Saliva-derived extracellular vesicles: a promising therapeutic approach for salivary gland fibrosis by Boyuan Peng, Xufei Guo, Jialing Kang, Shijiao Pan, Lili Wei, Lianhao Wang, Bo Li, Guangli Han, Yong Cheng

“…Methods We investigated the anti-fibrotic effects of saliva-derived extracellular vesicles (sEV) through in vitro and in vivo approaches. …”
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Taurine Supplementation Alleviates Blood Pressure via Gut–Brain Communication in Spontaneously Hypertensive Rats by Qing Su, Xiong-Feng Pan, Hong-Bao Li, Ling-Xiao Xiong, Juan Bai, Xiao-Min Wang, Xiao-Ying Qu, Ning-Rui Zhang, Guo-Quan Zou, Yang Shen, Lu Li, Li-Li Huang, Huan Zhang, Meng-Lu Xu

“…A range of evidence suggests that hypertension activates inflammatory responses and oxidative stress in the paraventricular nucleus (PVN), elevating the arterial tone and sympathetic activity, while it induces gut–brain axis dysfunction in the context of hypertension. However, the mechanism underlying taurine’s anti-hypertensive effects via the gut–brain axis remains unclear. …”
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<i>Centella asiatica</i> Promotes Antioxidant Gene Expression and Mitochondrial Oxidative Respiration in Experimental Autoimmune Encephalomyelitis by Payel Kundu, Kanon Yasuhara, Mikah S. Brandes, Jonathan A. Zweig, Cody J. Neff, Sarah Holden, Kat Kessler, Steven Matsumoto, Halina Offner, Carin S. Waslo, Arthur Vandenbark, Amala Soumyanath, Larry S. Sherman, Jacob Raber, Nora E. Gray, Rebecca I. Spain

“…These benefits, along with the anti-inflammatory effects of CAW, support further investigation of its neuropsychiatric effects in people with MS.…”
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Lycium barbarum Glycopeptide Alleviates Neomycin‐Induced Ototoxicity by Inhibiting Tryptophan Hydroxylase‐Mediated Serotonin Biosynthesis by Yunhao Wu, Li Zhang, Shengda Cao, Jingwen Zhang, Cheng Li, Yunlong Shan, Qiuping Liu, Zhexiong Yu, Qiaojun Fang, Yuhua Zhang, Xiaolong Fu, Kwok‐Fai So, Renjie Chai

“…Systemic delivery of 5‐HT increased neomycin‐induced apoptosis of cochlear hair cells and spiral ganglion neurons, and pharmacological Tph2 inhibition with P‐chlorophenylalanine or Tph2 knock down by AAV‐ie‐Tph2 effectively attenuated neomycin‐induced hearing dysfunction. …”
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Deep brain stimulation versus vagus nerve stimulation for the motor function of poststroke hemiplegia: study protocol for a multicentre randomised controlled trial by Bin Liu, Xinguang Yu, Qing Chang, Di Liu, Yanyang Zhang, Junpeng Xu, Haonan Yang, Zhiqi Mao, Guosong Shang, Shuzhen Liu, Zhebin Feng, Chen Yuhan

“…To ensure a thorough understanding of the long-term effects, we will conduct follow-ups at 9 and 12 months postsurgery, with additional long-term assessments at 15 and 18 months. …”
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Medical therapy to treat obesity and optimize fertility in women of reproductive age: a narrative review by Janelle Duah, David B. Seifer

“…Abstract Background Overweight and obesity—chronic illnesses in which an increase in body fat promotes adipose tissue dysfunction and abnormal fat mass resulting in adverse metabolic, biomechanical, and psychosocial health consequences—negatively impact female fertility. …”
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The mechanism of electroacupuncture-mediated improvement in Parkinson’s disease by inhibiting ferroptosis through activating the Nrf2/GPX4 signal pathway by Min Wang, He-Sheng Zheng, He-Sheng Zheng, Wei-Liang Ye, Jin-Dong Mao, Kun Zhang, Le Yang, Ming-Gao Zhao, Shui-Bing Liu, Rui Liu, Yu-Mei Wu, Yu-Mei Wu

“…It upregulated ferroptosis-suppressive proteins SLC7A11, GPX4, FTH1, and Nrf2, alongside ameliorating mitochondrial dysfunction. Crucially, AT administration abolished EA’s protective effects, confirming Nrf2 pathway dependency.DiscussionThese findings demonstrate that EA exerts neuroprotection in PD by inhibiting ferroptosis through activation of the Nrf2/SLC7A11/FTH1/GPX4 signaling axis. …”
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Research Progress of Intelligent Evaluation and Virtual Reality Based Training in Upper Limb Rehabilitation afrer Stroke by XIE Qiurong, LIN Wanqi, ZHANG Qi, SHENG Bo, ZHANG Yanxin, HUANG Jia

“…Stroke is the leading cause of disability worldwide, with approximately 85% of poststroke patients experiencing upper extremity dysfunction at first presentation and only 5% to 20% fully recovered at six months post-stroke. …”
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Can the Pupillary Light Reflex and Pupillary Unrest Be Used as Biomarkers of Parkinson’s Disease? A Systematic Review and Meta-Analysis by Aleksander Dawidziuk, Emilia Butters, Daniel Josef Lindegger, Campbell Foubister, Hugo Chrost, Michal Wlodarski, John Grogan, Paulina A Rowicka, Fion Bremner, Sanjay G Manohar

“…Pooled incidence and effect sizes were determined using a random-effects model with an inverse variance DerSimonian–Laird estimator. …”
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Arctiin, a lignan compound, enhances adipose tissue browning and energy expenditure by activating the adenosine A2A receptor by Yuanfeng Gu, Wenjun He, Wenxuan Li, Jingshu Cai, Zhuyun Wang, Kemeng Li, Guangcheng Qin, Xiaojie Gu, Xiaojing Lin, Li Ma, Xiaoqiu Xiao, Yi Hou, Ting Luo

“…Arctiin (ARC), a lignan compound known for its anti-inflammatory, anti-tumor, and hypoglycemic properties, has not been fully elucidated regarding its effects and mechanisms on obesity. Methods In the present study, we established both high-fat diet-induced obese mouse models and mature adipocyte cultures to comprehensively investigate the therapeutic effects of ARC on obesity. …”
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Rice bran oil rescues cognitive decline in D-galactose-induced aging mice by inhibiting Aβ accumulation and Tau hyperphosphorylation induced oxidative stress and neuroinflammation by Yadan Zhang, Diya Xu, Xiaoyu Zhang, Wenhua Zhou, Lin Zhang, Qinlu Lin

“…In this study, the effects of RBO on memory dysfunction in D-galactose (D-gal) mice and its molecular mechanisms were investigated via in vivo and in silico methods from the perspective of AD pathologies. …”
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Sacubitril/valsartan preserves regional cardiac function following myocardial infarction in rats by Einar Sjaastad Nordén, Bård Andre Bendiksen, Kaja Knudsen Bergo, Emil Knut Stenersen Espe, Gary McGinley, Almira Hasic, Ida Marie Hauge‐Iversen, Hege Katrin Ugland, Xin Shen, Michael Frisk, Nishani S. Mabotuwana, William E. Louch, Rizwan I. Hussain, Lili Zhang, Ivar Sjaastad, Alessandro Cataliotti, Geir Christensen

“…Abstract Aims Sacubitril/valsartan (Sac/Val) is used for treatment of heart failure. The effect of Sac/Val on regional dysfunction following myocardial infarction (MI) remains uncertain. …”
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Resveratrol Alleviates Ischemia-Reperfusion-Induced Neuronal Damage by Inhibiting NR3C2-Mediated TRIM28 Expression by Yan Li, Haiwei Xie, Shuang Liu, Zhongfan Ruan, Baiyun Wang

“…Mechanistically, NR3C2 was shown to directly regulate TRIM28 transcription, mediating the observed neuroprotective effects. …”
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Therapeutic Potential of Emricasan, a Pan-Caspase Inhibitor, in Reducing Cell Death and Extracellular Matrix Accumulation in Fuchs Endothelial Corneal Dystrophy by Sohya Fujimoto, Mako Endo, Shigehito Tonomura, Fuuga Tsuji, Hirotaka Haraguchi, Kanna Hasegawa, Taisuke Numao, Ayaka Izumi, Theofilos Tourtas, Ursula Schlötzer-Schrehardt, Friedrich Kruse, Yuki Oyama, Masahito Ikawa, Albert S. Jun, Noriko Koizumi, Naoki Okumura

“…Patient-derived FECD cells and stress-induced cell models were treated with emricasan to assess its effects on apoptosis and ECM production. Caspase-specific knockdown experiments were performed to identify key mediators. …”
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Danqi soft caspule alleviates myocardial ischemia-reperfusion injury induced cardiomyocyte apoptosis by attenuating mitochondrial fission by Ye Yang, Cuiting Lin, Yan Wang, Yu Liu, Qiuxiong Chen, Qiuxiong Chen, Shiyu Ma, Shiyu Ma, Jin Ma, Jin Ma

“…BackgroundMyocardial ischemia-reperfusion (I/R) injury which leads to continuously worsening ventricular remodeling and cardiac dysfunction in the chronic stage, is a significant contributor to the global prevalence of heart failure. …”
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Astrogliosis Occurs Selectively in Amygdala of Adolescent Primate and Rodent Following Daily Δ9-Tetrahydrocannabinol, Prevented by Cannabidiol Co-Treatment by Yalin Sun, Meenalochani Sivasubramanian, Marija Milenkovic, Andrew Gumbert, Jack Bergman, Preston Ge, Myriam Heiman, Marie-Eve Di Raddo, Sarah L. Withey, Bertha K. Madras, Susan R. George

“…Mitigation of specific THC-induced changes by CBD offers leads for attenuating some adverse effects of THC.…”
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Triclosan induces pyroptosis by activation of the caspase-9/3/gasdermin E axis by Shiqi Wu, Lei You, Shan He, Wenqaing Liu, Jinlin Lei, Jiahui Yang, Xiangyin Luo, Zhenxiu Ye, Yonghong Zhang, Jing Wang, Huailan Guo, Yan Zheng, Lanlan Zheng, Chen Li

“…In this study, we aimed to investigate the cytotoxic effects of 200 μM TCS on L02 cells and elucidate the molecular mechanisms involved in TCS-induced pyroptosis, a novel form of cell death. …”
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Gastrodin alleviates myocardial infarction by inhibiting inflammation, and apoptosis and promoting endothelial cell proliferation by Ruochen Du, Ying Guo, Wanting Zhong, Yuantao Gao, Miaomiao Xu, Chunfang Wang, Yitong Yuan

“…This study investigated the protective effect of gastrodin on myocardial infarction and its potential mechanism. …”
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Unveiling the therapeutic potential of natural products in Alzheimer’s disease: insights from in vitro, in vivo, and clinical studies by Nahida Aktary, Yerim Jeong, Seungji Oh, Yeju Shin, Yoonsoo Sung, Muntajin Rahman, Livia Ramos Santiago, Jinwon Choi, Han Gyeul Song, Fahrul Nurkolis, Rosy Iara Maciel Azambuja Ribeiro, Moon Nyeo Park, Bonglee Kim

“…Alzheimer’s disease (AD) is a multifactorial neurodegenerative disorder described as progressive cognitive decline and neuronal dysfunction, affecting millions globally. While current pharmacological treatments provide symptomatic relief and modestly slow disease progression, they fail to address the underlying pathophysiology and are often accompanied by severe adverse effects. …”
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Impact of <i>Lactobacillus</i>- and <i>Bifidobacterium</i>-Based Direct-Fed Microbials on the Performance, Intestinal Morphology, and Fecal Bacterial Populations of Nursery Pigs by Juan Castillo Zuniga, Anlly M. Fresno Rueda, Ryan S. Samuel, Benoit St-Pierre, Crystal L. Levesque

“…Traditionally, challenges at weaning have been managed by prophylactic use of antibiotics, which not only provides protection against diarrhea and other gut dysfunction but also has growth-promoting effects. With banning or major restrictions on the use of antibiotics for this purpose, various alternative products have been developed as potential replacements, including direct-fed microbials (DFMs) such as probiotics and postbiotics. …”
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