Selenium nanoparticles loaded nanofibers ameliorate cardiac function after acute myocardial infarction in rat MI model by Safieh Boroumand, Parisa Ahmadi, Faraz Sigaroodi, Mohammad Mahdi Khani, Fatemeh Ghanbari, Shahram Rabbani, Hossein Ahmadi Tafti, Asieh Heirani-Tabasi, Hossein Ghanbari

“…Objective(s): Acute myocardial infarction causes the heart to lose its proper function due to contractile dysfunction within the damaged ischemic cardiac tissue. …”
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Impact of the severe acute respiratory syndrome coronavirus 2 pandemic on the incidence of type 1 diabetes mellitus in children in Yamanashi, Japan by Tomohiro Saito, Mie Mochizuki, Kisho Kobayashi, Hiromune Narusawa, Daisuke Watanabe, Koichi Makino, Hideaki Yagasaki, Kazumasa Sato, Tomoaki Sano, Masanori Ohta, Hiroshi Yokomichi, Shin Amemiya, Koji Kobayashi

“…Abstract It has been hypothesized that the biopsychosocial stress associated with the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic, in combination with the immunological effects of SARS-CoV-2 and pancreatic β-cell dysfunction, may contribute to the onset of type 1 diabetes (T1D) in children. …”
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A new method for identifying and evaluating depressive disorders in young people based on cognitive neurocomputing: an exploratory study by Jiakang Liu, Kai Li, Kai Li, Shuwu Li, Shangjun Liu, Chen Wang, Shouqiang Huang, Yuting Tu, Bo Wang, Pengpeng Zhang, Yuntian Luo, Guanqun Sun, Tong Chen

“…The method evaluates cognitive impairments such as reduced attention, executive dysfunction, and slowed information processing speed that may exist in the youth depressive disorder population through an independently designed digital evaluation paradigm. …”
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Reversible Cortical Visual Impairment in an Adolescent Due to a Posterior Fossa Arachnoid Cyst: A Case Report by Jelena Škunca Herman, Dario Josip Živković, Ivana Orešković, Lana Knežević, Maja Malenica Ravlić, Blanka Doko Mandić, Goran Marić, Ante Vukojević, Hrvoje Sliepčević, Mia Zorić Geber, Vladimir Kalousek, Zoran Vatavuk

“…<b>Background</b>: Arachnoid cysts are typically benign and asymptomatic, but large cysts can exert a mass effect on adjacent neural structures. Based on the available literature, no cases of cortical visual impairment (CVI) in an adolescent caused by posterior fossa arachnoid cysts have been reported. …”
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Integrating network toxicology, transcriptomics, and metabolomics uncovers the hepatotoxic mechanisms of okadaic acid in LO2 cells by Zhiqiang Luo, Fulu Pan, Huixia Fan, Ruofan Guo, Jingqi Zheng, Shuo Zhang, Jiaru Shi, Wei Lin, Chen Wang, Yanli Pan, Guohua Yu

“…Further integration of transcriptomics and metabolomics revealed that OKA caused metabolic dysfunction by altering vital metabolites, including diisooctyl phthalate, gamma-glutamylglutamate, and gamma-glutamylglutamine. …”
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Adenosine deaminase mediates endothelial inflammation via an ADA1-CD26 interaction in post-COVID by Ada Kawecka, Klaudia Stawarska, Marzena Romanowska-Kocejko, Marta Żarczyńska-Buchowiecka, Agata Jędrzejewska, Alicja Braczko, Milena Deptuła, Małgorzata Zawrzykraj, Oliwia Król, Marika Frańczak, Gabriela Harasim, Michał Pikuła, Marcin Hellmann, Barbara Kutryb-Zając

“…IntroductionAdenosine deaminase (ADA) isoenzymes play a role in microvascular dysfunction following SARS-CoV-2 infection. This study analyzes the mechanisms behind ADA1-dependent endothelial inflammation in post-COVID-19 syndrome. …”
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Impact of Tributyltin (TBT) on Energy Metabolism and Redox Homeostasis in Blue Crab <i>Callinectes sapidus</i> by Leonardo Airton Ressel Simões, Rafaella Sanfelice Normann, Daniela Drosdowski, Bruna Selau, Marjoriane de Amaral, Alex Sander da Rosa Araujo, Anapaula Sommer Vinagre

“…<b>Background/Objectives</b>: Tributyltin (TBT), a potent biocide used in antifouling paints, is highly toxic to aquatic environments, causing oxidative stress, endocrine dysfunction, and metabolic disorders in aquatic organisms, including crustaceans. …”
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Microplastic exposure induces HSP90α secretion and aggravates asthmatic airway remodeling via PI3K-Akt-mTOR pathway by Mingming Xu, Jiyuan Chen, Lin Gao, Shaoxi Cai, Hangming Dong

“…It has potential side effects on human health. Microplastics can enter the human respiratory system, then deposit in the lung, destroying the structure of the bronchus and alveoli, and causing pulmonary inflammation, mucus production, and airway hyperresponsiveness, leading to the aggravation of asthma. …”
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Inflammatory Pathways in Parkinson’s Disease; A BNE Microarray Study by Pascal. F. Durrenberger, Edna Grünblatt, Francesca S. Fernando, Camelia Maria Monoranu, Jordan Evans, Peter Riederer, Richard Reynolds, David T. Dexter

“…Microarray technology contributed towards PD research with several studies to date and one gene, ALDH1A1 (Aldehyde dehydrogenase 1 family, member A1), consistently reappeared across studies including the present study, highlighting dopamine (DA) metabolism dysfunction resulting in oxidative stress and most probably leading to neuronal cell death. …”
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Strengthening monocarboxylate transporters by adiponectin receptor agonist ameliorates diabetic peripheral neuropathy by Tae Woo Kim, Sae-Jong Oum, Ji Hee Lim, Yaeni Kim, Eun Nim Kim, Yongjie Jin, Yu Ah Hong, Seung Yun Chae, Bum Soon Choi, Hye Won Kim, Cheol Whee Park

“…Abstract Background Disruption of energy support to peripheral nerves leads to dysfunction and degeneration of both neuronal axons and Schwann cells (SCs). …”
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Doublecortin regulates the mitochondrial-dependent apoptosis in glioma via Rho-A/Net-1/p38-MAPK signaling by Iqra Nadeem, Zhou Han, Hong Xiaoliang, Seyram Yao Adzraku, Piniel Alphayo Kambey, Kouminin Kanwore, Mu Peipei, Adebayo Oluwafemi Adekunle, Joseph Adu-Amankwaah, Abiola Abdulrahman Ayanlaja, Yi Zheng, Gao Dianshuai, Xiaomei Liu, Yuanjian Song

“…DCX depletion suppressed cell proliferation and enhanced the pro-apoptotic effects of temozolomide (TMZ) and γ-radiation treatment. …”
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Exploring the Impact of Mitoquinone Supplementation on Glycan Profiles in a Repeated Mild Traumatic Brain Injury Mouse Model by Mona Goli, Akeem Sanni, Sakshi Gautam, Khalil Mallah, W. Brad Hubbard, Mohammad Reslan, Muhammad Ali Haidar, Karim Halabi, Joseph Walker, Stefania Mondello, Firas Kobeissy, Yehia Mechref

“…Repeated exposure to mechanical impact can lead to metabolic and ionic imbalance, which can cause oxidative stress and worsen the cellular dysfunction initiated by the initial mild TBI (mTBI). …”
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Nrf2/UBE3B protects against acute lung injury by inhibiting ferritinophagy through the ubiquitination of NCOA4 by Yunfan Gu, Hui Dong, Yanjun Wang, Beibei Hu, Hong Jiang, Rong Hu

“…Moreover, UBE3B was involved in iron metabolism dysfunction and ferroptosis. UBE3B deficiency enhanced the process of nuclear receptor coactivator 4 (NCOA4)-mediated ferritinophagy and increased ferrous ion content, whereas overexpression of UBE3B reversed the harmful effects of Nrf2 knockdown on AECII, which may promote AECII ferroptosis. …”
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Synaptic modulation of glutamate in striatum of the YAC128 mouse model of Huntington disease by Judy Cheng, Ellen T. Koch, Daniel Ramandi, James P. Mackay, Timothy P. O’Leary, William Rees-Jones, Lynn A. Raymond

“…Results: Low-dose D2 agonist quinpirole reduced cortically-evoked glutamate release in dorsal striatum of premanifest YAC128 slices but not WT, and blocking type 1 cannabinoid receptors mitigated this effect. YAC128 corticostriatal brain slices also showed increased evoked dopamine and reduced evoked eCB release compared to WT, while acetylcholine signaling patterns remained relatively intact. …”
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Molecular constraints of sarcopenia in the ageing muscle by S. Damanti, S. Damanti, E. Senini, R. De Lorenzo, A. Merolla, S. Santoro, C. Festorazzi, M. Messina, G. Vitali, C. Sciorati, A. A. Manfredi, P. Rovere-Querini, P. Rovere-Querini

“…Concurrently, mitochondrial dysfunction, impaired proteostasis, and vascular rarefaction limit energy availability and regenerative capacity. …”
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HAX1, gene responsible for Kostmann syndrome, regulates gingival epithelial barrier function via intracellular trafficking of JAM1 by Keita Tanigaki, Tsukasa Tamamori, Naoko Sasaki, Risako Matsumura, Shunsuke Yamaga, Akito Sakanaka, Atsuo Amano, Michiya Matsusaki, Hiroki Takeuchi, Masae Kuboniwa

“…In the present study, the effects of HAX1 on gingival barrier function were investigated.ResultsExaminations of immortalized human gingival epithelial (IHGE) cells showed HAX1 localization in mitochondria. …”
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Association of Systemic Arterial Properties With Right Ventricular Morphology: The Multi‐Ethnic Study of Atherosclerosis (MESA)‐Right Ventricle Study by Nadine Al‐Naamani, Julio A. Chirinos, Payman Zamani, Robin Ruthazer, Jessica K. Paulus, Kari E. Roberts, R. Graham Barr, Joao A. Lima, David A. Bluemke, Richard Kronmal, Steven M. Kawut

“…Background Systemic arterial stiffness is recognized as a major contributor to development of left ventricular dysfunction and failure; however, the relationship of systemic arterial properties and the right ventricle (RV) is unknown. …”
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Multimodality Imaging in Aldosterone-Induced Cardiomyopathy: Early Detection and Prognostic Implications by Francesca Zoccatelli, Gabriele Costa, Matteo Merlo, Francesca Pizzolo, Simonetta Friso, Luigi Marzano

“…Chronic aldosterone excess leads to myocardial fibrosis, left ventricular hypertrophy, and diastolic dysfunction via mineralocorticoid receptor activation, oxidative stress, inflammation, and extracellular matrix dysregulation. …”
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Dopamine D2 receptor-mediated epidermal growth factor receptor signaling regulates neurogenesis in the subventricular zone of adult brain by Yea Jue Kim, Byeong Jun Kang, Jihee Seo, Sion Kim, Eun-chang Lee, Ha-yeon Cho, Donghoon Kim, Im Joo Rhyu, Ja-Hyun Baik

“…To analyze how alterations in the dopamine system, especially D2R signaling in association with EGFR, contribute to dopamine-related dysfunction in vivo, we established a D2R cell-specific EGFR-deleted animal model, Drd2-Cre; EGFRf/f mice. …”
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Thyroid Hormone Supplementation Restores Cognitive Deficit, Insulin Signaling, and Neuroinflammation in the Hippocampus of a Sporadic Alzheimer’s-like Disease Rat Model by Paulina Sepúlveda, Ana Flavia Fernandes Ferreira, Cristian Sandoval, Giovanna Bergoc, Ana Caroline Rippi Moreno, Maria Tereza Nunes, Andréa da Silva Torrão

“…Thyroid hormones play a crucial role in the development of the central nervous system and are considered pivotal to cognitive functions in the adult brain. Recently, thyroid dysfunction has been associated with Alzheimer’s disease. …”
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