TRIM25‐Mediated INSIG1 Ubiquitination Promotes MASH Progression Through Reprogramming Lipid Metabolism by Hao Zhang, Xiangxu Kong, Wei Wang, Huaxin Zhou, Haoran Qu, Zhengyao Guan, Honglei Wu, Xiangyu Zhai, Bin Jin

“…Abstract The global incidence of Metabolic dysfunction‐associated steatohepatitis (MASH) is increasing, highlighting the urgent need for new treatment strategies. …”
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Decoding mechanisms and protein markers in lung-brain axis by Shiqian Huang, Yuxi Zhou, Haipeng Ji, Tianhao Zhang, Shiya Liu, Lulin Ma, Daling Deng, Yuanyuan Ding, Linlin Han, Shaofang Shu, Yu Wang, Xiangdong Chen

“…Moreover, we analyze how pulmonary conditions, such as pneumonia, ALI/ARDS, and asthma, contribute to neurological dysfunction. Prolonged mechanical ventilation can also contribute to cognitive impairment. …”
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Targeting microglial NAAA-regulated PEA signaling counters inflammatory damage and symptom progression of post-stroke anxiety by Tianyue Yin, Shuaijie Sun, Li Peng, Mengmeng Yang, Mengyu Li, Xinlu Yang, Fengyun Yuan, Hongrui Zhu, Sheng Wang

“…Naaa knockout or pharmacological supplementation to boost PEA pool content can effectively promote stroke recovery and alleviate anxiety-like behaviors. …”
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Adaptive Phage Therapy in the Treatment of Patients with Recurrent Pneumonia (Pilot Study) by N. V. Beloborodova, A. V. Grechko, M. M. Gurkova, A. Yu. Zurabov, F. M. Zurabov, A. N. Kuzovlev, A. Yu. Megley, M. V. Petrova, V. M. Popova, I. V. Redkin, N. I. Sergeyev, E. A. Chernevskaya, M. Yu. Yuriev, A. A. Yakovlev

“…Good tolerability and absence of clinically significant side effects were observed during inhaled administration of the bacteriophage cocktail. …”
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Inhibition of miRNA-155 Alleviates High Glucose-Induced Podocyte Inflammation by Targeting SIRT1 in Diabetic Mice by Xiaolei Wang, Yanbin Gao, Wenming Yi, Yu Qiao, Hao Hu, Ying Wang, Yan Hu, Shuxin Wu, Hongfeng Sun, Taojing Zhang

“…Microinflammation plays a crucial role in podocyte dysfunction in diabetic nephropathy, but its regulatory mechanism is still unclear. …”
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Association Between Early Fluid Overload and Mortality in Critically Ill Children by Maria Anastasia Wibisono, Rina Amalia Caromina Saragih, Ayodhia Pitaloka Pasaribu, Siska Mayasari Lubis, Hendri Wijaya, Juliandi Harahap

“…These findings underscore the need to develop and evaluate strategies to mitigate the harmful effects of fluid accumulation.…”
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Tumor-associated bacteria activate PRDX1-driven glycolysis to promote immune evasion and PD-1 antibody resistance in hepatocellular carcinoma by Heng Zhang, Xi Lan, Liquan Cai, Xunfeng Gao, Feng Gao, Dan Yu, Jinlong Zhang, Jinhui Zhang, Qinwen Tai

“…In vivo, bacterial infection decreased the antitumor efficacy of PD-1 blockade by 43% (tumor volume vs. control; p = 0.008), an effect that was reversed upon PRDX1 inhibition.ConclusionOur findings identify PRDX1 as a central node in bacteria-driven metabolic reprogramming that facilitates immune evasion and resistance to PD-1 therapy in HCC. …”
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End-stage renal disease after renal cancer surgery: risk factors and overall survival by John Åkerlund, Börje Ljungberg, Sven Lundstam, Ralph Peeker, Erik Holmberg, Marianne Månsson, Anna Grenabo Bergdahl

“…This study aimed to investigate such risk factors and disclose the effect of developing ESRD, postoperatively, on overall survival. …”
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Multimodal integration of homotopic connectivity and transcriptomic signatures in major depressive disorder with sleep disorder comorbidity by Mingyu Li, Yudan Ding, Yangpan Ou, Huabing Li, Feng Liu, Dongsheng Lv, Ping Li, Bing Lang, Wenbin Guo

“…Relative to healthy controls, both MDD subgroups showed widespread network dysfunction. ROC analyses confirmed that VMHC in the precuneus and postcentral gyrus effectively distinguished MDD patients with and without SD, indicating diagnostic potential. …”
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Clinical features of hereditary transthyretin amyloidosis-polyneuropathy with transthyretin Ala97Ser(p.Ala117Ser) mutation in South Mainland China by Yeli Zhu, Jingxian Fan, Xiying Zhu, Wei Li, Zhaoyong Zhang, Hui Zheng, Zhihua Zhou, Lingchao Meng, Ruxu Zhang, Haishan Jiang

“…Eighteen patients (85.7%) had autonomic dysfunction. Cardiac, renal, and ocular dysfunctions were noted in 17 (80.9%), 4(19.0%), and 4(19.0%) patients, respectively. …”
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RORγt Mediates Angiotensin II‐Induced Pressor Responses, Microglia Activation, and Neuroinflammation by Disrupting the Blood–Brain Barrier in Rats by Yang Yu, Baojian Xue, Lei Tong, Alexander G. Bassuk, Alan K. Johnson, Shun‐Guang Wei

“…We previously demonstrated that IL‐17A promotes neuroinflammation and sympathetic excitation, contributing to cardiac dysfunction in heart failure and angiotensin II (ANG II)‐induced hypertension. …”
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COMPARATIVE STUDY FOR SUBCHRONIC TOXICITY OF VASELINE OIL AND GLYCELAX by A. V. Voronkov, A. Yu. Terekhov, I. N. Dyakova, S. A. Kuleshova, N. S. Avramenko, E. E. Zatsepina, D. I. Pozdnyakov

“…At long-term application of Vaseline oil, animals of both genders had heart disorders with possible development of arrhythmia, hepatotoxic effect, lipid exchange dysfunction. After excessive use of Glycelax the above mentioned is added with possible hemoglobin and rheological blood properties level decrease.…”
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Association of Subclinical Liver Fibrosis With Death in Patients With Coronary Artery Disease: A Post Hoc Analysis of the ISCHEMIA Trial by Tulio Caldonazo, Mohamed Rahouma, Sigrid Sandner, Bjorn Redfors, Lamia Harik, Markus Richter, Hristo Kirov, Torsten Doenst, Mario F. L. Gaudino

“…Current risk assessment models for patients with coronary artery disease undergoing percutaneous coronary intervention or coronary artery bypass grafting do not account for liver dysfunction apart from overt liver cirrhosis. We analyzed the distribution of the baseline FIB‐4 score and its association with all‐cause death in patients with coronary artery disease using data from the International Study of Comparative Health Effectiveness With Medical and Invasive Approaches (ISCHEMIA) trial. …”
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Incidental Cold Agglutinins in Lung Transplant Recipients by Isabelle Moneke, MD, Axel Semmelmann, MD, David Schibilsky, MD, Torsten Loop, MD, Elke Weinig, MD, Ömer Senbaklavaci, MD, Johannes Kalbhenn, MD, Florian Emmerich, MD

“…Most had a temperature amplitude of 4 °C; a broader temperature amplitude was detected in 9 of 78 (12%) patients. While there was no effect on overall long-term survival, cold agglutinins were associated with an increased incidence of reperfusion edema (P = 0.0002), severe primary graft dysfunction grade 2/3 (PGD2/3; P = 0.001), and early postoperative thromboembolism (P = 0.04). …”
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Outcomes of transcatheter vs surgical aortic valve replacement in pre-existing chronic liver disease patients: A meta-analysis of observational studies by Aizaz Ali, Muhammad Abdullah Ali, Asad Iqbal Khattak, Fazia Khattak, Abdullah Afridi, Touba Azeem, Umme Salma Shabbar Banatwala, Umama Alam, Ayesha Khan, Urba Jalal, Abdul Moeez, Malik W.Z. Khan, Peter Collins, Raheel Ahmed

“…Aortic valve stenosis in patients with chronic liver diseases, particularly liver cirrhosis and End-Stage Liver Disease, poses significant management challenges due to the interplay between cardiovascular and hepatic dysfunction. This systematic review and meta-analysis compared the safety and efficacy of Transcatheter Aortic Valve Replacement (TAVR) and Surgical Aortic Valve Replacement in this high-risk population. …”
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Green Coffea arabica Extract Ameliorates Testicular Injury in High-Fat Diet/Streptozotocin-Induced Diabetes in Rats by Wafa A. AL-Megrin, Manal F. El-Khadragy, Manal H. Hussein, Shahenda Mahgoub, Doaa M. Abdel-Mohsen, Heba Taha, Ashraf A. A. Bakkar, Ahmed E. Abdel Moneim, Hatem K. Amin

“…Administration of green coffee could represent a promising therapeutic agent which can help the treatment of type 2 DM-induced testicular dysfunction.…”
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Preservation of bronchial artery circulation on ex-vivo lung perfusion by Aravind Krishnan, Moeed Fawad, Stefan Elde, Elbert Heng, Alyssa Garrison, Ashley Y. Choi, Joseph Simmons, John P. McNulty, Blaine Chadwick, Chawannuch Ruaengsri, Y. Joseph Woo, John Ward MacArthur, Brandon A. Guenthart

“…This study demonstrates the feasibility of dual-circulation EVLP in a large animal model and reveals early protective effects of bronchial artery perfusion on airway tissues. …”
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Modulation of cognitive activity by plant-based extracts (Allium cepa, Coffea robusta, and Brassica oleracea) through the phosphodiesterase 4B inhibition: Insite from a Mice model... by Nazir Ahmad, Kaisun Nesa Lesa, Nanang Fakhrudin, Zullies Ikawati

“…Background: Cognitive dysfunction (CD) is a growing issue worldwide, despite extensive advancements and clinical research in therapeutic strategies. …”
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Paeoniflorin Alleviates Lipopolysaccharide-Induced Neuroinflammation and Depression Through the Keap1/Nrf2/HO-1 Signaling Pathway by Zhuoyue Hu, Xing Wang, Tian Shi, Lei Yang, Boxi Zhang, Bo Shang, Ruizhi He, Shichen Yi, Jiao He, Jing Hu, Yanjun Cao

“…This study investigates the therapeutic effects of PF on lipopolysaccharide (LPS)-induced depression-like behaviors in mice and neuroinflammation in BV2 microglial cells. …”
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Super‐Enhancer–Driven Syndecan‐4 Regulates Intercellular Communication in Hypoxic Pulmonary Hypertension by Xiaoying Wang, Xiangrui Zhu, Wei Huang, Zhaosi Wang, Jian Mei, Langlin Ou, Yunwei Chen, Cui Ma, Lixin Zhang

“…In addition, syndecan‐4 was enriched in exosomes secreted from hypoxic PASMCs, which subsequently transported and led to pulmonary artery endothelial cell dysfunction. Syndecan‐4 inhibition in hypoxia by serotype 5 adenovirus‐associated virus treatment attenuated the pulmonary artery remodeling and development of PH in vivo. …”
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