Influence of impaired renal function on the outcomes of patients with acute ischaemic stroke treated with intravenous tenecteplase and alteplase: a post hoc analysis of the TRACE-2... by Yongjun Wang, Yilong Wang, Xia Meng, Yuesong Pan, Yu Wu, Yilun Zhou, Wanliang Du, Shuya Li, Mengxing Wang

“…Comparative treatment effects between tenecteplase and alteplase according to renal function grades showed no heterogeneity.Conclusions A significant correlation was noted between kidney dysfunction and unfavourable outcomes in individuals with AIS who received treatment with either tenecteplase or alteplase.…”
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Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway by Zhang Z, Yu X, Li J, Shen X, Fu W, Liu Y, Dong X, Wang Z

“…Irisin, a myokine known for its metabolic regulation, has shown therapeutic effects on cardiovascular disease. This study investigates the potential cardioprotective function of irisin in reducing the cardiac injury induced by DOX.Methods: In vitro, H9c2 cells were pretreated with irisin (20 nM) for 24 hours before exposure to DOX (1 μM). …”
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Quality of life, neurocognitive functioning, psychological issues, sexuality and comorbidity more than 2 years after commencing immune checkpoint inhibitor treatment by Melanie M van der Klauw, T Jeroen N Hiltermann, Mathilde Jalving, Emoke Racz, Sjoukje Oosting, Anna K L Reyners, Wellington Candido, Annemarie Cecile Eggen, Ingeborg Bosma, Reinate D Horinga, Kelly C van Heuvelen, Janine Nuver

“…Men had a high prevalence of erectile dysfunction and low sexual satisfaction. Half of the survivors met the criteria for the metabolic syndrome.Conclusions At least 2 years after the start of ICI treatment, one-quarter of cancer survivors had a clinically relevant lower QOL. …”
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MECHANISMS OF CYTOKINE STORM DEVELOPMENT IN COVID-19 AND NEW POTENTIAL TARGETS OF PHARMACOTHERAPY by V. I. Petrov, A. A. Amosov, A. S. Gerasimenko, O. V. Shatalova, A. V. Ponomareva, A. N. Akinchits, I. S. Kulakova, V. S. Gorbatenko

“…In the RAAS, suppression of ACE2 leads to a decrease in its ability to degrade ATII, which, on the one hand, leads to a decrease in the amount of AT1-7, and, on the other hand, to the effect of ATII on AT1R with the subsequent development of vasoconstriction and lung damage. …”
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Rapid Screening of Illegal Addition of Compounds Regulating Sexual Function in Traditional Chinese Medicine Based on UPLC-Q-TOF MS Technique Combined with UNIFI Software by Min LIAO, Ying-chao WANG, Qi CHEN, Lian JIANG, Hai-ning WANG

“…These illegally added compounds may have specific pharmacological and toxic side effects, which can endanger lives when taken with other related therapeutic drugs. …”
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Changes in retinal microvasculature and serum Gremlin-1 levels in acromegaly: A case-control study by Gokcen Unal Kocabas, Onur Furundaoturan, Cumali Degırmencı, Su Ozgur, Meltem Kocamanoglu, Cigdem Gozde Arslan, Esma Pehlivan Koroglu, Filiz Afrashı, Yasemin Akcay, Ilgin Yildirim Simsir, Banu Sarer Yurekli

“…Objective: There are controversial results about the effects of GH/IGF-1 on retinal vasculature. Gremlin-1 has roles in both pituitary tumorigenesis and angiogenesis. …”
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Esketamine and neurocognitive disorders in adult surgical patients: a meta-analysis by Xing Lin, Xin Liu, Huoming Huang, Xiaohui Xu, Tianhong Zhang, Ju Gao

“…The primary aim of this meta-analysis was to conduct a comprehensive evaluation of the effects of esketamine on PND in adult surgical patients undergoing general anesthesia. …”
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Extracellular Vesicles Derived from FGF2-Primed Astrocytes Against Mitochondrial and Synaptic Toxicities in Parkinson’s Disease by Wen X, Cao W, Ding H, Chen A, Sun Z, Wang Y, Xi Y, Wu S

“…FGF2-EVs, in comparison with that of CON-EVs, effectively protected neurons from mitochondrial fragmentation and stimulated synaptogenesis, as evidenced by expression of Mitofusin 2 (Mfn2), postsynaptic density protein 95 (PSD-95) and synaptophysin (SYP). …”
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Evaluation and Management of Urological Complications Following Pediatric Kidney Transplantation: Experience from a Single Tertiary Center by Maria Sangermano, Enrico Montagnani, Serena Vigezzi, Marco Moi, Alessandro Morlacco, Nicola Bertazza Partigiani, Elisa Benetti

“…Early complications were often detected due to acute graft dysfunction, while late ones were mainly identified during routine clinical, laboratory, or ultrasound follow-up. …”
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Efficacy of Repetitive Transcranial Magnetic Stimulation (Ipsilateral Cortex) along with Physiotherapy to Contralateral Side on Tone and Function of Subacute Stroke Survivors: Prot... by Pallavi Lalchand Harjpal, Raghuveer Raghumahanti, Mohammed Irshad Qureshi

“…Aim: The present research aims to determine the effectiveness of a standard physiotherapy protocol for the contralateral side combined with rTMS of the ipsilateral (contralesional) cortex in improving tone and function in subacute stroke survivors. …”
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Bone marrow mesenchymal stem cell-derived exosomes alleviate DSS-induced inflammatory bowel disease in mice through inhibiting intestinal epithelial cell pyroptosis via delivery of... by Bihua Wu, Shuangyan Su, Xianyu Wang, Yuwei Li, Zhenghao Mei, Fenglin Lou, Le Guo

“…BackgroundInflammatory bowel disease (IBD), characterized by chronic intestinal inflammation and epithelial barrier dysfunction, remains a therapeutic challenge due to the limitations of current treatments, including drug resistance and invasive surgical risks. …”
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Cancer-specific senescence signature promotes malignant phenotypes and immunotherapy resistance in colorectal cancer by Wei Wang, Wei Wang, Fengyu Ling, Fengyu Ling, Dong Huang, Guomin Luo, Guomin Luo, Bixia Duan, Bixia Duan

“…CD24 ablation’s effects on malignant phenotypes were assessed using colony formation, Transwell invasion, wound healing, and proliferation/apoptosis assays (Ki67/Annexin V/TUNEL). …”
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Mesenchymal Stem Cell-Derived Extracellular Vesicles: Emerging Therapies for Neurodegenerative Diseases by Chen P, Wang F, Ling B, Zhu Y, Lin H, Huang J, Wang X

“…Their pathogenesis is complex, and it is difficult for the existing treatments to effectively slow down the progression of the disease. …”
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Sepsis Course and Outcome Depends on the Genetic Variant in the 3`-Region of Aquaporin 4 Gene <i>AQP4</i> and Comorbidities by A. G. Chumachenko, E. K. Grigoriev, R. A. Cherpakov, I. N. Tyurin, V. M. Pisarev

“…The aim of the study was to determine the effects of region 3` polymorphism in the AQP4 gene on the clinical course and outcome of sepsis.Materials and methods. …”
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Trial to assess the tolerability of using felodipine to upregulate autophagy as a treatment of Huntington’s disease (FELL-HD): a phase II, single-centre, open-label, dose-finding t... by Roger A Barker, Laura Oakley, Emma Cutting, David C Rubinsztein, Dimitrios Apostolopoulos, Nikolaos Demiris, Katie Andresen, Amy H Evans, Alimu Dayimu, Katherine Bongaerts, Robyn Staples, Wendy Gooding

“…It is caused by a Cytosine-adenin-guanine (CAG) expansion in exon 1 of the huntingtin gene which codes for mutant huntingtin (mHTT) that over time accumulates in cells, causing dysfunction and then death through new toxic gain-of-function mechanisms. …”
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Adaptive immune changes in colorectal cancer: a focus on T and B cell activation genes by Mona Rady, Albert Ashraf, Hesham Abdelaziz, Mohamed El-Azizi

“…Our findings provide insights into the adaptive immune dysfunction in CRC, offering a detailed profile of gene expression changes associated with T and B cell activation and antibody production. …”
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Cervicogenic Headache and Physiotherapy: A Systematic Review of Treatment Modalities by Manali Sanket Chitlange, Pallavi Harjpal

“…Pain is referred from cervical structures due to the convergence of sensory pathways in the trigeminal-cervical complex. Dysfunction or irritation of cervical joints, muscles, or nerves can contribute to CGH symptoms. …”
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Increased Herpes simplex virus 1, Toxoplasma gondii and Cytomegalovirus antibody concentrations in severe mental illness by Dimitrios Andreou, Nils Eiel Steen, Kjetil Nordbø Jørgensen, Thor Ueland, Laura A. Wortinger, Lynn Mørch-Johnsen, Ina Drabløs, Tereza Calkova, Robert H. Yolken, Ole A. Andreassen, Ingrid Agartz

“…Patients with severe mental illness exhibit a heightened immune system response to HSV1, TG, and CMV infections suggesting immune system dysfunction and/or a more severe infection. For HSV1, higher IgG concentrations were linked to a greater clinical burden.…”
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CXCL12/CXCR4 axis governs Treg spatial dominance over CD8+ T cells via IL-2 sequestration: a dual therapeutic target in prostate cancer by Junyi Li, Long Zhang, Ruoyang Liu, Changwen Xu, HuiHui Tang, Yunfei Zou, Qingfei Cao, Weichao Huang

“…Treatment with CXCR4 inhibitor and IL-2 demonstrated significant antitumor effects and reversed immune dysfunction in both in vivo and in vitro experiments, with combined treatment exhibiting superior efficacy.ConclusionThese findings elucidate the role of macrophages in mediating the CXCL12/CXCR4 axis to aggregate CD8+ effector T cells and Tregs, thereby influencing the TME. …”
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Fractionated plasma separation and adsorption integrated with continuous veno-venous hemofiltration in patients with acute bipyridine herbicide poisoning by Jian-Hua Dong, Minghong Zhang, Xi Yang, Bian Wu, Li Huang, Chuan Li, Yongchun Ge

“…FPSA-CVVH can effectively reduce cytokine levels, increase the survival rate of patients with acute bipyridine herbicide poisoning, and decrease the incidence of adverse events.…”
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