Oxidative balance score predicts chronic kidney disease risk in overweight adults: a NHANES-based machine learning study by Leying Zhao, Leying Zhao, Cong Zhao, Cong Zhao, Yuchen Fu, Yuchen Fu, Xiaochang Wu, Xiaochang Wu, Xuezhe Wang, Xuezhe Wang, Yaoxian Wang, Yaoxian Wang, Yaoxian Wang, Huijuan Zheng

“…BackgroundOxidative stress plays a pivotal role in the pathogenesis of chronic kidney disease (CKD), particularly in overweight and obese populations where adipose tissue dysfunction exacerbates systemic inflammation and metabolic derangements. …”
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Impact of diabetes mellitus on myocardial function and clinical outcomes in patients with significant aortic regurgitation by Yuting Tan, Yujie Zhang, Qiuyu Cai, Ruohan Zhao, Weidong Luo, Jingrong Jiang, Jiawei Shi, Tianshu Liu, Li Qiu, Jing Wang

“…Abstract Background Type 2 diabetes mellitus (T2DM) causes myocardial dysfunction and has been linked to an increased risk of unfavorable cardiovascular events. …”
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Mesenchymal stem cell-derived extracellular vesicles alleviate autism by regulating microglial glucose metabolism reprogramming and neuroinflammation through PD-1/PD-L1 interaction by Qian Qin, Linlin Fan, Xin Zeng, Danyang Zheng, Han Wang, Mengyue Li, Yutong Jiang, Hui Wang, Hao Liu, Shengjun Liang, Lijie Wu, Shuang Liang

“…Pharmacological blockade and genetic inhibition of PD-1 could weaken the effect of MSC-EVs and aggravate microglial dysfunction, glycolysis and autism-like behaviors in MIA offspring mice. …”
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Dynamic Electroneurostimulation in Rehabilitation: a Prospective Randomized Study of 60 Patients after Surgical Treatment of Colorectal Malignancies by Victor A. Drobyshev, Lubov A. Shpagina, Andrey A. Vlasov, Marina V. Umnikova, Tatyana M. Smarzh

“…AIM. To evaluate the effectiveness of incorporating dynamic electroneurostimulation in the rehabilitation of patients after surgicaltreatment for colorectal cancer to correct pain syndrome, autonomic dysfunction and quality of life indices. …”
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The Impact of Urodynamic Findings on Fatigue and Depression in People with Multiple Sclerosis by Anke K. Jaekel, Julius Watzek, Jörn Nielsen, Anna-Lena Butscher, John Bitter, Marthe von Danwitz, Pirmin I. Zöhrer, Franziska Knappe, Ruth Kirschner-Hermanns, Stephanie C. Knüpfer

“…Correlations between the symptoms of neurogenic lower urinary tract dysfunction (NLUTD), fatigue, and depression have been described, but the impact of pathological urodynamic study (UDS) findings has not been investigated to date. …”
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The role of melatonin in the regulation of the immune system and reproductive health: mechanisms and prospects for clinical application by M. M. Zhelavskyi, S. P. Kernychnyi, O. Ya. Dmytriv, T. V. Betlinska

“…Given its pleiotropic effects, melatonin holds substantial therapeutic potential for addressing immune dysfunction, reproductive disorders, and pregnancy complications. …”
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Clinical and Dosimetric Predictors of Early Onset Postradiation Hypothyroidism in Patients with Head and Neck Malignancies: A Logistic Regression Analysis by Ahmad Ameri, Zohreh Azma, Khashayar Fattah, Fereshteh Talebi, Pooya Ameri, Nazanin Rahnama, Mansour Lesan, Sanaz Poshtmahi, Farahnaz Rahimi, Marjan Mirsalehi, Farzad Taghizadeh-Hesary

“…The predictive model incorporating cancer histopathology, primary tumor site, V15,30, and VS15,30 effectively predicted postradiation thyroid dysfunction (area under the receiver operating characteristic curve [AUC-ROC] 0.84, 95% CI 0.73–0.95, p < 0.001). …”
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Elevation of p53 sensitizes obese kidney to adriamycin-induced aberrant lipid homeostasis via repressing HNF4α-mediated FGF21 sensitivity by Jiahao Li, Yufeng Tang, Guangping Lu, Qingbo Liu, Yuanfang Guo, Jie Wang, Mengjie Xiao, Ting Gao, Xiaohui Zhang, Junlian Gu

“…Results: Long-term HFD feeding mice exhibited compromised effects of FGF21 on alleviation of renal dysfunction and lipid accumulation following ADR administration. …”
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YOD1 regulates oxidative damage of dopamine neurons in Parkinson's disease by deubiquitinating PKM2 by Xia Zhao, Jinfeng Sun, Fan Chen, Hao Tang, Yuqing Zeng, Luyao Li, Qin Yu, Linjie Chen, Muzaffar Hammad, Xiaoxia Xu, Ziyao Meng, Wei Wang, Guang Liang

“…YOD1‐deficient exhibit a protective effect on neuronal oxidative injury. YOD1 targets PKM2-Nrf2 axis in response to oxidative stress.…”
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CD73-expressing endometrial regenerative cell-derived exosomes mitigate acute cardiac allograft rejection through regulating adenosine metabolism in mice by Chenglu Sun, Dejun Kong, Hong Qin, Shilong Li, Conglin Wang, Shaohua Ren, Yini Xu, Hongda Wang, Hao Wang

“…Abstract Background Organ transplantation is a life-saving option for end-stage organ dysfunction, but long-term graft survival is limited by unavoidable allograft rejection. …”
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Drug Pair of Astragali Radix–Ligustri Lucidi Fructus Alleviates Acute Kidney Injury in Mice Induced by Ischemia–Reperfusion Through Inhibiting Ferroptosis by Xuanhe Liu, Dan Zhang, Yuting Xie, Mengdan Wang, Xiaochun Chen, Weijie Yu, Yuming Ma, Jia Zeng, Qixuan Long, Guangrui Huang, Jie Geng, Anlong Xu

“…This study aimed to investigate DAL’s therapeutic effects on RIRI and its mechanisms. <b>Methods</b>: A mouse model of bilateral renal ischemia–reperfusion was established. …”
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Modulatory role of Spirulina platensis in oxidative stress, apoptosis, and gene expression in a rat model of dexamethasone-induced hepatotoxicity by Amina Zedan, Amira M. El-Moslemany, Rasha M. Bahnasy, Hanan Salah Eldeen Eldamaty, Suzan S. Ibraheim, Badriyah S. Alotaibi, Mohamed Abdelmegeid, Mohamed Abdelmegeid, Mustafa Shukry, Ahmed A. Elolimy

“…However, its potential hepatoprotective effects, particularly against glucocorticoid-induced liver damage, remain underexplored. …”
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Microglial cannabinoid receptor type II stimulation improves cognitive impairment and neuroinflammation in Alzheimer’s disease mice by controlling astrocyte activation by Akira Sobue, Okiru Komine, Fumito Endo, Chihiro Kakimi, Yuka Miyoshi, Noe Kawade, Seiji Watanabe, Yuko Saito, Shigeo Murayama, Takaomi C. Saido, Takashi Saito, Koji Yamanaka

“…Although there is growing evidence for the anti-neuroinflammatory and neuroprotective effects of the cannabinoid system modulation, the detailed mechanism remains unclear. …”
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Association between placental cortisol and neurodevelopment in 3-month-old infants by Shuangjie YU, Jinfang ZHANG, Ye LI, Jing FAN, Can LIU, Suzhen GUAN

“…Additionally, a mediation effect model was fitted using R 4.3.3 to assess possible mediating role of cortisol in the association between prenatal depression and neurodevelopmental delay in 3-month-old infants. …”
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Viral infections and immune modulation in bladder cancer: implications for immunotherapy by Lívia Bitencourt Pascoal, Mehrsa Jalalizadeh, Gabriela Barbosa, Andrea Nazare Monteiro Rangel da Silva, Maria Alice Freitas Queiroz, Ekaterina Laukhtina, Shahrokh F. Shariat, Alessandra Gambero, Leonardo O. Reis

“…This review discusses the interplay between viral antigenic load, immune dysfunction, and tumor microenvironment remodeling, highlighting their potential impact on immunotherapies. …”
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ADAM23 in Cardiomyocyte Inhibits Cardiac Hypertrophy by Targeting FAK‐AKT Signaling by Mei Xiang, Hongbo Luo, Jia Wu, Lingyun Ren, Xiangchao Ding, Chuangyan Wu, Jiuling Chen, Shanshan Chen, Hao Zhang, Lu Yu, Yanqiang Zou, Heng Xu, Ping Ye, Manhua Chen, Jiahong Xia

“…Mechanistically, ADAM23 exerts anti‐hypertrophic effects by specifically targeting the focal adhesion kinase‐protein kinase B (FAK‐AKT) signaling cascade. …”
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Apricot Bee Pollen Alleviates Deoxynivalenol-Induced Cellular Toxicity in Bovine Granulosa Cells by Ce Lv, Xiaoxue Zheng, Hanxiao Wu, Peihao Sun, Qun Lu, Fang Fang, Mingxiao Liu, Shuo Zhou, Rui Liu, Xiang Li, Liguo Yang, Aixin Liang

“…Importantly, we demonstrated that apricot bee pollen ethanol extract (ABPE) increased the cell viability of bGCs and alleviated the effects of DON-induced cell viability reduction and estrogen dysfunction. …”
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Exposure to the growth promoter tylosin elicits gut microbiota disruption and metabolic imbalance in mouse model by Hongyuhang Ni, Jing Wang, Haoze Wu, Bill Kwan-wai Chan, Kaichao Chen, Han Wang, Edward Wai-Chi Chan, Fuyong Li, Sheng Chen

“…The environmental risk associated with the usage of the antibiotic tylosin as an animal growth promoter (AGPs) needs to be assessed because such agents are used in abundance and contamination of the environment is common, yet their effects on the physiology and gut microbiota composition of animals and humans are poorly understood. …”
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Systematic review and meta‐analysis of the pelvic organ prolapse and vaginal prolapse among the global population by Tharanga Mudalige, Vindya Pathiraja, Gayathri Delanerolle, Heitor Cavalini, Shuqi Wu, Julie Taylor, Om Kurmi, Kathryn Elliot, Sharron Hinchliff, Carol Atkinson, Kristina Potocnik, Paula Briggs, Lucky Saraswat, Helen Felicity Kemp, George Eleje, Toh Teck Hock, Cristina Laguna Benetti‐Pinto, Irfan Muhammad, Rabia Kareem, Yassine Bouchareb, Peter Phiri, Ruishu Zhang, Yunfei Weng, Ieera Aggarwal, Jian Qing Shi, Ashish Shetty, Ian Litchfield, Nirmala Rathnayake, Sohier Elneil

“…Data were analysed using random‐effects and common‐effects models with subgroup and sensitivity analyses. …”
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Perinatal exposure to 4-hydroxy-4′-isopropoxydiphenylsulfone alters the adipogenesis in adult mice: A sex-specific study by Shengnan Zhang, Jiatong Shen, Kaini Hu, Yitong Zhou, Yumeng Wang, Xin Wang, Kashif Hayat, Mingrong Qian

“…This study explored the effects of early-life BPSIP exposure on obesity and metabolic dysfunction in a diet-induced obesity model. …”
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