Unlocking the dual healing powers of plant-based metallic nanoparticles: managing diabetes and tackling male infertility challenges by Ayesha Siddiqa, Rahmatullah Qureshi, Ghazala Yasmin, Shaista Rafique, Noor-Ul-Ain Zafar, Chudary Sadam Hussain, Sana ur Rehman, Neelum Naheed

“…DM impacts male reproductive health across four aspects: ejaculation, erectile dysfunction, structural alterations in reproductive organs, and alterations in semen quality. …”
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Characterization of feline nonsteroidal anti-inflammatory drug activated gene-1 (fNAG-1) and its protective function in kidney cells by Pattawika Lertpatipanpong, Hyunjin Moon, Jung Eun Seo, Minsu Kim, Seung Joon Baek

“…Future research should focus on further elucidating the molecular pathways involved and exploring therapeutic strategies to harness NAG-1 for managing obesity-related renal dysfunction in cats.…”
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ELAVL1-mediated USP29 mRNA degradation activates TAK1 driving M1 microglial polarization and neural stem cell differentiation dysregulation in spinal cord injury by Chunhe Sha, Feng Pan, Xiaodong Liu, Zhiqing Wang, Guohui Liu, Kai Huang

“…Abstract Spinal cord injury (SCI) represents a profound neurological condition characterized by motor dysfunction and sensory impairment. Microglial polarization significantly influences neurorepair and regeneration post SCI. …”
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Construction of a risk model associated with tryptophan metabolism and identification of related molecular subtypes in laryngeal squamous cell carcinoma by Feng Liu, Yanchao Qin, Wei Luo, XianHui Ruan, Lifang Lu, Bowei Feng, Jianfei Yu

“…So, in this study, the TCGA-LSCC, GSE27020, and 40 TMRGs were extracted via public databases to explore the effects of TMRGs on laryngeal squamous cell carcinoma. …”
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Long-term consumption of hydrogen-rich water provides hepatoprotection by improving mitochondrial biology and quality control in chronically stressed mice. by Qi He, Xiang Lan, Mengyuan Ding, Na Zhang

“…The liver, a pivotal organ responsible for metabolic equilibrium, is particularly vulnerable to its adverse effects. This study delves into the hepatoprotective properties of extended consumption of HRW in mice subjected to chronic stress.…”
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GDM enhanced acetylcholine induced vasoconstriction in human umbilical vein via CHRM3 and CACNA1C upregulation linked to promoter hypomethylation by Yun He, Qin Ni, Cuiyun Zhang, liulin Zhou, Shuang Li, Yu Tao, Lanhua Liu

“…Abstract Intrauterine exposure to hyperglycemia increases the risk of hypertension disorders in the offspring. Vascular dysfunction has a critical role in hypertension development. …”
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Sirtuin1 mitigates hypoxia-induced cardiomyocyte apoptosis in myocardial infarction via PHD3/HIF-1α by Yafen Chen, Shuyao Shan, Qiqi Xue, Yan Ren, Qihong Wu, Jiawei Chen, Ke Yang, Jiumei Cao

“…Notably, knockdown of Phd3 negated Sirt1’s inhibitory effect on Hif-1α, whereas Hif-1α knockdown promoted Sirt1 expression. …”
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Therapeutic Role of Additional Mirror Therapy on the Recovery of Upper Extremity Motor Function after Stroke: A Single-Blind, Randomized Controlled Trial by Xin Wen, Li Li, Xuelian Li, Huanghong Zha, Zicai Liu, Yang Peng, Xuejin Liu, Huiyu Liu, Quan Yang, Jing Wang

“…Objectives. To invest the effects of additional mirror therapy in improving upper limb motor function and activities of daily living in acute and subacute stroke patients, and further explore the effects of other factors on the efficacy of MT. …”
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Evaluation of the efficacy of enteral therapy in a patient with posttraumatic pancreatitis (clinical case) by M. S. Zhigalova, V. V. Kiselev, S. S. Petrikov, P. A. Yartsev, A. A. Ryk, Yu. S. Teterin, N. V. Shavrina, I. E. Selina, M. M. Rogal, K. V. Staleva

“…In the development of post-traumatic pancreatitis, an important role is played by microcirculatory disorders, developing against the background of inflammation and decreased capillary blood flow not only in the tissues of the pancreas, but also in other organs, including the intestine, which leads to neuroendocrine dysregulation, dysfunction and/or death of intestinal epithelial cells, disruption of the motor and evacuation functions of the intestine, and, as a consequence, the development of intestinal insufficiency syndrome.The objective was to demonstrate the effectiveness of enteral therapy in a patient with a closed abdominal injury, liver injury and posttraumatic pancreatitis.Materials and methods. …”
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Association between hand grip strength and quality of life in children with cerebral palsy: a cross-sectional study by Mshari Alghadier, Nada Almasoud, Dalia Alharthi, Omar Alrashdi, Reem Albesher

“…It is characterized by persistent motor and postural dysfunction caused by a non-progressing pathological lesion of the immature brain. …”
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Functional connectivity profiles in remitted depression and their relation to ruminative thinking by Zhuo Fang, Emma Lynn, Verner J. Knott, Natalia Jaworska

“…The triple network model suggests that dysfunction in three major brain networks – the default mode network (DMN), central executive network (CEN), and salience network (SN) – might contribute to cognitive impairments in various psychiatric disorders, including major depressive disorder (MDD). …”
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Engineered celastrol liposomes with glycyrrhizic acid augment synergistic antitumor efficacy in breast cancer by Wei Zhang, Jiping Li, Xiuli Gao, Likun Liu, Hong Liang, Liling Yue

“…Enhanced mitochondrial dysfunction (P < 0.05) and DNA (P < 0.05) damage were observed. …”
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Rivaroxaban alleviates hepatic sinusoidal obstruction syndrome in mice by modulating the gut microbiota and inhibiting the PI3K/Akt signaling pathway by Wencheng Liu, Yanbin Cheng, Xue Han, Junlin Xia, Qingyu Wei, Bing Chang, Quansheng Li

“…In addition, antimicrobial cocktail (ABX) treatment eliminated the beneficial effects of rivaroxaban on liver function and histopathological injury, whereas fecal microbiota transplantation (FMT) from rivaroxaban-treated donors significantly ameliorated liver dysfunction and histological damage in MCT-HSOS mice.DiscussionThese findings suggest that rivaroxaban alleviates hepatic sinusoidal obstruction syndrome in mice by modulating the gut microbiota and inhibiting the PI3K/Akt signaling pathway. …”
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Neuroprotective role of pyrroloquinoline quinone in folate deficiency-induced blood-brain barrier disruption by Sara Aboulhassane, Vishal Sangha, Md. Tozammel Hoque, Reina Bendayan

“…Using in vitro and in vivo models of folate deficiency, we investigated its impact on BBB integrity, inflammation, oxidative stress, mitochondrial dysfunction, and assessed PQQ’s ability to reverse these effects. …”
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Dose-escalation studies of mesenchymal stromal cell therapy for decompensated liver cirrhosis: phase Ia/Ib results and immune modulation insights by Lei Shi, Ziying Zhang, Song Mei, Zerui Wang, Zhe Xu, Weiqi Yao, Limin Liu, Mengqi Yuan, Yuefei Pan, Kaidi Zhu, Kai Liu, Fanglin Meng, Jiao Sun, Wenying Liu, Xiaohui Xie, Tengyun Dong, Lei Huang, Fanping Meng, Jun-Liang Fu, Yuanyuan Li, Chao Zhang, Xing Fan, Ming Shi, Yu Zhang, Yonggang Li, Wei-Fen Xie, Peng Zhang, Fu-Sheng Wang

“…Abstract Decompensated liver cirrhosis (DLC) is characterized by severe liver dysfunction and immune dysregulation, posing significant treatment challenges. …”
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Renin-angiotensin system inhibitors improve the clinical outcomes of COVID-19 patients with hypertension by Juan Meng, Guohui Xiao, Juanjuan Zhang, Xing He, Min Ou, Jing Bi, Rongqing Yang, Wencheng Di, Zhaoqin Wang, Zigang Li, Hong Gao, Lei Liu, Guoliang Zhang

“…The dysfunction of the renin-angiotensin system (RAS) has been observed in coronavirus infection disease (COVID-19) patients, but whether RAS inhibitors, such as angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin II type 1 receptor blockers (ARBs), are associated with clinical outcomes remains unknown. …”
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A small molecule directly targets NLRP3 to promote inflammasome activation and antitumor immunity by Xuemei Liu, Hongbin He, Minghui Qi, Zhongjun Jiang, Bolong Lin, Xiaqiong Wang, Di Wang, Ming Ma, Wei Jiang, Rongbin Zhou

“…Moreover, 2GBI treatment could overcome ICB resistance and exerted synergistic anti-tumor effects. These results suggest that targeting NLRP3 is a potential strategy to induce anti-tumor immunity and improve the efficacy of ICB.…”
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Cited4 is a sex‐biased mediator of the antidiabetic glitazone response in adipocyte progenitors by Irem Bayindir‐Buchhalter, Gretchen Wolff, Sarah Lerch, Tjeerd Sijmonsma, Maximilian Schuster, Jan Gronych, Adrian T Billeter, Rohollah Babaei, Damir Krunic, Lars Ketscher, Nadine Spielmann, Martin Hrabe de Angelis, Jorge L Ruas, Beat P Müller‐Stich, Mathias Heikenwalder, Peter Lichter, Stephan Herzig, Alexandros Vegiopoulos

“…Abstract Most antidiabetic drugs treat disease symptoms rather than adipose tissue dysfunction as a key pathogenic cause in the metabolic syndrome and type 2 diabetes. …”
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Clinical application of mesenchymal stem cells in immunosenescence: a qualitative review of their potential and challenges by Xu Wang, Dan Guo, Chengmei He, Xiaoxi Wang, Yi Wei, Fengchun Zhang, Li Wang, Yanlei Yang

“…Recent advancements have shed light on the molecular underpinnings of immune aging and pioneered novel therapeutic interventions to counteract its effects. Mesenchymal stem cells (MSCs)-a type of multipotent stromal cells with regenerative potential, low immunogenicity, and strong immunomodulatory properties-are increasingly recognized as a promising therapeutic option to reverse or alleviate immunosenescence-related dysfunction. …”
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Dissecting the Impact of Maternal Androgen Exposure on Developmental Programming through Targeting the Androgen Receptor by Haojiang Lu, Hong Jiang, Congru Li, Emilie Derisoud, Allan Zhao, Gustaw Eriksson, Eva Lindgren, Han‐Pin Pui, Sanjiv Risal, Yu Pei, Theresa Maxian, Claes Ohlsson, Anna Benrick, Sandra Haider, Elisabet Stener‐Victorin, Qiaolin Deng

“…Yet, further studies are required to understand the effects of elevated androgens on cell type‐specific placental dysfunction and fetal development. …”
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