A neuropatogenia do vírus da imunodeficiência humana Neuropathogenesis of HIV infection by Abelardo de Q-C Araújo, Alexandra Prufer Q-C Araújo, Sérgio A. Pereira Novis

“…The different neurologic manifestations caused by HIV are related to a variety of pathogenic mechanisms, as follows: immunodeficiency, autoimmunity, direct effects of the virus on the nervous system, and toxic and metabolic effects. …”
Get full text

Statin therapy for NAFLD: Molecular underpinnings of myopathic consequences and treatment strategies by Pratiksha Nanepag, Shubhada Mangrulkar, Aarti Shriwas, Mayur Kale, Sapana Kushwaha, Nitu Wankhede, Brijesh Taksande, Milind Umekar

“…Mechanistically, statins exert their beneficial effects by inhibiting cholesterol synthesis, modulating lipid metabolism, and exhibiting anti-inflammatory and antifibrotic properties. …”
Get full text

Fecal microbiota transplantation from Helicobacter pylori carriers following bismuth quadruple therapy exacerbates alcohol-related liver disease in mice via LPS-induced activation... by Huihui Gao, Hangming Bai, Yanyan Su, Yuting Gao, Hui Fang, Donghang Li, Youren Yu, Xing Lu, Dasheng Xia, Daqing Mao, Yi Luo

“…Furthermore, liver function and oxidative stress markers, including ALT, AST, MDA, GSSG/GSH ratio, and SOD, were significantly elevated, indicating severe liver dysfunction and increased oxidative stress. Finally, probiotic supplementation effectively mitigated the negative effects of BQT-induced gut microbiota remodeling on ALD in mice. …”
Get full text

Impact of pathogenic mutations of the GLUT1 glucose transporter on solute carrier dynamics using ComDYN enhanced sampling [version 2; peer review: 2 approved, 1 approved with reser... by K. Anton Feenstra, Akiko Higuchi, Kei Yura, Sanne Abeln, Halima Mouhib

“…To fully understand the impact of other mutations in the future, it is necessary to consider the effect of ligands, e.g., glucose, within the transport mechanism.…”
Get full text

Cyanidin-3-O-glucoside alleviates trimethyltin chloride-induced neurodegeneration by maintaining glutamate homeostasis through modulation of the gut microbiota by Yu Xi, Wenhui Li, Junru Wang, Meihong Yu, Xiangquan Zeng, He Li, Jian Li

“…C3G (50 mg/kg) significantly alleviated TMT-induced seizures and subsequent cognitive impairment by ameliorating hippocampal neurodegeneration and synaptic dysfunction. Furthermore, C3G treatment restored glutamate homeostasis in brain and reversed glutamine synthetase (GS) inhibition in reactive astrogliosis and neuroinflammation, which are critical for C3G’s neuroprotective effects. …”
Get full text

Endothelial Cell Inflammation and Barriers Are Regulated by the Rab26-Mediated Balance between β2-AR and TLR4 in Pulmonary Microvessel Endothelial Cells by Huaping Chen, Ming Yuan, Chunji Huang, Zhi Xu, Mingchun Li, Chun Zhang, Zhan Gao, Mingzhou Zhang, Jiancheng Xu, Hang Qian, Jiegen You, Binfeng He, Guansong Wang, Mingdong Hu

“…Here, we investigated the role of Rab26 in regulating the expression of β2-ARs and TLR4 in HPMECs and the effect of these receptors’ imbalance on endothelial cell barrier function. …”
Get full text

The Hormonal dysregulation and its consequences in Obese Women - overview by Katarzyna Maria Pala, Wiktoria Tomaszewska, Paweł Siudziński, Mateusz Łyko, Alicja Skoczylas, Maria Golińska, Anna Nowak, Jakub Kurasz, Wiktoria Podlasiewicz, Piotr Dudziak, Wojciech Maj

“…Mechanisms like insulin resistance, hyperandrogenism, and leptin dysfunction are central to these effects.   Conclusion   A multidimensional treatment approach, including lifestyle changes, pharmacotherapy (e.g., GLP-1 agonists), and surgical interventions, is essential. …”
Get full text

Sulforaphane Restores Mitochondrial β-Oxidation and Reduces Renal Lipid Accumulation in a Model of Releasing Unilateral Ureteral Obstruction by Ana Karina Aranda-Rivera, Isabel Amador-Martínez, Omar Emiliano Aparicio-Trejo, Juan Carlos León-Contreras, Rogelio Hernández-Pando, Emma Saavedra, Fernando E. García-Arroyo, José Pedraza-Chaverri, Laura Gabriela Sánchez-Lozada, Edilia Tapia

“…This study aimed to determine the therapeutic effect of pre-administering the antioxidant sulforaphane (SFN) in the RUUO model. …”
Get full text

Delayed atorvastatin delivery promotes recovery after experimental spinal cord injury by Samuel C. Buchl, Ha Neui Kim, Benjamin Hur, Whitney L. Simon, Monica R. Langley, Jaeyun Sung, Isobel A. Scarisbrick

“…Atorvastatin enhanced sensorimotor recovery within two weeks of treatment initiation, with effects persisting to the experimental endpoint. Pathway analysis showed atorvastatin enriched neural regeneration processes including Fatty Acid Transport, Axon Guidance, and the Endocannabinoid Developing Neuron Pathway; improved mitochondrial function via increased TCA Cycle II and reduced Mitochondrial Dysfunction; and decreased Inhibition of Matrix Metalloproteases. …”
Get full text

Inhalable microplastics of different shapes disrupt airway epithelial homeostasis: A comparative study of fibers and irregular particles by Yanting Li, Xinyi Zhang, Jiayin Sun, Haowen Chen, Zihao Han, Xiaoya Ji, Shuhan Tian, Sizhi Liu, Yuxin Zheng, Lianzhen Li, Jinglong Tang

“…Based on these toxic effects, fibrous microplastic resulted in more severe airway toxicity than irregular variant did. …”
Get full text

Diosgenin mitigates oxidative stress and inflammation within the hepatorenal system associated with epilepsy and alcohol use disorders in murine models by Emmanuel O. Chidebe, Benneth Ben-Azu, Benjamin Oritsemuelebi, Emuesiri G Moke, Itivere A. Omogbiya, Theresa Ezedom

“…Background: The relationship between alcohol consumption, multiorgan dysfunction and seizures is still largely unexplored. …”
Get full text

ESCRT III Regulates Lysosomal Perinuclear Clustering by Inhibiting Kinesin 1 Leading to Agnps Cytotoxicity in Human Cells by Tiantian Liu, Aiguo Xie, Chao Xing, RuiZhe He, Wei Ni, Yinbo Peng, Peng Xu, Yong Fang

“…This study investigates the role of lysosomal dysfunction in AgNP‐induced cytotoxicity, focusing on lysosomal perinuclear clustering (LPC) and its relationship with cellular apoptosis. …”
Get full text

Reduced Complexity of Pulse Rate Is Associated With Faster Cognitive Decline in Older Adults by Chenlu Gao, Andrew S. P. Lim, Shahab Haghayegh, Ruixue Cai, Jingyun Yang, Lei Yu, Agustin Ibanez, Aron S. Buchman, David A. Bennett, Lei Gao, Kun Hu, Peng Li

“…Subclinical cardiovascular functional changes, such as cardiac autonomic dysfunction, precede cardiovascular diseases and improve risk stratification. …”
Get full text

TRIM26 exacerbates pathological cardiac hypertrophy by activating TAK1 by Xiaochuang Xia, Huajing Shan, Zhaoxia Jin, Tengfei Ma, Yemao Liu, Jianqing Zhang, Han Tian, Bizhen Dong, Chengsheng Xu, Shaoze Chen

“…Mice with Trim26 deletion showed alleviated cardiomyocyte enlargement, inflammation, fibrosis, and cardiac dysfunction after TAC surgery. In PE-treated NRCMs, Trim26 overexpression promoted cardiomyocyte enlargement and inflammation, while Trim26 knockdown had the opposite effects. …”
Get full text

Preparation of Patchouli Oil Microemulsion Gel and Its Topical Application to Ameliorate Atopic Dermatitis in Mice by Tingting Chen, Changjin Xu, Min Wang, Yan Cui, Riqing Cheng, Wenyao Zhang, Xin Gao, Laibing Wang, Herima Qi, Shuyan Yu, Jianping Chen, Lan Ma, Huiqing Guo

“…Patchouli oil (PO) is a natural substance famous for its immune-enhancing and anti-inflammatory effects. Atopic dermatitis (AD) is characterized by epidermal gene mutations, skin barrier dysfunction, and immune dysregulation, making patchouli volatile oil a potential candidate for AD treatment. …”
Get full text

Late-onset Leber’s hereditary optic neuropathy and antiandrogens for prostate cancer: is there a causative link? by Giulia Amore, Giulia Amore, Michele Carbonelli, Diego D’Angeli, Luigi Bonan, Marco Faustini-Fustini, Alessandra Maresca, Valerio Carelli, Valerio Carelli, Chiara La Morgia, Chiara La Morgia

“…Late-onset cases (over 40 years of age) are usually associated to toxic exposure to tobacco smoke or drugs causing mitochondrial dysfunction.ResultsWe describe two cases of LHON remarkable for their late onset (> 60 years) in the absence of classic toxic factors. …”
Get full text

Compound exposure of 2.8 GHz and 9.3 GHz microwave causes learning and memory impairment in rats by Liu Sun, Xiaoya Wang, Ke Ren, Chuanfu Yao, Haoyu Wang, Xinping Xu, Hui Wang, Ji Dong, Jing Zhang, Binwei Yao, Xiaohui Wei, Ruiyun Peng, Li Zhao

“…However, the biological effects caused by compound microwave were largely unexplored. …”
Get full text

VEGFR3 mitigates hypertensive nephropathy by enhancing mitophagy via regulating crotonylation of HSPA1L by Qiuwen Wu, Jiaxin Fu, Bin Zhu, Wei Meng, Jingyi Ma, Ying Lv, Wenqi Zhao, Fan Wang, Jingjin Liu, Yongshun Wang, Cong Peng, Shuo Zhang

“…Activation of VEGFR3 mitigated renal dysfunction, pathological damage, and oxidative stress in Ang II-induced hypertensive mice. …”
Get full text

Berberine ameliorates septic cardiomyopathy through protecting mitochondria and upregulating Notch1 signaling in cardiomyocytes by Qi Shen, Yufan Yuan, Zelin Li, Ying Ling, Jian Wang, Mingjing Gao, Peng Wang, Mengli Li, Lizhong Lai, Jinlan Jin

“…IntroductionSeptic cardiomyopathy (SCM) arises as a consequence of sepsis-associated cardiovascular dysfunction, for which there is currently no specific targeted therapy available. …”
Get full text

UFBP1 Ameliorates Heat Stress-Induced Apoptosis via Mitochondria-Mediated Pathway in Bovine Mammary Epithelial Cells by Yuan Li, Ran Yu, Shujing Tan, Yunlong Jiang, Longwei Sun, Manman Shen, Chuanjian Zhang, Kunlin Chen, Chengmin Li

“…Therefore, the present study aimed to elucidate the effect of UFBP1 on heat stress-induced apoptosis through knockdown and overexpression of UFBP1 in BMECs. …”
Get full text