Chronic low-dose REV-ERBs agonist SR9009 mitigates constant light-induced weight gain and insulin resistance via adipogenesis modulation by Ming-Yu Yang, Hugo Y.-H. Lin, Yi-Ywan M. Chen, Ming-Luen Hu, I-Ya Chen, Chao-Hui Yang

“…Both adipose tissue and circadian rhythms play critical roles in maintaining energy homeostasis, and their dysfunction is closely linked to obesity. This study aimed to assess the effects of chronic low-dose SR9009, a REV-ERB ligand, on circadian disruption induced by constant light exposure in mice. …”
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Efficacy of combining aspirin with hydroxychloroquine in pregnancies at high risk for pre-eclampsia: a prospective, multicentre, open-label, single-arm clinical trial, investigator... by Hyun-Hwa Cha, Suk-Joo Choi, Soo-young Oh, Cheong-Rae Roh, Ji-Hee Sung, Won Joon Seong, Yoo-Min Kim, Jisu Seong, Ji Hoi Kim, Gina Nam, Gwang jun Kim

“…Mechanistically, the anti-inflammatory and immunomodulatory effects of HCQ can offer vascular protection and inhibit the placental dysfunction-associated thrombotic changes underlying the pathophysiology of PE, fetal growth restriction (FGR) and fetal death in utero (FDIU). …”
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Hepatic Estrogen Receptor Alpha Overexpression Protects Against Hepatic Insulin Resistance and MASLD by Ester S. Alves, Jessica D. M. Santos, Alessandra G. Cruz, Felipe N. Camargo, Carlos H. Z. Talarico, Anne R. M. Santos, Carlos A. A. Silva, Henrique J. N. Morgan, Sandro L. Matos, Layanne C. C. Araujo, João Paulo Camporez

“…<b>Background/Objectives:</b> Metabolic dysfunction-associated steatotic liver disease (MASLD) is associated with cardiometabolic risk. …”
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Relationship between cerebral small vessel disease and proteinopathies in the medial temporal lobe by Valentina Perosa, Jan Oltmer, Francesco Bax, Maarten L. van den Berg, Corinne A. Auger, Johanna Rotta, Romain Perbet, Jean Augustinack, Matthew P. Frosch, Theresa Connors, Steven M. Greenberg, Bradley T. Hyman, Susanne J. van Veluw

“…Moreover, arteriolosclerosis may contribute to perivascular clearance dysfunction.…”
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Sequential Release HydroLipo System for STING Gene Epigenetic Reprogramming and Immune Activation in Glioblastoma by Hao Yu, Wenjing Liu, Kaikai Ding, Jiangjie Wu, Cheng Wang, Siyuan Wang, Lingyun Wu, Qiuying Tang, Xin Yin, Kan Jiang, Danfang Yan, Xu Wang, Si Chen, Senxiang Yan

“…The SRHLS sequentially released decitabine and STING agonists, thereby correcting STING signaling dysfunction through epigenetic reprogramming and enhancing antitumor immunity. …”
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Use of speleotherapy in patients with post-COVID-19 syndrome by René Garbsch, René Garbsch, Mona Kotewitsch, Mona Kotewitsch, Hendrik Schäfer, Hendrik Schäfer, Marc Teschler, Marc Teschler, Frank C. Mooren, Frank C. Mooren, Boris Schmitz, Boris Schmitz

“…Further research is needed to investigate whether speleotherapy can alleviate pulmonary dysfunction in different PCS populations.…”
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Preliminary results of the EPIDIA4Kids study on brain function in children: multidimensional ADHD-related symptomatology screening using multimodality biometry by Yanice Guigou, Alexandre Hennequin, Théo Marchand, Théo Marchand, Mouna Chebli, Lucie Isoline Pisella, Pascal Staccini, Pascal Staccini, Vanessa Douet Vannucci, Vanessa Douet Vannucci

“…Each ADHD-related measure was evaluated with each biometric using linear mixed-effects models. In contrast to neuro-assessments, only two digit-tracking features had age and sex effects (p &lt; 0.001) among the biometrics. …”
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Amyloid β (Aβ) inhibits retinal angiogenesis in Alzheimer's disease via LncRNA-XIST/miRNA-126-5p/VEGF axis by Bin Wang, Wenwei Li, Chaoyang Hong, Fangfang Jin, Baisheng Xu, Zhongwei Guo, Shuyang Chen, Qi Zhang

“…Overexpression of LncRNA-XIST can reverse the inhibitory effect of Aβ on angiogenesis, while further overexpression of miR-126-5p can counteract the pro-angiogenic effect of LncRNA-XIST. …”
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circRNA-79530 regulates Twist-mediated mitochondrial damage via sponging miR-214 affecting hypoxia/reoxygenation-induced injury in H9c2 cardiomyocytes by Ziyang Yu, Wenbo Xu, Yirong Teng, Tingting Li, Ren Guo, Ju Li, Xichen Li, Yanping Li, Yinglu Hao

“…Additionally, overexpression of miR-214 mitigated Twist expression, further supporting the effect of miR-214 in H/R conditions. circRNA-79530 could worsen oxidative stress and mitochondrial dysfunction, and regulate Twist-mediated mitochondrial damage via sponging miR-214 in H9c2 cells under H/R conditions. …”
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Terlipressin at esophageal varicose bleeding at liver cirrhosis with portal hypertension syndrome by B. N. Kotiv, I. I. Dzidzava, D. P. Kashkin, A. V. Smorodsky, A. V. Slobodyanik, S. A. Soldatov, M. V. Koldin

“…Terlipressin has more significant effect on portal hemodynamics and possesses the greater efficacy in comparison to octreotide at bleeding of portal origin.…”
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Positive Collaboration in Rehabilitation Nursing Enhances Fall Efficacy and Confidence in Elderly Patients with Cerebral Infarction by Luo F, Xu W, Xu Y, Lou L, Xu C

“…This approach increases patient and family satisfaction, highlighting the potential benefits of integrating collaborative care into clinical practice.Keywords: cerebral infarction, elderly, positive collaboration concept rehabilitation nursing, fall efficacy, rehabilitation confidence, satisfaction, effect, impact…”
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Umbilical Cord-Derived Mesenchymal Stem Cells Infusion in Type 2 Diabetes Mellitus Patients: A Retrospective Cytopeutics&amp;rsquo; Registry Study by Chin SP, Kee LT, Mohd MA, Then KY

“…This retrospective study aimed to assess the clinical effectiveness of intravenous allogeneic umbilical cord-derived mesenchymal stem cells (UC-MSCs) infusion in T2DM patients through various clinical evaluations, focusing on systemic inflammation, metabolic dysfunction, and insulin resistance.Methods: The data from a total of 218 T2DM patients who attended for follow-up after 6 months, and 83 patients after 12 months after receiving 50– 100× 10⁶ allogeneic UC-MSCs were analyzed. …”
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Anemia in Patients with Axial Spondyloarthritis is Not Associated with an Increase of Arterial Stiffness and Intima-Media Thickness (Results of a Single-Center Cross-Sectional Stud... by K. N. Safarova, V. I. Makhina, K. D. Dorogoykina, A. P. Rebrov

“…The present study did not confirm the negative effect of anemia on vascular wall stiffness parameters and IMT in patients with axSpA. …”
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Bone transport combined with internal fixation in post-traumatic distal humerus defects and nonunions: retrospective analysis of 16 patients by Xiriaili Kadier, Aierbanjiang Shali, Yimurang Hamiti, Yang Xin, Alimujiang Abulaiti, Xiayimaierdan Maimaiti, Aihemaitijiang Yusufu

“…Pin tract infections were observed in 9 (56.26%) patients but were effectively managed with standardized dressing changes, without compromising the overall prognosis. …”
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Exercise-induced mitochondrial protection in skeletal muscle of ovariectomized mice: A myogenic E2 synthesis-independent mechanism by Xu Tian, Yi Hu, Tao Li, Fangfang Yu, Tingting Li, Xiangyang Tian, Yiwei Feng, Qiuling Zhong, Yifan Meng, Wei Chen, Rengfei Shi

“…Exercise intervention effectively attenuated these OVX-induced deficits, accompanied by a 66 % increase in E2 levels and upregulation of aromatase (ARO) activity and expression (p < 0.05). …”
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Long-Lasting Exendin-4-Coated Gold Nanoparticles: Synthesis and In Vivo Evaluation of Hypoglycemic Activity by Reeju Amatya, Amala Joseph, Gu Seob Roh, Yassmine Benmokadem, Kyoung Ah Min, Meong Cheol Shin

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Diabetic kidney disease: from pathogenesis to multimodal therapy–current evidence and future directions by Hui Zhang, Keding Wang, Hairui Zhao, Bowen Qin, Xiaojing Cai, Manyi Wu, Junhua Li, Junhua Li, Jielian Wang

“…Given the multifaceted pathophysiology of DKD, optimal management will require multimodal, patient-tailored regimens that address hyperglycemia, hypertension, inflammation, and fibrosis to effectively slow or halt disease progression.…”
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The Role of Serum Calcium Levels in the Progression of Arterial Stiffness: Cross‐Sectional and Longitudinal Analyses in a Multicenter Cohort by Kyung An Kim, Hae‐Ok Jung, Mi‐Jeong Kim, So‐Young Lee, Dong‐Hyeon Lee, Donghee Han, Hyuk‐Jae Chang, Su‐Yeon Choi, Jidong Sung, Eun Ju Chun

“…Subgroup analysis showed that the effect of serum calcium on baPWV progression had a significant interaction with baseline baPWV, systolic blood pressure, and the presence of diabetes (interaction p < 0.001). …”
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Correlations of oral behaviors, pain, and psychological distress among patients with temporomandibular disorders: clinical investigation of axial II evaluation by Yan Yu, Yan Yu, Lili Wang, Lili Wang, Chunxia Chen, Chunxia Chen, Mengmeng Wang, Mengmeng Wang, Shuai Nie, Shuai Nie, Lin Fu, Lin Fu

“…The effect of oral behavior on psychological distress is exerted indirectly through chronic pain. …”
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Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice by Zhangqiang Ma, Na Hu, Liping Zheng, Yue Xue, Chong Zhou, Wencan Wang, Xiu Cheng, Tao Luo, Jianlin Yu, Liaoliao Hu

“…This study investigates the therapeutic effects of tanshinone IIA on TOCP-damaged ovaries in mice, with focus on Hippo, AKT, and MAPK pathways. …”
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