Changes in coagulation parameters in polytrauma patients with different body mass index according to the enoxaparin-sodium dosing strategy under conventional versus restrictive flu... by М.О. Gogiya, S.V. Kursov, О.V. Markov, O.М. Kudrevych

“…Coagulopathy associated with fluid resuscitation and disseminated intravascular coagulation constitutes a devastating complication of polytrauma, leading to the development of multiple organ dysfunction syndrome. Purpose – to conduct a comparative study of the effects of intravenous fluid therapy and prophylactic low-molecular-weight heparin therapy in polytrauma patients with varying body mass indices, depending on the method of calculating infusion volume and anticoagulant dosage. …”
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Ginsenoside Rh2 repressed the progression of prostate cancer through the mitochondrial damage induced by mitophagy and ferroptosis by Zhen He, Zhen He, Jianxi Shi, Bing Zhu, Zhentao Tian, Zhihong Zhang, Changwen Zhang

“…It induced mitochondrial dysfunction (depolarized membrane, elevated ROS, disrupted ATP/ADP) and activated mitophagy, evidenced by upregulated PINK1/Parkin, reduced VDAC1/TOM20, and autophagosome accumulation. …”
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Taurine Alleviates Pancreatic β‐Cell Senescence by Inhibition of p53 Pathway by Baomin Wang, Ziyan Wang, Yumei Yang, Melody Yuen Man Ho, Runyue Yang, Huizi Yang, Siyi Liu, Huige Lin, Kenneth King Yip Cheng, Xiaomu Li

“…We and others previously demonstrated that p53 activation triggers β‐cell senescence and dysfunction in aging, but how its activity is controlled remains incompletely understood. …”
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Natural epigallocatechin-3-gallocarboxylate nanoformulation loaded doxorubicin to construct a novel and low cardiotoxicity chemotherapeutic drug for high-efficiency breast cancer t... by Ke Wang, Siqi Geng, Fang Wang, Baoru Fang, Huifeng Qian, Ying Li, Yiqing Zhou, Yanping Chen, Zhangsen Yu

“…According to current studies, the oxidative stress caused by the imbalance of reactive oxygen species (ROS) and reactive nitrogen species (RNS) production and mitochondrial dysfunction in myocardial cells are closely related to DIC. …”
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Investigating Bergamot Essential Oil (BEO) Properties: Cytoprotection in Neuronal Cells Exposed to Heavy Metals and Antibacterial Activities by Alexia Barbarossa, Rosanna Mallamaci, Eleonora Spinozzi, Filippo Maggi, Maria Noemi Sgobba, Antonio Rosato, Alessia Carocci, Daniela Meleleo

“…The epicarp of its fruit is a rich source of essential oil (BEO) containing mainly monoterpenes, which are known for their diverse biological activities, including antimicrobial, anti-inflammatory, antiproliferative, and neuromodulatory effects. Emerging evidence suggests that oxidative stress plays a central role in the pathogenesis of neurodegenerative diseases, particularly Alzheimer’s disease (AD), where it contributes to neuronal dysfunction and cell death. …”
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The role of sTNFSF14 in the liver mitochondrial dynamics in obese patients by A. A. Komar, D. A. Skuratovskaia, M. A. Vulf, H. Q. Vu, A. Darinskas, N. D. Gazatova, N. M. Todosenko, P. A. Zatolokin, E. V. Kirienkova, L. S. Litvinova

“…The pathogenesis of nonalcoholic fatty liver disease (NAFLD), which develops in obesity and type 2 diabetes mellitus (T2DM), is associated with the effects of inflammatory factors on the liver parenchyma and liver mitochondrial dysfunction.Aim. …”
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Xenobiotic-induced liver injury: Molecular mechanisms and disease progression by Lu Wang, Zigong Shao, Xiaobei Wang, Wenqiu Lu, Hong Sun

“…Mechanistically, xenobiotics exert hepatotoxic effects through pathways including cytochrome P450-mediated bioactivation, oxidative stress, mitochondrial impairment, DNA damage, inflammation, and immune dysregulation. …”
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Impact of online support of physical activity management using a wearable device on renal function in patients with acute coronary syndrome: a randomized controlled trial protocol by Toshimi Sato, Daisuke Suzuki, Yuichiro Sasamoto, Masahiro Ono, Namiko Shishito, Kohko Kanazawa, Akihito Watanabe, Koichi Naito, Shinichiro Morishita, Masahiro Kohzuki

“…In patients with ACS, combined renal dysfunction is associated with increased overall mortality and cardiovascular events. …”
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Dietary Choline Deprivation Exacerbates Kidney Injury in Streptozotocin-Induced Diabetes in Adult Rats by Ahmed W. Al-Humadi, Carel W. le Roux, Neil G. Docherty, Werd Al-Najim, Martin Tze Wah Kueh, Andreas C. Lazaris, Charis Liapi

“…<b>Aim</b>: This study aims to examine the effect of Ch-deprivation on the severity of kidney injury in streptozotocin (STZ)-induced diabetic rats. …”
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Exogenous TSG-6 treatment alleviates DSS-induced colitis in mice by modulating Pou2f3 and promoting tuft cells differentiation by Shaopeng Yang, Yuqi Li, Rongwei Ruan, Jiangping Yu, Bo Zhu, Haibin Lou, Xiaolan Zhang, Shi Wang

“…Abstract Background Whereas intestinal epithelial barrier dysfunction is implicated in inflammatory bowel disease (IBD), the underlying mechanisms remain elusive. …”
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Predictive study of machine learning combined with serum Neuregulin 4 levels for hyperthyroidism in type II diabetes mellitus by Huilan Gu, Ye Lu

“…Given the complex clinical characteristics of T2DM-FT patients, traditional statistical methods are often insufficient to effectively analyze nonlinear relationships among multiple variables. …”
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Integrated Data Mining and Animal Experiments to Investigate the Efficacy and Potential Pharmacological Mechanism of a Traditional Tibetan Functional Food Terminalia chebula Retz.... by Liu W, Zhang M, Tan J, Liu H, Wang L, Liao J, Huang D, Jie W, Jin X

“…Hyperuricemic rat models were treated with T. chebula to assess its effects on serum uric acid (UA) levels, renal inflammation, intestinal barrier integrity, and gut microbiota composition. …”
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Interoception as a key node in the multidimensional psychological structural model of depression: a structural equation model analysis of integrating environmental, cognitive and b... by Jikang Liu, Jiaxu Li, Tiantian Wang, Yuqing Wu, Xiaohong Liu, Xuezheng Gao, Zhenhe Zhou, Hongliang Zhou

“…EF had the largest total effect on MDD (βdirect = 0.365, βindirect = 0.150, βtotal = 0.515), IF (βdirect = − 0.309, βindirect = − 0.126, βtotal = − 0.434) are second only to EF. …”
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Sciatic nerve injury treated by acupuncture: a bibliometric study and visualization analysis by Yan Wang, Yan Wang, Fei Pei, Yahui Wang, Lijie Lv, Tianyi Li, Shujin Wang, Huan Qin

“…ObjectiveSciatic nerve injuries often lead to severe pain and motor dysfunction, causing serious impact on patients’ quality of life. …”
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Therapeutic Drug Monitoring of Antibiotics Is Needed in the Treatment of Sepsis by G. P. Plotnikov, A. N. Kudryavtsev, A. A. Kleuzovich, A. G. Chizhov, A. A. Ponomarev, S. S. Larin, E. A. Litvin, L. A. Anastasevich

“…Concentrations of drugs in blood plasma were studied by high-performance liquid chromatography with mass spectrometry. Analysis of the effectiveness of treatment was performed on the third day of therapy.Results. …”
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Oceanic feelings and their relationship to spirituality and personality organization by Sarah Straßnig, Tobias Herzl, Afrodita Latifi, Jürgen Fuchshuber, Jürgen Fuchshuber, Jürgen Fuchshuber, Paul Jimenez, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer, Human-Friedrich Unterrainer

“…Strengthening personality organization could serve as a protective factor against the destabilizing effects of negative oceanic experiences, offering insights for psychotherapy and spiritual counselling.…”
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Integrating network pharmacology and molecular docking to reveal the mechanism of Baihu Decoction in alleviating myocardial injury of heat stressed chicks by Mingyue Sun, Cuiyan Liu, Pengju Zhang, Hao Zhang, Hong Zhang, Tao Zhang, Chunyang Han

“…In conclusion, BHD effectively alleviates heat stress-induced myocardial injury and cardiac dysfunction in chicks, and its mechanism is closely associated with the inhibition of MAPK signaling pathway-mediated apoptosis. …”
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The Impact of Biodex Balance on Improving Coordination and Static Balance in Patients with Diabetic Peripheral Neuropathy by Kristo Xhardo, Elona Xhardo, Mircea Bratu, Alin Pandea, Mariana Cordun, Ana-Maria Vasiliu, Dan-Eugen Costin, George Sebastian Iacob, Marjan Mihajlov, Ilie Onu, Daniel-Andrei Iordan

“…Diabetic peripheral neuropathy (DPN), a common complication of type 2 diabetes mellitus (T2DM), significantly impairs postural control and increases fall risk due to sensory and motor nerve dysfunction. While conventional rehabilitation is widely used, the effectiveness of technology-assisted balance training remains underexplored. …”
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Empagliflozin ameliorates RSL3-induced ferroptosis in vascular endothelial cells via the NRF2/HO-1 pathway by ZiLin Wang, SiMiao Liu, JiaHao Shi, Di Chen, ShaoLin Li, ShengQin Yu, SiXu Liu, KaiJing Yang, Wan Zhang, Xue Gao, ShuYing Zhang

“…Abstract Endothelial cell dysfunction is a fundamental injury of atherosclerosis cardiovascular disease (ASCVD), closely linked to ferroptosis, which is a novel type of cell death induced by iron-dependent lipid peroxidation. …”
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Neuropsychiatric symptoms and apolipoprotein E genotypes in neurocognitive disorders by Madia Lozupone, Ivana Leccisotti, Anita Mollica, Giuseppe Berardino, Maria Claudia Moretti, Mario Altamura, Antonello Bellomo, Antonio Daniele, Vittorio Dibello, Vincenzo Solfrizzi, Emanuela Resta, Francesco Panza

“…Conversely, the APOE ε2 variant has been observed not to exert a protective effect equally in all neurodegenerative diseases. …”
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