ameliorated kidney damage in salt-sensitive hypertensive rats. However, its effect on the hypertensive rat heart remains unknown. …”
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Carotid Endarterectomy Ameliorates Cognitive Impairment in Clinical and Experimental Unilateral Carotid Artery Stenosis by Yijun Cheng, Bin Chen, Miao Zhang, Zhenghong Chen, Mingjian Liu, Ziqian Zhang, Hao Tang, Dapeng Wang, Wenwen Lv, Biao Li, Yuting Dai, Hanbing Shang

“…Background Carotid endarterectomy (CEA) is widely used to treat carotid artery stenosis (CAS). However, the effects of CEA on unilateral CAS‐induced cognitive impairment and the underlying mechanism remain poorly understood. …”
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Polystyrene nanoplastics exposure induces cognitive impairment in mice via induction of oxidative stress and ERK/MAPK-mediated neuronal cuproptosis by Yinuo Chen, Yiyang Nan, Lang Xu, Anqi Dai, Rosa Maria Martinez Orteg, Mantong Ma, Yan Zeng, Jinquan Li

“…Treatment with NAC alleviated these adverse effects. In SH-SY5Y cells, exposure to PS-NPs resulted in reduced cell viability (p < 0.01), an effect that was mitigated by TTM. …”
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Assessment of changes in synaptic density in the zQ175DN mouse model of Huntington’s disease: a [18F]SynVesT-1 study by Liesbeth Everix, Franziska Zajicek, Annemie Van Eetveldt, Longbin Liu, Jonathan Bard, Steven Staelens, Daniele Bertoglio

“…HD has been associated with synaptic dysfunction and loss of the synaptic vesicle protein 2A (SV2A). …”
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Gypenoside XLIX inhibiting PI3K/AKT/FOXO1 signaling pathway mediated neuronal mitochondrial autophagy to improve patients with ischemic stroke by Yonglei Liu, Yonglei Liu, Hongdie Mao, Zhengguang Sha, Jishuai Zhao, Hui Cai, Rong Xi, Zhenzhu Zhao, Xiaoling Yin, Lin Yang, Changyun Liu, Changyun Liu

“…Gypenoside XLIX, a major active metabolite of Gynostemma pentaphyllum, exhibits antioxidant and organ-protective properties, but its effects on neuronal mitochondrial damage in stroke remain unclear. …”
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Depression like-behavior and memory loss induced by methylglyoxal is associated with tryptophan depletion and oxidative stress: a new in vivo model of neurodegeneration by Md. Samsuzzaman, Seong-Min Hong, Jae Hyuk Lee, Hyunjun Park, Keun-A Chang, Hyun-Bum Kim, Myoung Gyu Park, Hyeyoon Eo, Myung Sook Oh, Sun Yeou Kim

“…Notably, co-treatment with MGO and Trp mirrored the effects observed after Trp-null treatment in neurons, including reduced TPH1 and TPH2 levels and inhibition of neuronal outgrowth. …”
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Homotherapy for heteropathy of chronic kidney disease and oligoasthenozoospermia through regulating SIRT1/NF-κB pathway by Shenqi pills by Shuo Huang, Qihan Luo, Xinyue Li, Yiming Liu, Jiale Wei, Sichen Wang, Ping Qiu, Changyu Li, Changyu Li

“…Additionally, in vitro assays were performed to validate SQP’s effects on OA using GC-1spg spermatogonia.Results41 compounds in SQP were identified. …”
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Human spindle-shaped urine-derived stem cell exosomes alleviate severe fatty liver ischemia–reperfusion injury by inhibiting ferroptosis via GPX4 by Shangheng Shi, Cunle Zhu, Shangxuan Shi, Xinqiang Li, Imran Muhammad, Qingguo Xu, Xinwei Li, Ziyin Zhao, Huan Liu, Guangming Fu, Meiying Song, Xijian Huang, Feng Wang, Jinzhen Cai

“…Abstract Background Severe hepatic steatosis can exacerbate Ischemia–reperfusion injury (IRI), potentially leading to early graft dysfunction and primary non-function. In this study, we investigated the heterogeneity of different subpopulations of Urine-derived stem cells (USCs) to explore the most suitable cell subtype for treating severe steatotic liver IRI. …”
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Incidence and Predictors of Right Ventricular Reverse Remodeling in Patients with Transthyretin Amyloid Cardiomyopathy Treated with Tafamidis by Nicoleta Nita, Dominik Felbel, Michael Paukovitsch, Felix von Sanden, Elene Walter, Rima Melnic, Wolfgang Rottbauer, Dominik Buckert, Johannes Mörike

“…<b>Background/Objectives</b>: In patients with transthyretin amyloid cardiomyopathy (ATTR-CM), the effect of tafamidis on right ventricular (RV) dysfunction has been poorly investigated. …”
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M2 macrophage-derived mitochondrial transplantation promotes periodontal bone regeneration by regulating metabolic homeostasis via activating p38-MAPK signaling pathway by Yuzhuo Ma, Xiang Han, Ke Yan, Yiyang Yang, Kewei Zhang, Yue Wang, Xuerong Lv, Feiyang Wang, Xiaoqian Wang

“…Mitochondrial transplantation has emerged as a promising treatment for mitochondrial dysfunction. In this study, we transplant M2 macrophage-derived mitochondria (M2-MT) into human periodontal ligament stem cells (hPDLSCs) in inflammatory states, and investigate its effect on the regulation and mechanism of osteogenic differentiation and metabolic status of hPDLSCs. …”
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<i>In Silico</i> Analysis of Phosphomannomutase-2 Dimer Interface Stability and Heterodimerization with Phosphomannomutase-1 by Bruno Hay Mele, Jessica Bovenzi, Giuseppina Andreotti, Maria Vittoria Cubellis, Maria Monticelli

“…PMM2-CDG is a rare autosomal recessive disease characterized by multisystemic dysfunction, including cerebellar atrophy, peripheral neuropathy, developmental delay, and coagulation abnormalities. …”
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HIV infection and exposure is associated with increased cariogenic taxa, reduced taxonomic turnover, and homogenized spatial differentiation for the supragingival microbiome by Allison E. Mann, Ciara Aumend, Suzanne Crull, Lauren M. O’Connell, Esosa Osagie, Paul Akhigbe, Ozoemene Obuekwe, Augustine Omoigberale, Matthew Rowe, Thomas Blouin, Ashlyn Soule, Colton Kelly, the DOMHaIN Study Team, Robert A. Burne, Modupe O. Coker, Vincent P. Richards

“…Results Both HIV infection and exposure have significant, if subtle, effects on the stability of the supragingival plaque microbiome. …”
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Fibroblast Growth Factor 23 and Sarcopenia in Maintenance Haemodialysis Population by Limy Wong, Rachel Kenny, Jenny Y. Y. Ooi, Yung Shing Tsang, Emily Schembri, Lawrence P. McMahon

“…FGF23 has previously been shown to have a direct role in cardiac dysfunction mediated through left ventricular hypertrophy. …”
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PATHOMORPHOLOGICAL DYNAMIC DUST CHANGES OF LUNG VESSELS IN KUZBASS MINERS WITH DIFFERENT WORK EXPERIENCE by Олег Иванович Бондарев, Арнольд Михайлович Сурков, Павел Алексеевич Азаров, Сергей Николаевич Филимонов

“…Although there is an opinion about the significant effect of products from the cytotoxic effect of silicate dust and industrial poisons on the endothelium with the development of perivascular sclerosis [1, 2]. …”
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HNF-1β alleviates podocyte injury in lupus nephritis by maintaining endoplasmic reticulum homeostasis by Jie Yu, Bing Guo, Fan Zhang, Miao Liu, Ying Xie, Hui-mei Zou, Yuan-yuan Ruan, Xiao-min An, Pei-lei Chen, Ying-qin Luo, Ming-jun Shi, Li-fen Xu

“…In vitro, glomerular podocytes were transfected with HNF1-β small interfering RNA (siRNA) or HNF1-β overexpression plasmids to explore their regulatory effects on the Derlin-1/VCP/VIMP complex and podocyte apoptosis. …”
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Associations of Cardiovascular Risk Factors and Genetic Markers with Development of Arterial Hypertension in the Population of Mountain Shoriya by T. A. Mulerova, S. A. Maksimov, M. Yu. Ogarkov, O. V. Gruzdeva, A. V. Ponasenko, V. N. Maksimov, M. I. Voyevoda, E. S. Filimonov, G. V. Artamonova

“…To study the combined effect of cardiovascular risk factors and genetic markers that encode the proteins of the main components of neurophysiological systems (renin-angiotensin-aldosterone, sympathetic-adrenal systems, endothelial dysfunction) on the development of arterial hypertension among the indigenous and non-indigenous population of Mountain Shoriya.Material and methods. …”
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