The relationship between social isolation and cognitive function in older patients with chronic obstructive pulmonary disease: a latent profile analysis by Minghua Han, Hongxia Wu, Huize Xu, Jian Zhao, Zhongwen Chang, Qian Zhao

“…Uni-variate and multivariate analyses were used to explore the influencing factors of different social isolation classes, and a mixed-effects regression model was applied to analyze the relationship between these classes and cognitive function. …”
Get full text

Elucidation of the Active Agents in a West African Ground Herbal Medicine Formulation That Elicit Antimalarial Activities in In Vitro and In Vivo Models by Solomon Owumi, John O. Olanlokun, Bocheng Wu, Abiola Marian Duro-Ladipo, Sophia E. Oyelere, Shabana I. Khan, Adegboyega K. Oyelere

“…The goal of this study is to evaluate a formulation of Agunmu made from <i>M. indica</i>, <i>A. repens</i>, <i>E. chlorantha</i>, <i>A. boonei</i>, and <i>B. ferruginea</i>, sold in the open market and commonly used for the treatment of malaria by the locals, for its antimalarial effects and to determine the active principles that may contribute to the antimalarial effect. …”
Get full text

2′-Fucosyllactose mitigates cognitive deficits in Alzheimer models: targeting amyloid pathology, oxidative stress, and synaptic plasticity by Yeasmin Akter Munni, Khoa Nguyen Tran, Seon-Min Jeon, Meeyul Hwang, Jong-Won Yoon, Young-Ha Song, Tae Woo Oh, Tae Woo Oh, Sang Il Gum, In-Jun Yang

“…IntroductionThe development of new drugs for Alzheimer’s disease (AD) remains a major challenge due to the disorder’s complex and multifactorial nature. 2′-Fucosyllactose (2′-FL), a human milk oligosaccharide, has demonstrated promising neuroprotective properties. However, its effects on AD-related cognitive decline are not yet fully understood. …”
Get full text

Right Ventricular Longitudinal Strain Predicts Weaning Success in Cardiogenic Shock Patients Supported by a Microaxial Flow Pump by Konstantinos Rapis, MD, Francesco Paolo Lo Muzio, PhD, Alessandro Faragli, MD, David Wainstejn, MD, Vivienne Nelki, Frank Spillmann, MD, Carsten Tschöpe, MD, Alessio Alogna, MD, PhD

“…The study included 41 ICU patients with CS due to LV dysfunction who required Impella support for at least 72 hours. …”
Get full text

The influence of a fentanyl and dexmedetomidine combination on external respiratory functions in acute hemorrhage model by Nikolay G. Vengerovich, Michael A. Yudin, Alexander S. Nikiforov, Georgiy S. Sagalov, Elina A. Ruzanova, Natalya V. Shperling, Alexander I. Vengerovskii, Igor A. Shperling, Alexander S. Makacheev

“…The synthetic opioid analgesic fentanyl is widely used for prophylaxis and therapy of traumatic shock associated with massive bleeding. Its side effects – skeletal muscle rigidity and respiratory center depression – are especially pronounced with repeated administration. …”
Get full text

Okra polysaccharide mitigates carrageenan-induced thrombosis in mice by regulating inflammation and oxidative stress by Jinping Ni, Jinping Ni, Xiwen Cao, Xianqing Hu, Xianqing Hu, Shenwen Fu, Shenwen Fu, Shenwen Fu, Meixiu Jiang, Yuqi Ni, Yuqi Ni

“…Liver and lung tissues were collected for H&amp;E staining, RT-qPCR, Western blot and GSH content detection. Injury or dysfunction of endothelial cells (ECs) was assessed using RT-qPCR, Western blot and cell adhesion assays.ResultsOP can effectively improve carrageenan-induced thrombosis in tissues of mice (tail, liver, and lung) in vivo. …”
Get full text

Clinical Utility of the Trajectory of Serum Bilirubin and International Normalized Ratio Values in Hepatitis B Virus-Related Acute-on-Chronic Liver Failure by Song YQ, Fu XY, Yan SY, Qi RB, Zhou YJ, Liang JW, Zhang JQ, Ye LP, Mao XL, Li SW

“…Trajectory grouping can complement existing scoring models, improving predictive effectiveness.Keywords: dynamic trajectories, short-term prognosis, artificial liver support, acute-on-chronic liver failure…”
Get full text

Design, Synthesis, and Biological Evaluation of Novel Hydroxytyrosol Derivatives as Protectors for Vascular Endothelium Against Lipid Overload by Hou XX, Wang S, Ma XX, Wen Y, Li ZJ, Liu XY, Zhang X, Zhang Y, Qin XY

“…Palmitic acid (PA) was used to induce lipid overload in HAEC cells, and P407 was used to induce acute hyperlipidemia in C57 mice.Results: We found that DP-ADM, combining ADM and dopamine (a HT analogues), exhibited potent protective effects against metabolic overload-induced endothelial dysfunction. …”
Get full text

The Impact of Exercise Training Plus Dietary Interventions on Ectopic Fat in Population with Overweight/Obesity with and without Chronic Disease: A Systematic Review, Meta-analysis... by Fatemeh Kazeminasab, Mohammad Hossein Mahboobi, Motahareh Mohebinejad, Maedeh Nojoumi, Saba Belyani, Donny M Camera, Sajjad Moradi, Reza Bagheri

“…Background: The growing prevalence of obesity and related chronic diseases has led to increased interest in interventions targeting ectopic fat reduction to which its accumulation is linked to metabolic dysfunction. Objectives: This study aimed to evaluate the effects of combined exercise training combined with dietary interventions compared with dietary interventions alone on ectopic fat [visceral fat area (VFA), liver fat, intramuscular fat (IMF), pancreatic fat, renal sinus fat, and pericardial and epicardial fats] in adults with overweight and obesity, both with and without chronic diseases. …”
Get full text

Mechanistic insights into the PAI-1 inhibitor PAItrap3: enhancing lipid metabolism in adipose tissue of diabetic db/db mice by Linxi Wang, Zhouyangyang Zhang, Menghua Lin, Liqin Qi, Libin Liu, Zhuo Chen, Shuzhi Tang, Lijing Wang

“…ObjectiveThis study aimed to investigate the effects of PAItrap3, a novel PAI-1 inhibitor, on lipid metabolism, and autophagy pathways in diabetic mice.Methodsdb/db diabetic mice were administered PAItrap3 (5.7 mg/kg/day, IV) for 21 consecutive days, and its impact on metabolic, gene expression, and lipidomic profiles was assessed. …”
Get full text

ABL1‒YAP1 axis in intestinal stem cell activated by deoxycholic acid contributes to hepatic steatosis by Tiancheng Mao, Xianjun Xu, Leheng Liu, Yulun Wu, Xiaowan Wu, Wenlu Niu, Dandan You, Xiaobo Cai, Lungen Lu, Hui Zhou

“…Abstract Background Yes-associated protein 1 (YAP1) regulates the survival, proliferation, and stemness of cells, and contributes to the development of metabolic dysfunction associated fatty liver disease (MAFLD). …”
Get full text

USP24 upregulation stabilizes PKA-Cα to promote lipogenesis, inflammation, and fibrosis during MASH progression by Beh Ning, Shao-An Wang, Ming-Jer Young, Yung-Ching Chen, Yun Hung, Tran Thu Huong, Wen-Chang Chang, Yi-Ching Wang, Ming-Lung Yu, Kai-Cheng Hsu, Jan-Jong Hung

“…It also explores the effect of targeting USP24 on metabolic disorders, focusing on high-fat diet (HFD)-induced obesity and liver diseases. …”
Get full text

СORONAVIRUS INFECTION WITH AN OBESITY by S. N. Ionov, S. S. Saidov, O. V. Abanina, M. Yu. Petrov, E. S. Klimova

“…Purpose of the study: to study literature data on the effect of obesity on the course of novel coronavirus infection. …”
Get full text

Gal-3 activates Tyro3 to ameliorate ferroptosis of hippocampal neurons after traumatic brain injury by Xiao Zhang, Manrui Li, Yang Xu, Jingting Wu, Ruixuan Yuan, Yihan Sun, Xiaogang Chen, Meili Lv, Bo Jin, Xiameng Chen, Weibo Liang

“…Moreover, treatment with the Tyro3 agonist Gal-3 conferred protective effects, improving both motor and cognitive functions through Tyro3 activation. …”
Get full text

Interplay of Oxidative Stress, Gut Microbiota, and Nicotine in Metabolic-Associated Steatotic Liver Disease (MASLD) by Irene Mignini, Linda Galasso, Giulia Piccirilli, Valentin Calvez, Fabrizio Termite, Giorgio Esposto, Raffaele Borriello, Luca Miele, Maria Elena Ainora, Antonio Gasbarrini, Maria Assunta Zocco

“…In particular, free radicals alter lipid metabolism and promote lipid accumulation in the liver, existing in the hepatic facet of metabolic syndrome, the metabolic dysfunction-associated steatotic liver disease (MASLD). …”
Get full text

Mesenchymal stem cells and exosomes: A novel therapeutic approach for aging by Dongfeng Lan, Dan Zhang, Xiaofang Dai, Ji Cai, He Zhou, Tao Song, Xianyao Wang, Qinghong Kong, Zhengzhen Tang, Jun Tan, Jidong Zhang

“…Mesenchymal stem cells (MSCs), a vital component of the adult stem cell repertoire, are distinguished by their dual capacity for self-renewal and multilineage differentiation. The therapeutic effects of MSCs are primarily mediated through mechanisms such as homing, paracrine signaling, and cellular differentiation. …”
Get full text

Development of an in vitro triculture model of intestine inflammation to assess the immunomodulatory properties of cassava and roselle, two African green leafy vegetables by Nelly Fioroni, Maria Del Carmen Ponce de León Rodríguez, Nicolas Leconte, Claire Mouquet-Rivier, Caroline Guzman, Frédéric Boudard, Claudie Dhuique-Mayer, Myriam Collin, Anaïs Deglos, Emmanuelle Reboul, Ángela Bravo-Núñez, Caroline Laurent-Babot

“…In sub-Saharan Africa, frequent infections and enteric dysfunction can cause intestinal inflammation that is associated with stunting. …”
Get full text

Transcranial near infrared therapy reprograms metabolism to rescue sleep and place cell functionality by Yue Dong, Yuping Wang, Xiaoyun Liu, Yinchang Wang, Ziteng Yue, Zhanjing Wang, Sheng Wang

“…This study explores the therapeutic potential of transcranial near-infrared (tNIR) therapy in mitigating hippocampal dysfunction caused by chronic sleep deprivation (SD) in a tauopathy mouse model of AD. …”
Get full text

Photoreceptor glucose metabolism determines normal retinal vascular growth by Zhongjie Fu, Chatarina A Löfqvist, Raffael Liegl, Zhongxiao Wang, Ye Sun, Yan Gong, Chi‐Hsiu Liu, Steven S Meng, Samuel B Burnim, Ivana Arellano, My T Chouinard, Rubi Duran, Alexander Poblete, Steve S Cho, James D Akula, Michael Kinter, David Ley, Ingrid Hansen Pupp, Saswata Talukdar, Ann Hellström, Lois EH Smith

“…APN pathway activation reversed these effects. Blockade of mitochondrial respiration abolished AdipoRon‐induced Pdgfb increase in photoreceptors. …”
Get full text

Fu’s subcutaneous needling facilitates muscle repair by regulating mitochondrial homeostasis in rat with chronic peripheral nervous pain by Po-En Chiu, Po-En Chiu, Zhonghua Fu, Zhonghua Fu, Hung-Chuan Pan, Hung-Chuan Pan, Hung-Chuan Pan, Hung-Chuan Pan, Yi-Ching Tsai, Chia-Yun Tsai, Wei-Jen Hsu, Li-Wei Chou, Li-Wei Chou, Li-Wei Chou, De-Wei Lai, De-Wei Lai

“…Sciatica, often resulting from lumbar disc herniation or nerve compression, disrupts electrical signal transmission, leading to muscle atrophy, mitochondrial dysfunction, and impaired energy metabolism. This study explored the therapeutic effects of Fu’s subcutaneous needling (FSN) in a chronic constriction injury (CCI) rat model, assessing its impact on neuropathic pain, muscle mass, and structural integrity. …”
Get full text