GMRSP encoded by lncRNA H19 regulates metabolic reprogramming and alleviates aortic dissection by Jizhong Wang, Jitao Liu, Fan Yang, Yinghao Sun, Jiaohua Chen, Jie Liu, Tucheng Sun, Ruixin Fan, Fang Pei, Songyuan Luo, Jie Li, Jianfang Luo

“…Importantly, pharmacological activation of PKM2 via TEPP-46 abrogates the protective effects of GMRSP in vivo and in vitro. Clinical relevance is shown by elevated plasma PKM2 levels in AD patients, which correlate with poor prognosis. …”
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Psychological stress-induced systemic corticosterone directly sabotages intestinal stem cells and exacerbates colitis by Xiaole Sheng, Lanfei Jin, Zhengrong Yao, Jiaji Gu, Longtao Zhu, Andi Huang, Junxuan Peng, Xin Xu, Xiaolong Ge, Wei Zhou, Jinghao Sheng, Zhengping Xu, Rongpan Bai

“…Abstract Psychological stress has profound impacts on the gastrointestinal tract via the brain‒gut axis. However, its effects on intestinal stem cells (ISCs) and the resulting implication for intestinal homeostasis remain poorly understood. …”
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Influence of Uric Acid on Vascular and Cognitive Functions: Evidence for an Ambivalent Relationship by Francesco Baratta, Federica Moscucci, Evaristo Ettorre, Raffaella Bocale, Arrigo F. G. Cicero, Pietro Cirillo, Federica Fogacci, Ilaria Lospinuso, Carmine Savoia, Alessandro Mengozzi, Agostino Virdis, Claudio Borghi, Giovambattista Desideri

“…These discrepancies might reflect a biological ambivalence for uric acid depending on a very complex interplay of factors that include its concentrations achieved in biological fluids, the nature, and concentration of free radicals, the presence and concentration of other antioxidant molecules, potentially responsible for bi-directional effects of uric acid on brain health/functioning. …”
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Maternal behavior promotes resilience to adolescent stress in mice through a microglia-neuron axis by Hongyu Chen, Ruifeng Xu, Jianhao Wang, Feng Gao, Yida Lv, Xiang Li, Fang Li, Junqin Zhao, Xi Zhang, Jiabei Wang, Ruicheng Du, Yuke Shi, Hang Yu, Shuai Ding, Wenxin Li, Jing Xiong, Jie Zheng, Liang Zhao, Xin-Ya Gao, Zhi-Hao Wang

“…Mechanistically, this differential effect depends on maternal behavior-stimulated IGF-1, which inhibits neuronal C/EBPβ through mTORC1-induced C/EBPβ-LIP translation. …”
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Ustilaginoidin D Induces Acute Toxicity and Hepatotoxicity in Mice by Bo Wang, Xiaolong Bai, Min Zhang, Xiangxiang Liu, Muhammad Zulqar Nain Dara, Lingjing Liu, Mingming Ou, Dayong Li, Jiyang Wang, Ling Liu, Wenxian Sun

“…Although previous studies have demonstrated the inhibitory effect of ustilaginoidin D on ATP synthesis and cancer cell growth in mice, its specific health risks remain unclear. …”
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Sleep prevents brain phosphoproteome disruption to safeguard survival by Jing Ma, Juhang Liu, Yu Li, Yikui Zhao, Yu Tian, Bing Hu, Kaiyue Yan, Ying Li, Kaihang Ding, Xiangyu Wang, Huiwen Tian, Wen Si, Ketong Liu, Huiran Zhang, Chongchong Zhao, Guangfu Wang, Zhiqiang Wang

“…Brain kinase or phosphatase dysfunction influences PONE status development and leads to corresponding sleep aberration concurrently. …”
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Long‐Lasting Auditory and Vestibular Recovery Following Gene Replacement Therapy in a Novel Usher Syndrome Type 1c Mouse Model by Weinan Du, Jun Huang, Aizhen Zhang, Fangfang Zhao, Tianwen Chen, Quinn M. McDermott, Tony Zheng, Haibo Wang, Rongli Zhang, Xiaolin Zhang, Jerome Allison, Hong Zhu, Wu Zhou, Qing Yin Zheng

“…USH1C leads to deafness and vestibular dysfunction in humans. An Ush1c knockout (KO) mouse model displaying these characteristic deficits is generated in our laboratory. …”
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Bacteroides Fragilis Transplantation Reverses Reproductive Senescence by Transporting Extracellular Vesicles Through the Gut‐Ovary Axis by Yan Xiong, Xiaoxue Lu, Bohao Li, Shiyao Xu, Beibei Fu, Zhou Sha, Rong Tian, Rui Yao, Qian Li, Jingmin Yan, Dong Guo, Zixuan Cong, Yongliang Du, Xiaoyuan Lin, Haibo Wu

“…Mechanistically, miR‐1246 is enriched in EVs derived from BF‐treated intestinal cells, and these miR‐1246‐enriched EVs are transferred to ovaries, thereby effectively improving reproductive senescence by reducing oxidative stress in the ovaries. …”
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Comparative Analysis of Letrozole and Estradiol Valerate PCOS Models: Reproductive and Metabolic Outcomes with and Without High-Fat Diet by Xóchitl Acuña Escalona, Rocio Sarahy Ayala, Karla Cortez, Sophie Fernández Sánchez, Teresa Tomé-Dehesa, Verónica Díaz-Hernández, Carlos Larqué, Rene Escalona

“…Letrozole treatment led to significant weight gain and increased visceral adiposity, effects that were amplified by HFD. Conversely, EV treatment showed a tendency toward reduced body mass. …”
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Therapeutic Benefits of Tocilizumab Vary in Different Organs of a Patient with AA Amyloidosis by Masaru Matsui, Satoshi Okayama, Hideo Tsushima, Kenichi Samejima, Tomoko Kanki, Ayako Hasegawa, Katsuhiko Morimoto, Yasuhiro Akai, Masato Takano, Shiro Uemura, Chiho Ohbayashi, Yoshihiko Saito

“…In conclusion, these observations suggest that the therapeutic effects of TCZ can vary among organs in patients with AA amyloidosis.…”
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Chchd10: A Novel Metabolic Sensor Modulating Adipose Tissue Homeostasis by Xiaoping Wu, Zixuan Zhang, Jingjing Li, Jiuyu Zong, Lufengzi Yuan, Lingling Shu, Lai Yee Cheong, Xiaowen Huang, Mengxue Jiang, Zhihui Ping, Aimin Xu, Ruby L.C. Hoo

“…Notably, the beneficial effect of Chchd10 deficiency is eliminated in hypertrophic adipocytes, where p62 is strikingly reduced. …”
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Diet and gut microbiome: Impact of each factor and mutual interactions on prevention and treatment of type 1, type 2, and gestational diabetes mellitus by Davide Menafra, Mattia Proganò, Nicola Tecce, Rosario Pivonello, Annamaria Colao

“…In addition, we discuss immune dysfunction associated with gut dysbiosis and its role in type 1, type 2, and gestational DM. …”
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Unraveling the liver metabolomic profile of ADB-BUTINACA-induced hepatotoxicity by Yilei Fan, Yingyu Huang, Yi Zhou, Xing Ke, Yimei Tian, Siyue Zheng, Yang Sun, Zhongping Huang, Jing Zhou, Li Wu

“…This interaction may disrupt the coenzyme A (CoA) synthesis pathway, resulting in energy and lipid metabolism imbalances, and ultimately causing hepatotoxic effects. Cellular experiments confirmed reduced HepG2 cell viability and elevated reactive oxygen species (ROS) levels in HepG2 and Huh7 cells. …”
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Enhanced expression of dystrophin, IGF-1, CD44 and MYH3 in plasma and skeletal muscles including diaphragm of mdx mice after oral administration of Neu REFIX beta 1,3-1,6 glucan by Senthilkumar Preethy, Shuji Sakamoto, Takuma Higuchi, Koji Ichiyama, Naoki Yamamoto, Nobunao Ikewaki, Masaru Iwasaki, Vidyasagar Devaprasad Dedeepiya, Subramaniam Srinivasan, Kadalraja Raghavan, Mathaiyan Rajmohan, Rajappa Senthilkumar, Samuel JK Abraham

“…Abstract Duchenne muscular dystrophy (DMD) is a rare genetic disease, causing muscle degeneration due to lack of dystrophin with inadequate muscle regeneration culminating in muscle dysfunction. The N-163 strain of Aureobasidium Pullulans produced Beta-1,3 − 1,6-glucan (Neu REFIX) reported to be safe with anti-inflammatory and anti-fibrotic efficacy earlier, herein we evaluated its effects on muscle regeneration in mdx mice. …”
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Serotonin- and Dopamine-Related Gene Expression in db/db Mice Islets and in MIN6 β-Cells Treated with Palmitate and Oleate by L. R. Cataldo, M. L. Mizgier, D. Busso, P. Olmos, J. E. Galgani, R. Valenzuela, D. Mezzano, E. Aranda, V. A. Cortés, J. L. Santos

“…Serotonin and dopamine might contribute to NEFA-dependent β-cell dysfunction, since extracellular signal of these monoamines decreases GSIS. …”
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Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis by Hao Yang, Yongfei Chen, Yanchao Rong, Yuxi Zhou, Shuting Li, Xiaohui Li, Honglin Wu, Dongming Lv, Xiaoling Cao, Peng Wang, Jiayuan Zhu, Bing Tang, Zhicheng Hu

“…Furthermore, the hydrogel mitigated oxidative stress and cellular senescence and promoted tissue remodelling. The synergistic effects of PNS and IGF-1 within the hydrogel established a pro-regenerative microenvironment to address both pathological ageing and vascular dysfunction. …”
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PD-1 induces autophagy via the PI3K/AKT/FoxO1 pathway to promote infectious bursal disease virus replication by Qiuyu Zhang, Qiuyu Zhang, Qiuyu Zhang, Feng Yue, Guopeng Sun, Liwei Jiang, Peng Li, Yanping Zhu, Zhike Liu, Zhike Liu, Yangzhao Zhu, Ruiyan Niu, Hua He, Zilong Sun, Xuannian Wang, Xuannian Wang

“…Programmed death-1 (PD-1) is a known immunoinhibitory receptor, and its expression causes immune dysfunction in B lymphocytes, resulting in increased progression of immunosuppressive diseases. …”
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Polyethylene terephthalate microplastics affect gut microbiota distribution and intestinal damage in mice by Xiangying Sun, Yin Zhuang, Yubang Wang, Zhenbo Zhang, Lihui An, Qiujin Xu

“…Polyethylene terephthalate microplastics (PET-MPs) have been detected in the environment and human metabolites or tissues; however, their potential effects on humans under actual exposure doses remain unclear. …”
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Preclinical efficacy and safety of adeno-associated virus 5 alpha-galactosidase: A gene therapy for Fabry disease by Jolanda M.P. Liefhebber, Giso Brasser, Elisabeth A. Spronck, Roelof Ottenhoff, Lieke Paerels, Maria J. Ferraz, Lukas K. Schwarz, Nikoleta Efthymiopoulou, Chi-Lin Kuo, Paula S. Montenegro-Miranda, Melvin M. Evers, Johannes M.F.G. Aerts, Ying Poi Liu

“…We assessed the preclinical potential of AAV5-GLA for treating Fabry disease, an X-linked hereditary metabolic disorder resulting from mutations in the gene encoding GLA that lead to accumulation of the substrates globotriaosylceramide and globotriaosylsphingosine, causing heart, kidney, and central nervous system dysfunction. Effects of intravenously administered AAV5-GLA were evaluated in (1) GLA-knockout mice aged 7–8 weeks (early in disease) and 20 weeks (nociception phenotype manifestation) and (2) cynomolgus macaques during an 8-week period. …”
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A Graph-Based Multimodal Fusion Framework for Assessment of Freezing of Gait in Parkinson’s Disease by Ningcun Xu, Chen Wang, Liang Peng, Xiao-Hu Zhou, Jingyao Chen, Zhi Cheng, Zeng-Guang Hou

“…Freezing of Gait (FOG) is a significant symptom contributing to gait dysfunction in Parkinson’s disease (PD) patients. …”
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