Deciphering the role of SEMA4A/MAPK signaling in sepsis: insights from Mendelian randomization, transcriptomic, single-cell sequencing analyses, and vitro experiments by Meng-Qin Pei, Yan-Ling Lin, Li-Ming Xu, Yu-Shen Yang, Zhen-Dong Sun, Ya-Fen Zeng, Gui-Dan Wang, He-Fan He, Li-Ying Yu, Li-Ying Yu

“…BackgroundSepsis is a condition with high mortality and multiple organ dysfunction, undergoing complex pathogenesis and limited treatment options. …”
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Prognostic value of mechanical dyssynchrony in patients with heart failure: a systematic review by Ziqi Chen, Qiang Qu, Iokfai Cheang, Xinyi Lu, Shengen Liao, Rongrong Gao, Yanli Zhou, Xinli Li

“…Conclusions The analysis demonstrated that phase information obtained from gated SPECT MPI is of significant prognostic value in patients with heart dysfunction. It effectively enhances clinical risk models, providing reliable guidance for patient treatment.…”
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YAP enhances mitochondrial OXPHOS in tumor-infiltrating Treg through upregulating Lars2 on stiff matrix by Hui Li, Yuan Yao, Yang Qu, Yihan Xu, Peng Jin, Yuhan Zhang, Liling Niu, Jingchao Bai, Meinan Yan, Youhui Wang

“…Whether YAP plays a part in regulating TI-Treg mitochondrial function and the underlying mechanisms are yet to be elucidated.Methods To gain insights into the effect of matrix stiffness on YAP activation in Tregs, alterations in stiffness were performed both in vitro and in vivo. …”
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Comparative Pathomorphological Characteristics of Placental Vessels from Pregnancies with High and Low Risk of Preeclampsia by Kamilya Makhambetova, Yevgeniy Kamyshanskiy, Olga Ponamareva, Zhanna Amirbekova, Nazerke Oshakhtiyeva

“…The large variability and inconsistency of histomorphometric changes in placental vessels as markers of placental dysfunction emphasize the need for their further research using standardized methods of morphometric analysis. …”
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The role of triglycerides in predicting new-onset arthritis in the general population over 45 years old: evidence from the China health and retirement longitudinal study by Weiwei Ma, Honggu Chen, Jing Deng, Qipeng Yuan, Huanan Li, Huanan Li

“…Due to its strong association with chronic pain and dysfunction, arthritis has become an important challenge in public health. …”
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Migraine and other headaches in transient ischemic attacks by E. R. Lebedeva, N. M. Gurary, J. Olesen

“…TIA patients included in the study (female 55% (n=120); mean age, 56.1 years) according to the existing definition of TIAs had a transient neurological dysfunction episode caused by focal brain damage or retinal ischemia for up to 24 hours without forming a new acute heart attack on diffusion-weighted MRI (n=112) or CT (n=8). …”
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Parkinson's disease and polymorphisms of the glutamatergic system genes GRIN2A, SLC1A2, and GRIK4 by Yu. S. Mironova, I. A. Zhukova, N. G. Zhukova, S. A. Ivanova, V. M. Alifirova, A. S. Boiko, D. Z. Osmanova, O. P. Izhboldina, A. V. Latypova

“…Parkinson's disease (PD) is now increasingly considered as a multi-system disorder associated with multi-neurotransmitter dysfunction, so it is important to search for genetic risk factors that determine different clinical types of this disease. …”
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Treatment of overactive bladder symptoms in women with Diunorm®: preliminary results report by S. V. Shkodkin, M. V. Pokrovsky, S. S. Krasnyak, A. V. Polichuk, S. V. Chirkov, O. V. Churikova, N. A. Kpavtsova

“…However, the frequency of occurrence in the female population averages about 25%.Purpose of the study. To assess the effectiveness and safety of the drug Diunorm® (in caps.) in the prevention and treatment of OAB in women.Materials and methods. …”
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MIIST305 mitigates gastrointestinal acute radiation syndrome injury and ameliorates radiation-induced gut microbiome dysbiosis by Debmalya Mitra, Gabriel K. Armijo, Elizabeth H. Ober, Shenda M. Baker, Helen C. Turner, Constantinos G. Broustas

“…High-dose radiation exposure results in gastrointestinal (GI) acute radiation syndrome identified by the destruction of mucosal layer, intestinal growth barrier dysfunction, and aberrant inflammatory responses. Further, radiation causes gut microbiome dysbiosis characterized by diminished microbial diversity, mostly commensal bacteria, and the spread of bacterial pathogens that trigger the recruitment of immune cells and the production of pro-inflammatory factors that lead to further GI tissue damage. …”
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The influence of the interaction of right ventricle and pulmonary artery system on the development of adverse outcomes in acute decompensation of chronic heart failure by Madina R. Islamova, Ayten F. Safarova, Zhanna D. Kobalava

“…In patients with RV-PA uncoupling, higher liver density was identified using transient elastography and reduced active and reactive resistance using bioimpedance vector analysis, regardless of right ventricular dysfunction. The effect of the RV-PA uncoupling on the overall hospitalization rate and related to ADCHF was shown. …”
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Plasma cytokine levels and PCOS risk: Mendelian randomization analysis reveals IL6R as a preventive factor by Xiaopei Li, Yan Li, Bumei Zhang, Jianmei Wang, Yang Yang, Yongrui Du

“…It is characterized by elevated androgen levels, ovulatory dysfunction, and morphological abnormalities. Despite extensive research from various perspectives, the etiology and pathogenesis of PCOS remain unclear. …”
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Exploring the impact of pregnancy on cognitive function: a comparative study in a low-income setting by Syed Aman Ali, Muhammad Sualeh, Ghana Raza, Mohammad Sabeeh ul haq, Laiba Hissan, Duaa Zafar, Muhammad Adnan, Syed Kauser Ali

“…Abstract Background Cognitive dysfunction is a significant contributor to mental health complexities during pregnancy, potentially leading to heightened rates of pregnancy-related mortality and inadequate prenatal care. …”
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Analysis of the correlation between RFC4 expression and tumor immune microenvironment and prognosis in patients with cervical cancer by Bifen Huang, Jianqing Zheng, Bizhen Chen, Min Wu, Lihua Xiao

“…However, patients with high RFC4 expression in CC have a better prognosis, possibly because RFC4 exerts antitumor effects by affecting the immunostimulatory tumor microenvironment, such as immunostimulatory and dendritic cell infiltration.…”
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Molecular and clinical profiles of T2DM, dyslipidemia, and periodontitis: insights into inflammatory and metabolic dysregulation by Peace Ngozi Okoro, Peace Ngozi Okoro, George Oche Ambrose, Victor Emmanuel Obaro, Chidiebere Valentine Ugwueze, Chidiebere Valentine Ugwueze, J. K. Olarinoye, Olalekan A. Agede

“…These findings underscore the need for personalized, sex-specific strategies to manage these comorbidities effectively.…”
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The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio and preserved ratio impaired spirometry: NHANES 2007–2012 by Qilei Zhu, Ran He, Yiqin Yan, Lihan Xiang, Yarong Li, Yi Yang, Dandan Hu, Liming Lou

“…This study offers distinctive perspectives that may contribute to the avoidance and management of early-stage pulmonary dysfunction.…”
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Intrathecal drug delivery systems: A case series advancing surgical, clinical, and technological safety with broader implications for invasive neuromodulation therapies by Bi Mo, Sandra Sacks, Jerry Markar

“…Although intrathecal drug delivery systems offer the potential for reduced systemic adverse effects compared to conventional routes, they are not without significant complications, including infections, device dysfunction, and severe neurological injuries. …”
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Correlation between serum thyroid hormone and lipid in patients with chronic kidney disease by HUANG Hai-ming, XIAO Xiao-fen, WANG Xiao-qin

“…Objective To study the changes of serum thyroid hormone(TH) and the underlying effects on lipid in patients with chronic kidney disease(CKD) stage3~5.Methods Serum free triiodothyronine(FT3),free thyroxine(FT4),and sensitive thyroid stimulating hormones(s-TSH) concentrations in 120 patients with CKD stage3~5 in hospital and 50 normal-control subjects were measured by a specific radioimmunoassay.Serum total cholesterol(TO,triglycerides(TG),high density lipoprotein(HDL-C),low density lipoprotein(LDL-C),serum creatinine(SCr),blood urea nitrogen(BUN),uric acid(UA),albumin(Alb) concentrationswere measured by a automatic biochemical analyzer,estimated glomerular filtration rate(eGFR) were measured by SCr.Results According to the analysis,serum contents of both FT3 and FT4 were significantly lower in patients with CKD stage3~5than in normal controls(P<0.01,P<0.05,respectively),and their s-TSH contents were not different compared with normal controls(P>0.05).CKD patients had significantly higher serum TG,TC and LDL-C contents than normal controls(P<0.01,P<0.01,P<0.05,respectively),but their HDL-C content is not more different than normal controls(P<0.05).Pearson correlation analysis revels negative correlation betweeen FT3 and TG,TC(r=- 0.288,P<0.05;r=- 0.312,P<0.05),but positive correlation between FT3 and HDL-C,Alb,Hb 0=0.356,P<0.01;r = 0.199,P<0.05;r=0.266,P<0.01;r=0.276,P<0.01).Negative correlation betweeen TC,LDL-C and FT4 were found(r=-0.199,P<0.01;r=- 0.297,P<0.05),and positive correlation between FT4 and eGFR,Alb,Hb(r=0.405,P<0.01;r=0.237,P<0.01;r=0.24,P<0.01),but there is no evidence correlaiton between FT4 and TG,HDL-C,eGFR,TG,TC,HDL-C,LDL-C are not correlated with s-TSH,except Alb.The results of regressive analysis showed that the independent risk factor of hyperlipidemia was eGFR and FT3,that TC was negatively related to eGFR(P<0.01).Conclusions It is very common in middle and advanced stage CKD patients with thyroid dysfunction,which mailnly presents low T3 syndrome and closely related to severity of renal damage.Hyperlipidemia is very common in CKD patients.The risk factors are complicated,which eGFR and FT3 are independent causes of dyslipidemia in CKD patients.…”
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Electroacupuncture Alleviates Neuropathic Pain and Negative Emotion in Mice by Regulating Gut Microbiota by Feng C, Pan H, Zhang Y, Ye Z, Zhou Y, Zou H, Wang K

“…To investigate the impact of gut microbiota on CCI mice, we employed a variety of methods, including various behavioral tests and 16S ribosomal DNA (rDNA) sequencing.Results: The results indicated that EA significantly ameliorated mechanical allodynia and emotional dysfunction induced by CCI in mice. Analysis through 16S rDNA sequencing revealed that the gut microbiota of NP model mice exhibited a marked increase in diversity. …”
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SURGICAL TREATMENT CHOICE FOR PATIENTS WITH NON-RESECTABLE PANCREATIC HEAD CANCER by Borys H. Bezrodnyi, Ihor V. Kolosovych, Yevhenii O. Nesteruk

“…The authors evaluated the effect of multiple organ failure and the Karnofsky index on the choice of patient treatment strategy, on the immediate and remote results, as well as the quality of life of patients in the postoperative period, using the EORTC QLQ-C30 V.3 and EORTC QLQ-PAN26 questionnaires. …”
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Efficacy of elongated needles for motor and balance function after a stroke: a systematic review and meta-analysis by Shuyan Zhang, Haichun Zhou

“…Therefore, the clinical effectiveness of this treatment still requires additional validation. …”
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