Analysis of toxicity and mechanisms of busulfan in non-obstructive azoospermia: A genomic and toxicological approach integrating molecular docking, single-cell sequencing, and expe... by Yanggang Hong, Qichao Yuan, Yi Wang, Deqi Wang, Xiaoju Guan, Congde Chen

“…Environmental pollutants, including chemical contaminants, heavy metals, and pesticides, have been linked to adverse effects on male reproductive health, particularly sperm quality. …”
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Recovery of Lysosomal Acidification and Autophagy Flux by Attapulgite Nanorods: Therapeutic Potential for Lysosomal Disorders by Yuanjing Hao, Xinru Fan, Xiaodan Huang, Zhaoying Li, Zhiyuan Jing, Guilong Zhang, Yuxue Xu, Na Zhang, Pengfei Wei

“…ATT could be effectively internalized into lysosome-related acidic compartments. …”
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Ellagic acid ameliorates cisplatin-induced acute kidney injury by regulating inflammation and SIRT6/TNF-α signaling by Yuqi Gao, Kezheng Peng, Yida Wang, Yannan Guo, Chenye Zeng, Rui Hua, Qingfei Liu, Xue Li, Ying Qiu, Zhao Wang

“…Moreover, ellagic acid ameliorated renal dysfunction, apoptosis and fibrosis induced by cisplatin in mice. …”
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Hepatoma-Derived Growth Factor Secreted from Mesenchymal Stem Cells Reduces Myocardial Ischemia-Reperfusion Injury by Yu Zhou, Panpan Chen, Qingnian Liu, Yingchao Wang, Ling Zhang, Rongrong Wu, Jinghai Chen, Hong Yu, Wei Zhu, Xinyang Hu, Jian-An Wang

“…The present study aimed to explore the major factors that account for the beneficial effects of mesenchymal stem cells (MSCs). Methods. …”
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Pathogenetic Mechanisms of the Occurrence of Rheumatoid Arthritis and Ankylosing Spondylitis with the Activation-Enzymatic and Phenotypic Features of Lymphocytes by Lychkovska N., Chopyak V., Vorobets Z.

“…The variety of visceral manifestations of inflammatory diseases testifies to the participation of universal mechanisms for the implementation of the systemic pathological process involving polypotent messengers with multifunctional effects. These universal messengers include nitrogen oxide (NO), calcium ions Ca2+, which directly or indirectly regulate various physiological and biochemical processes. …”
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Pedunculoside alleviates cognitive deficits and neuronal cell apoptosis by activating the AMPK signaling cascade by Liwei Li, Jinfeng Sun, Fan Chen, Li Xiong, Lingyu She, Tang Hao, Yuqing Zeng, Luyao Li, Wei Wang, Xia Zhao, Guang Liang

“…Abstract Background Mitochondrial dysfunction emerges as an early pathological hallmark of Alzheimer's disease (AD). …”
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Kinesio Taping versus Oromotor Therapy of Drooling in Down Syndrome: A Quasi-experimental Study by Radlia Azizah Yunus, Nilla Mayasari, Sylvia Evelyn Aritonang, Waode Nikmatiah, Wan Najwa Zohdi, Mohd Syazmin Sharial

“…Drooling is a prevalent issue for individuals with Down syndrome due to oral motor dysfunction and worsening other health complications. …”
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A randomized controlled trial of computerized cognitive training to improve working memory in individuals with elevated repetitive negative thinking: Behavioral and neural outcomes by Jessica Bomyea, Morgan M. Caudle, Nathalie Dugas, Raeanne C. Moore, Alan N. Simmons, Michael L. Thomas

“…Guided by the National Institute of Mental Health experimental therapeutics framework, this study aimed to investigate the cognitive effects and effects of two doses of a novel working memory training (WMT) intervention in individuals with elevated RNT across mood, anxiety, and traumatic stress disorders. …”
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Cassiae semen extract ameliorates hyperlipidemia in rats by modulating lipid metabolism and FcγR-mediated immune regulation by Mingyue Lv, Mingyue Lv, Yannan Zheng, Yannan Zheng, Man Yuan, Man Yuan, Errui Zhang, Min Zheng, Guangyao Liu, Min Zheng, Weiliang Gu, Hongxi Xu

“…This study aimed to investigate the effects of CSE on hyperlipidemia in rats and explore the potential mechanisms involved.Methods:Hyperlipidemic rats were induced by a high-fat diet (HFD) and treated with CSE. …”
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Impact of celastrol on mitochondrial dynamics and proliferation in glioblastoma by Lei Liang, Wenying Lv, Gang Cheng, Mou Gao, Junzhao Sun, Ning Liu, Hanbo Zhang, Baorui Guo, Jiayu Liu, Yanteng Li, Shengqiang Xie, Jiangting Wang, Junru Hei, Jianning Zhang

“…We studied the effects of Celastrol on mitochondrial dynamics, redox homeostasis, and the proliferation. …”
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Semaglutide and High-Intensity Interval Exercise Attenuate Cognitive Impairment in Type 2 Diabetic Mice via BDNF Modulation by Sijie Lai, Zhenghong Kang, Jianting Sun, Ziyu Wang, Yanzi Xu, Sisi Xing, Mengying Feng, Yiyi Wang, Hua Liu

“…This study examines the impact of high-intensity interval exercise (HIIE) alongside glucagon-like peptide-1 receptor agonist (GLP-1 RA) semaglutide on cognitive dysfunction associated with diabetes. <b data-eusoft-scrollable-element="1">Methods</b>: Db/db mice were divided into a control group, semaglutide group, HIIE group, and semaglutide combined with HIIE group to study metabolic and neurobehavioral effects. …”
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The New Phytocomplex AL0042 Extracted from Red Orange By-Products Inhibits the Minimal Hepatic Encephalopathy in Mice Induced by Thioacetamide by Loredana Vesci, Giulia Martinelli, Yongqiang Liu, Luca Tagliavento, Mario Dell’Agli, Yunfei Wu, Sara Soldi, Valeria Sagheddu, Stefano Piazza, Enrico Sangiovanni, Francesco Meneguzzo

“…Moreover, histological data confirmed the anti-inflammatory effect at liver and brain level. <b>Conclusions</b>: AL0042 treatment revealed a significant therapeutic effect on the TAA-induced MHE mouse model, curbing oxidative stress and peripheral and central inflammation, thus suggesting that its pharmacological activity deserves to be further investigated in clinical studies.…”
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The role of statins during pregnancy on maternal risk of preeclampsia: a systematic review and meta-analysis by Pantea Khalili, Zixing Zhong, Yanqing Peng

“…Secondary outcomes included the hypertensive disorders of pregnancy (HDP), preterm labor (PTB), neonatal birth defects, and neonatal intensive care unit (NICU) admission. The random-effects method (REM) or fixed-effects method (FEM) were employed depending on the heterogeneity. …”
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Association between perceived stress and MAFLD partially mediated by smoking and drinking by Yan Gong, Shengshu Wang, Jianan Jiang, Qiang Zeng, Weimin Wang, Yansong Zheng, Wenping Lv

“…BackgroundAlthough the association between stress and NAFLD has been suggested, the effect of perceived stress on MAFLD has yet to be investigated. …”
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Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…Transcriptome sequencing was performed on colon tissue and 16S rRNA gene sequencing was enforced on intestinal contents.Results: The administration of HED enhanced the survival rate of colitis mice, significantly restored body weight, DAI score, colon weight and index, spleen weight and index. HED effectively reshaped intestinal barrier dysfunction, inhibited the ratio of Th1 to Th2 cells, and preserved Th2/Th1 and Tregs/Th17 balance. …”
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17β estradiol activates autophagy and attenuates homocysteine mediated inflammation in endothelial cells through PI3K AKT MTOR signaling by Tong Yu, Dandan Zhang, Yi Yang, Yu Jiang, Jia Wang, Jing Li, Yannan Zhang, Rong Xie, Xiuqin Hong

“…As demonstrated in a preceding study, the protective effect of estradiol against vascular injury is attributable to its impact on autophagy. …”
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The Impact of Age and Pathogens Type on the Gut Microbiota in Infants with Diarrhea in Dalian, China by Qingjie Fan, Ming Yi, He Liu, Yushuang Wang, Xinke Li, Jieli Yuan, Lili Wang, Binbin Hou, Ming Li

“…Diarrhea in infants is a serious gastrointestinal dysfunction characterized by vomiting and watery bowel movements. …”
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DMF, an activator of Nrf2, could mitigate cholic-acid-induced liver damage in high-fat diet by Diana Abu-Halaka, Einat Rauchbach, Haim Zeigerman, Oren Tirosh

“…However, DMF treatment activated the Nrf2 pathway and partially mitigated the hepatotoxic effect of CA/high-fat diet, although some doses exhibited pro-oxidant effects. …”
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Chiglitazar ameliorates dehydroepiandrosterone-induced polycystic ovary syndrome in rats by Fuzhen Zhao, Wei Cui, Chengmei Fang, Yuanyuan Luo, Cheng Zhang

“…Chiglitazar, a pan-peroxisome proliferator-activated receptor (pan-PPAR) agonist, is also an insulin sensitizer; however, its therapeutic effects have not yet been studied in PCOS. We evaluated the therapeutic effects of chiglitazar in a rat model of PCOS. …”
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ANGPTL4 promoted the cognitive impairment in vascular dementia via increasing integrin/p-Syk signalings induced mitochondrial autophagy and apoptosis in the hippocampus by Chunhong Yao, Jinfeng Wang

“…A bilateral carotid artery ligation (2-VO) rat VaD was established to study the effects of ANGPTL4. Spatial memory was tested in rats using the Morris water maze. …”
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