Immune Checkpoint Inhibitors and Cardiovascular Adverse Events by Maria Luisa De Perna, Elia Rigamonti, Raffaele Zannoni, Vittoria Espeli, Giorgio Moschovitis

“…There is significant potential for accelerated atherosclerosis with ICIs as a long‐term effect, but atherosclerosis‐related CVAEs are not frequent, especially during treatment; increasing evidence associates ICIs with progression of atherosclerosis and increased atherosclerotic cardiovascular disease. …”
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Risk factors for mild cognitive impairment in type 2 diabetes: a systematic review and meta-analysis by Yi Zhao, Hanlin Wang, Guanghao Tang, Leilei Wang, Xuewen Tian, Ran Li

“…Data were analyzed using RevMan software, with odds ratio (OR) and 95% CI as effect size measures. Heterogeneity was assessed using I² statistics, and subgroup analyses were conducted for factors with ≥10 studies.Results30 studies with 10,469 participants were included. …”
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SUMOylation of TP53INP1 is involved in miR-30a-5p-regulated heart senescence by Yi-Xiang Hong, Chan Wu, Jing-Zhou Li, Fei Song, Yu Hu, Yue Han, Yi-Jie Mao, Wei-Yin Wu, Yan Wang, Gang Li

“…Cardiac-specific knockdown of miR-30a-5p using adeno-associated virus 9 in D-galactose-induced senescent wild-type mice resulted in effects similar to those observed in knockout mice. …”
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Are We Getting Better?: Ongoing Challenges of Atrioventricular Valve Repair in Children With Single Ventricle Physiology by Sachiko Kadowaki, Maelys Venet, Teerapong Tocharoenchok, Kok Hooi Yap, Chun‐Po Steve Fan, Yasmin Zahiri, Mimi X. Deng, Olivier Villemain, Alejandro Floh, David J. Barron, Osami Honjo

“…Background This study aimed to assess impact of atrioventricular valve (AVV) regurgitation onset, timing of AVV repair (AVVr), ventricular morphology, and era effect on AVVr outcomes in a single ventricle population. …”
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Incidence and prognostic value of acute kidney injury in pulmonary embolism: data from the SIRENA registry by M. V. Menzorov, V. V. Filimonova, A. D. Erlikh, O. L. Barbarash, S. A. Berns, E. A. Shmidt, D. V. Duplyakov

“…AKI led to an increase in mortality within following risk groups: at low risk, this effect was a trend (6 (5%) vs 6 (14%); p=0,052); at intermediate and high risk, significant differences was obtained (30 (13%) vs 41 (30%), p<0,001; 4 (14%) vs 19 (45%), p=0,006, respectively). …”
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Cardiac preservation using ex vivo organ perfusion: new therapies for the treatment of heart failure by harnessing the power of growth factors using BMP mimetics like THR-184 by William D. Carlson, William D. Carlson, William D. Carlson, Dattatreyamurty Bosukonda, Dattatreyamurty Bosukonda, Peter C. Keck, Philippe Bey, Shannon N. Tessier, Frederic R. Carlson

“…EVMP offers the promise of enabling the expansion of the overall number of heart transplants and lower rates of early graft dysfunction. These are realized through (1) safe extension of the time between procurement and transplantation and (2) ex vivo assessment of preserved hearts. …”
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Explainable machine learning reveals ribosome biogenesis biomarkers in preeclampsia risk prediction by Jingjing Chen, Dan Zhang, Chengxiu Zhu, Lin Lin, Kejun Ye, Ying Hua, Mengjia Peng

“…Ribosome biogenesis, critical for cellular homeostasis, is hypothesized to drive placental dysfunction in PE, though its role remains underexplored.MethodsWe integrated placental transcriptomic data from two datasets (GSE75010, GSE10588) to systematically investigate ribosome biogenesis dysregulation in preeclampsia. …”
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Positive End-Expiratory Pressure Titration Based on Lung Mechanics May Improve Pulse Pressure Variation Interpretation in Acute Respiratory Distress Syndrome Patients by Vasiliki Tsolaki, MD, PhD, George E. Zakynthinos, MD, Nikitas Karavidas, MD, Maria Eirini Papadonta, MD, Ilias Dimeas, MD, Kyriaki Parisi, MD, Theofilos Amanatidis, MD, Epaminondas Zakynthinos

“…OBJECTIVES:. To evaluate the effects of positive end-expiratory pressure (PEEP) on pulse pressure variation (PPV) in patients with moderate/severe acute respiratory distress syndrome (ARDS). …”
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HISTOGENETIC ASPECTS OF PNEUMOFIBROSIS DURING CONIOTIC CHANGES IN KUZBASS MINERS by Олег Иванович Бондарев, Сергей Николаевич Филимонов

“…Morphometry was performed in structures without signs of traumatic effects. Results. Coal industry workers have pronounced changes in lung tissue, which manifest themselves in pronounced fibroplastic tissue transformation. …”
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Finerenone attenuates downregulation of the kidney GLP-1 receptor and glucagon receptor and cardiac GIP receptor in mice with comorbid diabetes by Duc Tin Tran, Emily S. H. Yeung, Lisa Y. Q. Hong, Harmandeep Kaur, Suzanne L. Advani, Youan Liu, Madiha Zahra Syeda, Sri Nagarjun Batchu, Andrew Advani

“…Here, we examined the effects of the mineralocorticoid receptor antagonist finerenone in mice with comorbid diabetes, focusing on the regulation of expression of the glucagon-like peptide-1 receptor (GLP-1R), gastric inhibitory polypeptide receptor (GIPR) and glucagon receptor (GCGR), which are targets of approved or investigational therapies in diabetes. …”
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Comprehensive analysis of RFC4 as a potential biomarker for regulating the immune microenvironment and predicting immune therapy response in lung adenocarcinoma by Jianqing Zheng, Na Lin, Bifen Huang, Min Wu, Lihua Xiao, Bingwei Zeng

“…Functional prediction of RFC4 suggested that RFC4 mainly participated in DNA replication and repair, and reshaped the TIME.ConclusionsRFC4 proved to be a promising biomarker for tumorigenesis and could effectively predict immunotherapy response in LUAD. …”
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Highly Biocompatible Lamellar Liquid Crystals Based on Hempseed or Flaxseed Oil with Incorporated Betamethasone Dipropionate: A Bioinspired Multi-Target Dermal Drug Delivery System... by Vitek M, Medoš Ž, Lavrič Z, Jeras M, Planinšek O, Zvonar Pobirk A, Gosenca Matjaž M

“…Mercedes Vitek,1 Žiga Medoš,2 Zoran Lavrič,1 Matjaž Jeras,3 Odon Planinšek,1 Alenka Zvonar Pobirk,1 Mirjam Gosenca Matjaž1 1Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia; 2Chair of Physical Chemistry, Faculty of Chemistry and Chemical Technology, University of Ljubljana, Ljubljana, Slovenia; 3Department of Clinical Biochemistry, Faculty of Pharmacy, University of Ljubljana, Ljubljana, SloveniaCorrespondence: Alenka Zvonar Pobirk; Mirjam Gosenca Matjaž, Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Ljubljana, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia, Tel +386 147 69 652; +386 147 69 616, Email alenka.zvonar-pobirk@ffa.uni-lj.si; mirjam.gosenca.matjaz@ffa.uni-lj.siPurpose: Atopic dermatitis (AD) is the most common chronic inflammatory skin disease that severely impairs patient’s life quality and represents significant therapeutic challenge due to its pathophysiology arising from skin barrier dysfunction. Topical corticosteroids, the mainstay treatment for mild to moderate AD, are usually formulated into conventional dosage forms that are impeded by low drug permeation, resulting in high doses with consequent adverse effects, and also lack properties that would strengthen the skin barrier. …”
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Mapping the future: bibliometric insights into ferroptosis and diabetic nephropathy by Tangwen Wei, Yang Qin, Xiaohui Lin, Xiujuan Wang, Suyi Chen, Xia Chen, Nan Yan, Xinyi Wei, Zhichang Zhang, Bing Wei

“…Preclinical agents, including ginkgolide B (GB) and dapagliflozin, effectively restored iron homeostasis and attenuated oxidative damage.ConclusionFerroptosis is a promising therapeutic target for DN, yet its clinical translation remains in its infancy. …”
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Relationship of hypovitaminosis d and insulin resistance in patients with coronary heart disease and metabolic syndrome by V. F. Orlovsky, M. A. Hordina

“…Further studies are warranted the assotiation of hypovitaminosis D with the MS components, markers of subclinical inflammation and effectiveness of vitamin D supplementation.…”
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MAPK, PI3K/Akt Pathways, and GSK-3β Activity in Severe Acute Heart Failure in Intensive Care Patients: An Updated Review by Massimo Meco, Enrico Giustiniano, Fulvio Nisi, Pierluigi Zulli, Emiliano Agosteo

“…Activation of the PI3K/Akt pathway has been shown to confer cardioprotective effects by enhancing anti-apoptotic and pro-survival signaling; however, aberrant or sustained activation may contribute to maladaptive remodeling and progressive cardiac dysfunction. …”
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Thromboembolic and infectious complication risks in TKA and UKA: evidence from a Japanese nationwide cohort by Yu Mori, Kunio Tarasawa, Hidetatsu Tanaka, Masayuki Kamimura, Kento Harada, Naoko Mori, Kiyohide Fushimi, Toshimi Aizawa, Kenji Fujimori

“…UKA showed lower risks of cognitive dysfunction, pneumonia, transfusion requirements, and shorter hospital stays. …”
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EMDR in Competition with Fate: A Case Study in a Chinese Woman with Multiple Traumas by Maggie Wai-Ling Poon

“…It is also a proven, effective, and efficient treatment for trauma. In this client with multiple traumas, the etiological event that lay the foundation of her dysfunctional responses was reprocessed first. …”
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New Approach to Improving the Prognosis of Ischemic Stroke by Regulating SCFAs with Acupuncture-Rehabilitation Therapy Based on Gut-Brain Axis by TANG Qiang, LIU Chong, CHAI Fanglei, ZHANG Jinpeng, LI Hongyu, ZHU Luwen

“…They play a key role in maintaining the weak acidic environment of the intestine and anti-inflammatory effect, which can regulate brain function through a variety of pathways. …”
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Evaluating Renal Benefits of Rivaroxaban Versus Vitamin K Antagonists in Atrial Fibrillation: A Systematic Review and Meta-analysis of Real-world Evidence by Phong Phan Dinh, Tri Huynh Quang Ho, Hung Manh Pham, Hai Hoang Nguyen, Minh That Ton, Giang Song Tran, Nga Quynh Vu, Hung Nhu Pham, Son Cao Luong, Sy Van Hoang

“…Background: AF is a global health concern, with systemic complications including renal dysfunction. This systematic review and meta-analysis compares the effects of rivaroxaban, a Factor Xa inhibitor, and vitamin K antagonists (VKAs) on renal outcomes in AF patients. …”
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Per- and polyfluoroalkyl substances, genetic factors, and sleep health in reproductive-aged women: a cross-sectional study of the Shanghai Birth Cohort by Ruisi Wu, Xiaoqing He, Wen Jiang, Azhu Han, Ying Tian, Jun Zhang, Yun Huang

“…Polygenic risk scores were used to evaluate the cumulative genetic effects of sleep disturbances. 6:2Cl-PFESA was associated with increased snoring and less daytime dysfunction, though these associations did not remain significant after FDR correction. …”
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