Population pharmacokinetic study of colistin for dose optimization in patients with acute on chronic liver failure (ACLF) patients by Dr Ritika Bhandari, Prof. Nusrat Shafiq, Dr. Naveen Murali, Dr. Soumya Vij, Dr. Nipun Verma, Dr. Avaneesh Kumar Pandey, Prof. Vikram Prakash Gota, Dr. M Surulivel Rajan, Prof. Ajay Kumar Duseja, Prof. Samir Malhotra

“…We developed a population PK model using nonlinear mixed-effect modelling with the software program PUMAS AI. …”
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Percepción del funcionamiento familiar por adultos mayores dependientes del alcohol en comunidades terapéuticas internacionales de Holguín by Jorge Manuel Ruiz Diego, Margarita Rodríguez Diéguez, Marcia Ávila Oliva, Liset Rodríguez Martinez, Walter Ricardo Medina

“…The indicators such as communication, harmony, effectiveness and permeability were the most dysfunctional ones.   …”
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Hepcidin and MELD-XI score as markers of multiple organ failure in patients with heart failure with preserved and reduced ejection fraction by V. I. Podzolkov, N. A. Dragomiretskaya, S. K. Stolbova, A. V. Tolmacheva

“…Data on the changes in hepcidin levels in heart failure (HF) patients are contradictory and do not give an answer about its effect on the progression of multiple organ failure. …”
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‘Transauricular vagus nerve stimulation’ for prevention of postoperative delirium in elderly patients undergoing major surgery: a study protocol for a multicentre, participant-blin... by Jun Zhang, Xin Yu, Gang Chen, Yu Li, Qi-Hong Shen, Xinru Lin, Tieshuai Liu, Yunyun Yu, Keqin Song

“…Research has shown that neuroinflammation, postoperative pain and autonomic nervous system dysfunction play significant roles in its onset. Vagus nerve stimulation (VNS) has the potential to reduce inflammation, ease postoperative pain and aid in recovery by enhancing acetylcholine release and activating the cholinergic anti-inflammatory pathway. …”
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Usefulness of metabolic score for insulin resistance index in estimating the risk of mildly reduced estimate glomerular filtration rate: a cross-sectional study of rural population... by Ying Zhou, Zhao Li, Guozhe Sun, Yingxian Sun, Hongmei Yang, Xiaofan Guo, Liqiang Zheng, Shasha Yu, Xingang Zhang, Pengbo Wang, Qiyu Li

“…Hence, we believed MetS-IR was a suitable indicator to evaluate the risk of early-stage renal dysfunction.…”
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Autoimmune disease: genetic susceptibility, environmental triggers, and immune dysregulation. Where can we develop therapies? by Manoj Kumar, Manoj Kumar, Linda Yip, Fangyuan Wang, Saci-Elodie Marty, C. Garrison Fathman

“…Additionally, epigenetic modifications further compound these effects, creating lasting changes in gene expression and immune cell function. …”
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A multi-country time and motion study to describe the experience and burden associated with the treatment of Fabry disease with enzyme replacement therapy with agalsidase alfa and... by Ian Keyzor, Ana Maria Martins, Sema Kalkan Uçar, Hiroyuki Yamakawa, Yin-Hsiu Chien, Nur Arslan, Dau-Ming Niu, Leyla Tümer, Laura Baldock, Simon Shohet, Joseph D. Giuliano

“…Abstract Background Fabry disease (FD) is a rare inherited X-linked lysosomal disorder caused by the deficiency or dysfunction of the enzyme α-galactosidase. This leads to a detrimental accumulation of globotriaosylceramide (Gb3) within multiple cell types. …”
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The Upregulation of IL-1β Induced by Cisplatin Triggers PI3K/AKT/MMP9 Pathway in Pericytes Mediating the Leakage of the Blood Labyrinth Barrier by Yu M, Jiang WJ, Yu M, Zhou Z, Wang M, Li L

“…In vitro BLB models, the effect of IL-1β on MMP9 expression, PI3K-AKT pathway activation, and endothelial barrier permeability were examined via Western blot, TEER value test, and FITC extraction analysis. …”
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FUNCTIONAL POLYMORPHISM OF THE PRO-INFLAMMATORY CYTOKINE GENES IN PULMONARY TUBERCULOSIS by E. G. Churina, O. I. Urazova, V. V. Novitsky, A. V. Sitnikova, S. E. Barmina

“…The MBT antigens can cause dysfunction of the receptors and modulate the cytokine secreting function of immunocompetent cells. …”
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Obstructive hypertrophic cardiomyopathy: from genetic insights to a multimodal therapeutic approach with mavacamten, aficamten, and beyond by Khadija Sarwer, Saeeda Lashari, Nida Rafaqat, Maher, Abdul Raheem, Muneeb Ur Rehman, Syed Muhammad Iraj Abbas

“…Beta-blockers and calcium channel blockers are primary treatment options, although their effectiveness varies among patients. Recent clinical trials have highlighted the potential of novel cardiac myosin inhibitors, including mavacamten and aficamten, in enhancing exercise capacity, reducing LVOT obstruction, and improving overall cardiac function. …”
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Mortality and risk factors in hospitalised adult patients with tetanus: a systematic review and meta-analysis by Junbin Huang, Wenbin Zhang, Zhenlin Chen, Zhijie Lin, Hantian Hong, Zhishi Cai

“…Six risk factors associated with mortality in these patients were identified, including age ≥40 years (RR=1.89, 95% CI: 1.37 to 2.61), incubation period <7 days (RR=2.10, 95% CI: 1.47 to 3.00), onset period <2 days (RR=2.06, 95% CI: 1.30 to 3.29), Ablett classification ≥III (RR=3.40, 95% CI: 1.91 to 6.05), presence of autonomic dysfunction (RR=4.84, 95% CI: 2.36 to 9.94) and the need for mechanical ventilation (RR=2.46, 95% CI: 1.48 to 4.09).Conclusion The study findings have important implications for clinical practice and public health policy. …”
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Zinc sulfate improves insulin resistance, oxidative stress and apoptosis in liver tissues of PCOS rats through the NF-κB pathway by Yi-fan Kang, Jia-yi Zhao, Jian-rong Liu

“…Liver cell apoptosis and mitochondrial dysfunction are key pathological features of PCOS-associated liver diseases, contributing significantly to the progression of PCOS. …”
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Tumour lysis syndrome: modern aspects of the problem by N. V. Matinyan, T. T. Valiev, L. A. Martynov, V. P. Akimov, E. A. Kovaleva, Yu. V. Buidenok

“…Additional study of the pathogenetic mechanisms of ATLS development, identification of key targets of drug therapy, and a multidisciplinary approach in the treatment of an extremely unfavorable group of oncohematological patients with advanced stages of the tumor process are possible components for further increasing the effectiveness of ATLS therapy.…”
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Growth differentiation factor 15 aggravates sepsis-induced cognitive and memory impairments by promoting microglial inflammatory responses and phagocytosis by Lijiao Chen, Shiyuan Luo, Ting Liu, Zhewei Shuai, Yifan Song, Qianzi Yang, Ying Wang, Hongjun Huang, Yan Luo

“…Abstract Background Sepsis-associated encephalopathy (SAE) is a severe neurological condition caused by sepsis, and presents with symptoms ranging from delirium and coma to long-term cognitive dysfunction. SAE is acknowledged as a widespread brain impairment characterized by the activation of microglia. …”
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Relationship between Cardiometabolic index and endometriosis in a US nationally representative sample: results from NHANES 1999-2006 by Jiarui Hou, Wenting Chen, Rui Wang, Xuchun Huang, Xuchun Huang, Xiaojing Cao, Xiaojing Cao, Xiaoyun Wang, Xiaoyun Wang

“…The Cardiometabolic Index (CMI) is a novel indicator representing visceral adipose tissue distribution and metabolic dysfunction, integrating lipid metabolism indicators and the waist-to-height ratio. …”
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Short‐Term Multicomponent Exercise Impact on Muscle Function and Structure in Hospitalized Older at Risk of Acute Sarcopenia by Mikel L. Sáez de Asteasu, Nicolás Martínez‐Velilla, Fabricio Zambom‐Ferraresi, Yesenia García‐Alonso, Arkaitz Galbete, Robinson Ramírez‐Vélez, Eduardo L. Cadore, Mikel Izquierdo

“…ABSTRACT Background Hospitalization exacerbates sarcopenia and physical dysfunction in older adults. Whether tailored inpatient exercise prevents acute sarcopenia is unknown. …”
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Low-cost male urogenital simulator for penile implant surgery training: a 3D printing approach by Zixi Wang, Carlo Saija, Nicholas Raison, Abdullatif Aydin, Zhouyang Xu, Katie Zuo, Kawal Rhode, Antonia Pontiki

“…Abstract Background Penile implant surgery is the standard surgical treatment for end-stage erectile dysfunction. However, the growing complexity of modern high-tech penile prostheses has increased the demand for more practical training opportunities. …”
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Amide Proton Transfer-Weighted MR Imaging and Signal Variations in a Rat Model of Lipopolysaccharide-Induced Sepsis-Associated Encephalopathy by Donghoon Lee, HyunJu Ryu, Yeon Ji Chae, Hind Binjaffar, Chul-Woong Woo, Dong-Cheol Woo, Do-Wan Lee

“…<b>Introduction:</b> Sepsis-associated encephalopathy (SAE) is an acute brain dysfunction secondary to systemic infection, occurring without direct central nervous system involvement. …”
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Echocardiographic imaging in patients with conduction system pacing by Alexander Suchodolski, Ewa Jędrzejczyk-Patej, Wiktoria Kowalska, Michał Mazurek, Radosław Lenarczyk, Oskar Kowalski, Zbigniew Kalarus, Mariola Szulik

“…Baseline LVEF and follow-up observation of CSP effects: early in Global Longitudinal Strain (GLS), afterwards in LV volumes and LVEF may improve the future proper qualification of patients. …”
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Exploration of the multiomics-based mechanisms of Gancao Nourishing-Yin decoction in regulating mitochondrial metabolic genes CYB5R3 and PICK1 to influence glioma progression by Yufeng Chen, Anjing Zhang, Li Lei, Kangping Xiao, Wenchao Mao

“…Energy metabolism reprogramming, especially mitochondrial dysfunction, plays a pivotal role in tumour growth, survival, and progression. …”
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