Recent Advances in Iridology based Disease Detection: A Comprehensive Review by Alaa Abdulkareem Ahmed, Mohammad Tariq Yaseen

“…  The increasing demand for non-invasive, rapid, and cost-effective disease diagnostics has driven advancements in integrating Iridology with computer vision and Artificial Intelligence (AI). …”
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Sex-specific cardiovascular adaptations to simulated microgravity in Sprague-Dawley rats by Ebrahim Elsangeedy, Dina N. Yamaleyeva, Nicholas P. Edenhoffer, Allyson Deak, Anna Soloshenko, Jonathan Ray, Xuming Sun, Omar H. Shaltout, Nildris Cruz-Diaz, Brian Westwood, Daniel Kim-Shapiro, Debra I. Diz, Shay Soker, Victor M. Pulgar, April Ronca, Jeffrey S. Willey, Liliya M. Yamaleyeva

“…Pulse wave velocity (PWV) was greater in the aortic arch of females after HLU versus control females (n = 6–8). HLU had no effect on aortic PWV in males (n = 5–6). Aortic α smooth muscle actin, myosin, collagen, elastin, and collagen-to-elastin ratio were not different in rats of either sex following HLU. …”
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The Impact of Physical Activity on Skin Health and Skin Aging by Paulina Hetnar, Milena Fortuna, Sebastian Kiper, Sławomir Toczek, Magdalena Tomala, Katarzyna Jastrowicz-Chęć, Klaudia Koryszko, Natalia Pokrywka, Dawid Suwała, Marcelina Polak

“…Results: Skin aging results from both intrinsic factors such as genomic instability, epigenetics, telomere shortening, and mitochondrial dysfunction, and extrinsic factors including UV radiation, pollution, smoking, and poor lifestyle habits. …”
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Rescue of cardiomyopathy through U7snRNA‐mediated exon skipping in Mybpc3‐targeted knock‐in mice by Christina Gedicke‐Hornung, Verena Behrens‐Gawlik, Silke Reischmann, Birgit Geertz, Doreen Stimpel, Florian Weinberger, Saskia Schlossarek, Guillaume Précigout, Ingke Braren, Thomas Eschenhagen, Giulia Mearini, Stéphanie Lorain, Thomas Voit, Patrick A. Dreyfus, Luis Garcia, Lucie Carrier

“…Injection of newborn KI mice abolished cardiac dysfunction and prevented left ventricular hypertrophy. …”
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Perfluorohexane Sulfonic Acid Disrupts the Immune Microenvironment for Spermatogenesis by Damaging the Structure of the Blood‐Testis Barrier in Mice by Yan Zhang, Mingxue Shu, Shilin Shan, Huiying Liu, Yucheng Zhang, Chenyang Song, Qiaoqiao Xu, Yun Fan, Chuncheng Lu

“…In summary, the results of this study suggest that in the testes of PFHxS‐treated mice, inflammatory factors disrupt the mitochondrial function and metabolic profiles and hinder the progress of gene transcription through histone Kac, ultimately causing sperm dysfunction.…”
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Targeting Senescence with Apigenin Improves Chemotherapeutic Efficacy and Ameliorates Age‐Related Conditions in Mice by Hongwei Zhang, Qixia Xu, Zhirui Jiang, Rong Sun, Qun Wang, Sanhong Liu, Xin Luan, Judith Campisi, James L. Kirkland, Weidong Zhang, Yu Sun

“…Senescent cell burden increases with aging and contributes to age‐related organ dysfunction and multiple chronic disorders. In this study, a large scale screening of a natural product library for senotherapeutic candidates is performed. …”
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The Activation of the NF-κB Pathway in Human Adipose-Derived Stem Cells Alters the Deposition of Epigenetic Marks on H3K27 and Is Modulated by Fish Oil by Jussara de Jesus Simao, Andressa França de Sousa Bispo, Victor Tadeu Gonçalves Plata, Ana Beatriz Marques Abel, Raphael Justa Saran, Júlia Fernandes Barcella, João Carlos Cardoso Alonso, André Valente Santana, Lucia Maria Armelin-Correa, Maria Isabel Cardoso Alonso-Vale

“…Background: Chronic low-grade inflammation in obesity is linked to white adipose tissue (WAT) dysfunction. Plasma lipopolysaccharide (LPS) activates Toll-like receptor 4 (TLR4), triggering NF-κB and worsening these disturbances. …”
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CD63 Immunological Activation Versus Hemostatic Function: Platelet Alterations After Polytrauma by Gregor Roemmermann, Olivia Bohe, Laura Heimann, Franziska Wirth, Franziska Drumm, Peter Biberthaler, Philipp Moog, Christina Schwenk, Nadja Muehlhaupt, Li Wan, Marc Hanschen

“…Simultaneously, a hemostasiological dysfunction with reduced platelet maximum clot firmness (MCF) was observed. …”
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Injured tubule derived CCN1 exacerbates renal congestion-mediated acute kidney injury and fibrosis by Atsushi Minamida, Tomohiro Nakata, Ryo Kurose, Shinji Sawai, Masashi Nakamura, Minato Umehara, Hiroko Yamauchi-Sawada, Yasuto Sunahara, Yayoi Matoba, Natsuko Okuno-Ozeki, Itaru Nakamura, Kunihiro Nakai, Noriyuki Yamashita, Yuhei Kirita, Keiichi Tamagaki, Satoaki Matoba, Tetsuro Kusaba

“…We further examined the effects of CCN1 deletion in tubular epithelia and found that it reduced pFAK expression and alleviated tissue fibrosis. …”
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Tigecycline-induced coagulation gene prognostic prediction model and intestinal flora signature in AML by Feng-Luan Zhong, Jia-Jun He, Jia-Jun He, Kun-Hao Bai, Kun-Hao Bai, Ruo-Nan Shao, Guo-Yan Wu, Xiao-Peng Tian, Da-Wei Wang, Yu-Jun Dai, Yu-Jun Dai, Si-Liang Chen

“…Infection is among the most common causes of death in patients with acute myeloid leukemia (AML) after chemotherapy. The anti-tumor effect of the intestinal microbiota in patients with AML is increasingly being recognized. …”
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FGFC1 overcomes Ara-C resistance in acute myeloid leukemia by inducing apoptosis and pyroptosis by Xiaohui Hu, Zhijian Li, Rui Zhou, Bing Zhang, Ruoxian Wang, Tongtong Li, Jiangcheng Chang, Wenhui Wu, Wenhui Wu, Ning Liu, Ning Liu, Ning Liu, Ning Liu

“…Mechanistically, FGFC1 induced mitochondrial dysfunction and the accumulation of intracellular reactive oxygen species (ROS), leading to the release of cytochrome c (Cyto-C), which activated Caspase-3 and triggered both apoptosis and pyroptosis. …”
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Reduced frontotemporal connectivity during a verbal fluency task in patients with anxiety, sleep, and major depressive disorders by Fanxi Ding, Yiyang Ying, Yuqing Jin, Xuanru Guo, Xuanru Guo, You Xu, Zhenghe Yu, Haiteng Jiang, Haiteng Jiang, Haiteng Jiang

“…BackgroundIt has been well established that psychiatric disorders are often accompanied by cognitive dysfunction. Previous studies have investigated the verbal fluency task (VFT) for detecting executive function impairment in different psychiatric disorders, but the sensitivity and specificity of this task in different psychiatric disorders have not been explored. …”
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Wingless-Type MMTV Integration Site Family Member 5a Is a Key Secreted Islet Stellate Cell-Derived Product that Regulates Islet Function by Wei Xu, Jun Liang, H. F. Geng, Jun Lu, Rui Li, X. L. Wang, Qian Lv, Ying Liu, Jie Wang, X. K. Liu, Peter M. Jones, Zl Sun

“…Emerging evidence suggests that T2DM is attributable to the dysfunction of β-cells and the activation of islet stellate cells (ISCs). …”
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Intravenous esketamine in pediatric Rett syndrome: An open-label, early phase 1 pilot study by Huiping Li, Shu Liu, Caimei Lin, Yuchao Wu, Xiuping Wu, Yukun Huang, Yajun Wu, Xiubin Tong, Xiu Xu

“…This pilot study highlights the potential of esketamine treatment for improving behavioral dysfunction in patients with RTT. Investigating the appropriate dosage form of esketamine may enhance its beneficial effects in RTT with fewer undesirable features.…”
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Sex differences in diet-induced MASLD – are female mice naturally protected? by Jana Meyer, Ana Mendes Teixeira, Sandy Richter, Dean P. Larner, Asifuddin Syed, Nora Klöting, Madlen Matz-Soja, Susanne Gaul, Susanne Gaul, Anja Barnikol-Oettler, Wieland Kiess, Diana Le Duc, Diana Le Duc, Melanie Penke, Antje Garten

“…The underlying mechanism for this sex difference in the prevalence and manifestation of Metabolic dysfunction-associated Steatotic Liver Disease (MASLD) is not yet completely known. …”
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Persistent Activation of Sphingosine‐1‐Phosphate Receptor 1 by Phytosphingosine‐3,4‐Cyclic Phosphate Ameliorates Sepsis by Inhibiting Hyperinflammation and Vascular Hyperpermeabili... by Suhong Duan, Seung‐Gook Kim, Jiaying Bao, Hyung‐Jin Lim, Joon Woo Kim, Sung‐Il Yoon, Young Jun Park, Sanguk Yun, Kye‐Seong Kim, Hwa‐Ryung Song, Myeong Jun Choi, Myung‐Kwan Han

“…ABSTRACT Sepsis is a life‐threatening disease characterized by multiorgan dysfunction caused by an abnormal immune response to microbial infection. …”
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Enhancement of Phytochemicals and Antioxidant Activity of Thai Fermented Soybean Using Box–Behnken Design Guided Microwave-Assisted Extraction by Piya Temviriyanukul, Woorawee Inthachat, Ararat Jaiaree, Jirarat Karinchai, Pensiri Buacheen, Supachai Yodkeeree, Tanongsak Laowanitwattana, Teera Chewonarin, Uthaiwan Suttisansanee, Arisa Imsumran, Ariyaphong Wongnoppavich, Pornsiri Pitchakarn

“…TFSE also upregulated the phosphorylation of AKT (a key insulin signaling mediator) and the expression of adipogenic proteins (PPARγ, CEBPα) in TNF-α-exposed 3T3-L1, suggesting the mitigation of adipocyte dysfunction; however, the results did not reach statistical significance. …”
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Light-cured millineedle platform delivers “nano-pomegranate” for combinatorial electrodynamic therapy and cuproptosis against oral carcinoma by Guoyun Wan, Jiayu Chen, Yingying Zhou, Lina Dou, Dongmei Wang, Nannan Wang, Hongli Chen, Haijiao Wang, Xianwen Wang, Zhijun Yang, Dan Ding

“…When combined with the TLR7/8 agonist R848, the platform elicits systemic immune activation, effectively suppressing both primary and abscopal oral tumors. …”
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Stroke in Pregnancy Brings Epigenetic Changes in Correlation with Affected Mitochondrial Dynamics and Inflammasome Mediated Apoptosis in Rodents by Aishika Datta, Dipali Rahane, Gangadhar Bhurle, Soumya Akundi, Ushmita Mukherjee, Akshada Dubey, Anirban Barik, Gautam Karmarkar, Nikita Malik, Bijoyani Ghosh, Nikita Rana, Anupom Borah, Pallab Bhattacharya

“…In the present study we investigate the effect of stroke in pregnancy as a possible epigenetic modifier correlated with dysfunctional mitochondrial dynamics and exacerbated inflammasome mediated apoptosis in the offsprings. …”
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The Influence of Artificial Breast Volume Induction on Postural Stability, Postural Orientation, and Neuromuscular Control in Healthy Women: A Cross-Sectional Study by Diana C. Guedes, Daniela F. Carneiro, Leonel A. T. Alves, Ana S. C. Melo, Juliana Moreira, Bruno Cunha, Rubim Santos, Andreia Noites, Andreia S. P. Sousa

“…Additionally, significant differences were identified in the performance of the FRT and the associated subjective perceptions. (4) Conclusions: Breast implants with sizes of 220, 315, and 365 mL can alter scapular neuromuscular control, but these differences do not seem substantial enough to result in negative biomechanical effects in the short-term analysis.…”
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