Radiation-induced morphea of the breast – characterization and treatment of fibroblast dysfunction with repurposed mesalazine by Stephan R. Künzel, Erik Klapproth, Nick Zimmermann, Susanne Kämmerer, Mario Schubert, Karolina Künzel, Maximilian Hoffmann, Stephan Drukewitz, Anne Vehlow, Jiri Eitler, Marieke Arriens, Jessica Thiel, Romy Kronstein-Wiedemann, Maximiliane Tietze, Stefan Beissert, Bertold Renner, Ali El-Armouche, Claudia Günther

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From endothelial dysfunction correction to macrohemodynamics improvement in patients with chronic cor pulmonale by V. S. Zadionchenko, I. V. Pogonchenkova, A. M. Shchikota, O. I. Nesterenko, K. A. Aldushina, T. M. Terekhova

“…CCP patients were characterised by substantial endothelial dysfunction (ED), pathological NO hyper-production, elevated level of Willebrand factor, and increased apoptosis. …”
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Hypothalamic–Pituitary–Adrenal Axis Dysfunction in People With Cancer: A Systematic Review by Natalie G. Kanter, Sarah Cohen‐Woods, David Balfour, Morton G. Burt, Alison L. Waterman, Bogda Koczwara

“…HPA dysfunction was observed in patients of both sexes, diverse ages, stages of cancer and cancer treatments. …”
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Lack of sexual dimorphism in a mouse model of isoproterenol-induced cardiac dysfunction. by Marianne K O Grant, Ibrahim Y Abdelgawad, Christine A Lewis, Davis Seelig, Beshay N Zordoky

“…Intriguingly, gonadectomy of male and female mice did not have a significant impact on isoproterenol-induced cardiac dysfunction as compared to sham-operated animals. The current work demonstrated lack of significant sex-related differences in isoproterenol-induced cardiac hypertrophy, dysfunction, and fibrosis in C57Bl/6NCrl mice. …”
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Treatment with Sulodexide Downregulates Biomarkers for Endothelial Dysfunction in Convalescent COVID-19 Patients by Alejandro J Gonzalez-Ochoa MD, Gyozo Szolnoky MD, Ana G Hernandez-Ibarra MD, Jawed Fareed PhD

“…Introduction Persistent elevation of biomarkers associated with endothelial dysfunction in convalescent COVID-19 patients has been linked to an increased risk of long-term cardiovascular complications, including long COVID syndrome. …”
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Peripheral mitochondrial transplantation alleviates diabetes-associated cognitive dysfunction by suppressing cuproptosis by Juan Hu, Qiao Li, Shiqiu Jiang, Yingying Deng, Lan Yang, Mengyu Du, Shuxuan He, Fuxing Xu, Chaoying Yan, Wei Gao, Yansong Li, Yaomin Zhu

“…Mitochondrial dysfunction and neuronal impairment are hallmark features of Diabetes-Associated Cognitive Dysfunction (DACD), mitochondrial transplantation is also a therapeutic intervention for DACD. …”
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In Vivo TLR9 Inhibition Attenuates CpG-Induced Myocardial Dysfunction by O. Boehm, P. Markowski, M. van der Giet, V. Gielen, A. Kokalova, C. Brill, A. Hoeft, G. Baumgarten, R. Meyer, P. Knuefermann

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SIRT5 prevents mitochondrial dysfunction and cardiac hypertrophy induced by RIP140 by Liying Liang, Yi Huang, Qiujuan Wang, Ye Hong, Honghui Zhen, Yanfang Chen

“…Objective(s): To investigate the effect and mechanism of Sirtuin5 (SIRT5) on mitochondrial dysfunction and cardiac hypertrophy induced by receptor-interacting protein 140 (RIP140).Materials and Methods: The neonatal rat cardiomyocytes (NRCMs) and SD rats were treated with Angiotensin II (Ang II) to induce in vitro and in vivo model of cardiac hypertrophy. …”
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Insulin resistance-induced mitochondrial dysfunction and pyroptosis in trophoblasts: protective role of metformin by Runyu Du, Yu Bai, Ling Li, Ying Shao, Na Wu

“…This study aimed to investigate the impact of IR, a key feature of GDM, on mitochondrial dysfunction and pyroptosis in trophoblasts and to evaluate the protective effects of metformin. …”
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Clinical, diagnostic features and treatment of orgasmic dysfunctions in anxiety-depressive spectrum disorders by M. I. Yagubov, I. Yu. Kan, I. R. Ayriyants

“…The presented clinical and psychopathological features of orgasmic dysfunctions make it possible to identify the connection not only with the phenomenon of orgasm, but also with all components of the copulative cycle with affective and other psychopathological symptoms, which allows us to trace the mechanisms of their formation, improve the diagnosis and determination of the prognosis of these disorders, and choose the tactics of treatment and rehabilitation measures , allowing to increase the effectiveness of therapy for orgasmic disorders.…”
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Multivitamin supplementation and its impact in metabolic dysfunction-associated steatotic liver disease by Tom Ryu, Seung Yun Chae, Jaejun Lee, Ji Won Han, Hyun Yang, Beom Sun Chung, Keungmo Yang

“…These findings suggest that multivitamins might provide broader protective effects in populations with metabolic dysfunction. …”
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Patellar motion and dysfunction of its stabilizers in a biomechanical model of the knee joint by A. S. Yurova, A. I. Tyagunova, F. B.  Loginov, Yu. V. Vassilevski, A. V. Lychagin, E. B. Kalinsky, E. V. Larina, N.  V. Gorohova, K. A. Devyatyarov, O. N. Bogdanov, I. B. Kovalenko, K. V. Chesnokova, M. A.  Dergachev, E. Yu. Mychka, O. N. Kosukhin

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Testosterone Replacement in Men with Sexual Dysfunction: An Abridged Version of the Cochrane Systematic Review by Hunju Lee, Eu Chang Hwang, Cheol Kyu Oh, Solam Lee, Ho Song Yu, Jung Soo Lim, Hong Wook Kim, Thomas Walsh, Myung Ha Kim, Jae Hung Jung, Philipp Dahm

“…Purpose: To assess the effects of testosterone replacement therapy (TRT) compared to placebo or other medical treatments in men with sexual dysfunction. …”

Influence of diastolic dysfunction on cognitive impairment and prognosis in patients with coronary artery disease by O. O. Nudchenko, L. I. Konoplianyk, N. A. Kozhukharova, M. M. Dolzhenko

“…Influence of diastolic dysfunction on cognitive impairment and prognosis in patients with coronary artery disease The aim of the study is to evaluate the influence of left ventricular diastolic dysfunction on cognitive impairment and prognosis in patients with coronary artery disease. …”
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Poor communication impairs optimal care of patients with heart failure and erectile dysfunction by Lea Leist, Lenka Hausmann, Carla Pohlink

“…Abstract Aims Heart failure (HF) and erectile dysfunction (ED) share numerous risk factors and pathogenetic mechanisms, resulting in a high prevalence of ED among male patients with HF. …”
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Circulating leptin levels in thyroid dysfunction: a systematic review and meta-analysis by Shanshan Liu, Jun Ma, Leyuan Zhang, Yanlong Yang, Ziqi Han, Limin Tian

“…The purpose of this study was to investigate circulating leptin levels in thyroid dysfunction (TD) patients and the role of TH levels. …”
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Decreased IL-33 Production Contributes to Trophoblast Cell Dysfunction in Pregnancies with Preeclampsia by Hong Chen, Xiaobo Zhou, Ting-Li Han, Philip N. Baker, Hongbo Qi, Hua Zhang

“…Dysregulation of systemic inflammatory response and dysfunction of trophoblast cells have been proposed to be involved in the development and progression of PE. …”
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12/15-lipoxygenase mediates disturbed flow-induced endothelial dysfunction and atherosclerosis by Jia Wei Chen, Shi Li Chen, Xin Rui Wu, Xin Yi Shu, Si Yi Tang, He Yuan, You Ran Li, Jin Wei Quan, Shuo Feng, Rui Yan Zhang, Chen Die Yang, Lin Lu, Xiao Qun Wang

“…Abstract Background Disturbed flow regions in the vasculature are predisposed to endothelial dysfunction and atherosclerotic plaque formation. The enzyme 12/15-lipoxygenase (12/15-LOX, encoded by ALOX15) has emerged as a promising therapeutic target for atherosclerosis. …”
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Diagnosis and Treatment of Manifestations of Endothelial Dysfunction in ICU Patients with Severe Acute Pancreatitis by V. V. Kiselev, M. S. Zhigalova, S. S. Petrikov, E. V. Klychnikova, P. A. Yartsev

“…An important pathogenetic aspect of the severe course of acute pancreatitis is endothelial dysfunction. The latter often begins as a diffuse activation of coagulation, which further potentiates the progression of the systemic inflammatory response syndrome and, thereby, complicates the course of acute pancreatitis. …”
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Assessment of Diabetic Autonomic Nervous Dysfunction with a Novel Percussion Entropy Approach by Hai-Cheng Wei, Ming-Xia Xiao, Na Ta, Hsien-Tsai Wu, Cheuk-Kwan Sun

“…In conclusion, the results demonstrated that additional information on diabetic autonomic dysfunction can be obtained through comparing two simultaneously acquired physiological time series. …”
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