The mitochondrial E3 ligase MAPL SUMOylates Drp1 to facilitate mitochondrial fission in intervertebral disc degeneration by Zhidi Lin, Xiao Lu, Guangyu Xu, Jian Song, Hongli Wang, Xinlei Xia, Feizhou Lu, Jianyuan Jiang, Wei Zhu, Zuochong Yu, Xiaosheng Ma, Fei Zou

“…Additionally, mitochondrial fragmentation and dysfunction were induced by TNF-α stimulation. MAPL overexpression promoted mitochondrial SUMOylation and SUMO1 modification of Drp1, thereby facilitating the mitochondrial translocation of Drp1 and mitochondrial fission. …”
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Evaluation of the efficacy of complex analgesic therapy, including a combination of B vitamins, in patients with combination of osteoarthritis and chronic non-specific low back pai... by E. S. Filatova, A. E. Karateev, E. L. Shakhramanova, D. A. Ghukasyan, S. Yu. Shkireeva, A.  M. Lila

“…The vitamin B1, B6 and B12 complex (VBC) is frequently used to treat acute and chronic low back pain.Objective: to investigate the effect of a combination of a non-steroidal anti-inflammatory drug (NSAID) and a VBC on the main manifestations of nociceptive system dysfunction in patients with combination of osteoarthritis (OA) and chronic non-specific low back pain (NSLBP).Material and methods. …”
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From inserts to chips: microfluidic culture and 3D astrocyte co-culture drive functional and transcriptomic changes in hiPSC-derived endothelial cells by Tuuli-Maria Sonninen, Sanni Peltonen, Sara Kälvälä, Hoang-Tuan Nguyen, Marika Ruponen, Prateek Singh, Šárka Lehtonen

“…Abstract Background The blood-brain barrier (BBB) exhibits a hurdle for drug delivery and development. In addition, the dysfunction of the BBB has been seen in several neurodegenerative diseases, although the mechanisms remain poorly understood. …”
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Molecular mechanisms of diquat-induced brain injury: Insights from network toxicology and single-cell RNA sequencing by Minqi Qiu, Duo Zhao, Huahao Lin, Jinmin Zhao

“…In summary, PTGS2 likely amplifies inflammation, whereas NFE2L2 dysfunction may impair antioxidant defense, exacerbating oxidative stress. …”
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Isoginkgetin protects chondrocytes and inhibits osteoarthritis through NF-κB and P21 signaling pathway by Mengdai Xu, Xi Chen, Shasha Du, Huanhuan Xu, Changyu Liu

“…Isoginkgetin (IGK), a bioactive bioflavonoid derived from the medicinal herb Ginkgo Biloba, defends against obesity-induced heart diastolic dysfunction and harmful remodeling. Whether IGK has a regulatory effect on OA remains unknown. …”
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Clinical Efficacy and Safety of Botulinum Toxin A Injection into the Bulbospongiosus Muscle for Treating Lifelong Premature Ejaculation: A Systematic Review and Meta-Analysis by Dawei Gao, Chuyu Li, Yihan Jin, Dalin Sun, Zifeng Chen, Bo Tang, Weiping Chen, Baofang Jin

“…Adverse events occurred in 10.9% of patients, primarily erectile dysfunction ( n  = 5), and urinary disorders ( n  = 5). …”
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Cardiac structure and function in anabolic-androgenic steroid users: a 16-year follow-up study by Sigrun Halvorsen, Dan Atar, Anne Rossebø, Tea Sætereng Fyksen, Jørgen Gravning, Paul Vanberg, Ole Jørgen Grøtta

“…The aim of this study was to explore the effects of AAS on cardiac structure and function during long-term follow-up.Methods In this prospective cohort study, AAS users and strength-trained non-users were included and examined at two time points with echocardiography and coronary CT angiography. …”
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CircSmox knockdown alleviates PC12 cell apoptosis and inflammation in spinal cord injury by miR‐340‐5p/Smurf1 axis by Ziyin Han, Zufang Mou, Yulong Jing, Rong Jiang, Tao Sun

“…Abstract Background Spinal cord injury (SCI) is a traumatic central nervous system disorder that leads to irreversible neurological dysfunction. Emerging evidence has shown that differentially expressed circular RNAs (circRNAs) after SCI is closely associated with the pathophysiological process. …”
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Influence of occupational exposure to low-dose ionizing radiation on the plasma activity of superoxide dismutase and glutathione level by Đurović Branka, Spasić-Jokić Vesna, Đurović Branislav

“…During exposure to low-level doses (LLD) of ionizing radiation (IR), the most of harmful effects are produced indirectly, through radiolysis of water and formation of reactive oxygen species (ROS). …”
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Increase of serum pancreatic enzymes during hospitalization for acute heart failure by Marlene A.T. Vijver, Olivier C. Dams, Jozine M. terMaaten, Iris E. Beldhuis, Kevin Damman, Adriaan A. Voors, Robert C. Verdonk, Dirk J. vanVeldhuisen

“…Aims Acute heart failure (AHF) is associated with end‐organ dysfunction. The effect of AHF on the pancreas has not been studied. …”
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Panic Attacks in Patients with Supraventricular Tachycardia: Problems of Differential Diagnosis and Impact on Quality of Life by D. A. Tsaregorodtsev, P. A. Shelukha, L. V. Romasenko, M. M. Beraya, A. V. Sokolov

“…According to a visual analogue scale, in points from 0 to 6, we assessed the general state of our patients' health (0 points corresponded to complete health, and 6 points corresponded to a serious illness) and the effect of heartbeat on well-being (0 points - no arrhythmia, 6 points - arrhythmia «nterferes with life»).Results. …”
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Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity by Dana Battle, Xiangzhe Qiu, Marilyn Alex, London Rivers, Jamie A. G. Hamilton, Shuichi Takayama, Xueying Zhao

“…Palmitate-induced PARP cleavage, as well as endoplasmic reticulum (ER) stress and autophagy dysfunction, were blunted by triacsin C, an inhibitor of long-chain acyl-CoA synthetases. …”
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The Influence of Photoperiod on the Action of Exogenous Leptin on Gene Expression of Proinflammatory Cytokines and Their Receptors in the Thoracic Perivascular Adipose Tissue (PVAT... by Agata Krawczyńska, Andrzej P. Herman, Hanna Antushevich, Joanna Bochenek, Karolina Wojtulewicz, Dorota A. Zięba

“…In ewe, the sensitivity of PVAT on leptin action is dependent upon the photoperiodic condition with stronger effects stated in the SD season.…”
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Inulin supplementation improves some inflammatory indices, clinical outcomes, and quality of life in rheumatoid arthritis patients by Ali Tabatabaeyan, Ani Grigorian, Mansour Salesi, Awat Fiezi, Marzieh Kafeshani

“…Abstract Rheumatoid arthritis (RA) is a multifactorial autoimmune disease that causes joint dysfunction and is associated with changes in serum levels of some biomarkers. …”
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Gut Microbiome Engineering for Diabetic Kidney Disease Prevention: A <i>Lactobacillus rhamnosus GG</i> Intervention Study by Alaa Talal Qumsani

“…The <i>Prevotella</i>/<i>Bacteroides</i> ratio, an emerging marker of metabolic dysfunction, normalized following probiotic intervention in diabetic subjects. …”
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Acid sphingomyelinase promotes diabetic cardiomyopathy via disruption of mitochondrial calcium homeostasis by Yu Wei, Yang Ji, Jiahui Meng, Li Yu, Yongzhong Tang, Wei-Jin Fang

“…ASMase deletion restored HFD/STZ-induced cardiac dysfunction, remodeling, myocardial lipid accumulation and apoptosis. …”
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Galectin-3 as a Marker of Cardiorenal Syndrome in Patients with Chronic Heart Failure by V. I. Podzolkov, N. A. Dragomiretskaya, A. V. Kazadaeva, Yu. G. Belyaev, A. V. Tolmacheva

“…Aim. To assess the effect of renal dysfunction on the galectin-3 level in patients with chronic heart failure (HF) with preserved, intermediate and reduced left ventricular ejection fraction (EF).Material and methods. …”
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Disrupting Notch signaling related HES1 in myeloid cells reinvigorates antitumor T cell responses by Myung Sup Kim, Hyeokgu Kang, Jung-Hwan Baek, Moon-Gyu Cho, Eun Joo Chung, Seok-Jun Kim, Joon-Yong Chung, Kyung-Hee Chun

“…We further analyzed the TME composition, T cell infiltration and activation, and anti-tumor effects in these mice, both alone and in combination with PD-1 checkpoint blockade. …”
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Investigation of sexual life and perceived spousal support in female recipients after kidney transplantation by Sennur Kula Sahin, Semra Bulbuloglu

“…Introduction: End-stage renal failure has negative effects on sexual life, and solid kidney transplantation helps to recovery in sexuality. …”
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β-Hydroxybutyrate-induced mitochondrial DNA (mtDNA) release mediated innate inflammatory response in bovine mammary epithelial cells by inhibiting autophagy by Yihui Huo, Taiyu Shen, Tianyin Feng, Moli Li, Wanli Zhao, Juan J. Loor, Ben Aernouts, Androniki Psifidi, Chuang Xu

“…Abstract Background In perinatal dairy cows, ketosis is a prevalent metabolic disorder that lowers milk output and performance. Mitochondrial dysfunction and chronic inflammation in mammary tissue are linked to elevated blood ketone levels, particularly β-hydroxybutyrate (BHB). …”
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