Emodin induced hepatic steatosis in BALb/c mice by modulating the gut microbiota composition and fatty acid metabolism by Xinhua Xia, Xinhua Xia, Xueling He, Jinzhou Huang, Jinzhou Huang, Xuyang Hou, Xuyang Hou, Chen Lin, Chen Lin, Yaxiong Liu, Mei Liu

“…IntroductionThe aim of this study is to examine the physiological effects of emodin on intestinal microorganisms and the liver in the BALb/c mice.Method and ResultsFollowing an 8-week administration of emodin at doses of 25, 50, and 100 mg/kg/day,pathological analyses revealed that emodin significantly reduced the colon length, induced colonic crypt inflammation,diminished the colonic mucus layer,and decreased the fluorescence intensity of colonic tight junction proteins ZO-1 and Occludin. …”
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Low fluid shear stress stimulates the uptake of noxious endothelial extracellular vesicles via MCAM and PECAM‐1 cell adhesion molecules by Pierre‐Michaël Coly, Shruti Chatterjee, Fariza Mezine, Christelle El Jekmek, Cécile Devue, Thomas Nipoti, Stephane Mazlan, Maribel Lara Corona, Florent Dingli, Damarys Loew, Guillaume vanNiel, Xavier Loyer, Chantal M. Boulanger

“…Whilst previous studies have shown links between hemodynamic forces and EV release, the effects of shear stress on the release and uptake of endothelial EVs remains elusive. …”
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The relationship between childhood trauma, rs1360780 genotypes, FKBP5 intron 7 methylation and posttraumatic stress disorder in women who have experienced rape by Jani Nöthling, Jacqueline Samantha Womersley, Shibe Mhlongo, Carl Lombard, Naeemah Abrahams, Soraya Seedat, Sian Megan Joanne Hemmings

“…Background: Posttraumatic stress disorder (PTSD) is a common sequela of rape. Dysfunction of the hypothalamic–pituitary–adrenal (HPA) axis, a core regulator of the stress response, has been implicated in the aetiology and chronicity of PTSD. …”
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Three‐Dimensional Echocardiography for Transcatheter Aortic Valve Replacement Sizing: A Systematic Review and Meta‐Analysis by Lisa Q. Rong, Irbaz Hameed, Arash Salemi, Mohamed Rahouma, Faiza M. Khan, Harindra C. Wijeysundera, Dominick J. Angiolillo, Linda Shore‐Lesserson, Giuseppe Biondi‐Zoccai, Leonard N. Girardi, Stephen E. Fremes, Mario Gaudino

“…In patients with renal dysfunction, 3D TEE may be potentially advantageous for TAVR measurements because of the lack of contrast exposure.…”
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Calcium handling remodeling in dilated cardiomyopathy: From molecular mechanisms to targeted therapies by Yuhan Wang, Tingting Zhou, Jiajing Zhao, Hongjun Zhu, Xiaodong Tan, Jiahao Chen, Zhuojun Zhang, Lijuan Shen, Shu Lu

“…By integrating molecular insights with clinical phenotypes, structurally informed Ca2+-targeted therapies could pave the way for personalized DCM management, balancing efficacy with minimized off-target effects.…”
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Probiotic <i>Lactobacillus johnsonii</i> Reduces Intestinal Inflammation and Rebalances Splenic Treg/Th17 Responses in Dextran Sulfate Sodium-Induced Colitis by Hao-Yu Liu, Shicheng Li, Kennedy Jerry Ogamune, Peng Yuan, Xinyu Shi, Wael Ennab, Abdelkareem A. Ahmed, In Ho Kim, Ping Hu, Demin Cai

“…Increasing evidence highlights its pathogenesis as a multifactorial interplay of gut dysbiosis, intestinal barrier dysfunction, and dysregulated immune responses. While probiotics, particularly <i>Lactobacillus</i> spp., have emerged as potential therapeutics for IBD, restoring intestinal homeostasis, their systemic immunomodulatory effects remain underexplored. …”
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Construction and validation of a clinical prediction model for sepsis using peripheral perfusion index to predict in-hospital and 28-day mortality risk by Qirui Guo, Wenbo Li, Jie Wang, Guangjian Wang, Qingyu Deng, Hui Lian, Xiaoting Wang

“…Abstract Sepsis is a clinical syndrome caused by infection, leading to organ dysfunction due to a dysregulated host response. In recent years, its high mortality rate has made it a significant cause of death and disability worldwide. …”
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Dose-Dependent Pattern of Cochlear Synaptic Degeneration in C57BL/6J Mice Induced by Repeated Noise Exposure by Minfei Qian, Qixuan Wang, Zhongying Wang, Qingping Ma, Xueling Wang, Kun Han, Hao Wu, Zhiwu Huang

“…It is widely accepted that even a single acute noise exposure at moderate intensity that induces temporary threshold shift (TTS) can result in permanent loss of ribbon synapses between inner hair cells and afferents. However, effects of repeated or chronic noise exposures on the cochlear synapses especially medial olivocochlear (MOC) efferent synapses remain elusive. …”
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The neglected PCK1/glucagon (inter)action in nutrient homeostasis beyond gluconeogenesis: Disease pathogenesis and treatment by Romina Bertinat, Todd Holyoak, Rodrigo Gatica, Nery Jara, Iván González-Chavarría, Francisco Westermeier

“…In this (un)expected scenario, hepatic PCK1 deficiency and glucagon resistance appear to exert limited control over glycemia, but have broader metabolic effects related to lipid and amino acid dysregulation. …”
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Periplaneta americana extract improves recurrent oral ulcers through regulation of TLR4/NF-κB and Nrf2/HO-1 pathways by Weijun Li, Yi Chen, Kailing Li, Zhongze Chen, Jingyu Zhang, Guanhua Zhao, Fanfan Sun, Peiyun Xiao, Yongshou Yang

“…Abstract Recurrent oral ulcers (ROUs) of oral mucosa disease are difficult to cure and relapse easily, and immune imLbalance or dysfunction is considered an essential factor in their occurrence and recurrence. …”
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LncRNA MEG3 exacerbates diabetic cardiomyopathy via activating pyroptosis signaling pathway by Shengnan Zhuo, Yifeng Liu, Siyuan Wang, Zhuoling Chen, Xuran Shi, Yangjunna Zhang, Dengfeng Xu, Jingjin Hu, Yin Wang, Xuefeng Qu

“…Moreover, the use of miR-223 antisense oligonucleotide (AMO) counteracted the suppressive effects of lncMEG3 knockdown on NLRP3 inflammasome activation induced by high glucose in vitro.Conclusion:LncMEG3 exacerbates DCM by enhancing NLRP3 inflammasome activation through attenuating miR-223-mediated degradation of NLRP3 in the hearts of individuals with diabetes.…”
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Anthracycline‐Induced Cardiomyopathy After Nephro‐/Neuroblastoma in Childhood: The Importance of Cardiological Reference Assessment by Kristina Kleen, Judith Gebauer, Claudia Spix, Lea L. Kronziel, Inke König, Katja Baust, Gabriele Calaminus, Thorsten Simon, Barbara Hero, Oliver Zolk, Norbert Graf, Hashim Abdul‐Khaliq, Thorsten Langer

“…Conclusion Cardiac late effects after anthracycline‐based therapy in childhood affect a relevant proportion of long‐term CCS at pediatric age. …”
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Simulated Cam Morphology of the Hip Changes Sacroiliac Motion During Hip Motion and Loading in a Cadaveric Model by Mason E. Uvodich, M.D., Alex W. Hooke, M.A., Zachary V. Braig, M.D., Micah J. Nieboer, M.D., Evan M. Dugdale, M.D., William W. Cross, M.D., Aaron J. Krych, M.D., Mario Hevesi, M.D., Ph.D.

“…Clinical Relevance: This biomechanical connection between cam-type femoroacetabular impingement syndrome and the ipsilateral SI joint provides insight into SI joint dysfunction in patients with femoroacetabular impingement syndrome.…”
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Lipopolysaccharide and ARDS caused by new coronavirus infection: hypotheses and facts by I. A. Yatskov, V. A. Beloglazov, E. I. Ryapova

“…., worsening the course of inflammatory lung diseases due to decreased level of angiotensin-converting enzyme 2 (ACE2); increasing generation of reactive oxygen species (ROS) via NADPH oxidase and subsequent inactivation of endothelial nitric oxide synthase (eNOS) and decreasing bioavailability of endothelial NO, thus leading to endothelial dysfunction; interacting with proteins of surfactants. …”
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Prevalence and risk factors of metabolic-associated fatty liver disease in sub-Saharan Africa: a systematic review and meta-analysis by Emmanuel M. Sindato, Violet Dismas Kajogoo, Gloria Ngajilo, Wondwossen Amogne Degu, Zahid Khan, Gideon Mlawa

“…Among these diseases, metabolic dysfunction-associated fatty liver disease (MAFLD) has emerged as a rapidly increasing public health burden, but is inaccurately documented. …”
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Reward System EEG–fMRI-Pattern Neurofeedback for Major Depressive Disorder with Anhedonia: A Multicenter Pilot Study by Daniela Amital, Raz Gross, Nadav Goldental, Eyal Fruchter, Haya Yaron-Wachtel, Aron Tendler, Yaki Stern, Lisa Deutsch, Jeffrey D. Voigt, Talma Hendler, Tal Harmelech, Neomi Singer, Haggai Sharon

“…Cumulative evidence points to brain dysfunction in the reward system (RS), including in the ventral striatum, in patients with MDD with anhedonia. …”
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Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance by Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z

“…Liver histopathology (HE staining) and cytokine expression (IL-1β/TNF-α; IHC) were evaluated.Results: CLP mice exhibited elevated IL-1β (P&lt; 0.01) and lactate (P&lt; 0.01), confirming metabolic dysfunction and inflammation. Bioinformatics analysis identified 19 DEIRGs, with PPI networks implicating immune regulation (PPI enrichment p=3.35× 10-6). …”
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Koopman-based linearization of preparatory EEG dynamics in Parkinson’s disease during galvanic vestibular stimulation by Maryam Kia, Maryam Kia, Maryam S. Mirian, Saeed Soori, Saeed Saedi, Emad Arasteh, Mohamad Hosein Faramarzi, Abhijit Chinchani, Soojin Lee, Artur Luczak, Martin J. McKeown

“…IntroductionParkinson’s disease (PD) impairs motor preparation due to basal ganglia dysfunction, contributing to motor deficits. Galvanic Vestibular Stimulation (GVS), a non-invasive neuromodulation technique, shows promise in enhancing motor function in PD, but its underlying neural mechanisms are poorly understood. …”
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Jack Surgery: Reconstructing Collapsed Femoral Head in Association Research Circulation Osseous Stage III Osteonecrosis: A Series of 13 Cases by Ying Zhong, Yichen Gong, Shuaijie Lv, Wenxi Du, Xun Liu, Jianhua Zhang, Peijian Tong

“…Conclusion For young patients with ONFH of ACRO III, this surgical technique can effectively restore the original shape of the femoral head and achieve satisfactory hip function in the short term. …”
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Triglyceride-glucose index and cancer risk: a prospective cohort study in Taiwan by Hsiao-Yun Yeh, Mei-Hung Pan, Chih-Jen Huang, Shiao-Ya Hong, Hwai-I Yang, Ying-Ying Yang, Chia-Chang Huang, Hung-Cheng Tsai, Tzu-Hao Li, Chien-Wei Su, Ming-Chih Hou

“…The triglyceride-glucose (TyG) index, a validated surrogate marker of IR, has been linked to metabolic dysfunction; however, its association with cancer risk in large population-based cohorts remains unclear. …”
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