Unveiling the psychiatric dimensions of hypopituitarism: investigating associations, challenges, and treatment strategies by Ayesha Imran Butt, Muhammad Juniad Azhar

“… Dear Editor, Hypopituitarism is a disorder characterized by insufficient hormone production from the pituitary gland,1,2 manifesting as either pan or partial dysfunction.2 Hypopituitarism is considered a rare disorder by National Institute of Health and there is limited information on its occurrence. …”
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Novel homozygous frameshift mutation of ITGB3 in the Glanzmann thrombasthenia patient with abnormal bone metabolism and congenital bone defects by Yujiao Luo, Nina Guo, Yewei Wang, Ji Li

“…Abstract Background Glanzmann thrombasthenia (GT) is a rare inherited bleeding disorder caused by dysfunction of the integrin αIIbβ3 in platelets. The subunit β3, encoded by ITGB3 also plays a significant role in bone metabolism. …”
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Association of mitochondrial haplogroup H with reduced risk of type 2 Diabetes among Gulf Region Arabs by Mohammed Dashti, Naser M. Ali, Hussain Alsaleh, Sumi Elsa John, Rasheeba Nizam, Thangavel Alphonse Thanaraj, Fahd Al-Mulla

“…BackgroundNumerous studies have linked mitochondrial dysfunction to the development of type 2 diabetes (T2D) by affecting glucose-stimulated insulin secretion in pancreatic beta cells and reducing oxidative phosphorylation in insulin-responsive tissues. …”
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Chronic inflammation in post-acute sequelae of COVID-19 modulates gut microbiome: a review of literature on COVID-19 sequelae and gut dysbiosis by Najeeha Talat Iqbal, Hana Khan, Aqsa Khalid, Syed Faisal Mahmood, Nosheen Nasir, Iffat Khanum, Isadora de Siqueira, Wes Van Voorhis

“…The first mechanism is related to the dysfunction of angiotensin-converting enzyme 2 receptor due to Severe Acute Respiratory Syndrome Corona Virus 2 infection, leading to impaired mTOR pathway activation, reduced AMP secretion, and causing dysbiotic changes in the gut. …”
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Developing a novel aging assessment model to uncover heterogeneity in organ aging and screening of aging-related drugs by Yingqi Xu, Maohao Li, Congxue Hu, Yawen Luo, Xing Gao, Xinyu Li, Xia Li, Yunpeng Zhang

“…Results The 2A model effectively assessed aging states in both human and mouse tissues and demonstrated predictive capability for senescent cell clearance rates. …”
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Nicotinamide Mononucleotide Restores NAD⁺ Levels to Alleviate LPS-Induced Inflammation via the TLR4/NF-κB/MAPK Signaling Pathway in Mice Granulosa Cells by Mehboob Ahmed, Umair Riaz, Haimiao Lv, Muhammad Amjad, Sohail Ahmed, Shaokat Ali, Muhammad Usman Ghani, Guohua Hua, Liguo Yang

“…Inflammation disrupts the normal function of granulosa cells (GCs), which leads to ovarian dysfunction and fertility decline. Inflammatory conditions such as polycystic ovary syndrome (PCOS), primary ovarian insufficiency (POI), endometriosis, and age-related ovarian decline are often associated with chronic low-grade inflammation. …”
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Prognostic value of elevated cardiac troponin in aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis by Jiahui Zhao, Shujuan Gu, Xudong Zhao, Shisong Wang, Qichen Pan, Cunyi Zou

“…The total subarachnoid hemorrhage (toSAH) group included aSAH and traumatic SAH studies for analysis. The pooled effect size was calculated using R studio and Stata 14.0.ResultsIn the toSAH group, 1,559 out of 6,349 (24.55%) SAH patients from 33 studies exhibited elevated cTn levels, while 25.0% in the aSAH group also exhibited similar results. …”
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Prevalence of cardiovascular symptoms in post-acute COVID-19 syndrome: a meta-analysis by Li-wei Huang, Hua-min Li, Bei He, Xiao-bo Wang, Qi-zhi Zhang, Wen-xing Peng

“…The primary outcomes included hypertension, palpitations, and chest pain, with pooled effect estimate reported as proportions and odds ratios (ORs) with 95% confidence intervals (CIs). …”
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Qifuyin against CCL11-Induced cognitive impairment by inhibiting microglial senescence via CCR3 signaling by Sheng Tian, Tianyuan Ye, Chao Tian, Yipeng Zhang, He Li, Hui Shen, Youhua Xu, Xiaorui Cheng

“…CCR3 knockout/overexpression HMC3 cells were treated with five brain-entering components of Qifuyin to observe protective effects of Qifuyin. Results Here we found that Qifuyin improved the ability of object recognition and memory, spatial learning and memory and conditional fear memory in CCL11-induced cognitive dysfunction of C57BL/6 mice. …”
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Total glucose control: the role of post-prandial glucose by PAUL S JELLINGER

“…There are many other studies going back to the 1980s that relate post-challenge or post-prandial blood glucose to cardiovascular disease risk and mortality. Possible effects of acute hyperglycemia responsible for increased microvascular and macrovascular risk include endothelial dysfunction, increased oxidative load, a pro-inflammatory state, protein glycosylation and altered coagulation. …”
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Povidone Iodine Disinfection Associated with Hypothyroidism and Potentially Contributing to Prolonged Kidney Failure by Yasmine Vercammen, Dieter Dauwe, Greet De Vlieger, Sabrina Houthoofd, Lars Desmet, Michael P. Casaer

“…In critically ill children, however, toxic effects of PVP-I may occur due to repeated disinfection of less extended wounds. …”
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Transthyretin amyloid cardiomyopathy: Literature review and red‐flag symptom clusters for each cardiology specialty by Yasuhiro Izumiya, Toru Kubo, Jin Endo, Seiji Takashio, Masatoshi Minamisawa, Jun Hamada, Tomonori Ishii, Hajime Abe, Hiroaki Konishi, Kenichi Tsujita

“…Standard guideline‐directed pharmacological treatment for HF is not recommended for patients with ATTRwt‐CM because of its limited effectiveness. However, no established algorithms are available regarding HF management in this patient population. …”
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Anxiety and depression in patients with head and neck cancer: 6-month follow-up study by Wu Y, Lin P, Chien C, Fang F, Chiu N, Hung C, Lee Y, Chong M

“…Their HRQL was simultaneously evaluated using the quality of life questionnaire of the European Organisation for Research and Treatment of Cancer with a specific module for head and neck cancer; and depressed and nondepressed HNC patients were compared by using the generalized mixed-effect model for repeated measurements.Results: A total of 106 patients were recruited into this study. …”
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El papel de la inmunosupresión en trasplante hepático. Ventajas y desventajas by D. Aguirre-Villarreal, L. Rosales-Rentería, I. García-Juárez, A. Rosales-Padrón, F. Manzo-Santana

“…Minimizing or discontinuing immunosuppression has been shown to reduce those adverse effects in selected patients, especially those with potential immunotolerance. …”
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Association Between High-Density Lipoprotein Cholesterol and Length of Hospital Stay in Acute Pancreatitis: A Retrospective Cohort Study by Qiu L, Xu F, Dong B

“…High-density lipoprotein cholesterol (HDL-C), known for its cardioprotective properties, has been posited to influence AP outcomes; however, its relationship with LOS remains unclear.Objective: This study aimed to investigate the potential correlation between HDL-C levels and LOS in patients with AP, considering the effects of demographic factors, comorbidities, and other clinical parameters.Methods: A retrospective cohort study was conducted. …”
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Role of Interleukins in Type 1 and Type 2 Diabetes by Roha Asif, Ammara Khalid, Tolga Mercantepe, Aleksandra Klisic, Sana Rafaqat, Saira Rafaqat, Filiz Mercantepe

“…Anti-inflammatory mediators including IL-4, IL-10, and IL-13 exhibit protective effects but vary in expression across disease stages. …”
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PDZD8 Augments Endoplasmic Reticulum-Mitochondria Contact and Regulates Ca2+ Dynamics and Cypd Expression to Induce Pancreatic β-Cell Death during Diabetes by Yongxin Liu, Yongqing Wei, Xiaolong Jin, Hongyu Cai, Qianqian Chen, Xiujuan Zhang

“…Cypd overexpression alleviated the promoting effect of PDZD8 knockdown on the apoptosis of β-cells. …”
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Assessing quality of life and readmission rates among women in psychiatric care: a mixed-method study by Celso Gonçalves Alves, Blanca Elena Guerrero Daboin, Jussara de Azevedo Pereira, Esthefany Pereira Estevam, Italla Maria Pinheiro Bezerra, Carlos Eduardo Siqueira, Tassiane Cristina Morais

“…Despite a plethora of studies delineating the effects of gender on mental health, there exists a conspicuous deficiency in research investigating women’s viewpoints regarding their own experiences of rehospitalization. …”
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Comparison of remimazolam tosylate and propofol in hemodynamic stability, postoperative cognitive function, and recovery in general anesthesia combined with regional nerve blocks:... by Jiaman Li, Li Liao, Chunyang Shao, Yifeng Yang, Yan Tang, Qiang Wei, Li Xu

“…This study aimed to compare the hemodynamic effects and postoperative cognitive function between remimazolam tosylate and propofol in patients undergoing GA combined with RA. …”
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Diosgenin protects against cationic bovine serum albumin-induced membranous glomerulonephritis by attenuating oxidative stress and renal inflammation via the NF-κB pathway by Shiyan Jia, Ruihua Si, Guangzhen Liu, Qiming Zhong

“…Diosgenin (DG) has been reported to exert antioxidative and anti-inflammatory effects.Objective To investigate the renoprotective activity of DG in a cationic bovine serum albumin-induced rat model of MGN.Materials and methods Fourty male Sprague-Dawley rats were randomized into four groups. …”
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