Vestibular Infant Screening-Rehabilitation (VIS-REHAB): protocol for a randomised controlled trial on Vestibular Rehabilitation Therapy (VRT) in vestibular-impaired children by Ruth Van Hecke, Leen Maes, Ingeborg Dhooge, Marieke Fontaine, Cleo Dhondt, Frederic Acke, Lena Van den Bossche, Helen Van Hoecke, Els De Leenheer

“…Therefore, it is of utmost importance that vestibular-impaired problems are treated early and effectively through Vestibular Rehabilitation Therapy (VRT). …”
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Beta-boswellic acid facilitates diabetic wound healing by targeting STAT3 and inhibiting ferroptosis in fibroblasts by Ziyang Han, Weiping Wu, Zeming Bai, Yiping Xiu, Dapeng Zhou

“…Introducing a STAT3 inhibitor diminished the beneficial effects of β-BA on HG-induced cell dysfunction and suppressed its protective effect against ferroptosis. …”
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Transthoracic Salus Valve Feasibility Study: Short-Term Outcomes of a Transcatheter Self-Expandable Pulmonary Valve by Jun Dong, Junwu Su, Aijun Liu, Jing Du, Jing Yang, Qiangqiang Li, Bin Li, Ming Yang, Zhijun Wang, Qian Bao

“…The short-term effectiveness is clear, medium and long-term effectiveness requires longer follow-up.…”
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Dapagliflozin improves diabetic kidney disease by inhibiting ferroptosis through β-hydroxybutyrate production by Yan Tian, Chenxia Zhou, Qun Yan, Ziyi Li, Da Chen, Bo Feng, Jun Song

“…Sodium-glucose cotransporter protein 2 inhibitors (SGLT2i) are antihyperglycemic agents that provide additional renal-protective effects in patients with DKD, independent of their glucose-lowering effects. …”
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Long‐term treatment with carbamazepine restores cognitive abilities in a mouse model of KCNQ2 developmental and epileptic encephalopathy by Jordane Louis, Natalia Doudka, Marie‐Solenne Félix, Adeline Spiga Ghata, Camille Espanet, Romain Guilhaumou, Mathieu Milh, Laurent Villard

“…It is efficient to reduce or stop seizures in this context. However, its effect on the neurodevelopmental outcomes is debated. …”
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Risk of myocardial infarction and heart failure in gout patients: a systematic review and meta-analysis by Panpan Wang, Huanhuan Yang

“…Heterogeneity tests showed P = 0.15 and I 2  = 43%. Fixing effects analysis showed RR = 1.70, 95%CI = 1.57–1.83, and P < 0.001. …”
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Activation of GM-CSF and TLR2 signaling synergistically enhances antigen-specific antitumor immunity and modulates the tumor microenvironment by Shih-Jen Liu, Wan-Lun Yan, Chiao-Chieh Wu, Kuan-Yin Shen

“…Background The major challenge of antitumor immunotherapy is dealing with the immunosuppressive tumor microenvironment, which involves immature myeloid cell accumulation that results in T cell dysfunction. Myeloid cell activation is induced by Toll-like receptor agonists. …”
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Cardioprotection by poloxamer 188 is mediated through increased endothelial nitric oxide production by Gaoxian Chen, Hunter F. Douglas, Zhu Li, William J. Cleveland, Claudius Balzer, Demetris Yannopoulos, Ian Y. Chen, Detlef Obal, Matthias L. Riess

“…This cardioprotective effect was abrogated by NO inhibition, underscoring the pivotal role of NO. …”
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pPolyHb protects myocardial H9C2 cells against ischemia-reperfusion injury by regulating the Pink1-Parkin-mediated mitochondrial autophagy pathway by Wenjin Zhu, Fang Liu, Li Wang, Bo Yang, Yuwei Bai, Yanzhi Huang, Yaru Li, Wei Li, Yuemin Yuan, Chao Chen, Hongli Zhu

“…Mitochondrial dysfunction is a major contributory factor for myocardial ischemia-reperfusion (I/R) injury. …”
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AI-Driven Advances in Parkinson’s Disease Neurosurgery: Enhancing Patient Selection, Trial Efficiency, and Therapeutic Outcomes by José E. Valerio, Guillermo de Jesús Aguirre Vera, Maria P. Fernandez Gomez, Jorge Zumaeta, Andrés M. Alvarez-Pinzon

“…Parkinson’s disease (PD) is a progressive neurodegenerative disorder marked by motor and non-motor dysfunctions that severely compromise patients’ quality of life. …”
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β-ionone prevents dextran sulfate sodium-induced ulcerative colitis and modulates gut microbiota in mice by Jingjing Fang, Tingting Liu, Yumeng Wang, Seong-Gook Kang, Kunlun Huang, Tao Tong

“…β-ionone has various biological activities, such as anti-inflammatory, antimicrobial, and anticancer effects. The pathogenesis of ulcerative colitis is correlated with immune dysfunction, intestinal barrier damage, and gut microbiota imbalance. …”
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Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…In vitro experiments, compared with the OGD/R group, the bergenin group reduced the oxidative stress level, mitochondrial dysfunction and ferroptosis of H9C2 cells. We found that the protective effect of bergenin on the myocardium was abrogated by EX527. …”
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The Impact of Clinical Pharmacist Consultation on the Treatment of Multi-Drug Resistant Organisms (MDRO) Infections: A Retrospective Observational Study by Fang F, Zhai X, Bao S, Fan X, Bai R, Ma Y, Dong X

“…Multivariate analysis showed that there were significant association of liver dysfunction (adjusted OR = 0.331, 95% CI: 0.217– 0.504), severity of infection (adjusted OR = 0.292, 95% CI: 0.151– 0.562) and adopting pharmacists’ suggestions (adjusted OR = 1.987, 95% CI: 1.126– 3.507) with the effectiveness rate of consultation. …”
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Tear substitution therapy optimization of dry eye syndrome and cataract patients by S. N. Sakhnov, S. V. Yanchenko, A. V. Malyshev, A. R. Ceeva, L. M. Petrosyan, O. A. Baskakov, G. L. Kolomiec

“…Purpose: to evaluate the effectiveness of approaches to tear substitution in dry eye syndrome (DES) patients before cataract phacoemulsification (CPE). …”
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Oxytocin Protects PC12 Cells Against β-Amyloid-Induced Cell Injury by Mohammed Mufadhe Alanazi, Awatif B. Albaker, Lamia A. Alzaagi, Jawza F. Alsabhan, Fawaz Alasmari, Mohammed M. Almutairi, Metab S. Alharbi, Abdullah F. Alasmari, Faleh Alqahtani, Sary Alsanea

“…Western blotting was performed to analyze the effects on mitochondrial apoptosis and MAPK pathways. …”
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Ozone exposure and cardiovascular disease: A narrative review of epidemiology evidence and underlying mechanisms by Qiaoyi Hua, Xin Meng, Jicheng Gong, Xinghua Qiu, Jing Shang, Tao Xue, Tong Zhu

“…Ultimately, these processes contribute to vascular dysfunction and the development of CVD. However, some studies have reported the absence of associations between O3 and CVD, or even potentially protective effects of O3. …”
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Naphthalimide-polyamine conjugates: a promising avenue for targeted anticancer therapy by Zhiyong Tian, Luyao Tian, Chaojie Wang

“…We present a new Type I-VII classification approach that relates structural modifications—like heterocyclic fusion, polyamine chain adjustments, and substituent effects—to mechanistic outcomes. For example, compounds such as BND-12 inhibit metastasis in hepatocellular carcinoma by 61.8 % through ROS-induced mitochondrial dysfunction, whereas LU-79553 shows sub-micromolar effectiveness (IC50 ≤ 0.32 μM) in colorectal cancer with minimal hematotoxicity. …”
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The influence of intermittent venovenous hemodiafiltration on the course of acute kidney injury in multiple trauma victims by V.M. Dubyna, O.V. Kravets

“…HDF allowed to effectively reduce indicators of the renal complex and normalize the potassium level, and at the same time did not have a negative effect on hemostasis or other indicators of homeostasis. 72.9 % of victims needed two HDF sessions, 47.9 % — three, 31.3 % — four or more. …”
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Opioid sparing anesthesia in patients with liver cirrhosis undergoing liver resection: a controlled randomized double-blind study by Eman Sayed Ibrahim, Ahmed A. Metwally, Mohamed Abdullatif, Essam A. Eid, Mahmoud G. Mousa, Amany A. Sultan

“…Ketamine and dexmedetomidine are conventional anesthetics used in our daily practice. The opioid-sparing effects of this combination have not been evaluated in patients with liver cirrhosis undergoing liver resection. …”
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Association between family functions and antenatal depression symptoms: a cross-sectional study among pregnant women in urban communities of Hengyang city, China by Huilan Xu, Zhao Hu, Xidi Zhu, Baohua Zheng, Yunhan Yu, Wensu Zhou, Shilin Yin

“…Furthermore, self-efficacy level partially mediated the association between family functions and antenatal depressive symptoms(β=−0.05, 95% CI −0.07 to −0.03, p&lt;0.05) and the mediating effect accounted for 17.09% of the total effect.Conclusions This study reported 9.2% positive rates of antenatal depression symptoms among women in the third trimester of pregnancy in Hengyang city, China. …”
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