Intranasal delivery of blackberry-loaded Chitosan nanoparticles for antipsychotic potential in Ketamine-induced schizophrenia in rats by Mina Y. George, Nermeen Farag, Esther T. Menze, Reham S. Elezaby, Nayera A. Salem, Shereen K. Elrahmany, Nahed Adel, Rana M. ElKhatib, Menna Galal, Hams Assem, Radwa Elkhouly, Mariam Alkess Wesa, Noha Hesham, Nouran Hossam, Iriny M. Ayoub

“…RFE treatment ameliorated positive, negative, and cognitive symptoms of schizophrenia while mitigating clozapine-induced side effects such as weight gain, hyperglycemia, hyperlipidemia, agranulocytosis, and liver dysfunction. …”
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CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system by Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

“…While remarkable treatment advances have been made recently in the form of modulator drugs directly rescuing CFTR dysfunction, there is still considerable scope for improvement of therapeutic effectiveness. …”
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Unveiling the protective role of ESM1 in endothelial cell proliferation and lipid reprogramming by Yukun Li, Anbo Gao, Wenchao Zhou, Xing Tang, Tian Zeng, Tingyu Fan, Weimin Jiang, Min Tang, Fan Ouyang

“…The mouse model of AS was used to observe the effect of PA on the ESM1-ANGPTL4-autophagy signaling axis. …”
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In-vitro & in-vivo efficacy of liposomal β-carryophyllene in ethylene glycol induced urolithiasis in rats by Ranjith Kumar R, Suresh Janadri, Manjunatha PM, Madhu M V, Rakshitha K B, Preeti P Angadi, Uday Raj Sharma, Surrendra Vada, Nageena Taj, Jyotsna S Kharvi

“…BCP significantly reduced serum and urine markers of renal dysfunction and oxidative stress, with the highest dose (400 mg/kg) demonstrating effects similar to the standard drug (cystone). …”
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A ROLE OF ARGININE DEIMINASE FROM STREPTOCOCCUS PYOGENES M49-16 IN PROMOTING INFECTION AND INHIBITION OF ENDOTHELIAL CELL PROLIFERATION by E. A. Starikova, A. B. Karaseva, L. A. Burova, A. N. Suvorov, A. V. Sokolov, V. B. Vasilyev, I. S. Freidlin

“…Our studies have shown that arginine deiminase from Streptococcus pyogenes M22 exerts similar effects, i.e., inhibits proliferation and other endothelial cell functions related to angiogenesis. …”
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NLRP3 Mediates NOXs-Induced Iron Overload and Inflammation but Not Oxidative Damage in Colons of DSS-Treated Mice by Yu L, Wang M, Zhou Y, Qi J, Zheng Q, Song Z

“…Linna Yu,1,2,* Meng Wang,3,* Yunjiao Zhou,1,2 Jialong Qi,1,2 Qingqing Zheng,2,4 Zhengji Song1,2 1Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China; 2The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, People’s Republic of China; 3Department of Hematology and Oncology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou, Guangdong, People’s Republic of China; 4Department of Pathology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengji Song, Department of Gastroenterology, The First People’s Hospital of Yunnan Province, Kunming, Yunnan, People’s Republic of China, Email song4715@163.comBackground: Ulcerative colitis (UC) is an inflammatory bowel disease (IBD) with chronic and recurrent characteristics caused by multiple reasons, including iron overload, intestinal inflammation, and barrier dysfunction. Here, we investigated the effects of chemical inhibition of NOXs and NLRP3 activity on colonic iron metabolism and inflammatory reactions in a murine model of dextran sodium sulfate (DSS)-induced ulcerative colitis.Methods: The mice were randomly divided into five groups: normal control group, DSS-induced ulcerative colitis model group (DSS), DSS + Dapansutrile group, DSS + Diphenyleneiodonium chloride group, and DSS + Dapansutrile + Diphenyleneiodonium chloride group. …”
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Immune Regulation of TNFAIP3 in Psoriasis through Its Association with Th1 and Th17 Cell Differentiation and p38 Activation by Yanyun Jiang, Wenming Wang, Xiaofeng Zheng, Hongzhong Jin

“…TNFAIP3 downregulation associated with Th1 and Th17 cell differentiation and p38 activation might contribute in part to the mechanism of immune dysfunction in psoriasis. TNF-α antagonists might partly exert their effects on psoriasis via this pathway.…”
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Comparison of the Immune Enhancing Activity and Chemical Constituents Between Imitation Wild and Cultivated Astragali Radix by Shuo Zhao, Xueting Li, Yumeng Wang, Rui Xu, Xu Li, Jiushi Liu, Xiaolin Hou, Haitao Liu

“…Following 16 days of daily AR treatment, both the thymus and spleen coefficients were significantly increased, effectively reversing the immune dysfunction induced by cyclophosphamide (CTX). …”
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Gastric mucosal repair by Men’s Huwei Powder via EGF-NO/PGE2-PI3K-TLR4 in RELISH: Restoring Equilibrium through long-term integration of synergistic health by Kaijie Xu, Kaijie Xu, Jing Li, Shoupeng Guo, Jin Zhang, Xichun Zhang

“…Background:Gastric mucosal injury (GMI) involves inflammation, oxidative stress, and barrier dysfunction. Existing therapies offer limited efficacy with side effects. …”
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Dose-dependent immunotoxic mechanisms of celastrol via modulation of the PI3K-Akt signaling pathway by Shaohui Geng, Jingqi Wen, Chunli Shen, Li Liu, Yijin Jiang, Jingyuan Fu, Yiwei Guan, Zi Ye, Yuanhao Wu, Chen Li, Guangrui Huang

“…., is known for its anti-inflammatory and immunomodulatory effects, but its immunotoxicity is underexplored. …”
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Human placental mesenchymal stem cells ameliorates premature ovarian insufficiency via modulating gut microbiota and suppressing the inflammation in rats. by Shudan Liu, Ting Wang, Yuanyuan Liu, Yiwei Li, Junbai Ma, Qikuan Hu, Hao Wang, Xiaoxia Zhang

“…The core objective of this study was to explore the effects and potential mechanism of human placental mesenchymal stem cells (PMSCs) in improving early-onset ovarian dysfunction (POI). …”
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The accumulation of myeloid‐derived suppressor cells participates in abdominal infection‐induced tumor progression through the PD‐L1/PD‐1 axis by Yiding Wang, Ting Guo, Xiaofang Xing, Xijuan Liu, Xuejun Gan, Yingai Li, Yan Liu, Fei Shan, Zhouqiao Wu, Jiafu Ji, Ziyu Li

“…These findings emphasize the impact of sepsis on tumor progression and suggest targeting the PD‐1/PD‐L1 axis as a potential therapeutic strategy for managing immune dysfunction in patients with cancer.…”
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Specific immune-inflammatory profiles and neurocognitive deficits predict illness trajectories in people with type 2 diabetes mellitus or psychiatric disorders by Joan Vicent Sánchez-Ortí, Patricia Correa-Ghisays, Vicent Balanzá-Martínez, Gabriel Selva-Vera, Víctor M. Victor, Constanza San Martin Valenzuela, Pau Soldevila-Matías, Fabián Robledo-Yagüe, María Flores-Rodero, Jon Sánchez-Valle, Jaume Forés-Martos, Diego Macías Saint-Gerons, Inmaculada Fuentes-Durá, Rafael Tabarés-Seisdedos

“…Immune-inflammatory dysfunction is emerging as a critical factor in the progression of these disorders. …”
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Cholesterol crystal embolization induced kidney disease by Shohan Pervaze, Shreya Mohandas, Pushkas Gopalan, Stephen A. Morse, Siddhartha Bajracharya, Landon A. Krone, Farshid Yazdi

“…The pathophysiology of CCE includes complex pathways that lead to acute and chronic effects that can have direct deleterious effects on the kidney. …”
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Apelinergic System Affects Electrocardiographic Abnormalities Induced by Doxorubicin by Kasper Buczma, Hubert Borzuta, Katarzyna Kamińska, Dorota Sztechman, Katarzyna Matusik, Jan Pawlonka, Michał Kowara, Barbara Buchalska, Agnieszka Cudnoch-Jędrzejewska

“…<b>Results</b>: Lower doses of APJ agonists prevented the prolongation of QT and QTc intervals induced by DOX, while higher doses of these drugs exerted no such effect. The TTE examination confirmed DOX-induced LV systolic dysfunction. …”
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Lyophyllum decastes-derived polysaccharides alleviate DSS-induced colitis in mice by suppressing inflammation, enhancing intestinal barrier integrity, and restoring gut microbiota... by Eslam Ghaleb, Yamina Alioui, Jamalat Yazeed, Natheer Wahan, Ahmed Bashah, Ali AL-waqeerah, Aamna Atta, Yuxin Sun, Yi Xin, Liang Wang, Bin Feng, Weifeng Mao

“…However, its therapeutic effects on ulcerative colitis have not been studied. …”
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Salidroside can protect against ferroptosis in cardiomyocytes and may be related to the regulation of GGT1 by Tianhang Feng, Jing Shi, Jinghua Zhao, Qin Zhao, Tao Wang, Sha Wan, Chen Fan, Sijia Wang, Chunyou Lai, Yutong Yao

“…Salidroside (SAL), a natural bioactive compound derived from Rhodiola rosea, exhibits cardioprotective effects through multi-target mechanisms with minimal adverse effects, yet its precise role in ferroptosis regulation remains unclear.MethodsThis study systematically investigated SAL’s anti-ferroptotic effects using in vitro (RSL3-induced H9C2 cardiomyocytes) and in vivo (DOX-induced myocardial injury mouse model) approaches.ResultsSAL treatment significantly enhanced cardiomyocyte viability by attenuating ferroptotic hallmarks, including lipid ROS accumulation, iron overload, lipid peroxidation, and mitochondrial dysfunction. …”
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Prefrontal executive function enhanced by prior acute inhalation of low-dose hypoxic gas: Modulation via cardiac vagal activity by Dongmin Lee, Yudai Yamazaki, Ryuta Kuwamizu, Masahiro Okamoto, Hideaki Soya

“…It is essential to develop accessible methods of enhancing cardiac vagal activity (CVA) to mitigate these adverse effects. We previously demonstrated that inhaling low-dose hypoxic gas (FIO₂: 13.5 %) for 10 min acts as a hormetic stressor, inducing a supercompensation effect in CVA post-hypoxia. …”
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Targeting the CD39/CD73 pathway: New insights into cardiac fibrosis and inflammation in female cardiac surgery patients by Eitezaz Mahmood, Mark Robitaille, Yifan Bu, Adnan Khan, Marie-France Poulin, Feroze Mahmood, Ruma Bose, Kamal R. Khabbaz, Simon C. Robson, Robina Matyal

“…The reasons for this disparity are multifactorial, but the loss of the protective effects of estrogen likely plays a role. Estrogen acts on the CD39/CD73 purine pathway, and loss of estrogen effects may contribute to the increased inflammation seen in post-menopausal women. …”
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MiR-125a-5p in MSC-derived small extracellular vesicles alleviates Müller cells injury in diabetic retinopathy by modulating mitophagy via PTP1B pathway by Cong Liu, Jinjin Xiang, Yueqin Chen, Chang He, Jun Tong, Yinglin Liao, Huangyi Lei, Lingyun Sun, Genhong Yao, Zhenggao Xie

“…Oxidative stress and mitochondrial dysfunction play a critical role in the progression of DR. …”
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