Treadmill training protects valproic acid-induced autistic features via cerebellar AMPK/PPAR-γ dependent pathway and improves mitochondrial activity in mice by Anwaar M. Shaban, Omnia Ameen, Marwa Omar, Sara A. El Derbaly, Hend R. Omara, Asmaa I. Bayomi, Asmaa A. Abdel Latif, Zainab Ibrahim Elakabawy, Suzan A. Khodir

“…Endurance training could modulate mitochondrial dysfunction sharing in the pathophysiology of ASD. We investigated the neuroprotective effects of training on VPA-induced ASD in mice. …”
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Therapeutic potential of cedrol in alleviating cognitive impairments in aluminum chloride-induced Alzheimer's disease: A biomarker-based approach by Mohd Sajad, Rafat Ali, Rajesh Kumar, Nida Jamil Khan, Shadma Wahab, Saad Ali Alshehri, Sonu Chand Thakur

“…Cedrol is a bioactive sesquiterpene known for its health benefits and has been shown to reduce cellular dysfunction related to chronic conditions such as cardiovascular disease and cancer. …”
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Negative association between body roundness index and constipation: insights from NHANES by Lingting Chen, Huirong Xiao, Xuchao Yu, Bingbin Huang, Sirong Guo, Ting Yuan, Siyang Deng

“…Subgroup analyses identified significant interaction effects of BRI with age, alcohol consumption status, and hypertension on constipation risk (interaction P < 0.05). …”
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Impact of a 7-day short peptide diet on gut microbiota and metabolomics in septic mice by Dan Zuo, Binyu Zuo, Liuyang Wang, Dabi Hu, Yang Yang, Yong Chen, Biao Huang

“…A liquid chromatography-mass spectrometry-based metabolomics method was used to analyze changes in serum metabolites in septic mice.ResultsShort peptides showed effectiveness in reducing symptoms, mucosal inflammation, and intestinal function damage scores in septic mice. …”
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Exo70 Protects Against Memory and Synaptic Impairments Following Mild Traumatic Brain Injury by Matías Lira, Jorge Abarca, Rodrigo G. Mira, Pedro Zamorano, Waldo Cerpa

“…Our findings highlight Exo70’s crucial role in NMDAR trafficking, potentially counteracting oxidative stress effects. The exocyst complex may be a critical component of the machinery regulating NMDAR distribution in health and disease, particularly in pathologies featuring oxidative stress and NMDAR dysfunction, like mTBI.…”
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Quantitative comparison of mean macular thickness in COVID-19 patients versus healthy individuals using optical coherence tomography by Nagilton Bou Ghosn, Marcos Balbino, Ana Carolina Pasquini Raiza, Camila Sayuri Vicentini Otani, Victoria Moreira Fernandes, Vitor Kazuo Lotto Takahashi, Beatriz Silveira Seixas, Laura Vanalli Guimarães, Luiz Paulo Dias Mario, Regina Cele Silveira Seixas

“…These results highlight the importance of age-stratified analysis and support further investigation into the long-term ocular effects of COVID-19.…”
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Identification of RNA binding protein genes associated with colorectal cancer by bioinformatics analysis by Rong-Chao He, Haibo Wang, Jun He, Hou-Dong Wang, Zhong Shen

“…High-risk patients showed elevated tumor immune dysfunction and exclusion (TIDE) score and increased sensitivity to oxaliplatin, gemcitabine, and targeted therapies. …”
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A potential mechanism for tau protein modulating in schizophrenia with transcranial direct current stimulation intervention: A randomized controlled trial by Ali Reza Shafiee-Kandjani, Farnaz Chalabianloo, Sara Farhang, Dariush Shanehbandi, Behzad Shalchi

“…Researches indicate tau protein abnormalities may contribute to cognitive dysfunction in schizophrenia. While transcranial direct current stimulation (tDCS) shows promise in improving cognitive function, its effects on tau protein and working memory in schizophrenia remain unclear. …”
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Distinct Roles Between Eotaxin 1 and Eotaxin 2 in Asthmatic Airways by Soyoon Sim, Eun‐mi Yang, Yoo Seob Shin, Seon Beom Kim, Youngwoo Choi, Hae‐Sim Park

“…To assess neutralization effects, anti‐EOT1 or anti‐EOT2 antibodies were intranasally administered. …”
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Interdisciplinary Team Pilot to Reduce Time to Administration of Piperacillin/Tazobactam in the Emergency Department at a Veterans Affairs Medical Center by DiVittorio MM, Fisher T, Steadman B, Cone B, Elfessi Z

“…We assessed whether the change in practice had an effect on mortality in our population.Results: Patients were reviewed 6 months pre- and post-implantation of the practice changes. …”
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Novel NEK8 Mutations Cause Severe Syndromic Renal Cystic Dysplasia through YAP Dysregulation. by Valentina Grampa, Marion Delous, Mohamad Zaidan, Gweltas Odye, Sophie Thomas, Nadia Elkhartoufi, Emilie Filhol, Olivier Niel, Flora Silbermann, Corinne Lebreton, Sophie Collardeau-Frachon, Isabelle Rouvet, Jean-Luc Alessandri, Louise Devisme, Anne Dieux-Coeslier, Marie-Pierre Cordier, Yline Capri, Suonavy Khung-Savatovsky, Sabine Sigaudy, Rémi Salomon, Corinne Antignac, Marie-Claire Gubler, Alexandre Benmerah, Fabiola Terzi, Tania Attié-Bitach, Cécile Jeanpierre, Sophie Saunier

“…Ciliopathies are a group of genetic multi-systemic disorders related to dysfunction of the primary cilium, a sensory organelle present at the cell surface that regulates key signaling pathways during development and tissue homeostasis. …”
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Association Between Hyperaldosteronemia and Electrophysiological Myocardial Activity in Heart Failure with Preserved Ejection Fraction by A. N. Shevelok

“…Plasma aldosterone level has been shown to be an independent risk factor of life-threatening ventricular arrhythmia in patients with left ventricular systolic dysfunction following acute myocardial infarction. Whether either effect also occurs in patients with heart failure and preserved ejection fraction is currently unknown. …”
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Study protocol for a single-centre non-inferior double-blinded randomised controlled trial in China comparing the efficacy and safety of high-frequency irreversible electroporation... by Rui Chen, Bi-Ming He, Zhen-Kai Shi, Hai-Feng Wang

“…H-FIRE has been reported to be tissue-selective, which leads to fewer side effects. However, no data are available on whether H-FIRE is non-inferior compared with TURP in treating patients with LUTS/BPO regarding safety and efficacy.Methods and analysis This trial is a prospective, single-centre, randomised controlled, double-blinded and non-inferiority study in which all men with LUTS/BPO are included. …”
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Single-cell RNA sequencing technology was employed to construct a risk prediction model for genes associated with pyroptosis and ferroptosis in lung adenocarcinoma by Longfei Ji, Binyu Wang, Danfei Shi, Weiyun Shen, Xinmin Li, Yong Li

“…The seven gene prognostic model we constructed (CXCL2, SLC7A5, CAV1, IFNG, EPAS1, TNFAIP3, CYBB) can effectively distinguish high-risk LUAD patients. Functional enrichment analysis revealed that the IL-17 signaling pathway is active in high-risk populations, suggesting that apoptosis may promote the progression of LUAD through immune dysfunction. …”
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Insulin Modulates NK Cell Activity in Liver Fibrosis MASH Patients via the STING Pathway by Johnny Amer, Ahmad Salhab, Amiram Ariel, Rifaat Safadi

“…STING agonists (2′3′-cGAMP and DMXAA) were used to stimulate NK cells, and their effects on STING expression, NK cell activation, and cytotoxicity were measured. …”
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New-onset drug-resistant epilepsy in type 1 diabetes mellitus patient following COVID-19 vaccination: suspicious for autoimmune pathogenesis by Sally Shaaban, Nirmeen A. Kishk, Amani Nawito, Ahmed Hamdy, Hadeer Elsaeed AboElfarh, Mohamed Elfieshy, Mohamed Eladrousi, Michael Baghdadi, Marwa El Sayed Elktob, Ibrahim Elmenshawi

“…Abstract Introduction Within the spectrum of epilepsies, autoimmune-associated epilepsy (AAE) reflects the complexity of its presentations including refractory seizures along with cognitive decline and behavioral or psychiatric dysfunction. The suspicion of autoimmune epilepsy is heightened in individuals who have a pre-existing autoimmune condition, such as type 1 diabetes mellitus (T1DM). …”
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Exploring the tumor microenvironment of breast cancer to develop a prognostic model and predict immunotherapy responses by Ye Tian, Yong Yang, Lei He, Xiaocheng Yu, Hu Zhou, Juan Wang

“…Subsequently, we developed a prognostic model for patients with breast cancer. Tumor Immune Dysfunction and Exclusion (TIDE) values were used to assess patient’s responsiveness to breast cancer. …”
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Enterotype-stratified gut microbial signatures in MASLD and cirrhosis based on integrated microbiome data by Heng Yuan, Heng Yuan, Junyu Zhou, Junyu Zhou, Xuangao Wu, Shiwei Wang, Sunmin Park, Sunmin Park

“…IntroductionMetabolic dysfunction-associated steatotic liver disease (MASLD) is a growing global health challenge, characterized by significant variability in progression and clinical outcomes. …”
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Spatial characterization of RPE structure and lipids in the PEX1-p.Gly844Asp mouse model for Zellweger spectrum disorder by Samy Omri, Catherine Argyriou, Rachel S. Pryce, Erminia Di Pietro, Pierre Chaurand, Nancy Braverman

“…Zellweger Spectrum Disorder (ZSD) is caused by defects in PEX genes, whose proteins are required for peroxisome assembly and function. Peroxisome dysfunction in ZSD causes multisystem effects, with progressive retinal degeneration (RD) among the most frequent clinical findings. …”
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DDR2‐mediated autophagy inhibition contributes to angiotensin II‐induced adventitial remodeling by Gaojian Huang, Zhilei Cong, Yuhao Zhao, Tong Zhu, Ruosen Yuan, Zhen Li, Xuelian Wang, Jia Qi

“…Targeting DDR2 signalling attenuates autophagy dysfunction and inhibits AFs activation, thereby mitigating pathological adventitial remodelling. …”
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