Hepatocyte-specific GDF15 overexpression improves high-fat diet-induced obesity and hepatic steatosis in mice via hepatic FGF21 induction by Kento Takeuchi, Kanji Yamaguchi, Yusuke Takahashi, Kota Yano, Shinya Okishio, Hiroshi Ishiba, Nozomi Tochiki, Seita Kataoka, Hideki Fujii, Naoto Iwai, Yuya Seko, Atsushi Umemura, Michihisa Moriguchi, Takeshi Okanoue, Yoshito Itoh

“…Abstract GDF15 and FGF21, stress-responsive cytokines primarily secreted from the liver, are promising therapeutic targets for metabolic dysfunction-associated steatotic liver disease (MASLD). …”
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Retrospective Research of Clinical and Hematological Changes Occurred by del Nido Cardioplegia in the Perioperative Period of Patients who Underwent Open-Heart Surgery by Abdullah Özer, Başak Koçak, Mustafa Arslan, Elif Şimşek, Aycan Özdemirkan, Yusuf Ünal, Erkan İriz, Hakan Zor, Levent Oktar

“…Objective: Aortic cross-clamping and postischemic myocardial dysfunction are fundamentally related to myocardial protection during open-heart surgery. …”
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Beyond the beats: exploring the link between blood pressure fluctuations with anxiety, depression, and sleep by Yuvthi Lutchman, Suzanne M. Cosh, Suzanne M. Cosh, Fiona Cossey, Deborah A. Turnbull, Rosannah Byrt, Cassandra Sundaraja, Rakesh Agarwal, Rakesh Agarwal, Rajiv Mahajan, Rajiv Mahajan, Christophe Tzourio, John F. Beltrame, John F. Beltrame, Phillip J. Tully, Phillip J. Tully

“…These results support BPV’s role in autonomic dysfunction, emphasizing the need for longitudinal research to clarify its role in mental health.…”
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Cytochrome P450 2E1 aggravates DXR-induced myocardial injury through imbalanced mitochondrial OPA1 by Jiaxin Ma, Yaheng Wang, Huijiao Lv, Yu Lei, Feifei Guan, Wei Dong, He Wang, Lianfeng Zhang, Dan Lu

“…Myocardium-specific CYP2E1 overexpression and knockout rat models were employed to study its effects on myocardial injury, assessed via echocardiography and histopathology. …”
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Monocytes serve as Shiga toxin carriers during the development of hemolytic uremic syndrome by Xinlei Sun, Shuang Qu, Fenglian Zhou, Fujie Shi, Yunfei Wu, Lin Gu, Minghui Liu, Zhen Bian, Lei Shi, Zhihong Liu, Yuan Liu, Ke Zen

“…To exert its cytotoxic effect on renal cells, Stx must be delivered from the infected intestines to the kidney. …”
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Syngap1 regulates the synaptic drive and membrane excitability of Parvalbumin-positive interneurons in mouse auditory cortex by Ruggiero Francavilla, Bidisha Chattopadhyaya, Jorelle Linda Damo Kamda, Vidya Jadhav, Said Kourrich, Jacques L Michaud, Graziella Di Cristo

“…SYNGAP1 haploinsufficiency-related intellectual disability (SYNGAP1-ID) is characterized by moderate to severe ID, generalized epilepsy, autism spectrum disorder, sensory processing dysfunction, and other behavioral abnormalities. While numerous studies have highlighted a role of Syngap1 in cortical excitatory neurons development, recent studies suggest that Syngap1 plays a role in GABAergic inhibitory neuron development as well. …”
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Neutrophil extracellular traps drive osteoporosis via NCF2-dependent signaling: integrated transcriptomics with mechanistic validation by Xiangyun Guo, Liang Wang, Shuangliu Chen, Chuanrui Sun, Jinran Qin, Qingqing Liu, Yiwen Gan, Yan Li, Zikai Jin, Xu Wei, Yili Zhang

“…Osteoimmunology highlights immune dysregulation as a significant contributor to OP, but the specific biological mechanisms linking immune dysfunction to bone loss remain unclear. Understanding these mechanisms is essential for targeted therapies.Methods We established a rat OP model via bilateral ovariectomy. …”
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The Loss of Gonadal Hormones Has a Different Impact on Aging Female and Male Mice Submitted to Heart Failure-Inducing Metabolic Hypertensive Stress by Diwaba Carmel Teou, Emylie-Ann Labbé, Sara-Ève Thibodeau, Élisabeth Walsh-Wilkinson, Audrey Morin-Grandmont, Ann-Sarah Trudeau, Marie Arsenault, Jacques Couet

“…Conclusions: Our results suggest that MHS has sex-specific effects on old mice, and the loss of gonadal hormones significantly impacts the observed heart failure phenotype.…”
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Bioactive camel milk peptides as regulators of insulin receptor signaling: Experimental and computational perspectives by Issoufou Katambe Mohamed, Yufei Hua, Xiangzhen Kong, Xingfei Li, Yeming Chen, Caimeng Zhang, Mouhamed Fall

“…Our combined biochemical and computational framework provides a foundation for rational design of next-generation peptide-based therapeutics targeting IR dysfunction in T2DM.…”
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Inhibition of Sirtuin 2 enhances autophagy and restores neuronal function in aged hippocampal neurons by Zhenyuan Zhang, Lan Zhang, Yidan Zhang, Yuan Zhao, Ya Gao, Cong Zhang, Dongxiao Li, Xiangjian Zhang, Guofeng Yang, Jian Zhang

“…Age-related cognitive decline is linked to impaired autophagy and hippocampal dysfunction. This study investigates the role of Sirtuin 2 (SIRT2) in age-related cognitive decline, focusing on its impact on autophagy and hippocampal function. …”
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Cognitive Function Deficits Associated With Type 2 Diabetes and Retinopathy: Volumetric Brain MR Imaging Study by Ece Ozdemir Oktem, Dila Sayman, Sevilay Ayyildiz, Çaglar Oktem, Lutfiye Ipek, Behcet Ayyildiz, Fatih Aslan, Emin Utku Altindal, Nilay Yagci, Rumeysa Dikici, Ramazan Karaca, Şeyda Cankaya, Seda Avnioglu, Halil Aziz Velioglu, Burak Yulug

“…ABSTRACT Introduction Type 2 diabetes mellitus is a ubiquitous chronic inflammatory disease with deleterious effects on various tissues, including the kidney, retina, and peripheral nerves. …”
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The Use of Technetium-99m Radioactive Isotope in The Diagnosis and Treatment of Thyroid Diseases: A Review by Shlair I. Mohammed

“… A Tc-99m thyroid scanning is one of the most common diagnostic modalities in nuclear medicine for the evaluation of various thyroid dysfunctions and anomalies. Therefore, this review study will delve into the various dimensions related to patient exposure during Tc-99m thyroid scanning. …”
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Fc-Elabela mitigates heart failure without liver and renal toxicity in mice by Huifen Zhou, Huifen Zhou, Da-Wei Gong, Ling Chen, Hui Chen, Quan Wang, Mustajab Ullah, Saleem Ahmad, Ishtiaq Jeelani, Qingbin Zhao, Qingbin Zhao

“…We found that Fc-ELA-21 significantly improved cardiac systolic dysfunction, mitigated pulmonary congestion, slowed down weight gain, activated vascular endothelial growth factor receptor 3 (VEGFR3) and APJ-mediated extracellular signal-regulated kinase (ERK) 1/2 signaling, and promoted endothelial cell proliferation in post-infarct mice. …”
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Lipoprotein (a) integrates monocyte-mediated thrombosis and inflammation in atherosclerotic cardiovascular disease by Robert S. Rosenson, Ashley M. Tate, Olga G. Grushko, Dilna Damodaran, Qinzhong Chen, Michael Boffa, Marlys Koschinsky, Jagat Narula, Sascha N. Goonewardena

“…Lp(a) is thought to promote ASCVD through multiple mechanisms, including its effects on cholesterol transport, inflammation, and thrombosis. …”
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Alloimmune Causes of Recurrent Pregnancy Loss: Cellular Mechanisms and Overview of Therapeutic Approaches by Cristina Uța, Alexandru Tîrziu, Elena-Larisa Zimbru, Răzvan-Ionuț Zimbru, Marius Georgescu, Laura Haidar, Carmen Panaitescu

“…Recurrent pregnancy loss (RPL) is a complex early pregnancy complication affecting 1–2% of couples and is often linked to immune dysfunction. Aberrations in T and B cell subpopulations, as well as natural killer (NK) cell activity, are particularly influential, with studies showing that abnormal NK cell activation and imbalances in T and B cell subtypes contribute to immune-mediated miscarriage risk. …”
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PM2.5 exposure reprograms cell cycle dynamics in uterine immune cells at single-cell resolution by Lin Zhang, Lin Zhang, Lin Zhang, Jiaqi Tian, Jiaqi Tian, Jiaqi Tian, Yongfei Zheng, Shuyin Duan

“…BackgroundFine particulate matter (PM2.5) exposure has been associated with adverse effects on reproduction, yet the underlying cellular mechanisms remain poorly understood.MethodsUsing single-cell RNA sequencing, we systematically investigated cell cycle dynamics of immune cell populations in the mouse uterus following PM2.5 exposure. …”
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Long-term exposure to PM1 and thyroid diseases in China by Jing Wang, Di Teng, Kaijie Yang, Siying Liu, Cihang Lu, Zhongyan Shan, Weiping Teng, Yongze Li

“…In addition, iodine status significantly influenced PM1’s effects, with lower levels enhancing susceptibility to thyroid issues. …”
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ANO1: central role and clinical significance in non-neoplastic and neoplastic diseases by Yanghao Hu, Yanghao Hu, Yifei Zhang, Yifei Zhang, Jiali He, Jiali He, Huihuang Rao, Huihuang Rao, Duomi Zhang, Zhisen Shen, Chongchang Zhou

“…Modulating ANO1 activity may offer novel therapeutic strategies for effectively treating ANO1-associated diseases.…”
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Wearable peripheral nerve stimulator reduces essential tremor symptoms through targeted brain modulation by Cuong P. Luu, Jordan Ranum, Youngwon Youn, Jennifer L. Perrault, Bryan M. Krause, Matthew I. Banks, Laura Buyan-Dent, Kip A. Ludwig, Wendell B. Lake, Aaron J. Suminski

“…Background: Essential tremor (ET), the most common movement disorder in adults, presents with involuntary shaking of the upper extremities during postural hold and kinetic tasks linked to dysfunction in the cerebello-thalamo-cortical network. …”
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An Overview of Oxidative Stress in Sex Chromosome Aneuploidies in Pediatric Populations by Roberto Paparella, Fabiola Panvino, Francesca Tarani, Benedetto D’Agostino, Lucia Leonardi, Giampiero Ferraguti, Sabrina Venditti, Fiorenza Colloridi, Ida Pucarelli, Luigi Tarani, Marco Fiore

“…TS is marked by estrogen deficiency, cardiovascular anomalies, and metabolic dysfunction, all linked to heightened oxidative stress. …”
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